Interactions on record — worth a quick check against your medications. Based on 1 of 4 ingredients. Check your meds →
Dietary supplement

Pure CLA 1250 Ingredients & Drug Interactions

by SAN

Pure CLA 1250 label
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Softgel Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pure CLA 1250 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pure CLA 1250 is a dietary supplement by SAN with 4 active ingredients. Its ingredients are commonly taken for heart health, healthy cooking fat, skin moisturizing.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Oleic Acid. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pure CLA 1250 by SAN

Ask about any prescription or over-the-counter medication and we check it for interactions with Pure CLA 1250 by SAN — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pure CLA 1250 by SAN

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • “Conjugated Linoleic Acid” is listed as a grouped ingredient — the label gives one combined amount (1 Gram(s)) without saying how much of each component you get.
  • “ultra pure highly concentrated Safflower Oil” is listed as a grouped ingredient — the label gives one combined amount (1.25 Gram(s)) without saying how much of each component you get.

Pure CLA 1250 contains 6 active ingredients sourced from safflower oil and other fatty acid sources. The main component is conjugated linoleic acid (CLA)—a type of fat that your body uses differently than regular dietary fats.

The product also contains oleic acid, palmitic acid, stearic acid, and other isomers (slightly different molecular forms of these fatty acids). These are all delivered in softgel capsules with gelatin, glycerin, purified water, and caramel as inactive binders and capsule materials.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Oleic Acid's overall clinical evidence instead.

Moderate

Some clinical evidence supports Oleic Acid for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Coronary heart disease (CHD) — rated "Possibly Effective" (Natural Medicines).
  • On file: Hypercholesterolemia — rated "Possibly Effective" (Natural Medicines).

Oleic acid in this product is rated possibly effective for lowering cholesterol and supporting heart health. The evidence suggests it may help with both high cholesterol (hypercholesterolemia) and coronary heart disease, though the research isn't definitive.

We hold no effectiveness data for the other ingredients in the product facts on file.

The evidence, ingredient by ingredient Oleic Acid

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Oleic acid from food sources—like olive oil—is generally well tolerated and recognized as safe at normal dietary amounts. When concentrated in supplement form, though, safety data during pregnancy and breastfeeding is limited.

The facts note that food amounts are fine, but we don't have good evidence for supplement-level doses in pregnancy or while nursing. No adverse effects are listed in the data we hold.

Side effects, ingredient by ingredient Oleic Acid

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Oleic Acid.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antidiabetes drugs (blood sugar medications), check your specific medications with your pharmacist before starting Pure CLA 1250. Oleic acid in this product may increase how well these drugs work, which could lower your blood sugar more than intended.

We could not check several other ingredients in this product for interactions, so a full medication review with your own pharmacist is important.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and some safety-information gaps remain.

This product may be worth considering if you're interested in CLA supplementation and oleic acid's possible heart and cholesterol benefits. If you take diabetes medication, check with your doctor or pharmacist before starting, since oleic acid might intensify how your blood sugar drugs work.

You'll want to discuss this with your own healthcare provider, especially if you're pregnant, breastfeeding, or take any regular medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 23, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pure CLA 1250, straight from the product label.

Brand SAN
Barcode (UPC) 672898126027
Net contents 90 Softgel(s)
Market status On market
Date entered into DSLD Mar 23, 2018
DSLD ID 175260
Product type Fat/fatty Acid
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pure CLA 1250 by SAN, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
90
UPC/BARCODE
672898126027
IngredientAmount% DV
Calories12 Calorie(s)--
Stearic Acid24 mg--
Calories from Fat12 Calorie(s)--
Total Fat1 Gram(s)2%
Conjugated Linoleic Acid1 Gram(s)--
Oleic Acid100 mg--
Saturated Fat0 Gram(s)--
Palmitic Acid63 mg--
Cholesterol0 Gram(s)--
Conjugated Linoleic Acid450 mg--
Conjugated Linoleic Acid450 mg--
Other Isomers100 mg--
Trans Fat0 Gram(s)--
ultra pure highly concentrated Safflower Oil1.25 Gram(s)--

Other ingredients: Gelatin, Glycerin, purified Water, Caramel

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Recommended Use: Take 1 softgel 3-4 times daily with a meal or as directed by your health care provider.

Precautions

Warning: Do not exceed 6 softgels in any 24 hour period.

Use only under the advice of your physician if you have a medical condition or are taking medications. If you are pregnant or nursing, have heart disease, kidney disease, depression, diabetes or difficulty in urination due to enlargement of the prostate, seek the advice of a health care professional before using this product.

Keep out of reach of children.

Manufactured in a facility that also processes egg, shellfish, fish, soy, peanuts, tree nuts and milk ingredients.

Storage

Storage Instructions: Protect from heat, freezing, direct sunlight, and high humidity (above 65%). Keep container tightly closed when not in use.

Formula

Description: CLA or Conjugated Linolenic Acid is a naturally occurring fatty acid in animal tissue and food sources, including beef, poultry, eggs and dairy products such as cheeses, milk and yogurt.

