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Dietary supplement

SAMe & TMG Natural Lemon Flavor Ingredients & Drug Interactions

by XYMOGEN

SAMe & TMG Natural Lemon Flavor label
See full label image
Unknown Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking SAMe & TMG Natural Lemon Flavor against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

SAMe & TMG Natural Lemon Flavor is a dietary supplement by XYMOGEN with 2 active ingredients. Its ingredients are commonly taken for high homocysteine levels, liver health (fatty liver), exercise performance and strength.Based on those ingredients, 189 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are S-adenosyl-L-methionine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against SAMe & TMG Natural Lemon Flavor by XYMOGEN

Ask about any prescription or over-the-counter medication and we check it for interactions with SAMe & TMG Natural Lemon Flavor by XYMOGEN — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of SAMe & TMG Natural Lemon Flavor by XYMOGEN

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 2 active ingredients: betaine anhydrous and S-adenosyl-L-methionine (SAMe). Betaine anhydrous is an amino acid compound that your body uses to help regulate homocysteine levels—an amino acid linked to heart and brain health—and to support cellular function.

SAMe is a naturally occurring compound in your cells that plays a role in mood, joint health, and liver function. The product also contains inactive ingredients (sorbitol, calcium compounds, citric acid, malic acid, silica, turmeric extract, and natural lemon flavor) that serve as sweeteners, binders, and flavoring.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: methyl donor support for biochemical processes.
  • We looked for evidence on: Depression, Fibromyalgia, Osteoarthritis, Hyperhomocysteinemia, Homocystinuria, Nonalcoholic steatohepatitis (NASH) — and 4 related terms.
  • The strongest evidence on file: Betaine Anhydrous is rated "Effective" for Homocystinuria (Natural Medicines).
  • Also on file: Same is rated "Likely Effective" for Osteoarthritis.
  • Also on file: Same is rated "Possibly Effective" for Depression.

SAMe has solid evidence for osteoarthritis, where it's considered likely effective at reducing joint pain and stiffness. It's possibly effective for depression and liver cholestasis (bile flow problems).

Betaine anhydrous is effective for homocystinuria, a rare inherited metabolic condition, and possibly effective for elevated homocysteine levels. For other uses in the product—ADHD, Alzheimer disease, GERD, colorectal adenoma, and nonalcoholic fatty liver disease—the evidence isn't established in our data.

The evidence, ingredient by ingredient Betaine Anhydrous Same

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both ingredients are generally well tolerated at studied doses, but important cautions apply. SAMe may cause stomach upset, and there's a risk it could trigger mania in people with bipolar disorder.

Betaine anhydrous commonly causes body odor, GI distress, diarrhea, nausea, or vomiting; rarely, it may cause cerebral edema (swelling of the brain). For pregnancy, SAMe is rated possibly safe, but betaine anhydrous safety in pregnancy is not well established, so talk with your doctor before use.

Breastfeeding safety isn't well documented for either ingredient.

Side effects, ingredient by ingredient Betaine Anhydrous Same

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Same.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: Parkinson's medications.
  • For scale: 189 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take serotonergic drugs—antidepressants, anti-anxiety medications, certain migraine or pain relievers—because SAMe may increase the risk of serotonin syndrome. If you take levodopa for Parkinson disease, SAMe may reduce its effectiveness.

Use the medication checker on this page to look up your exact prescriptions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you have osteoarthritis or depression, SAMe is worth discussing with your doctor. Betaine anhydrous may help if you have high homocysteine levels.

Check your medications carefully before starting—especially if you take antidepressants or levodopa. Talk it over with your own doctor or pharmacist to make sure it's right for you and won't interfere with anything you're already taking.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about SAMe & TMG Natural Lemon Flavor, straight from the product label.

Brand XYMOGEN
Barcode (UPC) 871149002947
Net contents 30 Sachet(s); 87 Gram(s); 3.07 oz.
Market status On market
Date entered into DSLD Apr 25, 2014
DSLD ID 32409
Product type Non-nutrient/non-botanical
Supplement form Unknown
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for SAMe & TMG Natural Lemon Flavor by XYMOGEN, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2.9 Gram(s)
Maximum serving Sizes:
2.9 Gram(s)
Servings per container
30
UPC/BARCODE
871149002947
IngredientAmount% DV
Betaine Anhydrous600 mg--
S-adenosyl-L-methionine400 mg--

Other ingredients: Sorbitol, Calcium Carbonate, Citric Acid, Malic Acid, Stearic Acid, Calcium Chloride, Calcium Oxide, Silica, Turmeric extract, natural Lemon flavor

