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Dietary supplement

Raspberry Ketones Mega+ 250 mg Ingredients & Drug Interactions

by Natural Sport

Capsule Category: Other Combinations
Most serious interaction: Major
The interaction bottom line Most serious interaction: Major

Raspberry Ketones Mega+ 250 mg is a dietary supplement by Natural Sport with 3 active ingredients. Its ingredients are commonly taken for mental focus and alertness, coping with stress, fatigue and sleep loss.Based on those ingredients, 205 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Raspberry Ketones, L-Tyrosine, L-Phenylalanine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Raspberry Ketones Mega+ 250 mg by Natural Sport

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This supplement contains three active ingredients: L-tyrosine, L-phenylalanine, and raspberry ketones. L-tyrosine is an amino acid your body uses to make certain brain chemicals and thyroid hormones; it's also studied for memory and thinking.

L-phenylalanine is another amino acid involved in brain chemistry and mood. Raspberry ketones are compounds from raspberries that are marketed for weight and metabolism support, though the evidence for that isn't yet established.

The capsule also contains inactive ingredients—cellulose, magnesium stearate, and silica—which are binders and fillers that help hold the supplement together.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: nutritive support for body in motion.
  • We looked for evidence on: Athletic performance, exercise recovery, physical endurance, muscle support.
  • The closest evidence on file: Tyrosine is rated "Possibly Ineffective" for Athletic performance (Natural Medicines).

L-tyrosine is effective for phenylketonuria (PKU), a rare genetic condition, and possibly effective for cognitive function and memory. The evidence isn't enough to say whether it helps with athletic performance or alcohol use disorder.

L-phenylalanine is possibly effective for vitiligo (a skin condition) but possibly ineffective for ADHD; the evidence is insufficient for alcohol use disorder and multiple sclerosis. Raspberry ketones have insufficient evidence for obesity or hair loss—in other words, we don't yet have enough reliable data to know whether this ingredient does what the marketing claims.

The evidence, ingredient by ingredient Tyrosine Phenylalanine Raspberry Ketone

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-tyrosine and L-phenylalanine are generally well tolerated at typical doses, but the safety data is limited and they're not recommended for regular use without a doctor's guidance. The most common side effects from these amino acids include headache, nausea, heartburn, fatigue, anxiety, and insomnia.

Raspberry ketones resemble a stimulant compound and have been linked in some case reports to heart palpitations, elevated blood pressure, and arrhythmias, although human safety data at high supplement doses is very limited. For pregnancy: L-phenylalanine is rated unsafe during pregnancy—do not use.

L-tyrosine has not been adequately studied in pregnancy; there isn't enough data to know either way. Raspberry ketones lack sufficient safety information; the data advises against use in pregnancy.

For breastfeeding: L-phenylalanine and raspberry ketones are not advised due to lack of safety data; L-tyrosine data isn't on file. Talk with your doctor or pharmacist before using this product if you're pregnant, breastfeeding, or planning to become pregnant.

Side effects, ingredient by ingredient Tyrosine Phenylalanine Raspberry Ketone

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Phenylalanine, Tyrosine, Raspberry Ketone.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; Parkinson's medications.
  • For scale: 205 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this product if you use any of these: levodopa (a Parkinson's medication)—L-phenylalanine and L-tyrosine can both reduce its effectiveness; non-selective MAOIs such as pargyline (a blood pressure medication)—L-phenylalanine may raise your risk of dangerously high blood pressure; thyroid hormones—L-tyrosine might add to their effects; baclofen, a muscle relaxant; warfarin or other blood thinners; or stimulant drugs such as decongestants or ADHD medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

This product is for adults who want to try amino acid and plant-based metabolism support, but it's not for anyone taking levodopa, MAOIs, baclofen, thyroid medications, warfarin, or stimulant drugs without checking first. People with phenylketonuria (PKU) should not take it because of the L-phenylalanine content.

If you're pregnant, breastfeeding, or have heart concerns, talk with your doctor or pharmacist before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 24, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Raspberry Ketones Mega+ 250 mg, straight from the product label.

Brand Natural Sport
Barcode (UPC) 66040520812
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Jul 24, 2015
DSLD ID 47783
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Raspberry Ketones Mega+ 250 mg by Natural Sport, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
45
UPC/BARCODE
66040520812
IngredientAmount% DV
L-Tyrosine200 mg--
L-Phenylalanine100 mg--
Raspberry Ketones250 mg--

Other ingredients: Cellulose, Magnesium Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

2 Daily

Body in Motion

Precautions

Warning: Do not use if safety seal is broken or missing.

