Raspberry Ketones Mega+ 250 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Raspberry Ketones Mega+ 250 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Raspberry Ketones Mega+ 250 mg is a dietary supplement by Natural Sport with 3 active ingredients. Its ingredients are commonly taken for mental focus and alertness, coping with stress, fatigue and sleep loss.Based on those ingredients, 205 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Raspberry Ketones, L-Tyrosine, L-Phenylalanine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Raspberry Ketones Mega+ 250 mg by Natural Sport
Ask about any prescription or over-the-counter medication and we check it for interactions with Raspberry Ketones Mega+ 250 mg by Natural Sport — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Raspberry Ketones Mega+ 250 mg by Natural Sport
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This supplement contains three active ingredients: L-tyrosine, L-phenylalanine, and raspberry ketones. L-tyrosine is an amino acid your body uses to make certain brain chemicals and thyroid hormones; it's also studied for memory and thinking.
L-phenylalanine is another amino acid involved in brain chemistry and mood. Raspberry ketones are compounds from raspberries that are marketed for weight and metabolism support, though the evidence for that isn't yet established.
The capsule also contains inactive ingredients—cellulose, magnesium stearate, and silica—which are binders and fillers that help hold the supplement together.
Does it work?
Not established
L-tyrosine is effective for phenylketonuria (PKU), a rare genetic condition, and possibly effective for cognitive function and memory. The evidence isn't enough to say whether it helps with athletic performance or alcohol use disorder.
L-phenylalanine is possibly effective for vitiligo (a skin condition) but possibly ineffective for ADHD; the evidence is insufficient for alcohol use disorder and multiple sclerosis. Raspberry ketones have insufficient evidence for obesity or hair loss—in other words, we don't yet have enough reliable data to know whether this ingredient does what the marketing claims.
How safe is it?
Well-documented data
L-tyrosine and L-phenylalanine are generally well tolerated at typical doses, but the safety data is limited and they're not recommended for regular use without a doctor's guidance. The most common side effects from these amino acids include headache, nausea, heartburn, fatigue, anxiety, and insomnia.
Raspberry ketones resemble a stimulant compound and have been linked in some case reports to heart palpitations, elevated blood pressure, and arrhythmias, although human safety data at high supplement doses is very limited. For pregnancy: L-phenylalanine is rated unsafe during pregnancy—do not use.
L-tyrosine has not been adequately studied in pregnancy; there isn't enough data to know either way. Raspberry ketones lack sufficient safety information; the data advises against use in pregnancy.
For breastfeeding: L-phenylalanine and raspberry ketones are not advised due to lack of safety data; L-tyrosine data isn't on file. Talk with your doctor or pharmacist before using this product if you're pregnant, breastfeeding, or planning to become pregnant.
Meds to double-check
Major interaction found
Check with your doctor or pharmacist before taking this product if you use any of these: levodopa (a Parkinson's medication)—L-phenylalanine and L-tyrosine can both reduce its effectiveness; non-selective MAOIs such as pargyline (a blood pressure medication)—L-phenylalanine may raise your risk of dangerously high blood pressure; thyroid hormones—L-tyrosine might add to their effects; baclofen, a muscle relaxant; warfarin or other blood thinners; or stimulant drugs such as decongestants or ADHD medications.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.
This product is for adults who want to try amino acid and plant-based metabolism support, but it's not for anyone taking levodopa, MAOIs, baclofen, thyroid medications, warfarin, or stimulant drugs without checking first. People with phenylketonuria (PKU) should not take it because of the L-phenylalanine content.
If you're pregnant, breastfeeding, or have heart concerns, talk with your doctor or pharmacist before you start.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 24, 2015.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Raspberry Ketones Mega+ 250 mg, straight from the product label.
| Brand | Natural Sport |
|---|---|
| Barcode (UPC) | 66040520812 |
| Net contents | 90 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jul 24, 2015 |
| DSLD ID | 47783 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Raspberry Ketones Mega+ 250 mg by Natural Sport, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| L-Tyrosine | 200 mg | -- |
| L-Phenylalanine | 100 mg | -- |
| Raspberry Ketones | 250 mg | -- |
Other ingredients: Cellulose, Magnesium Stearate, Silica
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
2 Daily
Body in Motion
Precautions
Warning: Do not use if safety seal is broken or missing.
Keep out of reach of children.