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Methyl Donors

SAMe & TMG is a sweet, yet slightly tart lemon-flavored powder. SAMe (S-adenosyl-L-methionine) and TMG (trimethylglycine) are naturally occurring substances that act as methyl donors during vital biochemical processes in the body. Methylation is essential to normal cell health and function. It can decline with age or chronic alcohol consumption, and it can be limited in some individuals due to their genetic makeup. SAMe donates methyl groups, which are needed for the synthesis of neurotransmitters, proteins, nucleic acids, and phospholipids. It supports glutathione production, liver health, joint comfort, and a healthy mood. TMG is an especially important methyl donor involved in the metabolism of homocysteine and the formation of SAMe. TMG ultimately supports cardiovascular and neurological health, as well as normal cell-life regulation.

This concentration makes SAMe & TMG cost effective as most SAMe formulations on the market contain less than 44% active SS isomer. Nitrogen-purged foil sachets maximize stability.

Pharmaceutical Grade - Professional Use Only

EXCLUSIVE PROFESSIONAL FORMULAS

Suggested/Recommended/Usage/Directions

DIRECTIONS: Consume one sachet one to four times daily away from meals, or as directed by your healthcare practitioner. Preferably pour a small amount of the contents of the entire sachet directly into the mouth and allow contents to dissolve. Alternately, contents may be added to 2-4 oz of water or preferred liquid; stir and drink within 15 minutes.

Precautions

Children and pregnant or lactating women should consult their healthcare practitioner prior to use.

Children and pregnant or lactating women should consult their healthcare practitioner prior to use.

Use special caution in individuals with bipolar disorder. Do not use if tamper seal is damaged.

Keep closed in a cool, dry place out of reach of children.

Formula

XYMOGEN's SAMe & TMG formulation contains a minimum of 70% of the SS isomer of SAMe, the active form the body can use most readily.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

STORAGE: Keep closed in a cool, dry place out of reach of children.

Formulation

DOES NOT CONTAIN: Wheat, gluten, corn protein, yeast, soy, animal or dairy products, fish, shellfish, egg, artificial colors, artificial sweeteners, or preservatives.

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

European Patent # EP2189154A1

All XYMOGEN(R) Formulas Meet or Exceed cGMP Quality Standards.

(C) 2012 XYMOGEN

General

ZLB-SAME-01 REV. 091112

Seals/Symbols

This package is completely recyclable (recycle)

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

SAMe & TMG Natural Lemon Flavor by XYMOGEN label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

SAMe & TMG Natural Lemon Flavor label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in SAMe & TMG Natural Lemon Flavor by XYMOGEN

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size2.9 Gram(s) Dosage formUnknown Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Betaine Anhydrous

No known
interactions
600 mg per serving Form: Trimethylglycine

Betaine anhydrous (also called trimethylglycine) is a compound found in foods like beets, spinach, and whole grains, and is sold as a supplement and a...

Betaine Anhydrous monograph & interactions

S-adenosyl-L-methionine

Interacts with
189 drugs
400 mg per serving

SAM-e is a compound your body makes naturally that is sold as a supplement, most often for depression and osteoarthritis. Some research suggests it ma...

S-adenosyl-L-methionine monograph & interactions

Other (inactive) ingredients: Sorbitol, Calcium Carbonate, Citric Acid, Malic Acid, Stearic Acid, Calcium Chloride, Calcium Oxide, Silica, Turmeric extract, Natural Lemon flavor. These complete the product’s ingredient list but are not active constituents.

Interaction report

SAMe & TMG Natural Lemon Flavor by XYMOGEN Drug Interactions

Want to check YOUR meds against SAMe & TMG Natural Lemon Flavor?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
189Drugs
189 Moderate

Ingredients driving the most interactions

S-adenosyl-L-methionine 189

Individual Drug Interactions

The ingredients in SAMe & TMG Natural Lemon Flavor interact with 189 drugs. Click any drug to see the details.

1 of the 2 ingredients in SAMe & TMG Natural Lemon Flavor interact with drugs. Each result below shows which ingredient is responsible. S-adenosyl-L-methionine

Each ingredient & the kinds of drugs it affects

For each ingredient in SAMe & TMG Natural Lemon Flavor with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

S-adenosyl-L-methionine2 drug types · 189 drugs

Levodopa

SAMe might reduce the effectiveness of levodopa.
SAMe methylates levodopa, which might reduce its effectiveness for treating Parkinson disease.

