Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Ribomax Chews Ingredients & Drug Interactions

by HoltraCeuticals

Ribomax Chews label
See full label image
Tablet Or Pill Category: Fiber And Other Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Ribomax Chews against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Ribomax Chews is a dietary supplement by HoltraCeuticals with 2 active ingredients. Its ingredients are commonly taken for energy and fatigue, athletic performance and recovery, fibromyalgia symptoms.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are D-Ribose. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Ribomax Chews by HoltraCeuticals

Ask about any prescription or over-the-counter medication and we check it for interactions with Ribomax Chews by HoltraCeuticals — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Ribomax Chews by HoltraCeuticals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Ribomax Chews contains one active ingredient: D-ribose, a five-carbon sugar that your body uses to make and repair muscle and heart cells. The chewable tablet also holds inactive ingredients including xylitol, cellulose, natural orange and vanilla flavors, and several binders and flow agents to make the tablet stable and palatable.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Ribose's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: supports cardiac health and skeletal muscle function.
  • We looked for evidence on: Coronary heart disease (CHD), Heart failure, Athletic performance, Muscle soreness, Chronic fatigue syndrome (CFS), Fibromyalgia — and 3 related terms.
  • The closest evidence on file: Ribose is rated "Possibly Ineffective" for Athletic performance (Natural Medicines).
  • Also on file: Ribose is rated "Insufficient Reliable Evidence To Rate" for Coronary heart disease (CHD), Chronic fatigue syndrome (CFS), Congestive heart failure (CHF), Fibromyalgia, and more.

The evidence for D-ribose is mixed. For athletic performance and McArdle disease (a rare muscle disorder), it's rated possibly ineffective.

For restless legs syndrome, heart failure, muscle soreness, and recovery after heart bypass surgery, the data we have isn't yet reliable enough to say whether it works or not.

The evidence, ingredient by ingredient Ribose

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

D-ribose is generally well tolerated in the short term — up to about a month — but long-term safety hasn't been well studied. The most common side effects are diarrhea, nausea, gastrointestinal discomfort, headache, and low blood sugar.

Some people report a feeling of anxiety, lightheadedness, or increased appetite, though lowering the dose can resolve these symptoms. There is not enough safety information to use this product during pregnancy or while breastfeeding — talk it over with your doctor or pharmacist for personalized guidance.

Side effects, ingredient by ingredient Ribose

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Ribose.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this product if you use insulin or antidiabetes drugs (including metformin, sulfonylureas, GLP-1 agonists, SGLT2 inhibitors, or any other class). Ribose may lower your blood sugar more than your medication alone, raising the risk of hypoglycemia.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

D-ribose may be worth considering if you're looking to support muscle or heart health, though the evidence for most uses isn't strong. The main caution is if you take diabetes or insulin medications — ribose can lower your blood sugar further.

Talk with your own doctor or pharmacist before you start, especially if you're on any blood-sugar-lowering drugs or are pregnant or nursing.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Ribomax Chews, straight from the product label.

Brand HoltraCeuticals
Net contents 90 Chewable Tablet(s)
Market status On market
Date entered into DSLD Mar 25, 2013
DSLD ID 19858
Product type Fiber And Other Nutrients
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Ribomax Chews by HoltraCeuticals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
90
IngredientAmount% DV
Calories10 {Calories}--
Total Carbohydrates2 g2%
Sugar1.67 g--
D-Ribose1.67 g--
Sugar Alcohol0.5 g--

Other ingredients: Xylitol, Cellulose, Hydroxypropylcellulose, natural orange and vanilla flavors, Citric Acid, Mannitol, Vegetable Stearate, Stearic Acid, natural Palm Wax, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

This product contains NO salt, yeast, wheat, gluten, soy, corn, dairy products, artificial flavoring or colors, preservatives or ingredients of animal origin.

Precautions

Caution: Insulin-dependent diabetics and pregnant women should consult their healthcare professional before use.

Tamper resistant package, do not use if outer seal is missing.

KEEP OUT OF REACH OF CHILDREN.

Storage

For optimal storage conditions, store in a cool, dry place. (59(0)-77(0)F/15(0)-25(0)C) (35-65% relative humidity)

General Statements

Formula #201245 / 2260009

*Supports cardiac health and skeletal muscle function

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

HOLTORF MEDICAL GROUP(R) CENTERS FOR HORMONE IMBALANCE, HYPOTHYROIDISM AND FATIGUE

Protected by U.S. patents 6,159,942; 6,534,480; 6,218,366; 6,339,716; 6,703,370 and other U.S. and foreign patents issued and pending

(C)2008 Bioenergy, Inc.

Suggested/Recommended/Usage/Directions

Suggested Usage: Take one chewable tablet one to three times daily with food or as directed by your healthcare professional.

FDA Disclaimer Statement

This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Ribomax Chews by HoltraCeuticals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Ribomax Chews label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Ribomax Chews by HoltraCeuticals

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

1.67 g per serving

D-Ribose

Interacts with
86 drugs
1.67 g per serving

Ribose (D-ribose) is a simple sugar your body makes naturally and uses to build energy molecules like ATP. Some people take it for fatigue, fibromyalg...