Keep your licensed health practitioner informed when using this product.
Do not use if you are pregnant, nursing, or taking a prescription MAO inhibitor.
Suggested/Recommended/Usage/Directions
Directions: Use only as directed. Take 2 capsules daily with water, preferably with a meal.
Storage
Store in a cool, dry place.
Brand IP Statement(s)
Discussion: The Natural Sport(R) Raspberry Ketones Mega+ formula is an innovative blend of ingredients intended to provide nutritive support for the body in motion.
A Natural Sport(R) fun fact: You would need to eat 90 pounds of fresh raspberries to compare to a daily serving of Raspberry Ketones.
Formulation
Natural Sport(R) uses no artificial sweeteners, colors or flavors.
General
9763885 0212
Seals/Symbols
NS(R)
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Raspberry Ketones Mega+ 250 mg by Natural Sport label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Raspberry Ketones Mega+ 250 mg by Natural Sport
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container45 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
L-Tyrosine
Interacts with21 drugs
L-tyrosine is an amino acid your body uses to make brain chemicals like dopamine and norepinephrine. Some studies suggest it may help mental performan...
L-Tyrosine monograph & interactionsL-Phenylalanine
Interacts with16 drugs
Phenylalanine is an essential amino acid the body uses to make brain chemicals like dopamine and norepinephrine. Some people take it for mood, vitilig...
L-Phenylalanine monograph & interactionsRaspberry Ketones
Interacts with174 drugs
Raspberry ketone is a natural aroma compound found in red raspberries that is heavily marketed for weight loss, but there is no good human evidence th...
Raspberry Ketones monograph & interactionsOther (inactive) ingredients: Cellulose, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.
Raspberry Ketones Mega+ 250 mg by Natural Sport Drug Interactions
HelloPharmacist Interaction Report
Raspberry Ketones Mega+ by Natural Sport contains three active ingredients, and through its L-phenylalanine, L-tyrosine, and raspberry ketones content, this product does interact with medications.
The most serious interaction is L-phenylalanine with levodopa (a Parkinson's medication): phenylalanine competes with levodopa for transport into the brain, which can reduce levodopa's effectiveness and worsen tremor, rigidity, and the on-off effect in people with Parkinson disease.
Read the full breakdown — every affected drug type, severity by severity
L-phenylalanine also interacts with non-selective monoamine oxidase inhibitors (MAOIs, used for depression) — theoretically increasing the risk of a dangerous spike in blood pressure (hypertensive crisis). It may also reduce the absorption of baclofen, a muscle relaxant.
L-tyrosine can decrease levodopa's effectiveness through a similar competition mechanism and might have additive effects with thyroid hormone medications, potentially increasing thyroid hormone levels.
Raspberry ketones may increase the risk of heart-related side effects if combined with stimulant drugs and might increase warfarin (a blood thinner) dose requirements — one case report showed a patient needed a higher warfarin dose while taking raspberry ketone to maintain proper blood clotting.
Altogether, these interactions span 205 individual medications. Use the medication checker below to see whether any of yours are affected before you start this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Raspberry Ketones Mega+ 250 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Raspberry Ketones Mega+ 250 mg interact with 205 drugs. Click any drug to see the details.
3 of the 3 ingredients in Raspberry Ketones Mega+ 250 mg interact with drugs. Each result below shows which ingredient is responsible. Raspberry Ketones L-Tyrosine L-Phenylalanine
Benserazide, LevodopaMadopar, Prolopa
How Benserazide, Levodopa interacts with Raspberry Ketones Mega+ 250 mg — through 2 ingredients. Tap an ingredient for the detail:
L-phenylalanineLevodopa Major
Interaction Summary
Phenylalanine, especially in high doses, can reduce the effectiveness of levodopa.
Read the full L-phenylalanine + Benserazide, Levodopa interactionL-tyrosineLevodopa Moderate
Interaction Summary
Theoretically, tyrosine might decrease the effectiveness of levodopa.
Read the full L-tyrosine + Benserazide, Levodopa interactionCarbidopa, LevodopaDhivy, Rytary, Sinemet, Sinemet CR
How Carbidopa, Levodopa interacts with Raspberry Ketones Mega+ 250 mg — through 2 ingredients. Tap an ingredient for the detail:
L-phenylalanineLevodopa Major
Interaction Summary
Phenylalanine, especially in high doses, can reduce the effectiveness of levodopa.
