Interactions on record — worth a quick check against your medications. Based on 3 of 5 ingredients. Check your meds →
Dietary supplement

Regu-Fem Ingredients & Drug Interactions

by R-U-Ved

Regu-Fem label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Regu-Fem against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Regu-Fem is a dietary supplement by R-U-Ved with 5 active ingredients. Its ingredients are commonly taken for heart health and circulation, digestive problems (constipation, diarrhea), cholesterol support.Based on those ingredients, 1,227 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Arjuna, Sitawari, Wild Yam. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Regu-Fem by R-U-Ved

Ask about any prescription or over-the-counter medication and we check it for interactions with Regu-Fem by R-U-Ved — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Regu-Fem by R-U-Ved

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 4 of its 8 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (100 mg) without saying how much of each component you get.
  • “Extracts of:” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Regu-Fem contains 8 ingredients, most delivered in a proprietary blend of plant extracts: coral powder, arjuna, black cohosh, wild yam, ashoka, bamboo, a stemmed vine (Cissus quadrangularis), and sitawari (Asparagus racemosus root). The capsule itself is vegetarian.

Because several of these are combined in a blend, you won't see individual amounts on the label — that's a limitation of how the product is formulated. Each ingredient plays a traditional role in women's health, though the evidence for most of them remains limited.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: pre-menopausal and post-menopausal women's health support.
  • We looked for evidence on: Menopausal symptoms, Postmenopausal conditions, Premenstrual syndrome (PMS), Dysmenorrhea, hot flashes, menstrual health — and 1 related terms.
  • The strongest evidence on file: Black Cohosh is rated "Possibly Effective" for Menopausal symptoms (Natural Medicines).
  • Also on file: Wild Yam is rated "Possibly Ineffective" for Menopausal symptoms.
  • Also on file: Black Cohosh is rated "Insufficient Reliable Evidence To Rate" for Breast cancer-related hot flashes, Premenstrual syndrome (PMS), Dysmenorrhea.

Black cohosh is possibly effective for menopausal symptoms and hot flashes. Cissus quadrangularis (the stemmed vine) is possibly effective for obesity.

Coral powder is likely effective as a bone substitute, though quality and contamination concerns warrant caution. For the other ingredients and uses listed — including arjuna for heart health, wild yam for menopausal symptoms, bamboo for dental health, sitawari for lactation support — the evidence in our data is rated insufficient or not established.

That doesn't mean they don't work; it means rigorous studies are lacking or inconclusive.

The evidence, ingredient by ingredient Terminalia Wild Yam Asparagus Racemosus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 7 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 7.
  • General safety write-ups exist for 7 of 7.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Black cohosh and most other ingredients in this product are generally well tolerated in short-term use, though long-term safety data are sparse. Black cohosh carries rare but serious concerns about liver damage and effects on the uterus — medical guidance before use is wise.

Coral powder warrants caution due to quality and contamination concerns; it's largely a calcium source, and a tested prenatal calcium is preferable. Wild yam is likely fine short-term but has not been well studied long-term.

Bamboo shoots, when properly cooked, are widely eaten, but supplement safety hasn't been thoroughly studied, and raw shoots can be toxic. Cissus quadrangularis has reported headache and insomnia in some users, though rates were similar to placebo.

Sitawari is traditionally considered well tolerated, but high-quality safety data are limited.

Side effects, ingredient by ingredient Terminalia Wild Yam Asparagus Racemosus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 6 of the 7 matched ingredients can interact with medications — Bamboo, Terminalia, Black Cohosh, Wild Yam, Cissus Quadrangularis, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium.
  • For scale: 1,228 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Regu-Fem, check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (arjuna may increase bleeding risk); diabetes medications (arjuna and cissus may lower blood sugar); liver-metabolizing drugs processed by CYP2D6, CYP2C9, or CYP3A4 enzymes (arjuna may raise levels); serotonergic antidepressants like duloxetine or sertraline (black cohosh may cause serotonin syndrome); estrogen therapy or birth control (black cohosh and wild yam may interfere); antithyroid medications (bamboo may enhance effects); diuretics (sitawari may amplify effects); or lithium (sitawari may raise levels). These are the drug types with documented interactions; discuss your specific medications with your healthcare provider.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product combines herbs traditionally used for women's health, though evidence is strongest only for black cohosh in menopausal symptoms and cissus for weight management. If you take any medications — especially blood thinners, antidepressants, diabetes drugs, lithium, diuretics, estrogen therapy, or antithyroid medications — you need to check each one against this product's ingredients before starting.

