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Dietary supplement

Pure Phosphatidyl Serine Ingredients & Drug Interactions

by Intelligent Labs

Pure Phosphatidyl Serine label
See full label image
Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pure Phosphatidyl Serine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pure Phosphatidyl Serine is a dietary supplement by Intelligent Labs with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, age-related cognitive decline, attention and focus (adhd).Based on those ingredients, 219 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Phosphatidylserine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pure Phosphatidyl Serine by Intelligent Labs

Ask about any prescription or over-the-counter medication and we check it for interactions with Pure Phosphatidyl Serine by Intelligent Labs — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pure Phosphatidyl Serine by Intelligent Labs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This supplement contains one active ingredient: phosphatidylserine, a natural fatty compound found in cell membranes. It also contains methylcellulose, an inactive ingredient used to form the capsule.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: promote healthy brain function.
  • We looked for evidence on: Age-related cognitive decline, Alzheimer disease, Attention deficit-hyperactivity disorder (ADHD), Cognitive function, Dementia, Memory — and 3 related terms.
  • The strongest evidence on file: Phosphatidylserine is rated "Possibly Effective" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Phosphatidylserine is rated "Possibly Effective" for Alzheimer disease.
  • Also on file: Phosphatidylserine is rated "Insufficient Reliable Evidence To Rate" for Attention deficit-hyperactivity disorder (ADHD), Cognitive function, Dementia.

The evidence for phosphatidylserine is mixed depending on what you're taking it for. It's rated Possibly Effective for age-related cognitive decline and Alzheimer disease — those show enough promise in studies to be worth discussing with your doctor if you're concerned about memory or thinking.

For athletic performance, ADHD, general cognitive function, and dementia, the evidence isn't solid enough yet to rate whether it works.

The evidence, ingredient by ingredient Phosphatidylserine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Phosphatidylserine is generally well tolerated, but long-term safety hasn't been fully studied. The most common side effects are flatulence, stomach upset, headache, insomnia, and nausea — gas and digestive discomfort can show up at doses around 200–300 mg daily, and insomnia is more likely at higher doses (600 mg).

The safety data advises against use during pregnancy and breastfeeding; there isn't enough information to know it's safe in either situation, so talk with your doctor or pharmacist for personalized advice.

Side effects, ingredient by ingredient Phosphatidylserine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Phosphatidylserine.
  • The most serious interaction on file is rated Moderate.
  • For scale: 219 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before starting if you take anticholinergic drugs (such as those for overactive bladder or certain poisonings) or cholinergic drugs (such as those for myasthenia gravis or glaucoma) — phosphatidylserine may theoretically change how these medications work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you're interested in support for age-related memory loss or Alzheimer disease, this is a supplement worth discussing with your pharmacist. You'll want to double-check it against any anticholinergic or cholinergic medications you take — those are the main interactions to watch for.

Start with a lower dose if side effects like stomach upset or insomnia become a problem.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pure Phosphatidyl Serine, straight from the product label.

Brand Intelligent Labs
Barcode (UPC) X001R4UQKN
Net contents 90 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jul 25, 2024
DSLD ID 313161
Product type Fat/fatty Acid
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pure Phosphatidyl Serine by Intelligent Labs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
90
UPC/BARCODE
X001R4UQKN
IngredientAmount% DV
Phosphatidylserine100 mg--

Other ingredients: Methylcellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Take 1 capsule up to 3 times a day with a meal or as directed by your healthcare professional.

Precautions

Caution: If you have a medical condition, are taking any medications, or are pregnant, please consult a healthcare professional before using this or any other dietary supplement.

Warning: Consult your physician if you are pregnant or nursing, are taking medications, or have any medical conditions.

Keep out of the reach of children.

Do not use if seal is damaged or missing.

Formula

Phosphatidylserine is a phospholipid found in every cell membrane in the body. 50% of the body's stores of Phosphatidylserine are found in the brain and it promotes healthy brain function.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

100% Soy Free Animal & Gluten Free Non-GMO

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Made in USA with global Ingredients GMP Good Manufacturing Practice Quality Product

Storage

Store in a cool and dry place. Avoid excessive heat. Tighten cap when not in use.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pure Phosphatidyl Serine by Intelligent Labs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pure Phosphatidyl Serine label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pure Phosphatidyl Serine by Intelligent Labs

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Phosphatidylserine

Interacts with
219 drugs
100 mg per serving Form: Sunflower Lecithin

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinki...