Read the full L-phenylalanine + Carbidopa, Levodopa interactionL-tyrosineLevodopa Moderate
Interaction Summary
Theoretically, tyrosine might decrease the effectiveness of levodopa.
Read the full L-tyrosine + Carbidopa, Levodopa interactionCarbidopa, Levodopa, EntacaponeStalevo
How Carbidopa, Levodopa, Entacapone interacts with Raspberry Ketones Mega+ 250 mg — through 2 ingredients. Tap an ingredient for the detail:
L-phenylalanineLevodopa Major
Interaction Summary
Phenylalanine, especially in high doses, can reduce the effectiveness of levodopa.
Read the full L-phenylalanine + Carbidopa, Levodopa, Entacapone interactionL-tyrosineLevodopa Moderate
Interaction Summary
Theoretically, tyrosine might decrease the effectiveness of levodopa.
Read the full L-tyrosine + Carbidopa, Levodopa, Entacapone interactionLevodopaInbrija, Larodopa
How Levodopa interacts with Raspberry Ketones Mega+ 250 mg — through 2 ingredients. Tap an ingredient for the detail:
L-phenylalanineLevodopa Major
Interaction Summary
Phenylalanine, especially in high doses, can reduce the effectiveness of levodopa.
Read the full L-phenylalanine + Levodopa interactionL-tyrosineLevodopa Moderate
Interaction Summary
Theoretically, tyrosine might decrease the effectiveness of levodopa.
Read the full L-tyrosine + Levodopa interactionLevodopa, CarbidopaDuodopa
How Levodopa, Carbidopa interacts with Raspberry Ketones Mega+ 250 mg — through 2 ingredients. Tap an ingredient for the detail:
L-phenylalanineLevodopa Major
Interaction Summary
Phenylalanine, especially in high doses, can reduce the effectiveness of levodopa.
Read the full L-phenylalanine + Levodopa, Carbidopa interactionL-tyrosineLevodopa Moderate
Interaction Summary
Theoretically, tyrosine might decrease the effectiveness of levodopa.
Read the full L-tyrosine + Levodopa, Carbidopa interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Raspberry Ketones Mega+ 250 mg — through 1 ingredient. Tap an ingredient for the detail:
Raspberry KetonesStimulant Drugs Moderate
Interaction Summary
Theoretically, raspberry ketone might increase the risk of adverse cardiovascular effects with stimulant drugs.
Read the full Raspberry Ketones + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Raspberry Ketones Mega+ 250 mg — through 1 ingredient. Tap an ingredient for the detail:
Raspberry KetonesStimulant Drugs Moderate
Interaction Summary
Theoretically, raspberry ketone might increase the risk of adverse cardiovascular effects with stimulant drugs.
Read the full Raspberry Ketones + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Raspberry Ketones Mega+ 250 mg — through 1 ingredient. Tap an ingredient for the detail:
Raspberry KetonesStimulant Drugs Moderate
Interaction Summary
Theoretically, raspberry ketone might increase the risk of adverse cardiovascular effects with stimulant drugs.
Read the full Raspberry Ketones + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Raspberry Ketones Mega+ 250 mg — through 1 ingredient. Tap an ingredient for the detail:
Raspberry KetonesStimulant Drugs Moderate
Interaction Summary
Theoretically, raspberry ketone might increase the risk of adverse cardiovascular effects with stimulant drugs.
Read the full Raspberry Ketones + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Raspberry Ketones Mega+ 250 mg — through 1 ingredient. Tap an ingredient for the detail:
Raspberry KetonesStimulant Drugs Moderate
Interaction Summary
Theoretically, raspberry ketone might increase the risk of adverse cardiovascular effects with stimulant drugs.
Read the full Raspberry Ketones + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Raspberry Ketones Mega+ 250 mg — through 1 ingredient. Tap an ingredient for the detail:
Raspberry KetonesStimulant Drugs Moderate
Interaction Summary
Theoretically, raspberry ketone might increase the risk of adverse cardiovascular effects with stimulant drugs.
Read the full Raspberry Ketones + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Raspberry Ketones Mega+ 250 mg — through 1 ingredient. Tap an ingredient for the detail:
Raspberry KetonesStimulant Drugs Moderate
Interaction Summary
Theoretically, raspberry ketone might increase the risk of adverse cardiovascular effects with stimulant drugs.