D-Ribose monograph & interactions

Other (inactive) ingredients: Xylitol, Cellulose, Hydroxypropylcellulose, Natural orange and vanilla flavors, Citric Acid, Mannitol, Vegetable Stearate, Stearic Acid, Natural Palm Wax, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Ribomax Chews by HoltraCeuticals Drug Interactions

Want to check YOUR meds against Ribomax Chews?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

D-Ribose 86

Individual Drug Interactions

The ingredients in Ribomax Chews interact with 86 drugs. Click any drug to see the details.

1 of the 2 ingredients in Ribomax Chews interact with drugs. Each result below shows which ingredient is responsible. D-Ribose

Each ingredient & the kinds of drugs it affects

For each ingredient in Ribomax Chews with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

D-Ribose2 drug types · 86 drugs

Antidiabetes Drugs

Theoretically, taking ribose in combination with antidiabetes drugs might increase the risk of hypoglycemia.
In clinical research, ribose decreases serum glucose levels in a dose-dependent manner.

Likelihood Probable Evidence B
Insulin

Theoretically, taking ribose with insulin could increase the hypoglycemic effect of insulin.
In clinical pharmacokinetic studies, oral administration of ribose modestly increased serum insulin levels.

Likelihood Possible Evidence B
D-Ribose full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Ribomax Chews, from the product label.

HoltraCeuticals

See all HoltraCeuticals products
Web Address
HoltraCeuticals.com
Pharmacist Counseling Corner

Ribomax Chews by HoltraCeuticals: Common Questions

Does Ribomax Chews by HoltraCeuticals interact with any medications?
Yes. Based on its ingredients, Ribomax Chews has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Ribomax Chews contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Ribomax Chews if I have diabetes or take diabetes medication?
Not without checking with your doctor first. D-ribose can lower blood sugar, and if you're already taking a medication that does the same thing, your blood sugar could drop too far. Your doctor or pharmacist may need to adjust your dose or monitor you more closely.
What are the most common side effects?
Diarrhea, nausea, gastrointestinal discomfort, headache, and low blood sugar are the most often reported. Some people also experience lightheadedness, anxiety, or increased appetite. In studies, lowering the dose resolved nausea and anxiety in some cases.
Can I take this while pregnant or breastfeeding?
There isn't enough safety data available. It's best to avoid it during pregnancy and breastfeeding. Talk with your doctor or pharmacist about whether this is right for you.
Does D-ribose actually help athletic performance or muscle soreness?
The evidence doesn't support it for athletic performance — it's rated possibly ineffective. For muscle soreness, the research we have isn't reliable enough yet to say whether it works.
How long can I safely take this?
In studies, D-ribose is generally well tolerated for up to about one month. Long-term safety beyond that hasn't been well studied, so check with your pharmacist or doctor about how long you plan to use it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Ribomax Chews is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Ribomax Chews label
Go deeper

The Full Monographs Behind Ribomax Chews’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Ribose

Interacts with 86 drugs

Ribose (D-ribose) is a simple sugar your body makes naturally and uses to build energy molecules like ATP. Some people take it for fatigue, fibromyalgia, exercise recovery, or heart conditio...

Read the full Ribose monograph →
Sources

Sources & How We Checked

Ribomax Chews's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Ribose 8 references
  1. Segal S, Foley J. The metabolism of D-ribose in man. J Clin Invest 1958;37:719-35. PubMed
  2. Perlmutter NS, Wilson RA, Angello DA, et al. Ribose facilitates thallium-201 redistribution in patients with coronary artery disease. J Nucl Med 1991;32:193-200.
  3. Hegewald MG, Palac RT, Angello DA, et al. Ribose infusion accelerates thallium redistribution with early imaging compared with late 24-hour imaging without ribose. J Am Coll Cardiol 1991;18:1671-81. PubMed
  4. Pliml W, von Arnim T, Stalein A, et al. Effects of ribose on excercise-induced ischaemia in stable coronary artery disease. Lancet 1992;340:507-10.
  5. Burke ER. D-Ribose What You Need To Know. Garden City Park, NY: Avery Publishing Group 1999;1-43.
  6. Gross M, Reiter S, Zollner N. Metabolism of D-ribose administered continuously to healthy persons and to patients with myoadenylate deaminase deficiency. Klin Wochenschr 1989;67:1205-13. PubMed
  7. Teitelbaum JE, Johnson C, St Cyr J. The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study. J Altern Complement Med 2006;12:857-62. PubMed
  8. Thompson J, Neutel J, Homer K, Tempero K, Shah A, Khankari R. Evaluation of D-ribose pharmacokinetics, dose proportionality, food effect, and pharmacodynamics after oral solution administration in healthy male and female subjects. J Clin Pharmacol 2014;54 PubMed

See these in context on the Ribose monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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