Keep out of reach of children.

Keep your licensed health practitioner informed when using this product.

Do not use if you are pregnant, nursing, or taking a prescription MAO inhibitor.

Suggested/Recommended/Usage/Directions

Directions: Use only as directed. Take 2 capsules daily with water, preferably with a meal.

Storage

Store in a cool, dry place.

Brand IP Statement(s)

Discussion: The Natural Sport(R) Raspberry Ketones Mega+ formula is an innovative blend of ingredients intended to provide nutritive support for the body in motion.

A Natural Sport(R) fun fact: You would need to eat 90 pounds of fresh raspberries to compare to a daily serving of Raspberry Ketones.

Formulation

Natural Sport(R) uses no artificial sweeteners, colors or flavors.

General

9763885 0212

Seals/Symbols

NS(R)

FDA Statement of Identity

Dietary Supplement

See for yourself

Raspberry Ketones Mega+ 250 mg by Natural Sport label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Raspberry Ketones Mega+ 250 mg by Natural Sport

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container45 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Tyrosine

Interacts with
21 drugs
200 mg per serving

L-tyrosine is an amino acid your body uses to make brain chemicals like dopamine and norepinephrine. Some studies suggest it may help mental performan...

L-Tyrosine monograph & interactions

L-Phenylalanine

Interacts with
16 drugs
100 mg per serving

Phenylalanine is an essential amino acid the body uses to make brain chemicals like dopamine and norepinephrine. Some people take it for mood, vitilig...

L-Phenylalanine monograph & interactions

Raspberry Ketones

Interacts with
174 drugs
250 mg per serving

Raspberry ketone is a natural aroma compound found in red raspberries that is heavily marketed for weight loss, but there is no good human evidence th...

Raspberry Ketones monograph & interactions

Other (inactive) ingredients: Cellulose, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Raspberry Ketones Mega+ 250 mg by Natural Sport Drug Interactions

Want to check YOUR meds against Raspberry Ketones Mega+ 250 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
205Drugs
5 Major 200 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Raspberry Ketones Mega+ 250 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Raspberry Ketones2 drug types · 174 drugs

Stimulant Drugs

Theoretically, raspberry ketone might increase the risk of adverse cardiovascular effects with stimulant drugs.
Structurally, raspberry ketone resembles synephrine, a known stimulant agent. Heart palpitations, elevated blood pressure, coronary vasospasm, pulseless electrical activity arrest, and resistant polymorphic ventricular tachycardia have been reported in patients taking raspberry ketone.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, raspberry ketone might increase warfarin dose requirements.
In one case report, a patient taking warfarin 55 mg per week had a decrease in INR over a period of one month while taking raspberry ketone 250 mg daily. A warfarin dose increase to 70 mg per week was necessary to maintain a therapeutic INR while taking raspberry ketone. The mechanism for this potential interaction is not known.

Likelihood Possible Evidence D

L-Tyrosine2 drug types · 21 drugs

Levodopa

Theoretically, tyrosine might decrease the effectiveness of levodopa.
Tyrosine and levodopa compete for absorption in the proximal duodenum by the large neutral amino acid (LNAA) transport system. Advise patients to separate doses of tyrosine and levodopa by at least 2 hours.

Likelihood Probable Evidence D
Thyroid Hormone

Theoretically, tyrosine might have additive effects with thyroid hormone medications.
Tyrosine is a precursor to thyroxine and might increase levels of thyroid hormones.

Likelihood Probable Evidence D

L-Phenylalanine3 drug types · 16 drugs

Levodopa

Phenylalanine, especially in high doses, can reduce the effectiveness of levodopa.
Phenylalanine competes with levodopa for carrier-mediated transport into the brain. The resulting reduction in levels of levodopa in the brain can exacerbate tremor, rigidity, and the "on-off" phenomenon in patients with Parkinson disease.

Likelihood Probable Evidence B
Baclofen

Concomitant intake of phenylalanine may reduce the intestinal absorption of baclofen.
Phenylalanine and baclofen share the same intestinal carrier for absorption; phenylalanine competitively inhibits the absorption of baclofen, reducing its plasma levels.