Talk with your own doctor or pharmacist about whether it's right for you and whether it's safe to combine with what you're already taking.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 10, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Regu-Fem, straight from the product label.

Brand R-U-Ved
Barcode (UPC) 642392000543
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Oct 10, 2014
DSLD ID 37384
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult Female (18 - 50 Years), Menopause, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Regu-Fem by R-U-Ved, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
642392000543
IngredientAmount% DV
Proprietary Blend100 mg--
Extracts of:0 NP--
Coral powder0 NP--
Arjuna100 mg--
Black Cohosh0 NP--
Wild Yam100 mg--
Ashoka100 mg--
Bamboo0 NP--
stemmed Vine0 NP--
Sitawari100 mg--

Other ingredients: Vegetarian Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

NUTRITIONAL WOMEN’S HEALTH SUPPORT

Women’s Health Support

Brand IP Statement(s)

Regu-Fem(TM) is for pre-menopausal and post-menopausal support.

R.U.VED(R) Inc. is a subsidiary of Ayush Herbs(R) Inc.

Suggested/Recommended/Usage/Directions

Suggested Use: 1 capsule two times daily or as directed by your physician.

General Statements

Naturally Grown Himalayan Herbs In-house Extraction to ensure Purity Third Party Tested for Heavy Metals

ancient wisdom, modern lifestyle New Look. Same Quality Product.

Precautions

DO NOT USE IF SEAL IS BROKEN.

Warning: If pregnant, consult your physician before using this or any other product.

Keep Away From Reach Of Children

FDA Statement of Identity

Non-Dairy Dietary Supplement

Formulation

Free from Milk, Soy, Egg and Wheat.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Regu-Fem by R-U-Ved label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Regu-Fem label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Regu-Fem by R-U-Ved

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Extracts of:

0 NP per serving

Other (inactive) ingredients: Vegetarian Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Regu-Fem by R-U-Ved Drug Interactions

Want to check YOUR meds against Regu-Fem?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,227Drugs
1,219 Moderate 8 Minor

Ingredients driving the most interactions

Arjuna 933
Sitawari 76
Wild Yam 41

Individual Drug Interactions

The ingredients in Regu-Fem interact with 1,227 drugs. Click any drug to see the details.

3 of the 5 ingredients in Regu-Fem interact with drugs. Each result below shows which ingredient is responsible. Arjuna Sitawari Wild Yam

Each ingredient & the kinds of drugs it affects

For each ingredient in Regu-Fem with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Arjuna7 drug types · 933 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, concomitant use of Terminalia arjuna with anticoagulant or antiplatelet drugs may increase the risk of bleeding in some patients.
In vitro, Terminalia arjuna bark extract inhibits platelet aggregation, decreases platelet activation, and shows antithrombotic properties.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, concomitant use of Terminalia bellirica or Terminalia chebula with antidiabetes drugs could affect blood sugar control and increase the risk of hypoglycemia.
Animal and in vitro research shows that Terminalia bellirica and Terminalia chebula fruit and seed extract have hypoglycemic effects.

Likelihood Possible Evidence D
Chlorzoxazone (Parafon Forte, Paraflex)

Theoretically, use of Terminalia chebula may increase the risk of adverse effects from chlorzoxazone.
Animal research shows that enteral administration of Terminalia chebula for 15 days prior to administration of chlorzoxazone increases blood levels of chlorzoxazone and decreases chlorzoxazone clearance. It is speculated that Terminalia chebula reduces the metabolism of chlorzoxazone by inhibiting cytochrome P450 2E1.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2C9 substrates.
In vitro research shows that Terminalia arjuna extract inhibits CYP2C9 enzymes and reduces CYP2C9 substrate metabolism.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2D6 substrates.
In vitro research shows that Terminalia arjuna extract inhibits CYP2D6 enzymes and reduces CYP2D6 substrate metabolism.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that Terminalia arjuna extract inhibits CYP3A4 enzymes and reduces CYP3A4 substrate metabolism.

Likelihood Possible Evidence D
Omeprazole (Prilosec)

Theoretically, use of Terminalia chebula may increase the risk of adverse effects from omeprazole.
Animal research shows that enteral administration of Terminalia chebula for 15 days prior to administration of omeprazole increases blood levels of omeprazole and decreases omeprazole clearance. It is speculated that Terminalia chebula reduces the metabolism of omeprazole by inhibiting cytochrome P450 2C19.

