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Dietary supplement

Remifemin Good Night Ingredients & Drug Interactions

by Nature's Way

Remifemin Good Night label
See full label image
Tablet Or Pill Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Remifemin Good Night against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Remifemin Good Night is a dietary supplement by Nature's Way with 4 active ingredients. Its ingredients are commonly taken for insomnia and poor sleep, anxiety and stress, restlessness.Based on those ingredients, 1,158 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Valerian root extract, Hops strobile extract, RemiSure dry extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Remifemin Good Night by Nature's Way

Ask about any prescription or over-the-counter medication and we check it for interactions with Remifemin Good Night by Nature's Way — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Remifemin Good Night by Nature's Way

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 4 active ingredients.
  • “Restful Sleep Blend” is a proprietary blend — the label gives one combined amount (286 mg) without saying how much of each component you get.

Remifemin Good Night contains four active ingredients. Valerian root extract is included for its traditional sedative properties.

Hops strobile extract, lemon balm leaf extract, and black cohosh (provided as RemiSure dry extract) round out the formula. The product also contains several inactive ingredients—cellulose, hypromellose, maltodextrin, magnesium stearate, silica, titanium dioxide, soy lecithin, spirulina, and carnauba wax—which serve as fillers, binders, and capsule materials.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: relieve menopausal symptoms and support restful sleep.
  • We looked for evidence on: Menopausal symptoms, Insomnia, Anxiety, Stress, Night sweats, Hot flashes — and 1 related terms.
  • The strongest evidence on file: Lemon Balm is rated "Possibly Effective" for Stress (Natural Medicines).
  • Also on file: Black Cohosh is rated "Possibly Effective" for Menopausal symptoms.
  • Also on file: Valerian is rated "Possibly Effective" for Insomnia.

The evidence for this product's individual ingredients is mixed. Valerian root extract is possibly effective for insomnia—the main condition this product targets.

Lemon balm is possibly effective for stress and depression. Black cohosh is possibly effective for menopausal symptoms, though this product is marketed for sleep rather than menopause.

Hops has insufficient reliable evidence for insomnia and most other uses. Overall, the strongest evidence supports valerian for sleep, but the data for the combination as a whole isn't on file.

The evidence, ingredient by ingredient Valerian Hops Lemon Balm Black Cohosh

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Valerian is generally well tolerated short-term, though long-term safety isn't well studied. The most common side effects are dizziness, drowsiness, and mental slowness; headache, upset stomach, excitability, and vivid dreams have also been reported.

When you stop valerian after long use, withdrawal symptoms like rapid heartbeat, anxiety, and insomnia can occur—taper slowly rather than stopping abruptly. Hops is similarly well tolerated short-term but may cause drowsiness.

Lemon balm is generally well tolerated for short-term use and doesn't appear to cause more dizziness or sedation than placebo in studies. Black cohosh is generally well tolerated at typical doses, with the most common side effects being breast tenderness, dizziness, stomach upset, headache, and tiredness.

Rare but serious liver problems have been reported with black cohosh, so medical guidance is wise. During pregnancy, the safety data advises against valerian, hops, and black cohosh.

Lemon balm has insufficient data—talk with your doctor or pharmacist for personalized advice. While breastfeeding, avoid valerian and black cohosh; use caution with lemon balm and consult your doctor first.

Side effects, ingredient by ingredient Valerian Hops Lemon Balm Black Cohosh

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Lemon Balm, Hops, Black Cohosh, Valerian.
  • The most serious interaction on file is rated Moderate.
  • For scale: 1,159 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Remifemin Good Night, check with your pharmacist if you take serotonergic drugs such as antidepressants (SSRIs, SNRIs, tricyclics) or migraine medications—there's a Moderate risk of serotonin syndrome. Also double-check CNS depressants including sedatives, sleep aids, opioids, and anti-anxiety medications like alprazolam (Xanax); valerian, hops, and lemon balm can add to drowsiness.

If you take alprazolam specifically, note the heightened sedation risk. Check estrogen-based medications (birth control, hormone replacement therapy), thyroid replacements, hepatotoxic drugs, atorvastatin (Lipitor), or cisplatin—black cohosh and hops have documented Moderate interactions with these.

Avoid alcohol while taking this product, as valerian has additive sedative effects.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you're looking for help with sleep and don't take serotonergic antidepressants, CNS depressants, or thyroid or estrogen medications, this product may be worth trying—though the evidence for the combination is limited. Anyone on prescription medications, especially those for mood, anxiety, sleep, or liver health, should check with their pharmacist first.

