Rectum Lining Support Ingredients & Drug Interactions
by Herbal Terra
What is this page for?
First and foremost: checking Rectum Lining Support against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Rectum Lining Support is a dietary supplement by Herbal Terra with 3 active ingredients. Its ingredients are commonly taken for sore throat and cough, heartburn and acid reflux, digestive upset and ibs.Based on those ingredients, 2,124 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Marshmallow Leaf Extract, Dry, Slippery Elm Bark Extract, Dry, Garlic Bulb Extract, Dry. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Rectum Lining Support by Herbal Terra
Ask about any prescription or over-the-counter medication and we check it for interactions with Rectum Lining Support by Herbal Terra — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Rectum Lining Support by Herbal Terra
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Rectum Lining Support contains three active ingredients: slippery elm bark extract, garlic bulb extract, and marshmallow leaf extract, each included in dry form. These are mixed together in a proprietary extract blend and delivered as a liquid.
The product also contains alcohol, water, and glycerin as inactive ingredients to deliver the extracts.
Does it work?
Couldn't assess
The evidence for the active ingredients in this product hasn't been firmly established in our data. For slippery elm, there isn't enough reliable evidence to rate it for constipation, diarrhea, inflammatory bowel disease, cough, or cancer.
For marshmallow, we don't have established evidence for vaginal yeast infections, diarrhea, eczema, leg ulcers, or respiratory infections. Garlic extract, however, is rated possibly effective for diabetes, high blood pressure, atherosclerosis, and fatty liver disease — so that ingredient does have some supporting research for certain uses.
If you're taking this product for a specific condition, talk with your pharmacist about what the research actually shows for your situation.
How safe is it?
Well-documented data
Slippery elm is generally well tolerated for short-term use, though high-quality safety data are limited. It can cause contact dermatitis and hives if you're sensitive to it or its pollen.
Garlic is generally well tolerated when taken by mouth, but may cause abdominal pain, gas, bad breath, nausea, or allergic reactions in sensitive people. Food amounts are fine, but supplement doses are less studied.
Marshmallow is generally well tolerated for short-term use, but human safety data are sparse. For pregnancy and breastfeeding: garlic is rated likely safe during both, though one rating suggests possibly unsafe in pregnancy — talk with your doctor or pharmacist for personalized guidance.
Slippery elm has not enough data to know whether it's safe in pregnancy or while breastfeeding — don't assume it's fine without checking with your healthcare provider. Marshmallow should be avoided in pregnancy and breastfeeding due to lack of reliable safety information.
Meds to double-check
Moderate interaction found
Before starting Rectum Lining Support, double-check any blood thinners or antiplatelet drugs you're on (warfarin, aspirin, clopidogrel) — garlic may increase bleeding risk. Next, check blood pressure medications (antihypertensives), diabetes drugs, protease inhibitors for HIV, tacrolimus, lithium, and any drugs that require steady stomach absorption.
Slippery elm may slow how quickly oral medications enter your bloodstream, so timing matters. If you're on any of these, run them through the medication checker on this page — don't start without confirming it's safe with your pharmacist.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This product mixes three herbal ingredients with some research (especially garlic for certain conditions) but incomplete evidence overall. The main concern is interactions with blood thinners, blood pressure drugs, diabetes medications, and certain other prescription medications — especially if you're on warfarin or a protease inhibitor.
Check your exact medications with the tool on this page before taking it, and talk with your pharmacist or doctor to make sure it won't interfere with what you're already on.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Rectum Lining Support, straight from the product label.
| Brand | Herbal Terra |
|---|---|
| Barcode (UPC) | 7439500634690 |
| Net contents | 2 Fluid Ounce(s); 60 mL |
| Market status | On market |
| Date entered into DSLD | Aug 22, 2025 |
| DSLD ID | 325327 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Rectum Lining Support by Herbal Terra, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Extract Blend | 983 mg | -- |
| Slippery Elm Bark Extract, Dry | 0 NP | -- |
| Garlic Bulb Extract, Dry | 0 NP | -- |
| Marshmallow Leaf Extract, Dry | 0 NP | -- |
Other ingredients: Alcohol, Water, Glycerin
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Shake well before use. Adults take up to 30 drops (1 mL, one full squeeze of the dropper bulb) in 3-4 fl. oz. of juice or water up to 4 times a day.