Likelihood Possible Evidence D
Arjuna full monograph & interactions

Sitawari2 drug types · 76 drugs

Diuretic Drugs

Theoretically, asparagus racemosus root might increase diuresis and electrolyte loss when used with diuretic drugs.
Animal studies show that asparagus racemosus root has diuretic effects when used in high doses. This effect has not been reported in humans.

Likelihood Possible Evidence D
Lithium

Theoretically, Asparagus racemosus root could reduce excretion and increase levels of lithium.
Animal research suggests that Asparagus racemosus root has diuretic properties when used in high doses. Therefore, it might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Sitawari full monograph & interactions

Wild Yam1 drug type · 41 drugs

Estrogens

Theoretically, wild yam might increase or decrease the effects of estrogen.
Wild yam root shows estrogenic and anti-estrogenic effects in vitro. Theoretically, wild yam might interfere with hormone therapy.

Likelihood Possible Evidence D
Wild Yam full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Regu-Fem, from the product label.

R-U-Ved

See all R-U-Ved products
Web Address
www.ruved.net
Pharmacist Counseling Corner

Regu-Fem by R-U-Ved: Common Questions

Does Regu-Fem by R-U-Ved interact with any medications?
Yes. Based on its ingredients, Regu-Fem has a known interaction with 1,227 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Regu-Fem contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
Black cohosh and wild yam are not recommended during pregnancy — the data advises against them. Bamboo, cissus, and ashoka lack sufficient safety data and should be avoided in pregnancy. For breastfeeding, black cohosh is best avoided and safety data for the others are limited; talk with your doctor or pharmacist before use. Sitawari is traditionally used to support milk supply but requires professional guidance because reliable safety data are lacking.
What is black cohosh supposed to do in this product?
Black cohosh is possibly effective for menopausal symptoms, including hot flashes. It's the one ingredient in Regu-Fem with the strongest evidence, though the data on it remain incomplete.
Will this help me lose weight?
Cissus quadrangularis (the stemmed vine) in this blend is possibly effective for obesity, based on small studies showing it may reduce fasting blood sugar. The other ingredients lack reliable evidence for weight loss, so results would depend partly on the amount of cissus in the blend and partly on your individual response.
What are the most common side effects?
Black cohosh users most commonly report breast tenderness, dizziness, headache, upset stomach, and rash. Cissus may cause headache or insomnia at rates similar to placebo. Wild yam can cause headache, fever, upset stomach, and vomiting. Bamboo and sitawari have limited adverse effect data in the studies we hold.
Is this safe for long-term use?
Most ingredients in this product have been studied mainly short-term. Black cohosh carries rare liver concerns, and long-term safety for the others is not well established. For ongoing use, work with your doctor or pharmacist to monitor your health and adjust as needed.
What is coral powder and why is it in here?
Coral powder is likely effective as a bone substitute — it's a calcium source. However, quality and contamination concerns are real, and claims about it are often overstated. A tested, pharmaceutical-grade calcium product may be a safer choice if bone health is your goal; discuss options with your doctor.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Regu-Fem label
Go deeper

The Full Monographs Behind Regu-Fem’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Terminalia

Interacts with 933 drugs

Terminalia is a group of traditional Ayurvedic tree species (most notably Terminalia arjuna) used for heart, digestive, and general wellness purposes. Some small studies suggest possible ben...

Read the full Terminalia monograph → Herb & supplement monograph

Wild Yam

Interacts with 41 drugs

Wild yam is a root traditionally used for menopausal symptoms, cramps, and as a so-called 'natural' hormone supplement, but solid human evidence for these uses is lacking. Despite popular cl...

Read the full Wild Yam monograph → Herb & supplement monograph

Asparagus Racemosus

Interacts with 76 drugs

Asparagus racemosus, often called shatavari, is an Ayurvedic herb traditionally used to support women's health, digestion, and overall vitality. Human evidence for most of these uses is limi...