Read the full Raspberry Ketones + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Raspberry Ketones Mega+ 250 mg — through 1 ingredient. Tap an ingredient for the detail:
Raspberry KetonesStimulant Drugs Moderate
Interaction Summary
Theoretically, raspberry ketone might increase the risk of adverse cardiovascular effects with stimulant drugs.
Read the full Raspberry Ketones + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Raspberry Ketones Mega+ 250 mg — through 1 ingredient. Tap an ingredient for the detail:
Raspberry KetonesStimulant Drugs Moderate
Interaction Summary
Theoretically, raspberry ketone might increase the risk of adverse cardiovascular effects with stimulant drugs.
Read the full Raspberry Ketones + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Raspberry Ketones Mega+ 250 mg — through 1 ingredient. Tap an ingredient for the detail:
Raspberry KetonesStimulant Drugs Moderate
Interaction Summary
Theoretically, raspberry ketone might increase the risk of adverse cardiovascular effects with stimulant drugs.
Read the full Raspberry Ketones + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Raspberry Ketones Mega+ 250 mg — through 1 ingredient. Tap an ingredient for the detail:
Raspberry KetonesStimulant Drugs Moderate
Interaction Summary
Theoretically, raspberry ketone might increase the risk of adverse cardiovascular effects with stimulant drugs.
Read the full Raspberry Ketones + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Raspberry Ketones Mega+ 250 mg — through 1 ingredient. Tap an ingredient for the detail:
Raspberry KetonesStimulant Drugs Moderate
Interaction Summary
Theoretically, raspberry ketone might increase the risk of adverse cardiovascular effects with stimulant drugs.
Read the full Raspberry Ketones + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Raspberry Ketones Mega+ 250 mg — through 1 ingredient. Tap an ingredient for the detail:
Raspberry KetonesStimulant Drugs Moderate
Interaction Summary
Theoretically, raspberry ketone might increase the risk of adverse cardiovascular effects with stimulant drugs.
Read the full Raspberry Ketones + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Raspberry Ketones Mega+ 250 mg — through 1 ingredient. Tap an ingredient for the detail:
Raspberry KetonesStimulant Drugs Moderate
Interaction Summary
Theoretically, raspberry ketone might increase the risk of adverse cardiovascular effects with stimulant drugs.
Read the full Raspberry Ketones + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with Raspberry Ketones Mega+ 250 mg — through 1 ingredient. Tap an ingredient for the detail:
Raspberry KetonesStimulant Drugs Moderate
Interaction Summary
Theoretically, raspberry ketone might increase the risk of adverse cardiovascular effects with stimulant drugs.
Read the full Raspberry Ketones + Acetaminophen, Chlorpheniramine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with Raspberry Ketones Mega+ 250 mg — through 1 ingredient. Tap an ingredient for the detail:
Raspberry KetonesStimulant Drugs Moderate
Interaction Summary
Theoretically, raspberry ketone might increase the risk of adverse cardiovascular effects with stimulant drugs.
Read the full Raspberry Ketones + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine interacts with Raspberry Ketones Mega+ 250 mg — through 1 ingredient. Tap an ingredient for the detail:
Raspberry KetonesStimulant Drugs Moderate
Interaction Summary
Theoretically, raspberry ketone might increase the risk of adverse cardiovascular effects with stimulant drugs.
Read the full Raspberry Ketones + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with Raspberry Ketones Mega+ 250 mg — through 1 ingredient. Tap an ingredient for the detail:
Raspberry KetonesStimulant Drugs Moderate
Interaction Summary
Theoretically, raspberry ketone might increase the risk of adverse cardiovascular effects with stimulant drugs.
Read the full Raspberry Ketones + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, PhenyltoloxamineNorel Plus
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interacts with Raspberry Ketones Mega+ 250 mg — through 1 ingredient. Tap an ingredient for the detail:
Raspberry KetonesStimulant Drugs Moderate
Interaction Summary
Theoretically, raspberry ketone might increase the risk of adverse cardiovascular effects with stimulant drugs.