Precautions
We recommend to seek expert medical advice before taking. May have contraindications and cause adverse reaction.
Consult a physician before giving to children under 18, before using during pregnancy, if nursing, or if you are on any medications.
Consult a physician before giving to children under 18, before using during pregnancy, if nursing, or if you are on any medications. Keep out of the reach of children!
Do not use if you are allergic to any ingredients.
Storage
Store in a cool, dry, dark place.
FDA Disclaimer Statement
This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure or prevent any disease.
Formulation
cGMP Made in compliance with cGMP 21 CFR 111 in an FDA registered and inspected facility.
Sugar free
Expertly extracted 100% natural Premium product
Organic alcohol
No artificial ingredients, color additives, fillers or binders.
Natural Gluten free
Formula
Organic alcohol
FDA Statement of Identity
Herbal Supplement
General Statements
Extraction rate: about 1/3-4 (up to 333 mg of dry raw material per 1 ml of extract).
Seals/Symbols
Made in USA
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Rectum Lining Support by Herbal Terra label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Rectum Lining Support by Herbal Terra
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 mL Dosage formLiquid Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Extract Blend
Other (inactive) ingredients: Alcohol, Water, Glycerin. These complete the product’s ingredient list but are not active constituents.
Rectum Lining Support by Herbal Terra Drug Interactions
HelloPharmacist Interaction Report
Rectum Lining Support by Herbal Terra contains three active ingredients, and the product does interact with a number of medications.
The most serious interaction we've documented is with garlic bulb extract and blood thinners (anticoagulant or antiplatelet drugs) — garlic may increase your bleeding risk, and one specific concern is warfarin, where there's a case report of patients whose blood-thinning levels rose unexpectedly when they added garlic.
Read the full breakdown — every affected drug type, severity by severity
Garlic also interacts with antihypertensive drugs (used to lower blood pressure), raising the theoretical risk of blood pressure dropping too far. It may affect how your body processes drugs broken down by certain liver enzymes (CYP3A4 and CYP2E1 substrates), potentially raising or lowering their levels.
There's a documented risk with protease inhibitors (HIV medications) and a case report involving tacrolimus (an immunosuppressant after transplant). Garlic may also lower blood sugar, so if you take diabetes medications, there's a theoretical increased risk of low blood sugar (hypoglycemia).
Slippery elm bark extract may slow the absorption of oral medications and reduce how much gets into your bloodstream. Marshmallow leaf extract could theoretically interfere with lithium (a mood stabilizer) by reducing how your kidneys clear it, raising toxicity risk.
It may also slow absorption of oral drugs and theoretically increase bleeding risk with blood thinners, though animal research suggests this is mainly a concern with the flower part, not the leaf commonly used in supplements.
Altogether, these interactions span 2,105 individual medications. Before starting this product, use the medication checker on this page to look up your exact prescriptions — don't rely on drug class names alone.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Rectum Lining Support?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Rectum Lining Support interact with 2,124 drugs. Click any drug to see the details.
3 of the 3 ingredients in Rectum Lining Support interact with drugs. Each result below shows which ingredient is responsible. Marshmallow Leaf Extract, Dry Slippery Elm Bark Extract, Dry Garlic Bulb Extract, Dry
AltretamineHexalen
How Altretamine interacts with Rectum Lining Support — through 2 ingredients. Tap an ingredient for the detail:
Slippery Elm Bark Extract, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Bark Extract, Dry + Altretamine interactionMarshmallow Leaf Extract, DryOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Leaf Extract, Dry + Altretamine interactionAluminum ChlorideAluminum Chloride, Anhydrol Forte, Driclor, Drysol
How Aluminum Chloride interacts with Rectum Lining Support — through 2 ingredients. Tap an ingredient for the detail:
Slippery Elm Bark Extract, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Bark Extract, Dry + Aluminum Chloride interactionMarshmallow Leaf Extract, DryOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Leaf Extract, Dry + Aluminum Chloride interactionAluminum HydroxideAlu-Cap, Amphojel, Gaviscon
How Aluminum Hydroxide interacts with Rectum Lining Support — through 2 ingredients. Tap an ingredient for the detail:
Slippery Elm Bark Extract, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Bark Extract, Dry + Aluminum Hydroxide interactionMarshmallow Leaf Extract, DryOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Leaf Extract, Dry + Aluminum Hydroxide interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Rectum Lining Support — through 3 ingredients. Tap an ingredient for the detail:
Slippery Elm Bark Extract, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Bark Extract, Dry + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionGarlic Bulb Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Garlic may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Garlic Bulb Extract, Dry + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionMarshmallow Leaf Extract, DryAnticoagulant/antiplatelet Drugs, Oral Drugs Minor
Interaction Summary
Theoretically, marshmallow flower might have antiplatelet effects.
