Red Sage Alcohol Free Ingredients & Drug Interactions
by Herbal Terra
What is this page for?
First and foremost: checking Red Sage Alcohol Free against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Red Sage Alcohol Free is a dietary supplement by Herbal Terra with 1 active ingredient. Its ingredients are commonly taken for sore throat and mouth irritation, digestive upset, excessive sweating.Based on those ingredients, 1,297 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Red Sage Root Extract, Dry. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Red Sage Alcohol Free by Herbal Terra
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AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Red Sage Alcohol Free by Herbal Terra
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
The one active ingredient is red sage root extract, dry, the herbal component that gives this liquid its purpose. Its specific role is described through the effectiveness ratings below, and we hold no further detail on its mechanism.
The inactive ingredients listed are glycerin and water. These are non-active components that make up the liquid base rather than contributing to the product's intended use.
Does it work?
Moderate evidence
Red sage has been rated possibly effective for menopausal symptoms, for hyperlipidemia (high levels of fats such as cholesterol in the blood), and for cognitive function. These ratings mean the evidence is promising but not conclusive.
For postoperative pain, red sage is rated possibly ineffective, so it is not expected to help with that use.
How safe is it?
Well-documented data
Red sage seems to be generally well tolerated when taken orally, applied to the skin, or inhaled. The most common side effects by mouth are abdominal pain, agitation, diarrhea, dizziness, nausea, and vomiting.
On the skin, burning, dermatitis, and pain are most common. Serious effects are rare, and include generalized tonic-clonic seizures linked to the thujone, camphor, and cineole constituents.
Concentrated extracts and the essential oil call for extra caution. A case report describes acute sage toxicity from excessive consumption, which improved once intake stopped.
During pregnancy, the safety data advises against medicinal or concentrated amounts because of thujone content, while food amounts are likely fine. For breastfeeding, red sage is rated possibly unsafe, and it has traditionally been used to reduce milk supply, so talk with your doctor before using it.
Meds to double-check
Moderate interaction found
Double-check with your doctor or pharmacist before taking this product if you use CNS depressants, antihypertensive drugs, estrogens, or drugs processed by CYP2D6, CYP2C19, CYP2C9, CYP3A4, or the P-glycoprotein transporter. Each of these is rated Moderate in our data.
Use the search tool on this page to look up your exact medications.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
Red sage may be worth discussing with your own doctor if you are looking at it for menopausal symptoms, high cholesterol, or cognitive function, since the evidence is rated possibly effective. If you take sedatives, blood pressure medicines, hormone therapy, or drugs processed by the liver enzymes listed above, be especially careful and talk it over first.
If you are pregnant or breastfeeding, speak with your doctor or pharmacist for personalized advice before using it.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Red Sage Alcohol Free, straight from the product label.
| Brand | Herbal Terra |
|---|---|
| Barcode (UPC) | 7238360538342 |
| Net contents | 2 Fluid Ounce(s); 60 mL |
| Market status | On market |
| Date entered into DSLD | Mar 25, 2025 |
| DSLD ID | 324493 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Red Sage Alcohol Free by Herbal Terra, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Red Sage Root Extract, Dry | 1156 mg | -- |
Other ingredients: Glycerin, Water
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Shake well before use. Adults take up to 30 drops (1 mL, one full squeeze of the dropper bulb) in 3-4 fl. oz. of juice or water up to 4 times a day.
Precautions
We recommend to seek expert medical advice before taking. May have contraindications and cause adverse reaction.
Consult a physician before giving to children under 18, before using during pregnancy, if nursing, or if you are on any medications.
Consult a physician before giving to children under 18, before using during pregnancy, if nursing, or if you are on any medications. Keep out of the reach of children!
Do not use if you are allergic to any ingredients.
Storage
Store in a cool, dry, dark place.
FDA Disclaimer Statement
This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure or prevent any disease.