Talk to your pharmacist before starting, especially if you plan to use it long-term.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 27, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Remifemin Good Night, straight from the product label.

Brand Nature's Way
Barcode (UPC) 763948074808
Net contents 21 Tablet(s)
Market status On market
Date entered into DSLD Jul 27, 2021
DSLD ID 251927
Product type Botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Women (not pregnant or lactating), Adult Female (18 - 50 Years), Menopause, Seniors/Mature (>50 Years) - Women ONLY
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Remifemin Good Night by Nature's Way, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
21
UPC/BARCODE
763948074808
IngredientAmount% DV
Valerian root extract0 NP--
Hops strobile extract0 NP--
Lemon Balm leaf extract0 NP--
Restful Sleep Blend286 mg--
RemiSure dry extract5 mg--

Other ingredients: Cellulose, Hypromellose, Maltodextrin, Magnesium Stearate, Silica, Titanium Dioxide color, Soy Lecithin, Spirulina color, Carnauba Wax

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

This product has a tamper-evident foil pouch. Do not use if foil or pouch is punctured!

Do not take with other Cimicifuga (black cohosh) containing products concurrently.

Caution: Do not take if you are hypersensitive (allergic) to Cimicifuga rhizome (black cohosh rootstock), Valerian, hops, Melissa lemon balm, or any of the other ingredients, or if you are pregnant or nursing.

Caution: Do not take if you are hypersensitive (allergic) to Cimicifuga rhizome (black cohosh rootstock), Valerian, hops, Melissa lemon balm, or any of the other ingredients, or if you are pregnant or nursing.

Discontinue use and consult a healthcare professional if you have a live disorder or develop symptoms of liver trouble, such as abdominal pain, dark urine, or jaundice.

Consults a healthcare professional prior to use if you are taking sedatives, tranquilizers, prescription drugs, or if you have been treated for breast cancer or any other hormone-dependent cancer.

Avoid alcohol and do not drive or operate machinery while taking this product as it may cause drowsiness.

Women of childbearing potential should consider an effect method of contraception during the use of this product.

Contains soy.

Keep out of reach of children.

Formula

RemiSure Black Cohosh: clinically proven to relieve menopausal symptoms Restful Sleep Blend: supports restful sleep

Menopause relief

And night-time sleep support with our herbal Restful Sleep Blend. The Restful Sleep Blend contains valerian, lemon balm, and hops extracts to support restful sleep.

Formulation

Estrogen free

Reduces: Hot flashes - Night sweats - Mood swings - And - Supports restful sleep

Restful sleep and brighter days RemiSure Black Cohosh extract is clinically proven to provide significant relief of hot flashes, night sweats, irritability, and mood swings.

Estrogen-free - Remifemin Good Night menopause relief is ideal for women who choose not to take Hormone Replacement Therapy (HRT).

5 mg RemiSure Dry Extract is equivalent to 42 mg of black cohosh (Cimicifuga racemosa) root/rhizome per tablet (mean of concentration 8.5:1).

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Suggested/Recommended/Usage/Directions

One per night

Recommendation: Take 1 tablet one hour before bedtime with water. Best results with ongoing use up to 6 months.

General Statements

For further instructions please read the enclosed insert.

Nature's Way - Since 1969

Product of Germany

Storage

Store at room temperature. Avoid excess heat and direct sunlight.

Brand IP Statement(s)

Copyright 2021 Distributed by Nature's Way Brands, LLC (Previously branded Enzymatic Therapy, LLC) Remifemin, RemiSure, and associated butterfly logo & pill designs are registered trademarks of Schaper & Brummer GmbH & Co. KG.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Remifemin Good Night by Nature's Way label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Remifemin Good Night label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Remifemin Good Night by Nature's Way

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container21 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Restful Sleep Blend

286 mg per serving

RemiSure dry extract

Interacts with
652 drugs
5 mg per serving

Black cohosh is a North American plant most often used to ease menopause symptoms like hot flashes, but the research is mixed and far from settled. It...

RemiSure dry extract monograph & interactions

Other (inactive) ingredients: Cellulose, Hypromellose, Maltodextrin, Magnesium Stearate, Silica, Titanium Dioxide color, Soy Lecithin, Spirulina color, Carnauba Wax. These complete the product’s ingredient list but are not active constituents.

Interaction report

Remifemin Good Night by Nature's Way Drug Interactions

Want to check YOUR meds against Remifemin Good Night?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,158Drugs
815 Moderate 343 Minor

Ingredients driving the most interactions

Valerian root extract 902
Hops strobile extract 863
RemiSure dry extract 652
Lemon Balm leaf extract 264

Individual Drug Interactions

The ingredients in Remifemin Good Night interact with 1,158 drugs. Click any drug to see the details.

