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Dietary supplement

Rue Non-Alcohol Ingredients & Drug Interactions

by Hawaii Pharm

Rue Non-Alcohol label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Rue Non-Alcohol against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Rue Non-Alcohol is a dietary supplement by Hawaii Pharm with 1 active ingredient. Its ingredients are commonly taken for menstrual cramps, digestive upset, muscle spasms and pain.Based on those ingredients, 335 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are certified organic Rue extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Rue Non-Alcohol by Hawaii Pharm

Ask about any prescription or over-the-counter medication and we check it for interactions with Rue Non-Alcohol by Hawaii Pharm — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Rue Non-Alcohol by Hawaii Pharm

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.

This product contains one active ingredient: certified organic rue extract in a non-alcohol liquid form. The extract is mixed with vegetable palm glycerin and Hawaiian artesian water as inactive ingredients.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Rue product and its label doesn't state a use — see Rue's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold on rue doesn't support its use for any of the purposes people commonly buy it for—abortion, cancer, contraception, upset stomach, or insect repellent. All of these uses are rated as having insufficient reliable evidence to know whether they work.

The evidence, ingredient by ingredient Rue

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Rue in food amounts is generally well tolerated. The dried herb appears to be generally well tolerated when used in medicinal doses, though a full safety study hasn't been done.

Fresh rue, by contrast, is generally considered unsafe. Common side effects with medicinal dried rue include cramps, drowsiness, depression, dizziness, stomach upset, and sleep disturbances.

Topically, it can cause contact dermatitis and phototoxic skin reactions. At high doses, rue can trigger uterine contractions (potentially leading to miscarriage) and respiratory trouble.

Rue should be avoided during pregnancy—the safety data advises against it because it can stimulate the uterus and harm the pregnancy. It should also be avoided while breastfeeding because safety isn't established and potentially toxic compounds may pass to the baby.

Side effects, ingredient by ingredient Rue

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Rue.
  • The most serious interaction on file is rated Moderate.
  • For scale: 335 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take a photosensitizing drug (one that increases your skin's sensitivity to sunlight), check with your pharmacist before using this product. The interaction is moderate and involves an increased risk of phototoxic skin reactions when the two are combined.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Rue extract doesn't have good evidence for the purposes people usually buy it for. If you're taking a photosensitizing medication, you'll want to check before using this product.

It's not recommended during pregnancy or breastfeeding. Talk to your pharmacist about whether rue is right for you and whether it interacts with your specific medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Rue Non-Alcohol, straight from the product label.

Brand Hawaii Pharm
Barcode (UPC) 0748399921949
Net contents 4 Fluid Ounce(s); 120 mL
Market status Off market
Date entered into DSLD Oct 23, 2020
DSLD ID 238453
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Organic, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Rue Non-Alcohol by Hawaii Pharm, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
20 Drop(s)
Maximum serving Sizes:
30 Drop(s)
UPC/BARCODE
0748399921949
IngredientAmount% DV
certified organic Rue extract0 NP--

Other ingredients: Vegetable Palm Glycerin, crystal clear artesian Hawaiian Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Hawaii Pharm Non-Alcohol Herbal Extract Highest quality since 2008

Made with Aloha!

Formulation

Contains no gluten, artificial colors, pesticides, preservatives, heavy metals. Non GMO.

Super concentrated liquid herbal extract Dry herb/menstruum ratio: 1:3

Contains no alcohol

Description: We meticulously produced this extract according to precise standards where each herbs are individually extracted according to their distinct characteristic to ensure a broad spectrum of therapeutic plant compounds. We use a classic maceration extraction method in combination with ultrasonic extraction, so that the vitamins, minerals, alkaloids, flavonoids and other active constituents of the herbs are maintained.

Manufactured in an FDA registered facility. Ultra Sonic

Non GMO Gluten free

Made in USA, Hawaii

Suggested/Recommended/Usage/Directions

Directions for use: Shake well before using. Take about 20-30 drops in juice, water, tea or as desired up to four times per day.

Precautions

Warnings: Keep out of the reach of children.

Not to be used during pregnancy. Consult a physician before using if nursing or taking any medications.

Do not use if you are allergic to any ingredients.

Do not use if seal is broken or missing.

Storage

Refrigerate after opening.