Ultra pure CLA

1250 mg ultra-pure Safflower Oil

General Statements

CLA was discovered by accident in 1978 by Michael W. Pariza at the University of Wisconsin while looking for mutagen formations in meat during cooking. While small amounts can be obtained through your diet, supplementation may have been a substantial impact on how effectively our body chemically decomposes and deposits fat in our cells. Some of the more recent research has shown that use of CLA has proven to be extremely effective in reducing body fat and increasing lean muscle mass.

SAN products are manufactured under GMP (Good Manufacturing Practices) standards with stringent quality control guidelines. Additionally, each lot produced by SAN is independently tested for purity and potency by HPLC analysis to ensure only the highest quality ingredients in our innovative formulas.

Live a vibrant life!

90 full dosage servings HPLC tested & certified

General

Ver 3

Seals/Symbols

GMP Certified GMP Manufactured GMP Certified Facility

HPLC & FTIR Tested Quality approved

Made in the U.S.A.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pure CLA 1250 by SAN label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pure CLA 1250 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pure CLA 1250 by SAN

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Ultra pure highly concentrated Safflower Oil

1.25 Gram(s) per serving Form: Conjugated Linoleic Acid
  • › Stearic Acid
  • › Conjugated Linoleic Acid
  • › Oleic Acid
  • › Palmitic Acid

Other (inactive) ingredients: Gelatin, Glycerin, Purified Water, Caramel. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pure CLA 1250 by SAN Drug Interactions

Want to check YOUR meds against Pure CLA 1250?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Oleic Acid 86

Individual Drug Interactions

The ingredients in Pure CLA 1250 interact with 86 drugs. Click any drug to see the details.

1 of the 4 ingredients in Pure CLA 1250 interact with drugs. Each result below shows which ingredient is responsible. Oleic Acid

Each ingredient & the kinds of drugs it affects

For each ingredient in Pure CLA 1250 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Oleic Acid1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, oleic acid might increase the effects of antidiabetes drugs. Preliminary clinical research in patients with type 2 diabetes taking oral hypoglycemic drugs shows that eating a diet rich in oleic acid from olive oil decreases fasting blood glucose levels when compared to eating a diet rich in linoleic acid from sunflower oil. It is unknown if taking oleic acid supplements would have this effect or if this change is clinically significant. Until more is known, use caution. Dose adjustment may be necessary. Some antidiabetes drugs include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, metformin (Glucophage), pioglitazone (Actos), rosiglitazone (Avandia), and others.

Likelihood Possible Evidence B
Oleic Acid full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pure CLA 1250, from the product label.

SAN

See all SAN products
Name
San Corporation
City
Oxnard
State
CA
ZipCode
93030
Phone Number
(888) 519-9300
Web Address
www.sann.net
Pharmacist Counseling Corner

Pure CLA 1250 by SAN: Common Questions

Does Pure CLA 1250 by SAN interact with any medications?
Yes. Based on its ingredients, Pure CLA 1250 has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pure CLA 1250 contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is conjugated linoleic acid (CLA)?
CLA is a type of fat found naturally in safflower oil and other sources. Your body processes it differently than regular dietary fats. This product delivers concentrated CLA in softgel form.
Is this safe to take while pregnant or breastfeeding?
Safety data for this supplement at concentrated doses during pregnancy and breastfeeding isn't well established. While oleic acid from foods like olive oil is considered safe, we don't have solid evidence for supplement-level doses. Talk with your doctor or pharmacist for personalized advice if you're pregnant or nursing.
Can I take this if I'm on diabetes medication?
Possibly, but you'll need to check with your doctor or pharmacist first. Oleic acid in this product may boost how well your blood sugar medication works, which could lower your glucose more than expected. Your healthcare provider can help you decide if it's right for you and whether you need any monitoring.
Does this product contain any fillers?
The capsule and liquid fill contain gelatin, glycerin, purified water, and caramel as inactive ingredients—these are binders and capsule materials that help deliver the active ingredients.
Is oleic acid effective for cholesterol and heart health?
Research suggests oleic acid is possibly effective for both high cholesterol and supporting heart health. The evidence isn't conclusive, but preliminary studies are encouraging. Talk with your doctor about whether this fits your health goals.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pure CLA 1250 is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pure CLA 1250 label
Go deeper

The Full Monographs Behind Pure CLA 1250’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Oleic Acid

Interacts with 86 drugs

Oleic acid is a heart-healthy monounsaturated fat found mainly in olive oil, canola oil, avocados, and nuts. As part of a Mediterranean-style diet, it is widely viewed as a healthier replace...

