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Dietary supplement

Reishi Ingredients & Drug Interactions

by Samsara Herbs

Reishi label
See full label image
Powder Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Reishi against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Reishi is a dietary supplement by Samsara Herbs with 1 active ingredient. Its ingredients are commonly taken for immune support, fatigue and general well-being, stress and sleep.Based on those ingredients, 375 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Reishi. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Reishi by Samsara Herbs

Ask about any prescription or over-the-counter medication and we check it for interactions with Reishi by Samsara Herbs — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Reishi by Samsara Herbs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: reishi mushroom, a fungus traditionally used in herbal medicine. The powder form lets you mix it into beverages or food.

There are no other inactive ingredients listed.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Reishi Mushroom's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: immune response and stress support.
  • We looked for evidence on: Stress, Insomnia, Psychological well-being, Chronic fatigue syndrome (CFS), Cancer-related fatigue, Sleep quality — and 3 related terms.
  • The closest evidence on file: Reishi Mushroom is rated "Insufficient Reliable Evidence To Rate" for Chronic fatigue syndrome (CFS) (Natural Medicines).
  • Also on file: Reishi Mushroom is rated "Insufficient Reliable Evidence To Rate" for Cancer-related fatigue, Insomnia, Stress, Psychological well-being.

The evidence for reishi's effectiveness is limited. For high cholesterol (hyperlipidemia), it appears possibly ineffective based on available studies.

For altitude sickness, Alzheimer disease, and athletic performance, we don't have enough reliable evidence to say whether it works or not. If you're considering reishi for one of these reasons, talk with your doctor about what the research actually supports for your situation.

The evidence, ingredient by ingredient Reishi Mushroom

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Reishi is generally well tolerated in the short term, but long-term safety hasn't been well studied. Common side effects include dizziness, dry mouth, itching, nausea, rash, and stomach upset.

Some people experience respiratory allergy to reishi spores, with sore throat and runny nose reported. Rare effects include insomnia and headache.

The safety data advises against using reishi during pregnancy or while breastfeeding because there isn't enough information to know it's safe in those situations. If you're pregnant, nursing, or planning to become pregnant, talk with your doctor or pharmacist before starting it.

Side effects, ingredient by ingredient Reishi Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Reishi Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 375 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking reishi, double-check with your doctor or pharmacist if you take blood pressure medications, blood thinners or antiplatelet drugs, or diabetes medications. At higher doses, reishi may intensify the effects of these drugs, putting you at risk for low blood pressure, bleeding, or low blood sugar.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Reishi may be worth considering if you're interested in traditional herbal support, but the evidence for most health claims is weak or absent. Because it can lower blood pressure and blood sugar and potentially increase bleeding risk, it's not a casual add-on if you take medications for those conditions.

Check with your own doctor or pharmacist before starting, especially if you're on blood pressure meds, blood thinners, or diabetes drugs.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Reishi, straight from the product label.

Brand Samsara Herbs
Barcode (UPC) X0015U363N
Net contents 4 Ounce(s); 114 Gram(s)
Market status On market
Date entered into DSLD May 22, 2020
DSLD ID 220998
Product type Non-nutrient/non-botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Reishi by Samsara Herbs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2.468 Gram(s)
Maximum serving Sizes:
2.468 Gram(s)
Servings per container
46
UPC/BARCODE
X0015U363N
IngredientAmount% DV
Reishi2468 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Reshi (40% Polysaccharides)

Description Reishi, the "Mushroom of Immortality” has been used, historically, in traditional Chinese practices in Asia for 2,000+ years. Reishi mushroom extract contains numerous ingredients believed to support healthy immune response. Traditionally, it has been thought to support optimal health and longevity, as well as to regulate normal stress levels and overall brain health.

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

GMP Good Manufacturing Practice USA Tested 3rd party USA tested

General Statements

About us At Samsara Herbs, we believe that all positive change in the world must first begin with positive change from within. We invite you to tap into your own infinite power through the use of our potent herbal extracts! We seek out only quality herbs from our trusted sources from around the world for use in our herbal extracts. Samsara Herbs, dedicated to empowering your life force!