Formula

(Ruta graveolens)

FDA Statement of Identity

Herbal Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

FDA Registered Facility Made in United States of America USA

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Rue Non-Alcohol by Hawaii Pharm label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Rue Non-Alcohol label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Rue Non-Alcohol by Hawaii Pharm

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size20 Drop(s) Dosage formLiquid Amounts shown are per serving.

Certified organic Rue extract

Interacts with
335 drugs
0 NP per serving

Rue is a strong-smelling herb from southern Europe with a long history in folk medicine, but there is very little reliable human research to support i...

Certified organic Rue extract monograph & interactions

Other (inactive) ingredients: Vegetable Palm Glycerin, Crystal clear artesian Hawaiian Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Rue Non-Alcohol by Hawaii Pharm Drug Interactions

Want to check YOUR meds against Rue Non-Alcohol?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
335Drugs
335 Moderate

Ingredients driving the most interactions

certified organic Rue extract 335

Individual Drug Interactions

The ingredients in Rue Non-Alcohol interact with 335 drugs. Click any drug to see the details.

1 of the 1 ingredient in Rue Non-Alcohol interact with drugs. Each result below shows which ingredient is responsible. certified organic Rue extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Rue Non-Alcohol with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

certified organic Rue extract1 drug type · 335 drugs

Photosensitizing Drugs

Theoretically, rue might increase the risk for phototoxicity when used with photosensitizing drugs.
Rue contains photosensitizing furanocoumarins and psoralens and has been associated with multiple reports of phototoxic reactions. There is also one case report of an increased phototoxic response to psoralen and ultraviolet A (PUVA) therapy associated with ingestion of rue.

Likelihood Possible Evidence D
certified organic Rue extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Rue Non-Alcohol, from the product label.

Hawaii Pharm

See all Hawaii Pharm products
Name
Hawaii Pharm LLC
City
Honolulu
State
HI
ZipCode
96815
Pharmacist Counseling Corner

Rue Non-Alcohol by Hawaii Pharm: Common Questions

Does Rue Non-Alcohol by Hawaii Pharm interact with any medications?
Yes. Based on its ingredients, Rue Non-Alcohol has a known interaction with 335 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Rue Non-Alcohol contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I use this while pregnant?
No. Rue should be avoided during pregnancy—it can stimulate the uterus and may harm the pregnancy. If you're pregnant or planning to become pregnant, talk to your doctor or pharmacist before using any rue product.
Can I use this while breastfeeding?
No. Safety while breastfeeding isn't established, and potentially toxic compounds may pass to your baby. Avoid it during breastfeeding and talk to your pharmacist about alternatives.
What side effects might I get?
With the dried herb in medicinal doses, some people experience cramps, drowsiness, depression, dizziness, stomach upset, or sleep disturbances. On your skin, it can cause a rash or a phototoxic reaction (a severe sunburn-like response triggered by sun exposure). High doses can cause breathing trouble.
Is there evidence this actually works for what people use it for?
Not in our data. Abortion, cancer prevention, contraception, upset stomach, and insect repellent all have insufficient reliable evidence to know whether rue helps.
Why is fresh rue considered unsafe when the dried herb is okay?
Fresh rue is generally considered unsafe, while the dried herb appears generally well tolerated in medicinal doses. The difference likely comes from how the plant's compounds change during drying, but the details aren't in our safety data.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Rue Non-Alcohol is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Rue Non-Alcohol label
Go deeper

The Full Monographs Behind Rue Non-Alcohol’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Rue

Interacts with 335 drugs

Rue is a strong-smelling herb from southern Europe with a long history in folk medicine, but there is very little reliable human research to support its health uses. It can be toxic in large...

Read the full Rue monograph →
Sources

Sources & How We Checked

Rue Non-Alcohol's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Rue 8 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  3. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  4. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  5. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  6. Puig L. Pharmacodynamic interaction with phototoxic plants during PUVA therapy. Br J Dermatol 1997;136:973-4. PubMed
  7. Radotra I, Gardiner S, Barnes D. A phytophototoxic injury at a burns unit: the ungraceful after-effects of the "common rue" plant. J Burn Care Res. 2018;39(6):1064-6. PubMed
  8. Avallone G, Mastorino L, Agostini A, et al. Ruta graveolens phytophotodermatitis. Dermatol Online J 2021;27(7). PubMed

See these in context on the Rue monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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