Likelihood Possible Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, concomitant use of L-phenylalanine and non-selective MAOIs might increase the risk of hypertensive crisis.
L-phenylalanine is metabolized to tyrosine. Some evidence suggests that L-phenylalanine, given with the non-selective MAOI pargyline, might prevent the elimination of tyramine, increasing the risk of hypertensive crisis. However, this was not reported in a small number of patients when using L-phenylalanine with the partially selective MAO-B inhibitor, selegiline.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Raspberry Ketones Mega+ 250 mg, from the product label.

Natural Sport

See all Natural Sport products
Name
NutraPro, Inc.
Web Address
www.reachforlife.com
Pharmacist Counseling Corner

Raspberry Ketones Mega+ 250 mg by Natural Sport: Common Questions

Does Raspberry Ketones Mega+ 250 mg by Natural Sport interact with any medications?
Yes. Based on its ingredients, Raspberry Ketones Mega+ 250 mg has a known interaction with 205 medications, including 5 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Raspberry Ketones Mega+ 250 mg contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I have phenylketonuria (PKU)?
No. This product contains L-phenylalanine, which you cannot safely metabolize if you have PKU. Avoid it completely and talk with your doctor or pharmacist about any supplementation.
What are the most common side effects?
The amino acids in this product—L-tyrosine and L-phenylalanine—may cause headache, nausea, heartburn, fatigue, anxiety, or insomnia. Raspberry ketones can theoretically cause heart palpitations and elevated blood pressure, though they're not well studied in humans at high supplement doses.
Is this safe to take while pregnant?
No. L-phenylalanine is unsafe in pregnancy. L-tyrosine and raspberry ketones lack enough safety data; the data advises against use. Talk with your doctor about what's right for you.
Is this safe while breastfeeding?
The safety data for L-phenylalanine and raspberry ketones during breastfeeding is not sufficient to recommend use. L-tyrosine data isn't on file. Talk with your doctor or pharmacist before taking this if you're breastfeeding.
Does raspberry ketone actually help with weight loss?
The evidence isn't established yet. Our data shows insufficient reliable evidence to know whether raspberry ketones help with obesity, so we can't confirm that claim.
What does L-tyrosine do?
L-tyrosine is an amino acid your body uses to make brain chemicals and thyroid hormones. It's effective for phenylketonuria and possibly effective for memory and thinking, though it's possibly ineffective for athletic performance.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Raspberry Ketones Mega+ 250 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Raspberry Ketones Mega+ 250 mg label
Sources

Sources & How We Checked

Raspberry Ketones Mega+ 250 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 31 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tyrosine 4 references
  1. Meyer JS, Welch KM, Deshmukh VD, et al. Neurotransmitter precursor amino acids in the treatment of multi-infarct dementia and Alzheimer's disease. J Amer Geriat Soc 1977;25:289-98.
  2. DiPiro JT, Talbert RL, Yee GC, et al; eds. Pharmacotherapy: A pathophysiologic approach. 4th ed. Stamford, CT: Appleton & Lange, 1999.
  3. Wood DR, Reimherr FW, Wender PH. Amino acid precursors for the treatment of attention deficit disorder, residual type. Psychopharmacol Bull 1985;21:146-9.
  4. van Spronsen FJ, van Rijn M, Bekhof J. Phenylketonuria: tyrosine supplementation in phenylalanine-restricted diets. Am J Clin Nutr 2001;73:153-7. PubMed