4 of the 4 ingredients in Remifemin Good Night interact with drugs. Each result below shows which ingredient is responsible. Valerian root extract Hops strobile extract RemiSure dry extract Lemon Balm leaf extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Remifemin Good Night with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Valerian root extract6 drug types · 902 drugs

Alcohol (Ethanol)

Valerian can have additive sedative effects when used concomitantly with alcohol.
Valerian has sedative effects. Theoretically, valerian might have an additive sedative effect when combined with alcohol. Excessive sedation has been reported in an alcohol-abusing individual who took valerian and Gingko biloba. However, the potential interaction between valerian and alcohol has been disputed in other research. Limited evidence suggests that a combination of valerian 160 mg and lemon balm 80 mg (Euvegal) does not cause further deterioration in reaction ability and reaction rate when taken with alcohol as compared to the effects of alcohol alone.

Likelihood Possible Evidence B
Alprazolam (Xanax)

Valerian can have additive sedative effects when used with alprazolam. Also, valerian in high doses might modestly increase alprazolam levels, though this is not likely to be clinically significant.
Valerian has sedative effects. Theoretically, valerian might cause additive sedation when combined with alprazolam. Also, a small pharmacokinetic study shows that taking valerian extract 1000 mg daily (providing 11 mg valerenic acid) might increase alprazolam levels by about 19%. This might be due to valerian's mild inhibition of cytochrome P450 3A4 (CYP3A4). Despite being statistically significant, this increase is not likely to be clinically significant.

Likelihood Possible Evidence B
Cns Depressants

Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Theoretically, concomitant use of valerian and drugs with sedative and anesthetic properties may cause additive therapeutic and adverse effects.

Likelihood Possible Evidence D
Glucuronidated Drugs

Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
In vitro research shows that methanolic valerian extract and valerenic acid might competitively inhibit UDP-glucuronosyltransferase (UGT) 1A1 (UGT1A1) and UGT2B7.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP2D6.
Although some in vitro evidence suggests that valerian affects CYP2D6, clinical pharmacokinetic (PK) studies show that valerian is unlikely to affect the CYP2D6 enzyme. In one PK study, taking valerian 1000 mg (providing about 11 mg valerenic acid) nightly for 14 days did not affect the metabolism of dextromethorphan, a CYP2D6 substrate. In another PK study, taking valerian 125 mg three times daily for 28 days did not affect metabolism of debrisoquine, an accepted CYP2D6 probe-substrate.

Likelihood Unlikely Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Although some in vitro evidence suggests that valerian extract might inhibit or induce CYP3A4, clinical pharmacokinetic (PK) studies show that valerian does not have a clinically significant effect on the CYP3A4 enzyme. In one PK study, taking valerian 125 mg three times daily for 28 days did not affect metabolism of midazolam, an accepted CYP3A4 probe-substrate. In another PK study, taking valerian 1000 mg (providing about 11 mg valerenic acid) nightly for 14 days modestly increases levels of alprazolam, a CYP3A4 substrate, suggesting mild inhibition of CYP3A4. However, this mild inhibition is unlikely to be clinically relevant.

Likelihood Possible Evidence B
Valerian root extract full monograph & interactions

Hops strobile extract4 drug types · 863 drugs

Cns Depressants

Theoretically, concomitant use of hops with sedative drugs might cause additive sedation.
Some animal research shows that hops has sedative effects.

Likelihood Possible Evidence D
Estrogens

Theoretically, concomitant use of large amounts of hops might interfere with hormone replacement therapy due to competition for estrogen receptors.
In vitro research suggests that certain hops constituents can competitively bind to estrogen receptors. However, most hops extracts contain very small amounts of these constituents.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Hops extract does not seem to affect the metabolism of CYP1A2 substrates.
In vitro research suggests that flavonoid constituents of hops inhibit CYP1A2 enzyme activity. However, a pharmacokinetic study in healthy postmenopausal patients shows that taking a standardized extract of spent hops containing prenylated phenols, as 59.5 mg twice daily for 2 weeks, does not affect levels of caffeine, a CYP1A2 probe substrate.

Likelihood Unlikely Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, hops extract might alter metabolism of CYP3A4 substrates; however, this effect may not be clinically significant.
Animal research suggests that specific constituents of hops, called lupulones, can induce hepatic CYP3A4 enzyme activity. However, a pharmacokinetic study in healthy postmenopausal patients with normal metabolism shows that taking a standardized extract of spent hops containing prenylated phenols, as 59.5 mg twice daily for 2 weeks, decreases the concentration of alprazolam, a CYP3A4 probe substrate, by 7.6%. This reduction is unlikely to be clinically relevant.

