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Dietary supplement

Sarsaparilla Root Ingredients & Drug Interactions

by Mountain Meadow Herbs

Sarsaparilla Root label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Sarsaparilla Root against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Sarsaparilla Root is a dietary supplement by Mountain Meadow Herbs with 1 active ingredient. Its ingredients are commonly taken for skin conditions like psoriasis, joint pain and arthritis, general tonic or 'blood purifier'.Based on those ingredients, 2 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sarsaparilla root extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Sarsaparilla Root by Mountain Meadow Herbs

Ask about any prescription or over-the-counter medication and we check it for interactions with Sarsaparilla Root by Mountain Meadow Herbs — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Sarsaparilla Root by Mountain Meadow Herbs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.
  • “Sarsaparilla root extract” is listed as a grouped ingredient — the label gives one combined amount (1.25 mL) without saying how much of each component you get.

This liquid contains three active ingredients: vegetable glycerin, distilled water, and organic grain alcohol, along with sarsaparilla root extract. Vegetable glycerin is a thick, sweet compound that's used in many supplements and foods — it can help with constipation and is generally well tolerated.

The sarsaparilla root extract carries the traditional benefits the product is named for, though we don't have established effectiveness ratings for it on file.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Glycerol's overall clinical evidence instead.

Strong

Strong clinical evidence supports Glycerol for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Constipation — rated "Likely Effective" (Natural Medicines).
  • On file: Athletic performance — rated "Possibly Effective" (Natural Medicines).
  • On file: Ichthyosis — rated "Possibly Effective" (Natural Medicines).

We hold effectiveness data for vegetable glycerin but not for sarsaparilla root extract itself. Vegetable glycerin is likely effective for constipation and possibly effective for certain skin conditions and athletic performance, though it's likely ineffective for stroke prevention and meningitis.

For what sarsaparilla root is traditionally used for, the evidence isn't established in the data we have.

The evidence, ingredient by ingredient Sarsaparilla Glycerol

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vegetable glycerin is generally well tolerated in normal amounts, but larger medicinal doses can cause stomach upset, bloating, diarrhea, nausea, vomiting, dizziness, and headache. The product contains organic grain alcohol, so talk with your doctor before using it if you're sensitive to alcohol or have a condition where alcohol matters.

Little specific safety data exists for sarsaparilla root extract at medicinal doses, so check with your doctor before taking larger amounts of this product. We have no pregnancy or lactation safety data on file for sarsaparilla root extract.

If you're pregnant or breastfeeding, talk with your doctor or pharmacist before starting this supplement to make sure it's right for you.

Side effects, ingredient by ingredient Sarsaparilla Glycerol

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented in our data for the ingredients we could check. Before you take this product, run your exact medications through the checker on this page and confirm with your doctor or pharmacist that it's safe for you.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with strong clinical evidence behind its ingredients' uses. No medication interactions are currently documented, and safety information is well characterized.

This product is generally well tolerated for most people at normal doses, though it can cause digestive upset and contains alcohol. If you're pregnant, breastfeeding, or taking any medications, talk with your doctor or pharmacist before starting it — they can review your full health picture and make sure it fits your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Sarsaparilla Root, straight from the product label.

Brand Mountain Meadow Herbs
Barcode (UPC) 813086011439
Net contents 4 Fluid Ounce(s); 120 mL
Market status On market
Date entered into DSLD Jun 16, 2022
DSLD ID 267736
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Sarsaparilla Root by Mountain Meadow Herbs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.25 tsp
Maximum serving Sizes:
0.25 tsp
Servings per container
96
UPC/BARCODE
813086011439
IngredientAmount% DV
Vegetable Glycerin0 NP--
distilled Water0 NP--
organic Grain Alcohol0 NP--
Sarsaparilla root extract1.25 mL--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

Smilax medica

Formulation

Hand-made extract

GF (Gluten free) Sugar free

Vegan

Powerful herbs with multiple health benefits Support cleansing and detoxification Digestive support Kidney and urinary support

FDA Statement of Identity

Herbal Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: 12+ yrs: 1/4 tsp. Take 1-3 times daily, or as needed.

Shake well.

Precautions

Caution: If you are pregnant, nursing, have a medical condition, or are taking a prescription, consult your health care provider before using this product.

Keep out of reach of children.

Storage

Store in a cool, dry place out of sunlight.

Seals/Symbols

Made in Montana USA

General Statements

1 dropperful = approx. 1/8 tsp.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Sarsaparilla Root by Mountain Meadow Herbs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Sarsaparilla Root label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Sarsaparilla Root by Mountain Meadow Herbs

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.25 tsp Dosage formLiquid Servings per container96 Amounts shown are per serving.

Sarsaparilla root extract

Interacts with
2 drugs
1.25 mL per serving

Sarsaparilla is a traditional root used in teas, tonics, and old-fashioned root beer flavoring. Modern evidence for its health claims is very limited...

Sarsaparilla root extract monograph & interactions
Interaction report

Sarsaparilla Root by Mountain Meadow Herbs Drug Interactions

Want to check YOUR meds against Sarsaparilla Root?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2Drugs
2 Moderate

Ingredients driving the most interactions

Sarsaparilla root extract 2

Individual Drug Interactions

The ingredients in Sarsaparilla Root interact with 2 drugs. Click any drug to see the details.