Read the full Marshmallow Leaf Extract, Dry + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with Rectum Lining Support — through 3 ingredients. Tap an ingredient for the detail:
Garlic Bulb Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Garlic may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Garlic Bulb Extract, Dry + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionSlippery Elm Bark Extract, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Bark Extract, Dry + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionMarshmallow Leaf Extract, DryOral Drugs, Anticoagulant/antiplatelet Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Leaf Extract, Dry + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAluminum Hydroxide, Magnesium Hydroxide (otc Drug)Maalox, Mucogel
How Aluminum Hydroxide, Magnesium Hydroxide (otc Drug) interacts with Rectum Lining Support — through 2 ingredients. Tap an ingredient for the detail:
Slippery Elm Bark Extract, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Bark Extract, Dry + Aluminum Hydroxide, Magnesium Hydroxide (otc Drug) interactionMarshmallow Leaf Extract, DryOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Leaf Extract, Dry + Aluminum Hydroxide, Magnesium Hydroxide (otc Drug) interactionAluminum Hydroxide, Magnesium Hydroxide, Simethicone (otc Drug)Mylanta
How Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (otc Drug) interacts with Rectum Lining Support — through 2 ingredients. Tap an ingredient for the detail:
Slippery Elm Bark Extract, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Bark Extract, Dry + Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (otc Drug) interactionMarshmallow Leaf Extract, DryOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Leaf Extract, Dry + Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (otc Drug) interactionAluminum, CalciumDomeboro
How Aluminum, Calcium interacts with Rectum Lining Support — through 2 ingredients. Tap an ingredient for the detail:
Slippery Elm Bark Extract, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Bark Extract, Dry + Aluminum, Calcium interactionMarshmallow Leaf Extract, DryOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Leaf Extract, Dry + Aluminum, Calcium interactionAluminum, Magnesium (otc Drug)Almagel
How Aluminum, Magnesium (otc Drug) interacts with Rectum Lining Support — through 2 ingredients. Tap an ingredient for the detail:
Slippery Elm Bark Extract, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Bark Extract, Dry + Aluminum, Magnesium (otc Drug) interactionMarshmallow Leaf Extract, DryOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Leaf Extract, Dry + Aluminum, Magnesium (otc Drug) interactionAluminum, Magnesium Hydroxide (otc Drug)Wingel
How Aluminum, Magnesium Hydroxide (otc Drug) interacts with Rectum Lining Support — through 2 ingredients. Tap an ingredient for the detail:
Slippery Elm Bark Extract, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Bark Extract, Dry + Aluminum, Magnesium Hydroxide (otc Drug) interactionMarshmallow Leaf Extract, DryOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Leaf Extract, Dry + Aluminum, Magnesium Hydroxide (otc Drug) interactionAlvimopanEntereg
How Alvimopan interacts with Rectum Lining Support — through 2 ingredients. Tap an ingredient for the detail:
Slippery Elm Bark Extract, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Bark Extract, Dry + Alvimopan interactionMarshmallow Leaf Extract, DryOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Leaf Extract, Dry + Alvimopan interactionAmantadineGocovri, Osmolex ER, Symmetrel
How Amantadine interacts with Rectum Lining Support — through 2 ingredients. Tap an ingredient for the detail:
Slippery Elm Bark Extract, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Bark Extract, Dry + Amantadine interactionMarshmallow Leaf Extract, DryOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Leaf Extract, Dry + Amantadine interactionAmbenonium ChlorideMytelase
How Ambenonium Chloride interacts with Rectum Lining Support — through 2 ingredients. Tap an ingredient for the detail:
Slippery Elm Bark Extract, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Bark Extract, Dry + Ambenonium Chloride interactionMarshmallow Leaf Extract, DryOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Leaf Extract, Dry + Ambenonium Chloride interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with Rectum Lining Support — through 3 ingredients. Tap an ingredient for the detail:
Slippery Elm Bark Extract, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Bark Extract, Dry + Ambrisentan interactionGarlic Bulb Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates, Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Garlic Bulb Extract, Dry + Ambrisentan interactionMarshmallow Leaf Extract, DryOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Leaf Extract, Dry + Ambrisentan interactionAmifampridineRuzurgi
How Amifampridine interacts with Rectum Lining Support — through 2 ingredients. Tap an ingredient for the detail:
Slippery Elm Bark Extract, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Bark Extract, Dry + Amifampridine interactionMarshmallow Leaf Extract, DryOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Leaf Extract, Dry + Amifampridine interactionAmifampridine PhosphateFirdapse
How Amifampridine Phosphate interacts with Rectum Lining Support — through 2 ingredients. Tap an ingredient for the detail:
Slippery Elm Bark Extract, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Bark Extract, Dry + Amifampridine Phosphate interactionMarshmallow Leaf Extract, DryOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Leaf Extract, Dry + Amifampridine Phosphate interactionAmikacinAmikin, Arikayce
How Amikacin interacts with Rectum Lining Support — through 2 ingredients. Tap an ingredient for the detail:
Slippery Elm Bark Extract, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Bark Extract, Dry + Amikacin interactionMarshmallow Leaf Extract, DryOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Leaf Extract, Dry + Amikacin interactionAmilorideAmilamont, Midamor
How Amiloride interacts with Rectum Lining Support — through 3 ingredients. Tap an ingredient for the detail:
Slippery Elm Bark Extract, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Bark Extract, Dry + Amiloride interactionGarlic Bulb Extract, DryAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking garlic with antihypertensive drugs might increase the risk of hypotension.
Read the full Garlic Bulb Extract, Dry + Amiloride interactionMarshmallow Leaf Extract, DryOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Leaf Extract, Dry + Amiloride interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with Rectum Lining Support — through 3 ingredients. Tap an ingredient for the detail:
Garlic Bulb Extract, DryAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking garlic with antihypertensive drugs might increase the risk of hypotension.
Read the full Garlic Bulb Extract, Dry + Amiloride, Hydrochlorothiazide interactionSlippery Elm Bark Extract, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Bark Extract, Dry + Amiloride, Hydrochlorothiazide interactionMarshmallow Leaf Extract, DryOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Leaf Extract, Dry + Amiloride, Hydrochlorothiazide interactionAminobenzoate PotassiumPotaba
How Aminobenzoate Potassium interacts with Rectum Lining Support — through 2 ingredients. Tap an ingredient for the detail:
Slippery Elm Bark Extract, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Bark Extract, Dry + Aminobenzoate Potassium interactionMarshmallow Leaf Extract, DryOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Leaf Extract, Dry + Aminobenzoate Potassium interactionAminocaproic Acid (oral)Amicar
How Aminocaproic Acid (oral) interacts with Rectum Lining Support — through 2 ingredients. Tap an ingredient for the detail:
Slippery Elm Bark Extract, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Bark Extract, Dry + Aminocaproic Acid (oral) interactionMarshmallow Leaf Extract, DryOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Leaf Extract, Dry + Aminocaproic Acid (oral) interactionAminoglutethimideCytadren
How Aminoglutethimide interacts with Rectum Lining Support — through 2 ingredients. Tap an ingredient for the detail:
Slippery Elm Bark Extract, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Bark Extract, Dry + Aminoglutethimide interactionMarshmallow Leaf Extract, DryOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Leaf Extract, Dry + Aminoglutethimide interactionAminolevulinic Acid HydrochlorideAmeluz, Gleolan
How Aminolevulinic Acid Hydrochloride interacts with Rectum Lining Support — through 2 ingredients. Tap an ingredient for the detail:
Slippery Elm Bark Extract, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Bark Extract, Dry + Aminolevulinic Acid Hydrochloride interactionMarshmallow Leaf Extract, DryOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Leaf Extract, Dry + Aminolevulinic Acid Hydrochloride interactionAminophyllineAminophylline
How Aminophylline interacts with Rectum Lining Support — through 2 ingredients. Tap an ingredient for the detail:
Slippery Elm Bark Extract, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Bark Extract, Dry + Aminophylline interactionMarshmallow Leaf Extract, DryOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Leaf Extract, Dry + Aminophylline interactionAminophylline, Amobarbital, EphedrineAmesec
How Aminophylline, Amobarbital, Ephedrine interacts with Rectum Lining Support — through 2 ingredients. Tap an ingredient for the detail:
Slippery Elm Bark Extract, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Bark Extract, Dry + Aminophylline, Amobarbital, Ephedrine interactionMarshmallow Leaf Extract, DryOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Leaf Extract, Dry + Aminophylline, Amobarbital, Ephedrine interactionAminosalicylate SodiumTubasal
How Aminosalicylate Sodium interacts with Rectum Lining Support — through 2 ingredients. Tap an ingredient for the detail:
Slippery Elm Bark Extract, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Bark Extract, Dry + Aminosalicylate Sodium interactionMarshmallow Leaf Extract, DryOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Leaf Extract, Dry + Aminosalicylate Sodium interactionAminosalicylic AcidPaser
How Aminosalicylic Acid interacts with Rectum Lining Support — through 2 ingredients. Tap an ingredient for the detail:
Slippery Elm Bark Extract, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Bark Extract, Dry + Aminosalicylic Acid interactionMarshmallow Leaf Extract, DryOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Leaf Extract, Dry + Aminosalicylic Acid interactionAmiodaroneCordarone, Pacerone
How Amiodarone interacts with Rectum Lining Support — through 3 ingredients. Tap an ingredient for the detail:
Garlic Bulb Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Garlic Bulb Extract, Dry + Amiodarone interactionSlippery Elm Bark Extract, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Bark Extract, Dry + Amiodarone interactionMarshmallow Leaf Extract, DryOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Leaf Extract, Dry + Amiodarone interactionAmitriptylineElavil
How Amitriptyline interacts with Rectum Lining Support — through 3 ingredients. Tap an ingredient for the detail:
Slippery Elm Bark Extract, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Bark Extract, Dry + Amitriptyline interactionGarlic Bulb Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Garlic Bulb Extract, Dry + Amitriptyline interactionMarshmallow Leaf Extract, DryOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Leaf Extract, Dry + Amitriptyline interactionAmitriptyline, ChlordiazepoxideLimbitrol DS
How Amitriptyline, Chlordiazepoxide interacts with Rectum Lining Support — through 3 ingredients. Tap an ingredient for the detail:
Garlic Bulb Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Garlic Bulb Extract, Dry + Amitriptyline, Chlordiazepoxide interactionSlippery Elm Bark Extract, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Bark Extract, Dry + Amitriptyline, Chlordiazepoxide interactionMarshmallow Leaf Extract, DryOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Leaf Extract, Dry + Amitriptyline, Chlordiazepoxide interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Rectum Lining Support with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Marshmallow Leaf Extract, Dry
Lithium
Theoretically, due to potential diuretic effects, marshmallow might reduce excretion and increase levels of lithium.
Marshmallow is thought to have diuretic properties. To avoid lithium toxicity, the dose of lithium might need to be decreased when used with marshmallow.
Anticoagulant/Antiplatelet Drugs
Theoretically, marshmallow flower might have antiplatelet effects.
Animal research suggests that marshmallow flower extract has antiplatelet effects. However, the root and leaf of marshmallow, not the flower, are the plant parts most commonly found in dietary supplements. Theoretically, use of marshmallow flower with anticoagulant/antiplatelet drugs can have additive effects, and might increase the risk for bleeding in some patients.