See these in context on the Tyrosine monograph →

Phenylalanine 23 references
  1. Rouse B, Azen C, Koch R, et al. Maternal phenylketonuria collaborative Study (MPKUCS) offspring: facial anomalies, malformations, and early neurological sequelae. Am J Med Genet 1997;69:89-95. DOI
  2. Sturtevant FM. Use of aspartame in pregnancy. Int J Fertil 1985;30:85-7.
  3. Silkaitis RP, Mosnaim AD. Pathways linking L-phenylalanine and 2-phenylethylamine with p-tyramine in rabbit brain. Brain Res 1976;114:105-15.
  4. Lehmann WD, Theobald N, Fischer R, Heinrich HC. Stereospecificity of phenylalanine plasma kinetics and hydroxylation in man following oral application of a stable isotope-labelled pseudo-racemic mixture of L- and D-phenylalanine. Clin Chim Acta 1983;128 PubMed
  5. Mosnik DM, Spring B, Rogers K, Baruah S. Tardive dyskinesia exacerbated after ingestion of phenylalanine by schizophrenic patients. Neuropsychopharmacology 1997;16:136-46. PubMed
  6. Siddiqui AH, Stolk LM, Bhaggoe R, et al. L-phenylalanine and UVA irradiation in the treatment of vitiligo. Dermatology 1994;88:215-8. PubMed
  7. Birkmayer W, Riederer P, Linauer W, Knoll J. L-deprenyl plus L-phenylalanine in the treatment of depression. J Neural Transm 1984;59:81-7. PubMed
  8. Nutt JG, Woodward WR, Hammerstad JP, et al. The "on-off" phenomenon in Parkinson's disease. Relation to levodopa absorption and transport. N Engl J Med 1984;310:483-8. PubMed
  9. Baruzzi A, Contin M, Riva R, et al. Influence of meal ingestion time on pharmacokinetics of orally administered levodopa in parkinsonian patients. Clin Neuropharmacol 1987;10:527-37. PubMed
  10. Juncos JL, Fabbrini G, Mouradian MM, et al. Dietary influences on the antiparkinsonian response to levodopa. Arch Neurol 1987;44:1003-5. PubMed
  11. Eriksson T, Granerus AK, Linde A, et al. "On-off" phenomenon in Parkinson's disease: relationship between dopa and other large neutral amino acids in plasma. Neurology 1988;38:1245-8. PubMed
  12. Baker GB, Bornstein RA, Rouget AC, et al. Phenylethylaminergic mechanisms in attention-deficit disorder. Biol Psychiatry 1991;29:15-22.. PubMed
  13. Wood DR, Reimherr FW, Wender PH. Treatment of attention deficit disorder with DL-phenylalanine. Psychiatry Res 1985;16:21-6.. PubMed
  14. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids (Macronutrients). Washington, DC: National Academy Press, 2002. Available at: http://www.n
  15. Cederbaum S. Phenylketonuria: an update. Curr Opin Pediatr 2002;14:702-6. PubMed
  16. Cejudo-Ferragud, E., Nacher, A., Polache, A., Cercos-Fortea, T., Merino, M., and Casabo, V. G. Evidence of competitive inhibition for the intestinal absorption of baclofen by phenylalanine. Int J of Pharm (Amsterdam) 1996;132:63-69. DOI
  17. Fischer, E., Heller, B., Nachon, M., and Spatz, H. Therapy of depression by phenylalanine. Preliminary note. Arzneimittelforschung. 1975;25(1):132.
  18. Beckmann, H., Strauss, M. A., and Ludolph, E. Dl-phenylalanine in depressed patients: an open study. J.Neural Transm. 1977;41(2-3):123-134. PubMed
  19. Sabelli, H. C., Fawcett, J., Gusovsky, F., Javaid, J. I., Wynn, P., Edwards, J., Jeffriess, H., and Kravitz, H. Clinical studies on the phenylethylamine hypothesis of affective disorder: urine and blood phenylacetic acid and phenylalanine dietary supplem
  20. Cotzias, G. C., Van Woert, M. H., and Schiffer, L. M. Aromatic amino acids and modification of parkinsonism. N Engl.J Med 2-16-1967;276(7):374-379. PubMed
  21. Kravitz, H. M., Sabelli, H. C., and Fawcett, J. Dietary supplements of phenylalanine and other amino acid precursors of brain neuroamines in the treatment of depressive disorders. J Am Osteopath.Assoc 1984;84(1 Suppl):119-123. DOI
  22. Mann, J., Peselow, E. D., Snyderman, S., and Gershon, S. D-phenylalanine in endogenous depression. Am.J.Psychiatry 1980;137(12):1611-1612. PubMed
  23. Katoulis AC, Alevizou A, Bozi E, et al. A randomized, double-blind, vehicle-controlled study of a preparation containing undecylenoyl phenylalanine 2% in the treatment of solar lentigines. Clin Exp Dermatol 2010;35(5):473-6. PubMed

See these in context on the Phenylalanine monograph →

Raspberry Ketone 4 references
  1. Adverse Event Report. Raspberry Ketone. Natural MedWatch, April 27, 2012.
  2. Adverse Event Report. Raspberry Ketone. Natural MedWatch, September 18, 2011.
  3. Ansari SA, Patel F, Ashouri D, Dhaliwal JSS, Desai A. Resistant Polymorphic Ventricular Tachycardia in a Patient Taking Raspberry Ketones Weight Loss Supplement. Cureus 2022;14(12):e33089. PubMed
  4. Khattar A, Beeton I. Coronary vasospasm and raspberry ketones weight-loss supplement: Is there a connection? Anatol J Cardiol. 2020;24(3):205-208.

See these in context on the Raspberry Ketone monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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