Likelihood Possible Evidence D
Serotonergic Drugs

Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
SAMe has serotonergic effects. Theoretically, combining serotonergic drugs with SAMe might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders. In one case report, SAMe 100 mg intramuscularly was given daily with clomipramine (Anafranil) 25 mg per day. When the clomipramine dose was increased to 75 mg per day the patient experienced serotonin syndrome about 48-72 hours later, requiring hospitalization.

Likelihood Possible Evidence D
S-adenosyl-L-methionine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for SAMe & TMG Natural Lemon Flavor, from the product label.

XYMOGEN

See all XYMOGEN products
Name
XYMOGEN Exclusive Professional Formulas
Street Address
6900 Kingspointe Pkwy.
City
Orlando
State
FL
ZipCode
32819
Phone Number
800-647-6100
Web Address
www.xymogen.com
Pharmacist Counseling Corner

SAMe & TMG Natural Lemon Flavor by XYMOGEN: Common Questions

Does SAMe & TMG Natural Lemon Flavor by XYMOGEN interact with any medications?
Yes. Based on its ingredients, SAMe & TMG Natural Lemon Flavor has a known interaction with 189 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
SAMe & TMG Natural Lemon Flavor contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my depression?
SAMe, one of the two actives in this product, is rated possibly effective for depression. That means some people see benefit, but the evidence isn't conclusive. It's not a substitute for talking with your doctor about your options—especially important if you're on an antidepressant already, since mixing SAMe with those drugs carries a real risk.
What's the body odor from betaine anhydrous about?
Betaine anhydrous commonly causes body odor as a side effect when taken by mouth. It may also cause nausea, diarrhea, stomach upset, or vomiting. These are the most frequent side effects in the studies we have.
Is SAMe safe to take while breastfeeding?
SAMe is rated possibly safe in pregnancy, but safety while breastfeeding isn't well established. Betaine anhydrous also doesn't have clear breastfeeding safety data. Talk with your doctor or pharmacist before taking this if you're nursing—they can weigh the pros and cons for your situation.
Can I take this if I have bipolar disorder?
SAMe can trigger mania in people with bipolar disorder, so it's a real concern. If you have bipolar disorder, check with your doctor before using this product—don't start it on your own.
How much betaine is in here, and what does it do?
The product contains betaine anhydrous, a compound your body uses to help control homocysteine levels and support cell function. It's effective for homocystinuria, a rare genetic condition, and possibly effective for high homocysteine. The exact dose isn't listed here, so check the label or ask your pharmacist.
Does this interact with anything I take?
SAMe interacts with serotonergic drugs (like antidepressants and some migraine meds) and levodopa for Parkinson disease. Betaine anhydrous has no known medication interactions. Use the checker below to search your specific prescriptions.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

SAMe & TMG Natural Lemon Flavor label
Go deeper

The Full Monographs Behind SAMe & TMG Natural Lemon Flavor’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Betaine Anhydrous

Betaine anhydrous (also called trimethylglycine) is a compound found in foods like beets, spinach, and whole grains, and is sold as a supplement and as a prescription medicine for a rare gen...

Read the full Betaine Anhydrous monograph → Herb & supplement monograph

Same

Interacts with 189 drugs

SAM-e is a compound your body makes naturally that is sold as a supplement, most often for depression and osteoarthritis. Some research suggests it may help with these conditions, but the qu...

