Pygeum & Saw Palmetto Ingredients & Drug Interactions
by NOW
What is this page for?
First and foremost: checking Pygeum & Saw Palmetto against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Pygeum & Saw Palmetto is a dietary supplement by NOW with 3 active ingredients. Its ingredients are commonly taken for benign prostatic hyperplasia (bph) symptoms, urinary problems, hair loss.Based on those ingredients, 175 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Saw Palmetto extract, Pumpkin seed oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Pygeum & Saw Palmetto by NOW
Ask about any prescription or over-the-counter medication and we check it for interactions with Pygeum & Saw Palmetto by NOW — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Pygeum & Saw Palmetto by NOW
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This softgel delivers 5 ingredients: saw palmetto extract, pygeum extract, pumpkin seed oil, and monounsaturated and polyunsaturated fats. The saw palmetto and pygeum are the traditional active herbal extracts marketed for prostate health.
Pumpkin seed oil is included for similar urinary and prostate support. The fats are there to aid absorption of the fat-soluble components in the capsule.
Does it work?
Strong evidence
Pygeum extract is likely effective for benign prostatic hyperplasia (BPH) — enlarged prostate — based on the evidence we have. Saw palmetto shows only possibly ineffective for BPH in our data, though it is possibly effective for one specific prostate procedure (transurethral resection of the prostate, or TURP).
Pumpkin seed oil is possibly effective for BPH as well. For other uses like hair loss or lower urinary tract symptoms, the evidence we hold is insufficient to establish whether any of these ingredients work.
How safe is it?
Well-documented data
Saw palmetto is generally well tolerated, but side effects can occur: abdominal pain, constipation, diarrhea, dizziness, fatigue, headache, nausea, and vomiting are the most common. Rare cases of heart problems have been reported.
Pygeum is also generally well tolerated short-term; nausea and abdominal pain were reported in some trials but occurred at rates similar to placebo. Pumpkin seed oil is generally well tolerated, with mild abdominal discomfort, diarrhea, nausea, and vomiting possible — very rarely, anaphylaxis.
The safety data advises against saw palmetto during pregnancy and breastfeeding. For pygeum and pumpkin seed oil, there isn't enough data to know if they're safe in pregnancy or while breastfeeding; talk with your doctor or pharmacist if you're pregnant, planning to become pregnant, or nursing.
Meds to double-check
Moderate interaction found
Before taking this product, double-check if you're on any blood thinners or antiplatelet drugs (like warfarin, aspirin, or clopidogrel) — saw palmetto may raise bleeding risk. Also confirm you're not taking estrogens or contraceptive drugs, which saw palmetto might weaken.
If you take lithium for mood or bipolar disorder, the pumpkin seed oil in here could affect your levels. Your doctor or pharmacist can review your exact medications.
The bottom line
Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This product is intended for prostate and urinary health, and pygeum has solid evidence for BPH. But if you take blood thinners, contraceptives, estrogen, or lithium, you need to check with your doctor or pharmacist first — the interactions are real.
Pregnant or breastfeeding? Talk it over with your healthcare provider before starting.
Mild digestive side effects are common and usually reversible.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 24, 2017.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Pygeum & Saw Palmetto, straight from the product label.
| Brand | NOW |
|---|---|
| Barcode (UPC) | 733739047298 |
| Net contents | 120 Softgel(s) |
| Market status | On market |
| Date entered into DSLD | May 24, 2017 |
| DSLD ID | 74537 |
| Product type | Botanical With Nutrients |
| Supplement form | Softgel Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Kosher, Adult Male (18-50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Pygeum & Saw Palmetto by NOW, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 15 Calorie(s) | -- |
| Total Fat | 1.5 Gram(s) | 2% |
| Monounsaturated Fat | 0.75 Gram(s) | -- |
| Saw Palmetto extract | 160 mg | -- |
| Polyunsaturated Fat | 0.75 Gram(s) | -- |
| Pygeum extract | 50 mg | -- |
| Pumpkin seed oil | 1.5 Gram(s) | -- |
Other ingredients: Softgel Capsule
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested Usage: Take 2 softgels twice daily with food.