Formulation

Standardized herbal extracts contain isolated herbal compounds, in guaranteed amounts. Often having the prevalent compound found in an herb, in a significantly higher concentration than found in nature.

Suggested/Recommended/Usage/Directions

Our water soluble herbal extracts are best mixed in juice or a smoothie, although mixing in water is perfectly fine if you can tolerate the taste.

Suggested Use: Take 1 Scoop 1-3 times per day or as recommended by your health care professional.

Storage

Storage Cool dry place, out of direct sunlight.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Caution: If you have a medical condition, are pregnant or taking medications, consult your hearth care professional before using this product.

Keep out of reach of children.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Reishi by Samsara Herbs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Reishi label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Reishi by Samsara Herbs

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2.468 Gram(s) Dosage formPowder Servings per container46 Amounts shown are per serving.

Reishi

Interacts with
375 drugs
2468 mg per serving Form: Polysaccharides

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits...

Reishi monograph & interactions
Interaction report

Reishi by Samsara Herbs Drug Interactions

Want to check YOUR meds against Reishi?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
375Drugs
375 Moderate

Ingredients driving the most interactions

Reishi 375

Individual Drug Interactions

The ingredients in Reishi interact with 375 drugs. Click any drug to see the details.

1 of the 1 ingredient in Reishi interact with drugs. Each result below shows which ingredient is responsible. Reishi

Each ingredient & the kinds of drugs it affects

For each ingredient in Reishi with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Reishi3 drug types · 375 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
A dose of 1.5 grams daily of reishi mushroom does not seem to decrease platelet aggregation, but a higher dose of 3 grams daily does.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Animal research suggests that reishi mushroom decreases blood sugar. However, in patients with type 2 diabetes, taking reishi mushroom does not reduce fasting glucose levels, and its effects on glycated hemoglobin are inconsistent.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Reishi mushroom has shown hypotensive activity in animal research. Clinical evidence suggests that reishi mushroom reduces blood pressure in some, but not all, patients with hypertension.

Likelihood Possible Evidence D
Reishi full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Reishi, from the product label.

Samsara Herbs

See all Samsara Herbs products
Name
Aspen Copacking
Street Address
810 North 2800 West
City
Lindon
State
Utah
ZipCode
84042
Pharmacist Counseling Corner

Reishi by Samsara Herbs: Common Questions

Does Reishi by Samsara Herbs interact with any medications?
Yes. Based on its ingredients, Reishi has a known interaction with 375 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Reishi contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What exactly is reishi?
Reishi is a mushroom used in traditional herbal medicine. This product is the powdered form, which you can mix into drinks or food.
Can I take reishi if I'm pregnant or breastfeeding?
The safety data advises against it — there isn't enough information to know whether it's safe during pregnancy or while breastfeeding. Talk with your doctor or pharmacist about your specific situation.
What side effects might I notice?
Most common are dizziness, dry mouth, itching, nausea, rash, and stomach upset. Some people get a sore throat or runny nose from breathing in reishi spores. Insomnia and headache are rare.
Does reishi actually lower cholesterol?
Based on available evidence, it appears possibly ineffective for high cholesterol. If that's why you're considering it, you may want to talk with your doctor about options with stronger evidence.
How long has reishi been studied for safety?
Short-term use is generally well tolerated, but long-term safety hasn't been well studied. If you're thinking of taking it regularly, that's worth discussing with your doctor.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Reishi label
Go deeper

The Full Monographs Behind Reishi’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Reishi Mushroom

Interacts with 375 drugs

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits is limited or low-quality, so it should...