Oral Drugs
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Marshmallow contains mucilage which can affect oral drug absorption. To avoid changes in absorption, take marshmallow 30-60 minutes after oral medications.
Slippery Elm Bark Extract, Dry
Oral Drugs
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Slippery elm inner bark contains mucilage, which may interfere with the absorption of orally administered drugs.
Garlic Bulb Extract, Dry
Anticoagulant/Antiplatelet Drugs
Garlic may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Raw garlic and a variety of garlic extracts have antiplatelet activity and can increase prothrombin time.
Antidiabetes Drugs
Theoretically, taking garlic with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research suggests that garlic and garlic extract lower blood glucose levels in healthy and diabetic individuals.
Antihypertensive Drugs
Theoretically, taking garlic with antihypertensive drugs might increase the risk of hypotension.
In human research, both garlic and garlic extracts have blood pressure-lowering effects.
Atazanavir (Reyataz)
Theoretically, garlic might decrease levels and effects of atazanavir.
In a case report, a patient consuming six stir-fried garlic cloves three times weekly developed suboptimal atazanavir levels and increases in HIV viral load. While the exact cause of this interaction is unclear, there is speculation that garlic might decrease the intestinal absorption of atazanavir or increase its metabolism by inducing cytochrome P450 3A4 (CYP3A4). Until more is known, advise patients not to consume large amounts of garlic while taking atazanavir.
Cytochrome P450 2E1 (Cyp2E1) Substrates
Garlic might increase levels of drugs metabolized by CYP2E1.
Clinical research suggests garlic oil can inhibit the activity of CYP2E1 by 39%. Use garlic oil cautiously in patients taking drugs metabolized by these enzymes.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4. This may increase or decrease levels of drugs metabolized by CYP3A4.
Some human research suggests that garlic may induce INTESTINAL CYP3A4, reducing levels of drugs metabolized by this enzyme. This is primarily based on a study showing that taking a specific allicin-containing garlic product (GarliPure Maximum Allicin Formula, Natrol Inc.) twice daily for 3 days reduces saquinavir levels by approximately 50%. It is speculated that the allicin constituent induced CYP3A4 in the gut mucosa. Another study shows that giving docetaxel intravenously, bypassing the CYP3A4 enzymes in the gut mucosa, along with the same specific garlic product for 12 consecutive days, does not affect docetaxel levels. Conversely, there is concern that garlic may inhibit HEPATIC CYP3A4. In a single case report, increased tacrolimus levels and liver injury occurred in a liver transplant patient after taking a specific garlic supplement (Garlicin Cardio, Nature's Way) at up to three times the manufacturer recommended dose for 7 days. Several other studies have evaluated the impact of other garlic formulations on CYP3A4 substrates and have found no effect. Most of the products in these studies provided little or no allicin.
Isoniazid
Theoretically, garlic might decrease levels of isoniazid.
Animal research suggests that an aqueous extract of garlic reduces isoniazid levels by about 65%. Garlic reduced the maximum concentration (Cmax) and area under the curve (AUC), but not the half-life, of isoniazid. This suggests that garlic extract might inhibit isoniazid absorption across the intestinal mucosa; however, the exact mechanism of this potential interaction is not known.
Protease Inhibitors (Pis)
Theoretically, garlic products containing allicin might decrease levels of PIs.
Protease inhibitors are metabolized by cytochrome P450 3A4 (CYP3A4) isoenzymes. There is concern that garlic products containing allicin might induce intestinal CYP3A4, reducing plasma levels of protease inhibitors. This is primarily based on a study showing that taking a specific garlic product (GarliPure Maximum Allicin Formula, Natrol Inc.) twice daily for 3 days reduces levels of saquinavir, a PI, by approximately 50%. It is speculated that the allicin constituent induce CYP3A4 in the gut mucosa. Several studies have evaluated the impact of other garlic formulations on CYP3A4 substrates and have found no effect. Most of the products in these studies provided little or no allicin.