General Statements
Pygeum & Saw Palmetto is a combination of botanical extracts that promote healthy urinary tract function.* Each of these plant extracts is known to help support healthy urinary flow and healthy prostate function.*
Natural color variation may occur in this product.
Softgel size
Botanicals/Herbs Family owned since 1968.
Please recycle.
Formula
NOW has utilized Pumpkin Seed Oil as a base for this product as a nutritional oil contributing essential fatty acids and phytosterols that are important for men's health.*
Men's health*
~ With Pumpkin Seed Oil
~ Supports healthy prostate function*
Triangle K
Contains gelatin
FDA Disclaimer Statement
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Formulation
Not manufactured with yeast, wheat, gluten, soy, milk, egg, fish or shellfish ingredients.
Non-GMO
Precautions
Not manufactured with yeast, wheat, gluten, soy, milk, egg, fish or shellfish ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.
Caution: For adults only.
Consult physician if pregnant/nursing, taking medication, or have a medical condition.
Keep out of reach of children.
General
CODE 4729 V5
Seals/Symbols
Non-GMO
Triangle K
GMP Quality Assured
FDA Statement of Identity
A Dietary Supplement
Storage
Store in a cool, dry place after opening.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Pygeum & Saw Palmetto by NOW label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Pygeum & Saw Palmetto by NOW
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Softgel(s) Dosage formSoftgel Capsule Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Saw Palmetto extract
Interacts with174 drugs
Saw palmetto is a plant extract most often used for urinary symptoms linked to an enlarged prostate (BPH). The best research suggests it works no bett...
Saw Palmetto extract monograph & interactionsPygeum extract
No knowninteractions
Pygeum is an extract from the bark of the African cherry tree that is most often used to ease urinary symptoms linked to an enlarged prostate. Some st...
Pygeum extract monograph & interactionsPumpkin seed oil
Interacts with1 drug
Pumpkin is a nutritious squash, and its seeds and seed oil are the parts most often used as supplements, mainly for urinary and prostate symptoms. The...
Pumpkin seed oil monograph & interactionsOther (inactive) ingredients: Softgel Capsule. These complete the product’s ingredient list but are not active constituents.
Pygeum & Saw Palmetto by NOW Drug Interactions
HelloPharmacist Interaction Report
Pygeum & Saw Palmetto by NOW contains ingredients that do interact with medications.
The most serious concern is through saw palmetto, which may interfere with how your body handles blood thinners and antiplatelet drugs (like warfarin, aspirin, and clopidogrel), potentially raising your bleeding risk. Saw palmetto also carries Moderate-severity interactions with estrogens and contraceptive drugs — it may reduce how well they work by interfering with how your body processes them.
Read the full breakdown — every affected drug type, severity by severity
Pumpkin seed oil in this product interacts with lithium, a medication for bipolar disorder. It might prevent your body from clearing lithium efficiently, which could raise lithium levels in your blood and require a dose adjustment.
Pygeum extract itself has no documented interactions in our data. We could not check monounsaturated fat or polyunsaturated fat — no interaction data is held for those.
Altogether, these interactions span 175 individual medications. Before you start this supplement, run your exact medications through the interaction checker on this page, and talk with your doctor or pharmacist about any blood thinners, hormonal contraceptives, estrogens, or lithium you're taking.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Pygeum & Saw Palmetto?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Pygeum & Saw Palmetto interact with 175 drugs. Click any drug to see the details.
