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Dietary supplement

DMAE L-Bitartrate Ingredients & Drug Interactions

by Hard Rhino

DMAE L-Bitartrate label
See full label image
Powder Category: Non-nutrient/non-botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking DMAE L-Bitartrate against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

DMAE L-Bitartrate is a dietary supplement by Hard Rhino with 1 active ingredient. Its ingredients are commonly taken for memory and focus, mood and mental clarity, adhd-type symptoms.Based on those ingredients, 219 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are DMAE L-Bitartrate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against DMAE L-Bitartrate by Hard Rhino

Ask about any prescription or over-the-counter medication and we check it for interactions with DMAE L-Bitartrate by Hard Rhino — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of DMAE L-Bitartrate by Hard Rhino

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This is a single-ingredient powder: DMAE L-Bitartrate (also known as deanol). There are no other active ingredients.

The product contains no inactive fillers or excipients.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Deanol's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: memory and focus, mood and mental clarity.
  • We looked for evidence on: Attention deficit-hyperactivity disorder (ADHD), Cognitive function, brain health, mental clarity.
  • The closest evidence on file: Deanol is rated "Insufficient Reliable Evidence To Rate" for Attention deficit-hyperactivity disorder (ADHD) (Natural Medicines).
  • Also on file: Deanol is rated "Insufficient Reliable Evidence To Rate" for Cognitive function.

The evidence for DMAE L-Bitartrate is limited and largely unfavorable. It's rated likely ineffective for Alzheimer disease and tardive dyskinesia (a movement disorder).

For aging skin, ADHD, and athletic performance, the evidence isn't established well enough to rate it one way or the other. If you're considering this for any of those uses, the data we hold doesn't show strong support.

The evidence, ingredient by ingredient Deanol

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Deanol is generally well tolerated by mouth, but side effects do occur. The most common ones reported in trials are abdominal cramps, abdominal pain, diarrhea, drowsiness, nausea, and vomiting.

Less commonly, it's been linked to constipation, headache, insomnia, overstimulation, confusion, depression, and in people with schizophrenia, worsening of symptoms. At higher doses (above 1,000 mg daily), mood changes including depression and hypomania have been reported in people with psychiatric conditions.

The safety data in pregnancy is too limited to know either way — talk with your doctor or pharmacist for personalized advice if you're pregnant or planning to be. The data advises against use while breastfeeding because safety is unknown.

Side effects, ingredient by ingredient Deanol

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Deanol.
  • The most serious interaction on file is rated Minor.
  • For scale: 219 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this, double-check any anticholinergic drugs (used for overactive bladder and certain poisonings) or cholinergic drugs (such as those for myasthenia gravis) — deanol may decrease the effectiveness of the first group and increase the effects and side effects of the second. Use the medication checker on this page to confirm your exact prescriptions and over-the-counter drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Only minor medication interactions are documented, and safety information is well characterized.

DMAE L-Bitartrate may be worth considering if you're exploring options for cognition or skin, but the evidence for it is thin. Before you take it, check your medications against the interaction list on this page — especially if you take anticholinergic or cholinergic drugs.

If you have a history of psychiatric symptoms or schizophrenia, talk with your doctor or pharmacist first, because higher doses have been reported to affect mood. And if you're pregnant, breastfeeding, or planning either, discuss this with your own healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about DMAE L-Bitartrate, straight from the product label.

Brand Hard Rhino
Barcode (UPC) 818132961805
Net contents 125 Gram(s); 4.4 Oz(s)
Market status On market
Date entered into DSLD Mar 24, 2017
DSLD ID 72387
Product type Non-nutrient/non-botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for DMAE L-Bitartrate by Hard Rhino, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
100 mg
Maximum serving Sizes:
100 mg
Servings per container
5000
UPC/BARCODE
818132961805
IngredientAmount% DV
DMAE L-Bitartrate100 mg--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

No added fillers

Allergens: This product contains no soy, dairy, dairy byproducts, eggs, shellfish, wheat, gluten, tree nuts, or sesame seeds.