Read the full Raspberry Ketones + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interactionAcetaminophen, Chlorpheniramine, PseudoephedrineAlka-Seltzer PLUS Liquid Gels, Children's Tylenol Cold, Codimal, Comtrex, Extra Strength Tylenol Allergy Sinus, Lorsin +3 more
How Acetaminophen, Chlorpheniramine, Pseudoephedrine interacts with Raspberry Ketones Mega+ 250 mg — through 1 ingredient. Tap an ingredient for the detail:
Raspberry KetonesStimulant Drugs Moderate
Interaction Summary
Theoretically, raspberry ketone might increase the risk of adverse cardiovascular effects with stimulant drugs.
Read the full Raspberry Ketones + Acetaminophen, Chlorpheniramine, Pseudoephedrine interactionAcetaminophen, Dexbrompheniramine, PseudoephedrineSinadrin Plus
How Acetaminophen, Dexbrompheniramine, Pseudoephedrine interacts with Raspberry Ketones Mega+ 250 mg — through 1 ingredient. Tap an ingredient for the detail:
Raspberry KetonesStimulant Drugs Moderate
Interaction Summary
Theoretically, raspberry ketone might increase the risk of adverse cardiovascular effects with stimulant drugs.
Read the full Raspberry Ketones + Acetaminophen, Dexbrompheniramine, Pseudoephedrine interactionAcetaminophen, Dextromethorphan, Doxylamine, PseudoephedrineVicks NyQuil
How Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interacts with Raspberry Ketones Mega+ 250 mg — through 1 ingredient. Tap an ingredient for the detail:
Raspberry KetonesStimulant Drugs Moderate
Interaction Summary
Theoretically, raspberry ketone might increase the risk of adverse cardiovascular effects with stimulant drugs.
Read the full Raspberry Ketones + Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PhenylephrineConar-A
How Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interacts with Raspberry Ketones Mega+ 250 mg — through 1 ingredient. Tap an ingredient for the detail:
Raspberry KetonesStimulant Drugs Moderate
Interaction Summary
Theoretically, raspberry ketone might increase the risk of adverse cardiovascular effects with stimulant drugs.
Read the full Raspberry Ketones + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PhenylpropanolamineAnatuss
How Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interacts with Raspberry Ketones Mega+ 250 mg — through 1 ingredient. Tap an ingredient for the detail:
Raspberry KetonesStimulant Drugs Moderate
Interaction Summary
Theoretically, raspberry ketone might increase the risk of adverse cardiovascular effects with stimulant drugs.
Read the full Raspberry Ketones + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PseudoephedrineRobitussin Cold, Severe Cold, Suphedrine Cold/Cough
How Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interacts with Raspberry Ketones Mega+ 250 mg — through 1 ingredient. Tap an ingredient for the detail:
Raspberry KetonesStimulant Drugs Moderate
Interaction Summary
Theoretically, raspberry ketone might increase the risk of adverse cardiovascular effects with stimulant drugs.
Read the full Raspberry Ketones + Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Raspberry Ketones Mega+ 250 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Raspberry Ketones
Stimulant Drugs
Theoretically, raspberry ketone might increase the risk of adverse cardiovascular effects with stimulant drugs.
Structurally, raspberry ketone resembles synephrine, a known stimulant agent. Heart palpitations, elevated blood pressure, coronary vasospasm, pulseless electrical activity arrest, and resistant polymorphic ventricular tachycardia have been reported in patients taking raspberry ketone.
Warfarin (Coumadin)
Theoretically, raspberry ketone might increase warfarin dose requirements.
In one case report, a patient taking warfarin 55 mg per week had a decrease in INR over a period of one month while taking raspberry ketone 250 mg daily. A warfarin dose increase to 70 mg per week was necessary to maintain a therapeutic INR while taking raspberry ketone. The mechanism for this potential interaction is not known.
L-Tyrosine
Levodopa
Theoretically, tyrosine might decrease the effectiveness of levodopa.
Tyrosine and levodopa compete for absorption in the proximal duodenum by the large neutral amino acid (LNAA) transport system. Advise patients to separate doses of tyrosine and levodopa by at least 2 hours.
Thyroid Hormone
Theoretically, tyrosine might have additive effects with thyroid hormone medications.
Tyrosine is a precursor to thyroxine and might increase levels of thyroid hormones.
L-Phenylalanine
Levodopa
Phenylalanine, especially in high doses, can reduce the effectiveness of levodopa.
Phenylalanine competes with levodopa for carrier-mediated transport into the brain. The resulting reduction in levels of levodopa in the brain can exacerbate tremor, rigidity, and the "on-off" phenomenon in patients with Parkinson disease.