2 of the 3 ingredients in Pygeum & Saw Palmetto interact with drugs. Each result below shows which ingredient is responsible. Saw Palmetto extract Pumpkin seed oil
AbciximabReoPro
How Abciximab interacts with Pygeum & Saw Palmetto — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Pygeum & Saw Palmetto — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Abrocitinib interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Pygeum & Saw Palmetto — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Pygeum & Saw Palmetto — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Pygeum & Saw Palmetto — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Pygeum & Saw Palmetto — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Acetaminophen, Ibuprofen interactionAcetylsalicylic AcidEntrophen
How Acetylsalicylic Acid interacts with Pygeum & Saw Palmetto — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Acetylsalicylic Acid interactionAlteplase, TpaActilyse, Activase
How Alteplase, Tpa interacts with Pygeum & Saw Palmetto — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Alteplase, Tpa interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Pygeum & Saw Palmetto — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with Pygeum & Saw Palmetto — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAnacaulase-bcdbNexoBrid
How Anacaulase-bcdb interacts with Pygeum & Saw Palmetto — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Anacaulase-bcdb interactionAnagrelideAgrylin
How Anagrelide interacts with Pygeum & Saw Palmetto — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Anagrelide interactionAnisindioneMiradon
How Anisindione interacts with Pygeum & Saw Palmetto — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Anisindione interactionAntithrombin IiiThrombate III
How Antithrombin Iii interacts with Pygeum & Saw Palmetto — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Antithrombin Iii interactionApixabanEliquis
How Apixaban interacts with Pygeum & Saw Palmetto — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Apixaban interactionArgatrobanArgatroban
How Argatroban interacts with Pygeum & Saw Palmetto — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Argatroban interactionAspirinAngettes 75, ASA, Asaphen, Aspirin, Caprin, Cartia +8 more
How Aspirin interacts with Pygeum & Saw Palmetto — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Aspirin interactionAspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #3
How Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interacts with Pygeum & Saw Palmetto — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interactionAspirin, ButalbitalAxotal
How Aspirin, Butalbital interacts with Pygeum & Saw Palmetto — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Aspirin, Butalbital interactionAspirin, Butalbital, CaffeineFiorinal
How Aspirin, Butalbital, Caffeine interacts with Pygeum & Saw Palmetto — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Aspirin, Butalbital, Caffeine interactionAspirin, Butalbital, Caffeine, Codeine PhosphateFiorinal w/ Codeine
How Aspirin, Butalbital, Caffeine, Codeine Phosphate interacts with Pygeum & Saw Palmetto — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Aspirin, Butalbital, Caffeine, Codeine Phosphate interactionAspirin, Butalbital, Caffeine, PhenacetinMarnal
How Aspirin, Butalbital, Caffeine, Phenacetin interacts with Pygeum & Saw Palmetto — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Aspirin, Butalbital, Caffeine, Phenacetin interactionAspirin, CaffeineAnacin
How Aspirin, Caffeine interacts with Pygeum & Saw Palmetto — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Aspirin, Caffeine interactionAspirin, Caffeine, Codeine PhosphateAnacin w/ Codeine
How Aspirin, Caffeine, Codeine Phosphate interacts with Pygeum & Saw Palmetto — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Aspirin, Caffeine, Codeine Phosphate interactionAspirin, Caffeine, Dihydrocodeine BitartrateSynalgos DC
How Aspirin, Caffeine, Dihydrocodeine Bitartrate interacts with Pygeum & Saw Palmetto — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Aspirin, Caffeine, Dihydrocodeine Bitartrate interactionAspirin, Caffeine, Dover's PwdAcedoval, Dovacet
How Aspirin, Caffeine, Dover's Pwd interacts with Pygeum & Saw Palmetto — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Aspirin, Caffeine, Dover's Pwd interactionAspirin, Caffeine, HydrocodoneDamason-P
How Aspirin, Caffeine, Hydrocodone interacts with Pygeum & Saw Palmetto — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Aspirin, Caffeine, Hydrocodone interactionAspirin, Caffeine, Isobutylallylbarbituric Acid, PhenacetinLanorinal
How Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interacts with Pygeum & Saw Palmetto — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interactionAspirin, Caffeine, OrphenadrineInvagesic, Invagesic Forte, Norgesic, Norgesic Forte, Orphengesic, Orphengesic Forte
How Aspirin, Caffeine, Orphenadrine interacts with Pygeum & Saw Palmetto — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Aspirin, Caffeine, Orphenadrine interactionAspirin, Caffeine, Phenacetin, PropoxypheneMargesic Comp. 65
How Aspirin, Caffeine, Phenacetin, Propoxyphene interacts with Pygeum & Saw Palmetto — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Aspirin, Caffeine, Phenacetin, Propoxyphene interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Pygeum & Saw Palmetto with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Saw Palmetto extract
Anticoagulant/Antiplatelet Drugs
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Saw palmetto is reported to prolong bleeding time. Theoretically, it might increase the risk of bleeding when used concomitantly with anticoagulant or antiplatelet drugs.
Contraceptive Drugs
Saw palmetto might reduce the effectiveness of contraceptive drugs.