Formulation
cGMP Made in compliance with cGMP 21 CFR 111 in an FDA registered and inspected facility.
Sugar free
Expertly extracted 100% natural Premium product
No alcohol (ethyl), artificial ingredients, color additives, fillers or binders.
Natural Gluten free
Formula
Salvia miltiorrhiza
FDA Statement of Identity
Herbal Supplement
General Statements
Organic raw material.
Seals/Symbols
Made in USA
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Red Sage Alcohol Free by Herbal Terra label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Red Sage Alcohol Free by Herbal Terra
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 mL Dosage formLiquid Servings per container60 Amounts shown are per serving.
Red Sage Root Extract, Dry
Interacts with1,297 drugs
Sage is a common kitchen herb that is generally safe in food amounts and is traditionally used for sore throats, digestion, sweating, and memory. Some...
Red Sage Root Extract, Dry monograph & interactionsOther (inactive) ingredients: Glycerin, Water. These complete the product’s ingredient list but are not active constituents.
Red Sage Alcohol Free by Herbal Terra Drug Interactions
HelloPharmacist Interaction Report
Red Sage Alcohol Free from Herbal Terra has one active ingredient, red sage root extract, and it does have documented interactions with medications.
Its most serious flagged interaction is with CNS depressants (drugs that slow the brain and nervous system), rated Moderate, because sage constituents may add to their sedative effects. Altogether, these interactions span 1,298 individual medications.
Read the full breakdown — every affected drug type, severity by severity
Several other drug types are also flagged. Blood pressure medicines (antihypertensive drugs) may have their effects increased or decreased, and clinical research suggests Spanish sage can raise blood pressure in some people with hypertension.
Hormone therapy (estrogens) may be interfered with, though the clinical significance is unclear. Drugs processed by several liver enzymes (CYP2D6, CYP2C19, CYP2C9, and CYP3A4) and drugs moved by the P-glycoprotein transporter are also flagged.
Each of these types is rated Moderate, but the liver enzyme and transporter links come from lab studies, and they have not been reported in humans.
We have no separate interaction data for any other ingredient, since this product contains only the one. To check your exact medications, use the search tool on this page, and talk with your own doctor or pharmacist before combining the product with anything you take.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Red Sage Alcohol Free?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Red Sage Alcohol Free interact with 1,297 drugs. Click any drug to see the details.
1 of the 1 ingredient in Red Sage Alcohol Free interact with drugs. Each result below shows which ingredient is responsible. Red Sage Root Extract, Dry
DoxorubicinAdriamycin, Caelyx, Doxil, Myocet, Rubex
How Doxorubicin interacts with Red Sage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Red Sage Root Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates, P-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Red Sage Root Extract, Dry + Doxorubicin interactionDoxycyclineDoryx, Doxy, Doxy-D, Doxycin, Doxycycline Injection, Doxylin +6 more
How Doxycycline interacts with Red Sage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Red Sage Root Extract, DryP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, sage might increase levels of drugs transported by P-glycoprotein.
Read the full Red Sage Root Extract, Dry + Doxycycline interactionDoxycycline HyclateActiclate, Acticlate Cap, Lymepak
How Doxycycline Hyclate interacts with Red Sage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Red Sage Root Extract, DryP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, sage might increase levels of drugs transported by P-glycoprotein.
Read the full Red Sage Root Extract, Dry + Doxycycline Hyclate interactionDoxycycline MonohydrateErfacea
How Doxycycline Monohydrate interacts with Red Sage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Red Sage Root Extract, DryP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, sage might increase levels of drugs transported by P-glycoprotein.
Read the full Red Sage Root Extract, Dry + Doxycycline Monohydrate interactionDoxycylineDoxychel
How Doxycyline interacts with Red Sage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Red Sage Root Extract, DryP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, sage might increase levels of drugs transported by P-glycoprotein.