Read the full Asparagus Racemosus monograph →
Sources

Sources & How We Checked

Regu-Fem's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 99 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Coral 5 references
  1. Schulz A, Hilgers RD, Niedermeier W. The effect of splinting of teeth in combination with reconstructive periodontal surgery in humans. Clin Oral Investig 2000;4:98-105.. PubMed
  2. Vuola J, Bohling T, Kinnunen J, et al. Natural coral as bone-defect-filling material. J Biomed Mater Res 2000;51:117-22.. DOI
  3. Thalgott JS, Klezl Z, Timlin M, Giuffre JM. Anterior lumbar interbody fusion with processed sea coral (coralline hydroxyapatite) as part of a circumferential fusion. Spine 2002;27:E518-25.. PubMed
  4. Marchac D, Sandor G. Use of coral granules in the craniofacial skeleton. J Craniofac Surg 1994;5:213-7. PubMed
  5. Roux FX, Brasnu D, Menard M, et al. Madreporic coral for cranial base reconstruction. 8 years experience. Acta Neurochir (Wien) 1995;133:201-205. PubMed

See these in context on the Coral monograph →

Terminalia 9 references
  1. Sabu, M. C. and Kuttan, R. Anti-diabetic activity of medicinal plants and its relationship with their antioxidant property. J Ethnopharmacol. 2002;81(2):155-160. PubMed
  2. Rao, N. K. and Nammi, S. Antidiabetic and renoprotective effects of the chloroform extract of Terminalia chebula Retz. seeds in streptozotocin-induced diabetic rats. BMC.Complement Altern.Med 2006;6:17. PubMed
  3. Murali, Y. K., Anand, P., Tandon, V., Singh, R., Chandra, R., and Murthy, P. S. Long-term effects of Terminalia chebula Retz. on hyperglycemia and associated hyperlipidemia, tissue glycogen content and in vitro release of insulin in streptozotocin induced
  4. Senthilkumar, G. P. and Subramanian, S. Evaluation of antioxidant potential of Terminalia chebula fruits studies in streptozotocin-induced diabetic rats. Pharmaceutical Biology (Netherlands) 2007;45:511-518.
  5. Malik N, Dhawan V, Bahl A, Kaul D. Inihbitory effects of Terminalia arjuna on platelet activation in vitro in healthy subjects and patients with coronary artery disease. Platelets. 2009;20(3):183-1190.
  6. Varghese A, Savai J, Pandita N, Gaud RS. In vitro modulatory effects of Terminalia arjuna, arjunic acid, arjunetin, and arjungenin on CYP3A4, CYP2D6, and CYP2C9 enzyme activity in human liver microsomes. Toxicology Reports. 2015(2):806-16. PubMed
  7. Wu G, Dong Z, Dong J, et al. Effects of mongolian medicine Terminalia chebula Retz. on 6 CYP450 enzymes in rats. Int J Clin Exp Pathol 2020;13(12):3128-3138.
  8. Das A, Naveen J, Sreerama YN, Gnanesh Kumar BS, Baskaran V. Low-glycemic foods with wheat, barley and herbs (Terminalia chebula, Terminalia bellerica and Emblica officinalis) inhibit a-amylase, a-glucosidase and DPP-IV activity in high fat and low dose st
  9. Eltimamy M, Elshamarka M, Aboelsaad M, Sayed M, Moawad H. Effects of alcoholic extract of Terminalia Chebula dried fruit on blood biochemical profile in diabetic rats. J Diabetes Metab Disord 2022;21(1):159-170. PubMed