Baclofen
Concomitant intake of phenylalanine may reduce the intestinal absorption of baclofen.
Phenylalanine and baclofen share the same intestinal carrier for absorption; phenylalanine competitively inhibits the absorption of baclofen, reducing its plasma levels.
Monoamine Oxidase Inhibitors (Maois)
Theoretically, concomitant use of L-phenylalanine and non-selective MAOIs might increase the risk of hypertensive crisis.
L-phenylalanine is metabolized to tyrosine. Some evidence suggests that L-phenylalanine, given with the non-selective MAOI pargyline, might prevent the elimination of tyramine, increasing the risk of hypertensive crisis. However, this was not reported in a small number of patients when using L-phenylalanine with the partially selective MAO-B inhibitor, selegiline.
Brand information
Manufacturer and brand details for Raspberry Ketones Mega+ 250 mg, from the product label.
Raspberry Ketones Mega+ 250 mg by Natural Sport: Common Questions
Does Raspberry Ketones Mega+ 250 mg by Natural Sport interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I have phenylketonuria (PKU)?
What are the most common side effects?
Is this safe to take while pregnant?
Is this safe while breastfeeding?
Does raspberry ketone actually help with weight loss?
What does L-tyrosine do?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Raspberry Ketones Mega+ 250 mg is safe with your meds?
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Raspberry Ketones Mega+ 250 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Tyrosine
Interacts with 21 drugsL-tyrosine is an amino acid your body uses to make brain chemicals like dopamine and norepinephrine. Some studies suggest it may help mental performance during short-term stress, sleep loss,...
Read the full Tyrosine monograph → Herb & supplement monographPhenylalanine
Interacts with 16 drugsPhenylalanine is an essential amino acid the body uses to make brain chemicals like dopamine and norepinephrine. Some people take it for mood, vitiligo, or pain, but the evidence is mostly l...
Read the full Phenylalanine monograph → Herb & supplement monographRaspberry Ketone
Interacts with 174 drugsRaspberry ketone is a natural aroma compound found in red raspberries that is heavily marketed for weight loss, but there is no good human evidence that it helps people lose weight. Most cla...
Read the full Raspberry Ketone monograph →Sources & How We Checked
Raspberry Ketones Mega+ 250 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 31 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Tyrosine 4 references
- Meyer JS, Welch KM, Deshmukh VD, et al. Neurotransmitter precursor amino acids in the treatment of multi-infarct dementia and Alzheimer's disease. J Amer Geriat Soc 1977;25:289-98.
- DiPiro JT, Talbert RL, Yee GC, et al; eds. Pharmacotherapy: A pathophysiologic approach. 4th ed. Stamford, CT: Appleton & Lange, 1999.
- Wood DR, Reimherr FW, Wender PH. Amino acid precursors for the treatment of attention deficit disorder, residual type. Psychopharmacol Bull 1985;21:146-9.
- van Spronsen FJ, van Rijn M, Bekhof J. Phenylketonuria: tyrosine supplementation in phenylalanine-restricted diets. Am J Clin Nutr 2001;73:153-7. PubMed
Phenylalanine 23 references
- Rouse B, Azen C, Koch R, et al. Maternal phenylketonuria collaborative Study (MPKUCS) offspring: facial anomalies, malformations, and early neurological sequelae. Am J Med Genet 1997;69:89-95. DOI
- Sturtevant FM. Use of aspartame in pregnancy. Int J Fertil 1985;30:85-7.
- Silkaitis RP, Mosnaim AD. Pathways linking L-phenylalanine and 2-phenylethylamine with p-tyramine in rabbit brain. Brain Res 1976;114:105-15.