Read the full Red Sage Root Extract, Dry + Doxycyline interactionDoxylamine SuccinateUnisom
How Doxylamine Succinate interacts with Red Sage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Red Sage Root Extract, DryAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, sage might decrease the clinical effects of anticholinergic drugs.
Read the full Red Sage Root Extract, Dry + Doxylamine Succinate interactionDoxylamine Succinate, Pyridoxine HydrochlorideBonjesta, Diclegis
How Doxylamine Succinate, Pyridoxine Hydrochloride interacts with Red Sage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Red Sage Root Extract, DryAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, sage might decrease the clinical effects of anticholinergic drugs.
Read the full Red Sage Root Extract, Dry + Doxylamine Succinate, Pyridoxine Hydrochloride interactionDronabinolMarinol, Syndros
How Dronabinol interacts with Red Sage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Red Sage Root Extract, DryCytochrome P450 2c9 (cyp2c9) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP2C9.
Read the full Red Sage Root Extract, Dry + Dronabinol interactionDronedaroneMultaq
How Dronedarone interacts with Red Sage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Red Sage Root Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Red Sage Root Extract, Dry + Dronedarone interactionDrospirenoneDrospirenone
How Drospirenone interacts with Red Sage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Red Sage Root Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Red Sage Root Extract, Dry + Drospirenone interactionDrospirenone, EstetrolNextstellis
How Drospirenone, Estetrol interacts with Red Sage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Red Sage Root Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates, P-glycoprotein Substrates +1 Moderate
Interaction Summary
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Red Sage Root Extract, Dry + Drospirenone, Estetrol interactionDrospirenone, Ethinyl EstradiolAngeliq, Gianvi, Yasmin
How Drospirenone, Ethinyl Estradiol interacts with Red Sage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Red Sage Root Extract, DryEstrogens, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, sage might interfere with hormone therapy.
Read the full Red Sage Root Extract, Dry + Drospirenone, Ethinyl Estradiol interactionDulaglutideTrulicity
How Dulaglutide interacts with Red Sage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Red Sage Root Extract, DryAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking sage with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Red Sage Root Extract, Dry + Dulaglutide interactionDuloxetineCymbalta, Drizalma Sprinkle, Irenka
How Duloxetine interacts with Red Sage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Red Sage Root Extract, DryCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP2D6.
Read the full Red Sage Root Extract, Dry + Duloxetine interactionDutasterideAvodart
How Dutasteride interacts with Red Sage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Red Sage Root Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Red Sage Root Extract, Dry + Dutasteride interactionDutasteride, TamsulosinJalyn
How Dutasteride, Tamsulosin interacts with Red Sage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Red Sage Root Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Red Sage Root Extract, Dry + Dutasteride, Tamsulosin interactionDuvelisibCopiktra
How Duvelisib interacts with Red Sage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Red Sage Root Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Red Sage Root Extract, Dry + Duvelisib interactionDyphylline, Ephedrine, Guaifenesin, PhenobarbitalLufyllin-EPG
How Dyphylline, Ephedrine, Guaifenesin, Phenobarbital interacts with Red Sage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Red Sage Root Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, taking sage might increase the sedative and adverse effects of CNS depressants.
Read the full Red Sage Root Extract, Dry + Dyphylline, Ephedrine, Guaifenesin, Phenobarbital interactionEchothiophatePhospholine Iodide
How Echothiophate interacts with Red Sage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Red Sage Root Extract, DryCholinergic Drugs Moderate
Interaction Summary
Theoretically, sage might have additive effects when used with cholinergic drugs.
Read the full Red Sage Root Extract, Dry + Echothiophate interactionEdrophoniumEnlon, Reversol, Tensilon
How Edrophonium interacts with Red Sage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Red Sage Root Extract, DryCholinergic Drugs Moderate
Interaction Summary
Theoretically, sage might have additive effects when used with cholinergic drugs.