Likelihood Possible Evidence D
Hops strobile extract full monograph & interactions

RemiSure dry extract7 drug types · 652 drugs

Atorvastatin (Lipitor)

Taking black cohosh with atorvastatin might increase the risk for elevated liver function tests.
In one case report, a patient taking atorvastatin (Lipitor) developed significantly elevated liver function enzymes after starting black cohosh 100 mg four times daily. Liver enzymes returned to normal when black cohosh was discontinued. It is unclear whether the elevated liver enzymes were due to black cohosh itself or an interaction between atorvastatin and black cohosh.

Likelihood Possible Evidence D
Cisplatin (Platinol-Aq)

Theoretically, black cohosh may reduce the clinical effects of cisplatin.
Animal research suggests that black cohosh might decrease the cytotoxic effect of cisplatin on breast cancer cells.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Some research suggests that black cohosh might inhibit CYP2D6, but there is conflicting evidence.
Some clinical research suggests that black cohosh might modestly inhibit CYP2D6 and increase levels of drugs metabolized by this enzyme. However, contradictory clinical research shows a specific black cohosh product (Remifemin, Enzymatic Therapy) 40 mg twice daily does not significantly inhibit metabolism of a CYP2D6 substrate in healthy study volunteers. Until more is known, use black cohosh cautiously in patients taking drugs metabolized by CYP2D6.

Likelihood Possible Evidence B
Estrogens

Theoretically, black cohosh may alter the effects of estrogen therapy.
Some research suggests that black cohosh has estrogenic effects. This may enhance or inhibit the effects of estrogen therapy.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking black cohosh with hepatotoxic drugs may increase the risk of liver damage.
There is concern that black cohosh might be linked to cases of liver failure and autoimmune hepatitis.

Likelihood Possible Evidence D
Serotonergic Drugs

Combining serotonergic drugs with black cohosh might cause additive serotonergic effects.
Black cohosh might increase the risk of serotonin syndrome when combined with other serotonergic drugs. Black cohosh acts as an agonist at several serotonin receptor subtypes and might interact with other serotonergic medications. In one case, a 55-year-old female who had been on stable treatment with sertraline 50 mg and duloxetine 60 mg daily developed serotonin syndrome after taking black cohosh extract 40 mg daily for 3 days.

Likelihood Possible Evidence D
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Black cohosh may inhibit one form of OATP, OATP2B1, which could reduce the bioavailability and clinical effects of OATP2B1 substrates.
In vitro research shows that black cohosh modestly inhibits OATP2B1. OATPs are expressed in the small intestine and liver and are responsible for the uptake of drugs and other compounds into the body. Inhibition of OATP may reduce the bioavailability of oral drugs that are substrates of OATP.

Likelihood Possible Evidence D
RemiSure dry extract full monograph & interactions

Lemon Balm leaf extract2 drug types · 264 drugs

Cns Depressants

Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Lemon balm seems to have CNS depressant activity in animals and in humans.

Likelihood Possible Evidence B
Thyroid Hormone

Theoretically, lemon balm might interfere with thyroid hormone replacement therapy.
In vitro, constituents of lemon balm extract bind to thyroid stimulating hormone (TSH), preventing TSH receptor-binding and leading to the inhibition of TSH-stimulated adenylate cyclase activity. In animals, lemon balm extract has been shown to decrease levels of circulating TSH and inhibit thyroid secretion.

Likelihood Possible Evidence D
Lemon Balm leaf extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Remifemin Good Night, from the product label.

Nature's Way

See all Nature's Way products
Name
Nature's Way Brands, LLC
City
Green Bay
State
WI
ZipCode
54311
Phone Number
1-800-962-8873
Web Address
naturesway.com
Pharmacist Counseling Corner