Read the full Reishi Mushroom monograph →
Sources

Sources & How We Checked

Reishi's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 17 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Reishi Mushroom 17 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Tao J, Feng KY. Experimental and clinical studies on inhibitory effect of ganoderma lucidum on platelet aggregation. J Tongji Med Univ 1990;10:240-3. PubMed
  3. Singh AB, Gupta SK, Pereira BM, Prakash D. Sensitization to Ganoderma lucidum in patients with respiratory allergy in India. Clin Exp Allergy 1995;25:440-7.
  4. Lee SY, Rhee HM. Cardiovascular effects of mycelium extract of Ganoderma lucidum: inhibition of sympathetic outflow as a mechanism of its hypotensive action. Chem Pharm Bull (Tokyo) 1990;38:1359-64. PubMed
  5. Kwok Y, Ng KFJ, Li, CCF, et al. A prospective, randomized, double-blind, placebo-controlled study of the platelet and global hemostatic effects of Ganoderma lucidum (Ling-Zhi) in healthy volunteers. Anesth Analg 2005;101:423-6. PubMed
  6. Wanmuang, H., Leopairut, J., Kositchaiwat, C., Wananukul, W., and Bunyaratvej, S. Fatal fulminant hepatitis associated with Ganoderma lucidum (Lingzhi) mushroom powder. J Med Assoc Thai. 2007;90(1):179-181.
  7. Seto, S. W., Lam, T. Y., Tam, H. L., Au, A. L., Chan, S. W., Wu, J. H., Yu, P. H., Leung, G. P., Ngai, S. M., Yeung, J. H., Leung, P. S., Lee, S. M., and Kwan, Y. W. Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db
  8. Chu, T. T., Benzie, I. F., Lam, C. W., Fok, B. S., Lee, K. K., and Tomlinson, B. Study of potential cardioprotective effects of Ganoderma lucidum (Lingzhi): results of a controlled human intervention trial. Br.J.Nutr. 2012;107(7):1017-1027.
  9. Jin, X., Ruiz, Beguerie J., Sze, D. M., and Chan, G. C. Ganoderma lucidum (Reishi mushroom) for cancer treatment. Cochrane.Database.Syst.Rev. 2012;6:CD007731.
  10. Kabir, Y., Kimura, S., and Tamura, T. Dietary effect of Ganoderma lucidum mushroom on blood pressure and lipid levels in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol.(Tokyo) 1988;34(4):433-438. PubMed
  11. Kanmatsuse, K., Kajiwara, N., Hayashi, K., Shimogaichi, S., Fukinbara, I., Ishikawa, H., and Tamura, T. [Studies on Ganoderma lucidum. I. Efficacy against hypertension and side effects]. Yakugaku Zasshi 1985;105(10):942-947. PubMed
  12. Gao, Y., Lan, J., Dai, X., Ye, J., and Zhou, S. A Phase I/II Study of Ling Zhi Mushroom Ganoderma lucidum(W.Curt: Fr.) Lloyd (Aphyllophoromycetideae) Extract in Patients with Type II Diabetes Mellitus. International Journal of Medicinal Mushrooms 2004;6. DOI
  13. Jin H, Zhang G, Cao X, and et al. Treatment of hypertension by linzhi combined with hypotensor and its effects on arterial, arteriolar and capillary pressure and microcirculation. In: Niimi H, Xiu RJ, Sawada T, and et al. Microcirculatory Approach to Asi
  14. Klupp NL, Chang D, Hawke F, Kiat H, Cao H, Grant SJ, Bensoussan A. Ganoderma lucidum mushroom for the treatment of cardiovascular risk factors. Cochrane Database Syst Rev. 2015 Feb 17;2:CD007259. PubMed
  15. Zhao H, Zhang Q, Zhao L, Huang X, Wang J, Kang X. Spore Powder of Ganoderma lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial. Evid Based Complement Alternat Med. 2012;2012:809614.
  16. Pazzi F, Adsuar JC, Domínguez-Muñoz FJ, García-Gordillo MA, Gusi N, Collado-Mateo D. Ganoderma lucidum effects on mood and health-related quality of life in women with fibromyalgia. Healthcare (Basel) 2020;8(4):520. PubMed
  17. Kogure T, Koiwai A, Fukushi D, et al. Hypereosinophilia with hepatic nodule formation caused by Ganoderma lucidum. Intern Med 2021;60(24):3897-3903.

See these in context on the Reishi Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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