Read the full Same monograph →
Sources

Sources & How We Checked

SAMe & TMG Natural Lemon Flavor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 42 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Betaine Anhydrous 11 references
  1. Cystadane (betaine anhydrous for oral solution) Package insert. Orphan Medical, Inc. Minnetonka, MN. November 2005.
  2. Abdelmalek MF, Angulo P, Jorgensen RA, et al. Betaine, a promising new agent for patients with nonalcoholic steatohepatitis: results of a pilot study. Am J Gastroenterol 2001;96:2711-7.. PubMed
  3. Schwab U, Torronen A, Toppinen L, et al. Betaine supplementation decreases plasma homocysteine concentrations but does not affect body weight, body composition, or resting energy expenditure in human subjects. Am J Clin Nutr 2002;76:961-7. PubMed
  4. McGregor DO, Dellow WJ, Robson RA, et al. Betaine supplementation decreases post-methionine hyperhomocysteinemia in chronic renal failure. Kidney Int 2002;61:1040-6. PubMed
  5. Olthof MR, van Vliet T, Verhoef P, et al. Effect of homocysteine-lowering nutrients on blood lipids: results from four randomised, placebo-controlled studies in healthy humans. PloS Med 2005;2:e135. PubMed
  6. Knopman, D. and Patterson, M. An open-label, 24-week pilot study of the methyl donor betaine in Alzheimer disease patients. Alzheimer Dis.Assoc.Disord. 2001;15(3):162-165. PubMed
  7. Moat, S. J., Madhavan, A., Taylor, S. Y., Payne, N., Allen, R. H., Stabler, S. P., Goodfellow, J., McDowell, I. F., Lewis, M. J., and Lang, D. High- but not low-dose folic acid improves endothelial function in coronary artery disease. Eur J Clin Invest 2 PubMed
  8. Abdelmalek, M. F., Sanderson, S. O., Angulo, P., Soldevila-Pico, C., Liu, C., Peter, J., Keach, J., Cave, M., Chen, T., McClain, C. J., and Lindor, K. D. Betaine for nonalcoholic fatty liver disease: results of a randomized placebo-controlled trial. Hepa PubMed
  9. Ashtary-Larky D, Bagheri R, Ghanavati M, et al. Effects of betaine supplementation on cardiovascular markers: a systematic review and meta-analysis. Crit Rev Food Sci Nutr. 2021 Mar 25:1-18. PubMed
  10. Zawieja EE, Zawieja B, Chmurzynska A. Betaine supplementation moderately increases total cholesterol levels: a systematic review and meta-analysis. J Diet Suppl. 2021;18(1):105-117. PubMed
  11. Imbard A, Toumazi A, Magréault S, et al. Efficacy and pharmacokinetics of betaine in CBS and cblC deficiencies: a cross-over randomized controlled trial. Orphanet J Rare Dis 2022;17(1):417. PubMed