Remifemin Good Night by Nature's Way: Common Questions

Does Remifemin Good Night by Nature's Way interact with any medications?
Yes. Based on its ingredients, Remifemin Good Night has a known interaction with 1,158 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Remifemin Good Night contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is valerian root extract and what does it do in this product?
Valerian root extract is a traditional herbal ingredient included for its sedative properties to help with sleep. It's possibly effective for insomnia. Most people tolerate it well short-term, though the long-term safety profile isn't firmly established.
Can I take this product while I'm pregnant?
No—the safety data advises against valerian, hops, and black cohosh during pregnancy. Lemon balm has insufficient data, so talk with your doctor or pharmacist for personalized advice if you're pregnant or planning to become pregnant.
Can I take this while breastfeeding?
Valerian and black cohosh are best avoided while breastfeeding. Hops and lemon balm also carry safety concerns, so consult your doctor or pharmacist before using any of these ingredients while nursing.
What are the most common side effects?
Dizziness, drowsiness, and mental slowness are the most frequently reported side effects, along with headache, stomach upset, vivid dreams, and excitability. These typically occur short-term, and long-term safety data is limited.
If I've been taking this for a while, can I just stop taking it?
It's better to taper off slowly rather than stop abruptly, especially after extended use. Stopping suddenly can trigger withdrawal symptoms like rapid heartbeat, anxiety, irritability, and insomnia. Reduce your dose gradually over time.
Does this product contain fillers or other inactive ingredients?
Yes—it contains several inactive ingredients including cellulose, hypromellose, maltodextrin, magnesium stearate, silica, titanium dioxide, soy lecithin, spirulina, and carnauba wax, which serve as binders, fillers, and capsule materials.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Remifemin Good Night label
Go deeper

The Full Monographs Behind Remifemin Good Night’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Valerian

Interacts with 902 drugs

Valerian is an herb whose root is widely used as a natural sleep aid and for calming nerves. The evidence is mixed and often weak, so it may help some people sleep but does not work reliably...

Read the full Valerian monograph → Herb & supplement monograph

Hops

Interacts with 863 drugs

Hops are most often used for sleep and mild anxiety, frequently combined with valerian, but the human evidence is limited and not very strong. They are generally well tolerated when used sho...

Read the full Hops monograph → Herb & supplement monograph

Lemon Balm

Interacts with 264 drugs

Lemon balm is a gentle, lemon-scented mint-family herb traditionally used to ease stress, support sleep, and calm digestion, and topically for cold sores. Early studies are promising but gen...

Read the full Lemon Balm monograph → Herb & supplement monograph

Black Cohosh

Interacts with 652 drugs

Black cohosh is a North American plant most often used to ease menopause symptoms like hot flashes, but the research is mixed and far from settled. It is generally well tolerated for short-t...

Read the full Black Cohosh monograph →
Sources

Sources & How We Checked

Remifemin Good Night's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 132 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Valerian 37 references
  1. Willey LB, Mady SP, Cobaugh DJ, Wax PM. Valerian overdose: a case report. Vet Hum Toxicol 1995;37:364-5.
  2. Kuhlmann J, Berger W, Podzuweit H, Schmidt U. The influence of valerian treatment on "reaction time, alertness and concentration" in volunteers. Pharmacopsychiatry 1999;32:235-41. PubMed
  3. Klepser TB, Klepser ME. Unsafe and potentially safe herbal therapies. Am J Health Syst Pharm 1999;56:125-38. PubMed
  4. Houghton PJ. The scientific basis for the reputed activity of Valerian. J Pharm Pharmacol 1999;51:505-12. PubMed
  5. Garges HP, Varia I, Doraiswamy PM. Cardiac complications and delirium associated with Valerian root withdrawal. [Letter to the Editor]. JAMA 1998;280:1566-7. PubMed
  6. Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
  7. MacGregor FB, Abernethy VE, Dahabra S, et al. Hepatotoxicity of herbal remedies. BMJ 1989;299:1156-7. PubMed
  8. Leathwood PD, Chauffard F. Aqueous extract of valerian reduces latency to fall asleep in man. Planta Med 1985;2:144-8. PubMed
  9. Hadley S, Petry JJ. Valerian. Am Fam Physician 2003;67:1755-8..
  10. Glass JR, Sproule BA, Herrmann N, et al. Acute pharmacological effects of temazepam, diphenhydramine, and valerian in healthy elderly subjects. J Clin Psychopharmacol 2003;23:260-8. PubMed
  11. Lefebvre T, Foster BC, Drouin CE, et al. In vitro activity of commercial valerian root extracts against human cytochrome P450 3A4. J Pharm Pharmaceut Sci 2004;7:265-73.
  12. Yuan CS, Mehendale S, Xiao Y, et al. The gamma-aminobutyric acidergic effects of valerian and valerenic acid on rat brainstem neuronal activity. Anesth Analg 2004;98:353-8. PubMed
  13. Donovan JL, DeVane CL, Chavin KD, et al. Multiple night-time doses of valerian (Valeriana officinalis) had minimal effects on CYP3A4 activity and no effect on CYP2D6 activity in healthy volunteers. Drug Metab Dispos 2004;32:1333-6. PubMed
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Hops 15 references
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Black Cohosh 68 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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