Saquinavir (Fortovase, Invirase)
Theoretically, garlic containing allicin might decrease levels of saquinavir.
Saquinavir is a substrate of cytochrome P450 3A4 (CYP3A4) isoenzymes. There is concern that garlic products containing allicin might induce intestinal CYP3A4 and cause subtherapeutic levels of saquinavir. This is primarily based on a pharmacokinetic study showing that taking a specific garlic product (GarliPure Maximum Allicin Formula, Natrol Inc.) twice daily for 3 days reduces saquinavir levels by approximately 50%. It is speculated that the allicin constituent induces CYP3A4 in the gut mucosa. Several pharmacokinetic studies have evaluated the impact of other garlic formulations on CYP3A4 substrates and have found no effect. Most of the products in these studies provided little or no allicin. Until more is known about this potential interaction, use garlic containing allicin cautiously in patients taking saquinavir.
Sofosbuvir (Sovaldi)
Theoretically, taking garlic with sofosbuvir might decrease its effectiveness.
Animal research in rats shows that giving aged garlic extract 120 mg/kg orally daily for 14 days decreases the area under the concentration time curve (AUC) after a single sofosbuvir dose of 40 mg/kg by 36%, increases the clearance by 63%, and decreases the plasma concentrations at 1 and 8 hours by 35% and 58%, respectively. This interaction is hypothesized to be due to induction of intestinal P-glycoprotein expression by garlic.
Tacrolimus (Prograf)
Theoretically, garlic might increase levels of tacrolimus.
In one case report, a liver transplant patient taking tacrolimus experienced increased tacrolimus levels and liver injury after taking a specific garlic supplement (Garlicin Cardio, Nature's Way) at up to three times the manufacturer recommended dose for 7 days. It is speculated that garlic inhibited hepatic cytochrome P450 3A4 (CYP3A4), which increased plasma levels of tacrolimus.
Warfarin (Coumadin)
Theoretically, garlic might increase the risk of bleeding with warfarin.
Raw garlic and a variety of garlic extracts have antiplatelet activity and can increase prothrombin time. In addition, there is a report of two patients who experienced an increase in a previously stabilized international normalized ratio (INR) with concomitant garlic and warfarin use. However, this report has been subsequently debated due to limited clinical information. Other clinical studies have not identified an effect of garlic on INR, warfarin pharmacokinetics, or bleeding risk. More evidence is needed to determine the safety of using garlic with warfarin.
Brand information
Manufacturer and brand details for Rectum Lining Support, from the product label.
Herbal Terra
See all Herbal Terra products- Name
- Herbal Terra LLC
- Phone Number
- +18083857868
- Web Address
- herbalterra.com
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Rectum Lining Support’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Slippery Elm
Interacts with 2,022 drugsSlippery elm is a traditional herbal remedy made from the inner bark of a North American elm tree, used mainly to soothe sore throats and irritated digestive tracts. Its mucilage can coat an...
Read the full Slippery Elm monograph → Herb & supplement monographGarlic
Interacts with 989 drugsGarlic is a common food and supplement that may modestly help with blood pressure and cholesterol, though the evidence is mixed and effects are usually small. It is generally safe in food am...
Read the full Garlic monograph → Herb & supplement monographMarshmallow
Interacts with 2,040 drugsMarshmallow root is a traditional herb rich in soothing, gel-like fibers called mucilage, which is why it has long been used for coughs, sore throats, and stomach irritation. Evidence for th...
Read the full Marshmallow monograph →Sources & How We Checked
Rectum Lining Support's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 162 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Slippery Elm 3 references
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
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- Czarnecki D, Nixon R, Bekhor P, and et al. Delayed prolonged contact urticaria from the elm tree. Contact Dermatitis 1993;28:196-197. PubMed
Garlic 154 references
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- McMahon FG, Vargas R. Can garlic lower blood pressure? A pilot study. Pharmacotherapy 1993;13:406-7. DOI
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- Garty BZ. Garlic burns. Pediatrics 1993;91:658-9.