Saw palmetto might have antiestrogenic effects. Theoretically, it might interfere with contraceptive drugs taken concomitantly.
Estrogens
Saw palmetto might reduce the effectiveness of estrogens.
Saw palmetto might have antiestrogenic effects. Theoretically, it might interfere with estrogens taken concomitantly.
Pumpkin seed oil
Lithium
Pumpkin might reduce excretion and increase levels of lithium.
Pumpkin is thought to have diuretic properties. Theoretically, this might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.
Brand information
Manufacturer and brand details for Pygeum & Saw Palmetto, from the product label.
NOW
See all NOW products- Name
- NOW Foods
- Street Address
- 395 S. Glen Ellyn Rd.
- City
- Bloomingdale
- State
- IL
- ZipCode
- 60108
- Web Address
- nowfoods.com
Pygeum & Saw Palmetto by NOW: Common Questions
Does Pygeum & Saw Palmetto by NOW interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does this help with an enlarged prostate?
Can I take this if I'm on birth control?
What side effects should I expect?
Is it safe to take while pregnant or breastfeeding?
Can I take this with my blood thinner?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Pygeum & Saw Palmetto is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Pygeum & Saw Palmetto’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Saw Palmetto
Interacts with 174 drugsSaw palmetto is a plant extract most often used for urinary symptoms linked to an enlarged prostate (BPH). The best research suggests it works no better than a placebo for most men, though i...
Read the full Saw Palmetto monograph → Herb & supplement monographPygeum
Pygeum is an extract from the bark of the African cherry tree that is most often used to ease urinary symptoms linked to an enlarged prostate. Some studies suggest modest benefit for these s...
Read the full Pygeum monograph → Herb & supplement monographPumpkin
Interacts with 1 drugPumpkin is a nutritious squash, and its seeds and seed oil are the parts most often used as supplements, mainly for urinary and prostate symptoms. The evidence for these uses is limited and...
Read the full Pumpkin monograph →Sources & How We Checked
Pygeum & Saw Palmetto's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 30 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Saw Palmetto 22 references
- Wilt TJ, Ishani A, Stark G, et al. Saw palmetto extracts for treatment of benign prostatic hyperplasia: a systematic review. JAMA 1998;280:1604-9. PubMed
- Carraro JC, Raynaud JP, Koch G, et al. Comparison of phytotherapy (Permixon) with finasteride in the treatment of benign prostate hyperplasia: a randomized international study of 1,098 patients. Prostate 1996;29:231-40. DOI
- Di Silverio F, D'Eramo G, Lubrano C, et al. Evidence that Serenoa repens extract displays an antiestrogenic activity in prostatic tissue of benign prostatic hypertrophy patients. Eur Urol 1992;21:309-14. PubMed
- Stepanov VN, Siniakova LA, Sarrazin B, Raynaud JP. Efficacy and tolerability of the lipidosterolic extract of Serenoa repens (Permixon) in benign prostatic hyperplasia: a double-blind comparison of two dosage regimens. Adv Ther 1999;16:231-41.
- Cheema P, El-Mefty O, Jazieh AR. Intraoperative haemorrhage associated with the use of extract of Saw Palmetto herb: a case report and review of literature. J Intern Med 2001;250:167-9. PubMed
- Jibrin I, Erinle A, Saidi A, Aliyu ZY. Saw palmetto-induced pancreatitis. South Med J 2006;99:611-2. PubMed
- Prager N, Bickett K, French N, Marcovici G. A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia. J Altern Complement Med 2002
- Avins AL, Bent S, Staccone S, et al. A detailed safety assessment of a saw palmetto extract. Complement Ther Med 2008;16:147-54. PubMed
- Morgia, G., Mucciardi, G., Gali, A., Madonia, M., Marchese, F., Di, Benedetto A., Romano, G., Bonvissuto, G., Castelli, T., Macchione, L., and Magno, C. Treatment of chronic prostatitis/chronic pelvic pain syndrome category IIIA with Serenoa repens plus
- Aliaev, IuG, Vinarov, A. Z., Lokshin, K. L., and Spivak, L. G. [Efficiency and safety of prostamol-Uno in patients with chronic abacterial prostatitis]. Urologiia. 2006;(1):47-50.
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