Read the full Red Sage Root Extract, Dry + Edrophonium interactionEdrophonium, AtropineEnlon-Plus
How Edrophonium, Atropine interacts with Red Sage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Red Sage Root Extract, DryCholinergic Drugs, Anticholinergic Drugs Moderate
Interaction Summary
Theoretically, sage might have additive effects when used with cholinergic drugs.
Read the full Red Sage Root Extract, Dry + Edrophonium, Atropine interactionEfavirenzSustiva
How Efavirenz interacts with Red Sage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Red Sage Root Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Red Sage Root Extract, Dry + Efavirenz interactionEfavirenz, Lamivudine, Tenofovir Disoproxil FumarateSymfi
How Efavirenz, Lamivudine, Tenofovir Disoproxil Fumarate interacts with Red Sage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Red Sage Root Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Red Sage Root Extract, Dry + Efavirenz, Lamivudine, Tenofovir Disoproxil Fumarate interactionEffientPrasugrel
How Effient interacts with Red Sage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Red Sage Root Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2c9 (cyp2c9) Substrates +1 Moderate
Interaction Summary
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Red Sage Root Extract, Dry + Effient interactionElagolix SodiumOrilissa
How Elagolix Sodium interacts with Red Sage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Red Sage Root Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates, P-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Red Sage Root Extract, Dry + Elagolix Sodium interactionElagolix, Estradiol Norethindrone Acetate, ElagolixOriahnn
How Elagolix, Estradiol Norethindrone Acetate, Elagolix interacts with Red Sage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Red Sage Root Extract, DryP-glycoprotein Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, sage might increase levels of drugs transported by P-glycoprotein.
Read the full Red Sage Root Extract, Dry + Elagolix, Estradiol Norethindrone Acetate, Elagolix interactionElbasvir, GrazoprevirZepatier
How Elbasvir, Grazoprevir interacts with Red Sage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Red Sage Root Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Red Sage Root Extract, Dry + Elbasvir, Grazoprevir interactionElexacaftor, Tezacaftor, IvacaftorTrikafta
How Elexacaftor, Tezacaftor, Ivacaftor interacts with Red Sage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Red Sage Root Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Red Sage Root Extract, Dry + Elexacaftor, Tezacaftor, Ivacaftor interactionEliglustatCerdelga
How Eliglustat interacts with Red Sage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Red Sage Root Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Red Sage Root Extract, Dry + Eliglustat interactionElvitegravirVitekta
How Elvitegravir interacts with Red Sage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Red Sage Root Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Red Sage Root Extract, Dry + Elvitegravir interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Red Sage Alcohol Free with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Red Sage Root Extract, Dry
Anticholinergic Drugs
Theoretically, sage might decrease the clinical effects of anticholinergic drugs.
In vitro evidence suggests that common sage (Salvia officinalis) and Spanish sage (Salvia lavandulaefolia) can inhibit acetylcholinesterase and might increase acetylcholine levels.
Anticonvulsants
Theoretically, sage might interfere with the clinical effects of anticonvulsant drugs.
Some species of sage can cause convulsions when consumed in large quantities.
Antidiabetes Drugs
Theoretically, taking sage with antidiabetes drugs might increase the risk of hypoglycemia.
In patients with polycystic ovary syndrome (PCOS) or inadequately controlled type 2 diabetes, common sage (Salvia officinalis) has demonstrated hypoglycemic activity. However, other clinical research in patients with inadequately controlled type 2 diabetes shows that common sage extract does not lower fasting blood glucose levels.
Antihypertensive Drugs
Theoretically, sage might increase or decrease the effects of antihypertensive drugs.
Animal research suggests that common sage (Salvia officinalis) can cause prolonged blood pressure reduction. However, clinical research suggests that Spanish sage (Salvia lavandulaefolia) can increase blood pressure in some people with hypertension. Until more is known, use with caution.
Benzodiazepines
Theoretically, taking sage might increase the sedative and adverse effects of benzodiazepines.
In vitro evidence suggests that certain components of common sage (Salvia officinalis) can bind to benzodiazepine receptors. This effect has not been reported in humans.