This is a non-GMO ingredient.

General Statements

Only pure ingredients

Pure powder

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 100 mg with 6-8 ounces of water or suitable beverage. Taken 1-3 times daily, preferably between meals or as recommended by your qualified health professional. A micro scale is recommended for accurate and precise measuring.

1 Carefully measure out suggested serving size using a microscale. 2 Add to preferred beverage. 3 Mix well. 4 Drink within 10-15 minutes. How to use

FDA Disclaimer Statement

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any diseases.

Precautions

Warning: Keep out of the reach of children. Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions and/or taking prescription drug(s) or OTC medication(s).

Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions and/or taking prescription drug(s) or OTC medication(s).

Always consult with a qualified health physician before taking any new dietary supplement.

Do not use or consume if pressure seal is broken.

Do not use or consume if seal is broken.

Seals/Symbols

Lab tested for purity and quality

Packaged in USA

FDA Statement of Identity

Dietary Supplement

Storage

Storage: Store in a cool, dry place. Re-seal zipper immediately after use to preserve freshness.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

DMAE L-Bitartrate by Hard Rhino label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

DMAE L-Bitartrate label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in DMAE L-Bitartrate by Hard Rhino

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size100 mg Dosage formPowder Servings per container5000 Amounts shown are per serving.

DMAE L-Bitartrate

Interacts with
219 drugs
100 mg per serving

Deanol (DMAE) is a compound related to choline that is marketed for memory, focus, and mood, but solid human evidence for most of these uses is limite...

DMAE L-Bitartrate monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

DMAE L-Bitartrate by Hard Rhino Drug Interactions

Want to check YOUR meds against DMAE L-Bitartrate?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
219Drugs
219 Minor

Ingredients driving the most interactions

DMAE L-Bitartrate 219

Individual Drug Interactions

The ingredients in DMAE L-Bitartrate interact with 219 drugs. Click any drug to see the details.

1 of the 1 ingredient in DMAE L-Bitartrate interact with drugs. Each result below shows which ingredient is responsible. DMAE L-Bitartrate

Each ingredient & the kinds of drugs it affects

For each ingredient in DMAE L-Bitartrate with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

DMAE L-Bitartrate2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, deanol might decrease the effectiveness of anticholinergic drugs.
Deanol is thought to increase acetylcholine levels.

Likelihood Unlikely Evidence D
Cholinergic Drugs

Theoretically, deanol might increase the effects and adverse effects of cholinergic drugs.
Deanol is thought to increase acetylcholine levels.

Likelihood Unlikely Evidence D
DMAE L-Bitartrate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for DMAE L-Bitartrate, from the product label.

Hard Rhino

See all Hard Rhino products
Name
Guardian Wholesale
Street Address
1607 West Whispering Wind Drive
City
Phoenix
State
AZ
ZipCode
85085
Phone Number
(866) 961-8378
Web Address
HardRhino.com
Pharmacist Counseling Corner

DMAE L-Bitartrate by Hard Rhino: Common Questions

Does DMAE L-Bitartrate by Hard Rhino interact with any medications?
Yes. Based on its ingredients, DMAE L-Bitartrate has a known interaction with 219 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
DMAE L-Bitartrate contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is DMAE L-Bitartrate and what does it do?
DMAE L-Bitartrate is a form of deanol, a compound believed to increase acetylcholine, a chemical messenger in your brain. It's been studied for memory, skin aging, and attention, but the evidence for most of these uses is either weak or not well established.
Can I take this if I'm pregnant or breastfeeding?
The safety data in pregnancy isn't clear enough to say either way — talk with your doctor or pharmacist about your personal situation. For breastfeeding, the data advises against use because safety is unknown.
What are the most common side effects?
The most frequent ones reported are abdominal cramps and pain, diarrhea, drowsiness, nausea, and vomiting. Most people tolerate it, but side effects can happen.
Does this work for Alzheimer disease or ADHD?
For Alzheimer disease, it's rated likely ineffective. For ADHD, there isn't enough reliable evidence to say whether it works or not. If you're thinking about trying it for either condition, have that conversation with your doctor or pharmacist first.
I have a psychiatric condition — should I be careful with this?
Yes. At higher doses (above 1,000 mg daily), mood changes including depression and hypomania have been reported in people with psychiatric conditions, and it's been linked to worsening of schizophrenia symptoms. Talk with your doctor or pharmacist before taking it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if DMAE L-Bitartrate is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