Read the full Oleic Acid monograph →
Sources

Sources & How We Checked

Pure CLA 1250's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 19 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Oleic Acid 19 references
  1. Madigan C, Ryan M, Owens D, et al. Dietary unsaturated fatty acids in type 2 diabetes: higher levels of postprandial lipoprotein on a linoleic acid-rich sunflower oil diet compared with an oleic acid-rich olive oil diet. Diabetes Care 2000;23:1472-7. PubMed
  2. Gillingham, L. G., Gustafson, J. A., Han, S. Y., Jassal, D. S., and Jones, P. J. High-oleic rapeseed (canola) and flaxseed oils modulate serum lipids and inflammatory biomarkers in hypercholesterolaemic subjects. Br J Nutr 2011;105(3):417-427. PubMed
  3. Jones PJ, Senanayake VK, Pu S, Jenkins DJ, Connelly PW, Lamarche B, Couture P, Charest A, Baril-Gravel L, West SG, Liu X, Fleming JA, McCrea CE, Kris-Etherton PM. DHA-enriched high-oleic acid canola oil improves lipid profile and lowers predicted cardiova
  4. Cater, N. B., Heller, H. J., and Denke, M. A. Comparison of the effects of medium-chain triacylglycerols, palm oil, and high oleic acid sunflower oil on plasma triacylglycerol fatty acids and lipid and lipoprotein concentrations in humans. Am.J Clin.Nutr PubMed
  5. Mozaffarian D, Clarke R. Quantitative effects on cardiovascular risk factors and coronary heart disease risk of replacing partially hydrogenated vegetable oils with other fats and oils. Eur J Clin Nutr. 2009;63(Suppl 2):S22-33. PubMed
  6. Cao Y, Hou L, Wang W. Dietary total fat and fatty acids intake, serum fatty acids and risk of breast cancer: A meta-analysis of prospective cohort studies. Int J Cancer. 2016;138(8):1894-904. doi: 10.1002/ijc.29938. PubMed
  7. FDA completes review of qualified health claim petition for oleic acid and the risk of coronary heart disease. November 2018. Available at: www.fda.gov/Food/NewsEvents/ConstituentUpdates/ucm624758.htm. Accessed January 25, 2019.
  8. Liu X, Kris-Etherton PM, West SG, et al. Effects of canola and high-oleic-acid canola oils on abdominal fat mass in individuals with central obesity. Obesity. 2016;24(11):2261-2268. PubMed
  9. Bowen KJ, Kris-Etherton PM, West SG, et al. Diets enriched with conventional or high-oleic acid canola oils lower atherogenic lipids and lipoproteins compared to a diet with a western fatty acid profile in adults with central adiposity. J Nutr. 2019;149(3 PubMed
  10. Steffen BT, Duprez D, Szklo M, Guan W, Tsai MY. Circulating oleic acid levels are related to greater risks of cardiovascular events and all-cause mortality: The Multi-Ethnic Study of Atherosclerosis. J Clin Lipidol. 2018;12(6):1404-1412. PubMed
  11. Banim PJ, Luben R, Khaw KT, Hart AR. Dietary oleic acid is inversely associated with pancreatic cancer - Data from food diaries in a cohort study. Pancreatology. 2018;18(6):655-660. PubMed
  12. Morin SJ, Gaziano JM, Djoussé L. Relation between plasma phospholipid oleic acid and risk of heart failure. Eur J Nutr. 2018;57(8):2937-2942. PubMed
  13. Samieri C, Féart C, Proust-Lima C, et al. Olive oil consumption, plasma oleic acid, and stroke incidence: the Three-City Study. Neurology. 2011;77(5):418-25. PubMed
  14. Compher CW, Kinosian BP, Rubesin SE, Ratcliffe SJ, Metz DC. Energy absorption is reduced with oleic acid supplements in human short bowel syndrome. JPEN J Parenter Enteral Nutr. 2009;33(1):102-8. PubMed
  15. Ben Fradj MK, Ouanes Y, Hadj-Taieb S, et al. Decreased oleic acid and marine n?-?3 polyunsaturated fatty acids in Tunisian patients with urothelial bladder cancer. Nutr Cancer. 2018;70(7):1043-1050.
  16. de Silva PS, Luben R, Shrestha SS, Khaw KT, Hart AR. Dietary arachidonic and oleic acid intake in ulcerative colitis etiology: a prospective cohort study using 7-day food diaries. Eur J Gastroenterol Hepatol. 2014;26(1):11-8. PubMed
  17. Higashi K, Shige H, Ito T, et al. Effect of a low-fat diet enriched with oleic acid on postprandial lipemia in patients with type 2 diabetes mellitus. Lipids. 2001;36(1):1-6. PubMed
  18. Lin HC, van Citters GW, Heimer F, Bonorris G. Slowing of gastrointestinal transit by oleic acid: a preliminary report of a novel, nutrient-based treatment in humans. Dig Dis Sci. 2001;46(2):223-9. PubMed
  19. Li D, Tong Y, Li Y. Associations between dietary oleic acid and linoleic acid and depressive symptoms in perimenopausal women: The Study of Women's Health Across the Nation. Nutrition. 2020 Mar;71:110602. PubMed

See these in context on the Oleic Acid monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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