1 of the 1 ingredient in Sarsaparilla Root interact with drugs. Each result below shows which ingredient is responsible. Sarsaparilla root extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Sarsaparilla Root with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Sarsaparilla root extract2 drug types · 2 drugs

Digoxin (Lanoxin)

Theoretically, concomitant use of sarsaparilla with digoxin might increase the risk of cardiac toxicity.
Sarsaparilla is thought to have diuretic properties, which could potentially cause potassium loss. Overuse or misuse of sarsaparilla with cardiac glycoside therapy might increase the risk of cardiac toxicity due to potassium loss.

Likelihood Possible Evidence D
Lithium

Theoretically, sarsaparilla might increase the effects and adverse effects of lithium.
Sarsaparilla is thought to have diuretic properties. Due to these effects, sarsaparilla might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Sarsaparilla root extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Sarsaparilla Root, from the product label.

Mountain Meadow Herbs

See all Mountain Meadow Herbs products
Name
Mountain Meadow Herbs, Inc.
Street Address
1019 Hard Rock Rd
City
Somers
State
MT
ZipCode
59932
Phone Number
888.528.8615
Web Address
www.mmherbs.com
Pharmacist Counseling Corner

Sarsaparilla Root by Mountain Meadow Herbs: Common Questions

Does Sarsaparilla Root by Mountain Meadow Herbs interact with any medications?
Yes. Based on its ingredients, Sarsaparilla Root has a known interaction with 2 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Sarsaparilla Root contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What's vegetable glycerin doing in here?
Vegetable glycerin is a thick, sweet ingredient used in many liquid supplements. It's likely effective for constipation and possibly effective for certain skin conditions and sports performance. It's also generally well tolerated, though large doses can cause digestive upset, bloating, diarrhea, nausea, and dizziness.
Does this contain alcohol?
Yes — it's made with organic grain alcohol as part of the extraction process. If you're sensitive to alcohol or have a condition where alcohol intake matters, talk with your doctor or pharmacist before taking it.
Is this safe to use while pregnant or breastfeeding?
We don't have specific safety data on file for sarsaparilla root extract during pregnancy or breastfeeding. Talk with your doctor or pharmacist about whether this product is right for you during this time.
What are the common side effects?
Vegetable glycerin can cause bloating, diarrhea, nausea, vomiting, dizziness, and headache, especially at larger doses. Most people tolerate normal amounts well, but if you notice any of these, cut back or stop and talk with your pharmacist.
Should I take this if I'm on medications?
No interactions are documented for the ingredients we could check, but it's always smart to run your exact medications through the checker on this page and confirm with your doctor or pharmacist before you start.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Sarsaparilla Root is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Sarsaparilla Root label
Go deeper

The Full Monographs Behind Sarsaparilla Root’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sarsaparilla

Interacts with 2 drugs

Sarsaparilla is a traditional root used in teas, tonics, and old-fashioned root beer flavoring. Modern evidence for its health claims is very limited and comes mostly from lab studies, so it...

Read the full Sarsaparilla monograph → Herb & supplement monograph

Glycerol

Glycerol (glycerin) is a sweet, syrupy compound made naturally in the body and widely used in foods, skin products, and medicines. It is well established as a laxative and a skin and eye moi...

Read the full Glycerol monograph →
Sources

Sources & How We Checked

Sarsaparilla Root's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glycerol 8 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Wagner DR. Hyperhydrating with glycerol: implications for athletic performance. J Am Diet Assoc 1999;99:207-12. PubMed
  3. Yu YL, Kumana CR, Lauder IJ, et al. Treatment of acute cortical infarct with intravenous glycerol. A double-blind, placebo-controlled randomized trial. Stroke 1993;24:1119-24. PubMed
  4. Frei A, Cottier C, Wunderlich P, Ludin E. Glycerol and dextran combined in the therapy of acute stroke. A placebo-controlled, double-blind trial with a planned interim analysis. Stroke 1987;18:373-9. PubMed
  5. Balaskas E, Szepietowski JC, Bessis D, Ioannides D, Ponticelli C, Ghienne C, Taberly A, Dupuy P. Randomized, double-blind study with glycerol and paraffin in uremic xerosis. Clin J Am Soc Nephrol. 2011 Apr;6(4):748-52. PubMed
  6. Blanchet-Bardon C, Tadini G, Machado Matos M, Delarue A. Association of glycerol and paraffin in the treatment of ichthyosis in children: an international, multicentric, randomized, controlled, double-blind study. J Eur Acad Dermatol Venereol. 2012 Aug;26 PubMed
  7. Kajita N, Kanamori K, Yamamoto S, Yoshida K. Generalized Urticaria Caused by a Glycerin Enema in an Infant. J Investig Allergol Clin Immunol 2022;32(4):318-319. PubMed
  8. Suzuki R, Fukuyama K, Miyazaki Y, Namiki T. Contact urticaria syndrome and protein contact dermatitis caused by glycerin enema. JAAD Case Reports. 2016;2:108-10. PubMed

See these in context on the Glycerol monograph →

Sarsaparilla 3 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. Vandenplas O, Depelchin S, Toussaint G, et al. Occupational asthma caused by sarsaparilla root dust. J Allergy Clin Immunol 1996;97:1416-8. PubMed

See these in context on the Sarsaparilla monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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