DMAE L-Bitartrate label
Go deeper

The Full Monographs Behind DMAE L-Bitartrate’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Deanol

Interacts with 219 drugs

Deanol (DMAE) is a compound related to choline that is marketed for memory, focus, and mood, but solid human evidence for most of these uses is limited or mixed. It can cause side effects in...

Read the full Deanol monograph →
Sources

Sources & How We Checked

DMAE L-Bitartrate's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Deanol 15 references
  1. Davies C, Maidment S, Hanley P, et al. Dimethylaminoethanol (DMAE). HSE. Risk assessment document; EH72/2;1997. (TOXLINE).
  2. Re O. 2-Dimethylaminoethanol (deanol): a brief review of its clinical efficacy and postulated mechanism of action. Curr Ther Res Clin Exp 1974;16:1238-42.
  3. Pieralisi G, Ripari P, Vecchiet L. Effects of a standardized ginseng extract combined with dimethylaminoethanol bitartrate, vitamins, minerals, and trace elements on physical performance during exercise. Clin Ther 1991;13:373-82.
  4. George J, Pridmore S, Aldous D. Double blind controlled trial of deanol in tardive dyskinesia. Aust N Z J Psychiatry 1981;15:68-71. PubMed
  5. Penovich P, Morgan JP, Kerzner B, et al. Double-blind evaluation of deanol in tardive dyskinesia. JAMA 1978;239:1997-8. DOI
  6. de Montigny C, Chouinard G, Annable L. Ineffectiveness of deanol in tardive dyskinesia: a placebo controlled study. Psychopharmacology (Berl) 1979;65:219-23. PubMed
  7. Lindeboom SF, Lakke JP. Deanol and physostigmine in the treatment of L-dopa-induced dyskinesias. Acta Neurol Scand 1978;58:134-8. PubMed
  8. Jus A, Villeneuve A, Gautier J, et al. Deanol, lithium and placebo in the treatment of tardive dyskinesia. A double-blind crossover study. Neuropsychobiology 1978;4:140-9. PubMed
  9. Lewis JA, Young R. Deanol and methylphenidate in minimal brain dysfunction. Clin Pharmacol Ther 1975;17:534-40. PubMed
  10. Fisman M, Mersky H, Helmes E. Double-blind trial of 2-dimethylaminoethanol in Alzheimer's disease. Am J Psychiatry 1981;138:970-2. PubMed
  11. Ferris SH, Sathananthan G, Gershon S, et al. Senile dementia: treatment with deanol. J Am Geriatr Soc 1977;25:241-4. PubMed
  12. Haug BA, Holzgraefe M. Orofacial and respiratory tardive dyskinesia: potential side effects of 2-dimethylaminoethanol (deanol)? Eur Neurol 1991;31:423-5. PubMed
  13. Casey DE. Mood alterations during deanol therapy. Psychopharmacology (Berl) 1979;62:187-91. PubMed
  14. Sergio W. Use of DMAE (2-dimethylaminoethanol) in the induction of lucid dreams. Med Hypotheses 1988;26:255-7. PubMed
  15. Osol A, Hoover JE, eds. Remington's Pharmaceutical Science, 15th ed. Easton, PA: Mack Publishing Company, 1975.

See these in context on the Deanol monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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