See these in context on the Betaine Anhydrous monograph →

Same 31 references
  1. Perna AF, Castaldo P, Ingrosso D, et al. Homocysteine, a new cardiovascular risk factor, is also a powerful uremic toxin. J Nephrol 1999;12:230-40.
  2. Mato JM, Camara J, Fernandez de Paz J, et al. S-adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial. J Hepatol 1999;30:1081-9. PubMed
  3. Iruela LM, Minguez L, Merino J, Monedero G. Toxic interaction of S-adenosylmethionine and clomipramine. Am J Psychiatry 1993;150:522. PubMed
  4. Bradley JD, Flusser D, Katz BP, et al. A randomized, double blind, placebo controlled trial of intravenous loading with S-adenosylmethionine (SAM) followed by oral SAM therapy in patients with knee osteoarthritis. J Rheumatol 1994;21:905-11.
  5. Berlanga C, Ortega-Soto HA, Ontiveros M, Senties H. Efficacy of S-adenosyl-L-methionine in speeding the onset of action of imipramine. Psychiatry Res 1992;44:257-62. PubMed
  6. Kagan BL, Sultzer DL, Rosenlicht N, Gerner RH. Oral S-adenosylmethionine in depression: a randomized, double-blind, placebo-controlled trial. Am J Psychiatry 1990;147:591-5. PubMed
  7. Rosenbaum JF, Fava M, Falk WE, et al. The antidepressant potential of oral S-adenosyl-l-methionine. Acta Psychiatr Scand 1990;81:432-6. PubMed
  8. Domljan Z, Vrhovac B, Durrigl T, Pucar I. A double-blind trial of ademetionine vs naproxen in activated gonarthrosis. Int J Clin Pharmacol Ther Toxicol 1989;27:329-33.
  9. Konig B. A long-term (two years) clinical trial with S-adenosylmethionine for the treatment of osteoarthritis. Am J Med 1987;83:89-94. PubMed
  10. Lipinski JF, Cohen BM, Frankenburg F, et al. Open trial of S-adenosylmethionine for treatment of depression. Am J Psychiatry 1984;141:448-50.
  11. Almasio P, Bortolini M, Pagliaro L, Coltorti M. Role of S-adenosyl-L-methionine in the treatment of intrahepatic cholestasis. Drugs 1990;40:111-23. PubMed
  12. Friedel HA, Goa KL, Benfield P. S-adenosyl-L-methionine. A review of its pharmacological properties and therapeutic potential in liver dysfunction and affective disorders in relation to its physiological role in cell metabolism. Drugs 1989;38:389-416. PubMed
  13. Bottiglieri T, Hyland K, Reynolds EH. The clinical potential of ademetionine (S-adenosylmethionine) in neurological disorders. Drugs 1994;48:137-52. PubMed
  14. Frezza M, Centini G, Cammareri G, et al. S-adenosylmethionine for the treatment of intrahepatic cholestasis of pregnancy. Results of a controlled clinical trial. Hepatogastroenterology 1990;37:122-5.
  15. Singhal AB, Caviness VS, Begleiter AF, et al. Cerebral vasoconstriction and stroke after use of serotonergic drugs. Neurology 2002;58:130-3. PubMed
  16. Charlton CG, Crowell B Jr. Parkinson's disease-like effects of S-adenosyl-L-methionine: effects of L-dopa. Pharmacol Biochem Behav 1992;43:423-31..
  17. Goren JL, Stoll AL, Damico KE, et al. Bioavailability and lack of toxicity of S-adenosyl-L-methionine (SAMe) in humans. Pharmacotherapy 2004;24:1501-7. PubMed
  18. Arnold O, Saletu B, Anderer P, et al. Double-blind, placebo-controlled pharmacodynamic studies with a nutraceutical and a pharmaceutical dose of ademetionine (SAMe) in elderly subjects, utilizing EEG mapping and psychometry. Eur Neuropsychopharmacol 2005; PubMed
  19. Nelson JC. S-adenosyl methionine (SAMe) augmentation in major depressive disorder. (Editorial). Am J Psychiatry 2010;167:889-91.
  20. Kim J, Lee EY, Koh EM, et al. Comparative clinical trial of S-adenosylmethionine versus nabumetone for the treatment of knee osteoarthritis: an 8-week, multicenter, randomized, double-blind, double-dummy, Phase IV study in Korean patients. Clin Ther 2009; PubMed
  21. Manzillo G, Piccinino F, Surrenti C, et al. Multicentre double-blind placebo-controlled study of intravenous and oral S-adenosyl-L-methionine (SAMe) in cholestatic patients with liver disease. Drug Invest 1992;4 (Suppl 4):90-100. DOI
  22. Carrieri PB, Indaco A, Gentile S, et al. S-adenosylmethionine treatment of depressioin in patients with Parkinson's disease: a double-blind, crossover study versus placebo. Curr Ther Res 1990;48(1):154-60.
  23. Pancheri P, Scapicchio P, Delle Chiaie R. A double-blind, randomized parallel-group, efficacy and safety study of intramuscular S-adenosyl-L-methionine 1,4-butanedisulphonate (SAMe) versus imipramine in patients with major depressive disorder. Int J Neuro PubMed
  24. Medici V., Virata M. C., Peerson J. M., Stabler S. P., French S. W., Gregory J. F. III, Albanese A., Bowlus C. L., Devaraj S., Panacek E. A., Richards J. R., Halsted C. H. S-adenosyl-L-methionine treatment for alcoholic liver disease: a double-blinded, ra
  25. Chitiva, H., Audivert, F., and Alvarez, C. Suicide attempt by self-burning associated with ingestion of S-adenosylmethionine: a review of the literature and case report. J.Nerv.Ment.Dis. 2012;200(1):99-101. PubMed
  26. Carney, M. W., Edeh, J., Bottiglieri, T., Reynolds, E. M., and Toone, B. K. Affective illness and S-adenosyl methionine: a preliminary report. Clin Neuropharmacol. 1986;9(4):379-385. PubMed
  27. Miccoli, L., Porro, V., and Bertolino, A. Comparison between the antidepressant activity and of S- adenosylmethionine (SAMe) and that of some tricyclic drugs. Acta Neurol (Napoli) 1978;33 (3):243-255.
  28. Bacci, Ballerini F., Lopez, Anguera A., Alcaraz, P., and Hernandez, Reyes N. [SAMe in the management of postconcussional syndrome]. Medicina Clinica (Barc.) 1983;80(4):161-164.
  29. Muscettola G, Galzenati M, Balbi A. SAMe versus placebo: a double blind comparison in major depressive disorders. Advances in Biochemical Psychopharmacology 1982;32:151-6.
  30. Capretto C, Cremona C, and Canaparo L. A double-blind controlled study of S-adenosylmethionine (SAMe) v. ibuprofen in gonarthrosis, coxarthrosis and spondylarthrosis. Clin Trials J 1985;22(1):15-24.
  31. Ancarani E, Biondi B, Bolletta A, et al. Major depression complicating hemodialysis in patients with chronic renal failure: a multicenter, double-blind, controlled clinical trial of S-adenosyl-L-methionine versus placebo. Curr Ther Res 1993;54(6):680-6. DOI

See these in context on the Same monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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