- Rose KD, Croissant PD, Parliament CF, Levin MB. Spontaneous spinal epidural hematoma with associated platelet dysfunction from excessive garlic ingestion: a case report. Neurosurg 1990;26:880-2. PubMed
- Burnham BE. Garlic as a possible risk for postoperative bleeding. Plast Reconstr Surg 1995;95:213.
- Sunter WH. Warfarin and garlic. Pharm J 1991;246:722.
- Berthold HK, Sudhop T, von Bergmann K. Effect of a garlic oil preparation on serum lipoproteins and cholesterol metabolism. JAMA 1998;279:1900-2.
- Steiner M, Khan AH, Holbert D, Lin RI. A double-blind crossover study in moderately hypercholesterolemic men that compared the effect of aged garlic extract and placebo administration on blood lipids. Am J Clin Nutr 1996;64:866-70. PubMed
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- Rahman K, Billington D. Dietary supplementation with aged garlic extract inhibits ADP-induced platelet aggregation in humans. J Nutr 2000;130:2662-5. PubMed
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- Mader FH. Treatment of hyperlipidaemia with garlic-powder tablets. Evidence from the German Association of General Practitioners' multicentric placebo-controlled double-blind study. Arzneimittelforschung 1990;40:1111-6.
- Vorberg G, Schneider B. Therapy with garlic: results of a placebo-controlled, double-blind study. Br J Clin Pract Symp Suppl 1990;69:7-11.
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- Smyth, A. R., Cifelli, P. M., Ortori, C. A., Righetti, K., Lewis, S., Erskine, P., Holland, E. D., Givskov, M., Williams, P., Camara, M., Barrett, D. A., and Knox, A. Garlic as an inhibitor of Pseudomonas aeruginosa quorum sensing in cystic fibrosis--a p
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- Adachi, A. [Two cases of eosinophilic gastroenteritis whose causative allergens are usefully diagnosed by patch test]. Arerugi 2010;59(5):545-551.
- Ried, K., Frank, O. R., and Stocks, N. P. Aged garlic extract lowers blood pressure in patients with treated but uncontrolled hypertension: a randomised controlled trial. Maturitas 2010;67(2):144-150. PubMed
- Hansanugrum, A. and Barringer, S. A. Effect of milk on the deodorization of malodorous breath after garlic ingestion. J.Food Sci. 8-1-2010;75(6):C549-C558. PubMed
- Hurley, M. N., Forrester, D. L., and Smyth, A. R. Antibiotic adjuvant therapy for pulmonary infection in cystic fibrosis. Cochrane.Database.Syst.Rev. 2010;(10):CD008037. PubMed
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- Takeuchi, S., Matsuzaki, Y., Ikenaga, S., Nishikawa, Y., Kimura, K., Nakano, H., and Sawamura, D. Garlic-induced irritant contact dermatitis mimicking nail psoriasis. J.Dermatol. 2011;38(3):280-282. PubMed
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- Ashraf, R., Khan, R. A., and Ashraf, I. Garlic (Allium sativum) supplementation with standard antidiabetic agent provides better diabetic control in type 2 diabetes patients. Pak.J.Pharm.Sci. 2011;24(4):565-570.
- Bakhshi, M., Taheri, J. B., Shabestari, S. B., Tanik, A., and Pahlevan, R. Comparison of therapeutic effect of aqueous extract of garlic and nystatin mouthwash in denture stomatitis. Gerodontology. 2012;29(2):e680-e684. PubMed
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- Fedder, S. L. Spinal epidural hematoma and garlic ingestion. Neurosurgery 1990;27(4):659. DOI
- Lissiman, E., Bhasale, A. L., and Cohen, M. Garlic for the common cold. Cochrane.Database.Syst.Rev. 2012;3:CD006206. PubMed
- Kaplan, B., Schewach-Millet, M., and Yorav, S. Factitial dermatitis induced by application of garlic. Int J Dermatol. 1990;29(1):75-76. PubMed
- Harenberg, J., Giese, C., and Zimmermann, R. Effect of dried garlic on blood coagulation, fibrinolysis, platelet aggregation and serum cholesterol levels in patients with hyperlipoproteinemia. Atherosclerosis 1988;74(3):247-249. PubMed
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