- Lehmann WD, Theobald N, Fischer R, Heinrich HC. Stereospecificity of phenylalanine plasma kinetics and hydroxylation in man following oral application of a stable isotope-labelled pseudo-racemic mixture of L- and D-phenylalanine. Clin Chim Acta 1983;128 PubMed
- Mosnik DM, Spring B, Rogers K, Baruah S. Tardive dyskinesia exacerbated after ingestion of phenylalanine by schizophrenic patients. Neuropsychopharmacology 1997;16:136-46. PubMed
- Siddiqui AH, Stolk LM, Bhaggoe R, et al. L-phenylalanine and UVA irradiation in the treatment of vitiligo. Dermatology 1994;88:215-8. PubMed
- Birkmayer W, Riederer P, Linauer W, Knoll J. L-deprenyl plus L-phenylalanine in the treatment of depression. J Neural Transm 1984;59:81-7. PubMed
- Nutt JG, Woodward WR, Hammerstad JP, et al. The "on-off" phenomenon in Parkinson's disease. Relation to levodopa absorption and transport. N Engl J Med 1984;310:483-8. PubMed
- Baruzzi A, Contin M, Riva R, et al. Influence of meal ingestion time on pharmacokinetics of orally administered levodopa in parkinsonian patients. Clin Neuropharmacol 1987;10:527-37. PubMed
- Juncos JL, Fabbrini G, Mouradian MM, et al. Dietary influences on the antiparkinsonian response to levodopa. Arch Neurol 1987;44:1003-5. PubMed
- Eriksson T, Granerus AK, Linde A, et al. "On-off" phenomenon in Parkinson's disease: relationship between dopa and other large neutral amino acids in plasma. Neurology 1988;38:1245-8. PubMed
- Baker GB, Bornstein RA, Rouget AC, et al. Phenylethylaminergic mechanisms in attention-deficit disorder. Biol Psychiatry 1991;29:15-22.. PubMed
- Wood DR, Reimherr FW, Wender PH. Treatment of attention deficit disorder with DL-phenylalanine. Psychiatry Res 1985;16:21-6.. PubMed
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids (Macronutrients). Washington, DC: National Academy Press, 2002. Available at: http://www.n
- Cederbaum S. Phenylketonuria: an update. Curr Opin Pediatr 2002;14:702-6. PubMed
- Cejudo-Ferragud, E., Nacher, A., Polache, A., Cercos-Fortea, T., Merino, M., and Casabo, V. G. Evidence of competitive inhibition for the intestinal absorption of baclofen by phenylalanine. Int J of Pharm (Amsterdam) 1996;132:63-69. DOI
- Fischer, E., Heller, B., Nachon, M., and Spatz, H. Therapy of depression by phenylalanine. Preliminary note. Arzneimittelforschung. 1975;25(1):132.
- Beckmann, H., Strauss, M. A., and Ludolph, E. Dl-phenylalanine in depressed patients: an open study. J.Neural Transm. 1977;41(2-3):123-134. PubMed
- Sabelli, H. C., Fawcett, J., Gusovsky, F., Javaid, J. I., Wynn, P., Edwards, J., Jeffriess, H., and Kravitz, H. Clinical studies on the phenylethylamine hypothesis of affective disorder: urine and blood phenylacetic acid and phenylalanine dietary supplem
- Cotzias, G. C., Van Woert, M. H., and Schiffer, L. M. Aromatic amino acids and modification of parkinsonism. N Engl.J Med 2-16-1967;276(7):374-379. PubMed
- Kravitz, H. M., Sabelli, H. C., and Fawcett, J. Dietary supplements of phenylalanine and other amino acid precursors of brain neuroamines in the treatment of depressive disorders. J Am Osteopath.Assoc 1984;84(1 Suppl):119-123. DOI
- Mann, J., Peselow, E. D., Snyderman, S., and Gershon, S. D-phenylalanine in endogenous depression. Am.J.Psychiatry 1980;137(12):1611-1612. PubMed
- Katoulis AC, Alevizou A, Bozi E, et al. A randomized, double-blind, vehicle-controlled study of a preparation containing undecylenoyl phenylalanine 2% in the treatment of solar lentigines. Clin Exp Dermatol 2010;35(5):473-6. PubMed
Raspberry Ketone 4 references
- Adverse Event Report. Raspberry Ketone. Natural MedWatch, April 27, 2012.
- Adverse Event Report. Raspberry Ketone. Natural MedWatch, September 18, 2011.
- Ansari SA, Patel F, Ashouri D, Dhaliwal JSS, Desai A. Resistant Polymorphic Ventricular Tachycardia in a Patient Taking Raspberry Ketones Weight Loss Supplement. Cureus 2022;14(12):e33089. PubMed
- Khattar A, Beeton I. Coronary vasospasm and raspberry ketones weight-loss supplement: Is there a connection? Anatol J Cardiol. 2020;24(3):205-208.
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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