Cholinergic Drugs
Theoretically, sage might have additive effects when used with cholinergic drugs.
In vitro evidence suggests that common sage (Salvia officinalis) and Spanish sage (Salvia lavandulaefolia) can inhibit acetylcholinesterase and might increase acetylcholine levels.
Cns Depressants
Theoretically, taking sage might increase the sedative and adverse effects of CNS depressants.
Some constituents of sage have CNS depressant activity.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP2C19.
In vitro evidence suggests that aqueous extracts of sage can inhibit CYP2C19. So far, this interaction has not been reported in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP2C9.
In vitro evidence suggests that aqueous extracts of sage can inhibit CYP2C9. So far, this interaction has not been reported in humans.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP2D6.
In vitro evidence suggests that aqueous extracts of sage can inhibit CYP2D6. So far, this interaction has not been reported in humans.
Cytochrome P450 2E1 (Cyp2E1) Substrates
Theoretically, sage might decrease the levels and clinical effects of drugs metabolized by CYP2E1.
Animal research suggests that drinking common sage (Salvia officinalis) tea increases the expression of CYP2E1. So far, this interaction has not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP3A4.
In vitro evidence suggests that aqueous extracts of sage can inhibit CYP3A4. So far, this interaction has not been reported in humans.
Estrogens
Theoretically, sage might interfere with hormone therapy.
In vitro evidence suggests that geraniol, a constituent of Spanish sage (Salvia lavandulaefolia), exerts estrogenic activity. The clinical significance of this effect is unclear.
P-Glycoprotein Substrates
Theoretically, sage might increase levels of drugs transported by P-glycoprotein.
In vitro research suggests that common sage (Salvia officinalis) can inhibit the multi-drug transporter protein, P-glycoprotein. This effect has not been reported in humans.
Brand information
Manufacturer and brand details for Red Sage Alcohol Free, from the product label.
Herbal Terra
See all Herbal Terra products- Name
- Herbal Terra LLC
- Phone Number
- +18083857868
- Web Address
- herbalterra.com
Red Sage Alcohol Free by Herbal Terra: Common Questions
Does Red Sage Alcohol Free by Herbal Terra interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is red sage safe to use during pregnancy?
Can red sage cause side effects?
Does red sage work for high cholesterol?
Does red sage help with pain after surgery?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Red Sage Alcohol Free is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Red Sage Alcohol Free’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Red Sage Alcohol Free's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 27 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Sage 27 references
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Todorov S, Philianos S, Petkov V, et al. Experimental pharmacological study of three species from genus Salvia. Acta Physiol Pharmacol (Bulg) 1984;10:13-20.
- Perry NS, Bollen C, Perry EK, Ballard C. Salvia for dementia therapy: review of pharmacological activity and pilot tolerability clinical trial. Pharmacol Biochem Behav 2003;75:651-9.. PubMed
- Saller R, Buechi S, Meyrat R, Schmidhauser C. Combined herbal preparation for topical treatment of Herpes labialis. Forsch Komplementarmed Klass Naturheilkd 2001;8:373-82. PubMed
- Akhondzadeh S, Noroozian M, Mohammadi M, et al. Salvia officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease: a double blind, randomized and placebo-controlled trial. J Clin Pharm Ther 2003;28:53-9.
- Perry NB, Anderson RE, Brennan NJ, et al. Essential oils from dalmatian sage (Salvia officinalis l.): variations among individuals, plant parts, seasons, and sites. J Agric Food Chem 1999;47:2048-54..
- Foster BC, Vandenhoek S, Hana J, et al. In vitro inhibition of human cytochrome P450-mediated metabolism of marker substrates by natural products. Phytomedicine 2003;10:334-42.. PubMed
- Burkhard PR, Burkhardt K, Haenggeli CA, Landis T. Plant-induced seizures: reappearance of an old problem. J Neurol 1999;246:667-70. PubMed
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