See these in context on the Terminalia monograph →

Black Cohosh 68 references
  1. McFarlin BL, Gibson MH, O'Rear J, Harman P. A national survey of herbal preparation use by nurse-midwives for labor stimulation. Review of the literature and recommendations for practice. J Nurse Midwifery 1999;44:205-16. PubMed
  2. Whiting PW, Clouston A, Kerlin P. Black cohosh and other herbal remedies associated with acute hepatitis. Med J Aust 2002;177:440-3. PubMed
  3. Pepping J. Black cohosh: Cimicifuga racemosa. Am J Health Syst Pharm 1999;56:1400-2. PubMed
  4. Liske E. Therapeutic efficacy and safety of Cimicifuga racemosa for gynecologic disorders. Adv Ther 1998;15:45-53.
  5. Kruse SO, Lohning A, Pauli GF, et al. Fukiic and piscidic acid esters from the rhizome of Cimicifuga racemosa and the in vitro estrogenic activity of fukinolic acid. Planta Med 1999;65:763-4.
  6. Jacobson JS, Troxel AB, Evans J, et al. Randomized trial of black cohosh for the treatment of hot flashes among women with a history of breast cancer. J Clin Oncol 2001;19:2739-45. PubMed
  7. Gunn TR, Wright IM. The use of black and blue cohosh in labour. N Z Med J 1996;109:410-1.
  8. Baillie N, Rasmussen P. Black and blue cohosh in labour. N Z Med J 1997;110:20-1.
  9. Lontos S, Jones RM, Angus PW, Gow PJ. Acute liver failure associated with the use of herbal preparations containing black cohosh. Med J Aust 2003;179:390-1.. DOI
  10. Wuttke W, Seidlova-Wuttke D, Gorkow C. The Cimicifuga preparation BNO 1055 vs. conjugated estrogens in a double-blind placebo-controlled study: effects on menopause symptoms and bone markers. Maturitas 2003;44:S67-77. PubMed
  11. Huntley A, Ernst E. A systematic review of the safety of black cohosh. Menopause 2003;10:58-64.. DOI
  12. Cohen SM, O'Connor AM, Hart J, et al. Autoimmune hepatitis associated with the use of black cohosh: a case study. Menopause 2004;11:575-7. PubMed
  13. Vitetta L, Thomsen M, Sali A. Black cohosh and other herbal remedies associated with acute hepatitis. Med J Aust 2003;178:411-2.. PubMed
  14. Thomsen M, Vitetta L, Schmidt M, Sali A. Acute liver failure associated with the use of herbal preparations containing black cohosh. Med J Aust 2004;180:598-600.. DOI
  15. Cohen B, Schardt D. Center for Science in the Public Interest. Letter to Food and Drug Administration. Commissioner Mark McClellan, MD, PhD. March 4, 2004.
  16. Seidlova-Wuttke D, Hesse O, Jarry H, et al. Evidence for selective estrogen receptor modulator activity in a black cohosh (Cimicifuga racemosa) extract: comparison with estradiol-17beta. Eur J Endocrinol 2003;149:351-62. PubMed
  17. Rockwell S, Liu Y, Higgins SA. Alteration of the effects of cancer therapy agents on breast cancer cells by the herbal medicine black cohosh. Breast Cancer Res Treat 2005;90:233-9. PubMed
  18. Levitsky J, Alli TA, Wisecarver J, Sorrell MF. Fulminant liver failure associated with the use of black cohosh. Dig Dis Sci 2005;50:538-9. PubMed
  19. Cheong JL, Bucknall R. Retinal vein thrombosis associated with a herbal phytoestrogen preparation in a susceptible patient. Postgrad Med J 2005;81:266-7.. PubMed
  20. Nappi RE, Malavasi B, Brundu B, Facchinetti F. Efficacy of Cimicifuga racemosa on climacteric complaints: a randomized study versus low-dose transdermal estradiol. Gynecol Endocrinol 2005;20:30-5.
  21. Gurley BJ, Gardner SF, Hubbard MA, et al. In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypes. Clin Pharmacol Ther 2005;77:415-26. PubMed
  22. Minciullo PL, Saija A, Patafi M, et al. Muscle damage induced by black cohosh (Cimicifuga racemosa). Phytomedicine 2006;13:115-8. PubMed
  23. Wuttke W, Gorkow C, Seidlova-Wuttke D. Effects of black cohosh (Cimicifuga racemosa) on bone turnover, vaginal mucosa, and various blood parameters in postmenopausal women: a double-blind, placebo-controlled, and conjugated estrogens-controlled study. Men PubMed
  24. MHRA. Black cohosh (Cimicifuga racemosa) - risk of liver problems. Herbal Safety News July 2006. Available at: http://www.mhra.gov.uk/home/idcplg?IdcService=SS_GET_PAGE&useSecondary= true&ssDocName=CON2024131&ssTargetNodeId=663.
  25. Dugoua JJ, Seely D, Perri D, et al. Safety and efficacy of black cohosh (cimicifuga racemosa) during pregnancy and lactation. Can J Clin Pharmacol 2006;13:e257-61.
  26. Raus K, Brucker C, Gorkow C, Wuttke W. First-time proof of endometrial safety of the special black cohosh extract (Actaea or Cimicifuga racemosa extract) CR BNO 1055. Menopause 2006;13:678-91. PubMed
  27. Lynch CR, Folkers ME, Hutson WR. Fulminant hepatic failure associated with the use of black cohosh: a case report. Liver Transpl 2006;12:989-92. PubMed
  28. Bai W, Henneicke-von Zepelin HH, Wang S, et al. Efficacy and tolerability of a medicinal product containing an isopropanolic black cohosh extract in Chinese women with menopausal symptoms: A randomized, double blind, parallel-controlled study versus tibol
  29. Meyer S, Vogt T, Obermann EC, et al. Cutaneous pseudolymphoma induced by Cimicifuga racemosa. Dermatology 2007;214:94-6.
  30. Gori L, Firenzuoli F. Is black cohosh a hepatotoxic medicinal herb? Forsch Komplementarmed 2007;14:109-10. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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