Phosphatidylserine monograph & interactions

Other (inactive) ingredients: Methylcellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pure Phosphatidyl Serine by Intelligent Labs Drug Interactions

Want to check YOUR meds against Pure Phosphatidyl Serine?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
219Drugs
219 Moderate

Ingredients driving the most interactions

Phosphatidylserine 219

Individual Drug Interactions

The ingredients in Pure Phosphatidyl Serine interact with 219 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pure Phosphatidyl Serine interact with drugs. Each result below shows which ingredient is responsible. Phosphatidylserine

Each ingredient & the kinds of drugs it affects

For each ingredient in Pure Phosphatidyl Serine with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Phosphatidylserine2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically interfere with the activity of anticholinergic agents.

Likelihood Possible Evidence B
Cholinergic Drugs

Theoretically, phosphatidylserine might have additive effects with cholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically lead to additive cholinergic effects when used with cholinergic drugs.

Likelihood Possible Evidence B
Phosphatidylserine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pure Phosphatidyl Serine, from the product label.

Intelligent Labs

See all Intelligent Labs products
Name
Intelligent Labs
Street Address
4283 Express Lane Suite 447-067
City
Sarasota
State
FL
ZipCode
34238
Web Address
https://www.intelligentlabs.org
Pharmacist Counseling Corner

Pure Phosphatidyl Serine by Intelligent Labs: Common Questions

Does Pure Phosphatidyl Serine by Intelligent Labs interact with any medications?
Yes. Based on its ingredients, Pure Phosphatidyl Serine has a known interaction with 219 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pure Phosphatidyl Serine contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does phosphatidylserine do?
It's a fatty compound that may help with memory and thinking in aging and Alzheimer disease, though evidence is stronger for those two conditions than for other uses like ADHD or general cognitive sharpness.
What are the most common side effects?
Flatulence, stomach upset, headache, insomnia, and nausea. Gas and digestive trouble tend to happen at doses around 200–300 mg daily, and sleep problems are more likely if you take 600 mg or higher.
Is it safe to take during pregnancy or breastfeeding?
No — the safety data advises against use during both pregnancy and breastfeeding because there isn't enough information to know either way. Talk with your doctor or pharmacist if you're pregnant, planning to become pregnant, or nursing.
How many active ingredients are in this product?
One: phosphatidylserine. The only other ingredient is methylcellulose, which is inactive and used to make the capsule.
Can I take this with my blood pressure or heart medication?
Most blood pressure and heart medications don't have documented interactions with phosphatidylserine, but some medications like anticholinergics (used for overactive bladder) or cholinergics (used for myasthenia gravis) do. Use the medication checker on this page with your exact drugs to be sure.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pure Phosphatidyl Serine is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pure Phosphatidyl Serine label
Go deeper

The Full Monographs Behind Pure Phosphatidyl Serine’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Phosphatidylserine

Interacts with 219 drugs

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinking. Some research suggests possible bene...

Read the full Phosphatidylserine monograph →
Sources

Sources & How We Checked

Pure Phosphatidyl Serine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Phosphatidylserine 9 references
  1. Crook T, Petrie W, Wells C, Massari DC. Effects of phosphatidylserine in Alzheimer's disease. Psychopharmacol Bull 1992;28:61-6.
  2. Pepping J. Phosphatidylserine. Am J Health-Syst Pharm 1999;56:2038,2043-4.
  3. Kidd PM. Phosphatidylserine; Membrane nutrient for memory. A clinical and mechanistic assessment. Altern Med Rev 1996;1:70-84.
  4. Kim HY, Akbar M, Lau A, et al. Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3). Role of phosphatidylserine in antiapoptotic effect. J Biol Chem 2000;275:35215-23.. PubMed
  5. Zanotti A, Valzelli L, Toffano G. Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats. Psychopharmacology (Berl) 1989;99:316-21.. PubMed
  6. Schreiber S, Kampf-Sherf O, Gorfine M, et al. An open trial of plant-source derived phosphatydilserine for treatment of age-related cognitive decline. Isr J Psychiatry Relat Sci 2000;37:302-7.
  7. Pepping, J. Phosphatidylserine. Am J Health Syst.Pharm. 10-15-1999;56(20):2038, 2043-2038, 2044.
  8. Monteverde, A., Gnemmi, P., Rossi, F., Monteverde, A., and Finali, G. C. Selegiline in the treatment of mild to moderate Alzheimer-type dementia. Clin.Ther 1990;12(4):315-322.
  9. Vakhapova V, Cohen T, Richter Y, Herzog Y, Kam Y, Korczyn AD. Phosphatidylserine containing omega-3 Fatty acids may improve memory abilities in nondemented elderly individuals with memory complaints: results from an open-label extension study. Dement Geri PubMed

See these in context on the Phosphatidylserine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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