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Dietary supplement

Saw Palmetto 580 mg Ingredients & Drug Interactions

by Solaray

Saw Palmetto 580 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Saw Palmetto 580 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Saw Palmetto 580 mg is a dietary supplement by Solaray with 1 active ingredient. Its ingredients are commonly taken for benign prostatic hyperplasia (bph) symptoms, urinary problems, hair loss.Based on those ingredients, 174 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Saw Palmetto. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Saw Palmetto 580 mg by Solaray

Ask about any prescription or over-the-counter medication and we check it for interactions with Saw Palmetto 580 mg by Solaray — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Saw Palmetto 580 mg by Solaray

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Solaray's Saw Palmetto 580 mg contains one active ingredient: saw palmetto extract at 580 mg per capsule. Saw palmetto is a botanical extract from the berry of the saw palmetto plant, traditionally used in herbal practice for urinary and prostate health.

The capsule also contains cellulose as an inactive ingredient.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Saw Palmetto's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Urinary tract support.
  • We looked for evidence on: Benign prostatic hyperplasia (BPH), Non-neurogenic lower urinary tract symptoms (LUTS), Prostatitis, Chronic prostatitis and chronic pelvic pain syndrome (CP/CPPS), prostate health, urinary symptoms.
  • The closest evidence on file: Saw Palmetto is rated "Possibly Ineffective" for Benign prostatic hyperplasia (BPH) (Natural Medicines).
  • Also on file: Saw Palmetto is rated "Insufficient Reliable Evidence To Rate" for Chronic prostatitis and chronic pelvic pain syndrome (CP/CPPS), Prostatitis, Non-neurogenic lower urinary tract symptoms (LUTS).

The evidence for saw palmetto is mixed. It's rated possibly ineffective for benign prostatic hyperplasia (BPH)—the noncancerous enlargement of the prostate that causes urinary symptoms.

For transurethral resection of the prostate (TURP), it's rated possibly effective. For other uses listed here—chronic bronchitis, androgenic alopecia (male pattern hair loss), and lower urinary tract symptoms unrelated to the nervous system—the evidence is insufficient to say whether it works.

If you're considering saw palmetto for a specific symptom, talk it over with your doctor to see if the evidence supports its use for your situation.

The evidence, ingredient by ingredient Saw Palmetto

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Saw palmetto is generally well tolerated, and adverse effects are mild and uncommon when they do occur. The most common ones reported in studies are abdominal pain, constipation, diarrhea, dizziness, fatigue, headache, nausea, and decreased libido.

Rarely, a fixed drug eruption (localized blisters and skin lesions) or worsening acne has been reported; a handful of cases of heart rhythm changes and high or low blood pressure have also been documented, though these are very unusual. Saw palmetto is rated likely unsafe during pregnancy because of possible hormonal effects and lack of safety data, and should be avoided while breastfeeding due to insufficient safety information.

If you're pregnant, planning to become pregnant, or nursing, do not use this product without talking to your doctor or pharmacist first.

Side effects, ingredient by ingredient Saw Palmetto

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Saw Palmetto.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 174 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Solaray's Saw Palmetto 580 mg, double-check with your doctor or pharmacist if you're on estrogens or hormone replacement therapy, contraceptive drugs (birth control pills, patches, or other hormonal methods), or anticoagulant or antiplatelet drugs (blood thinners like warfarin, apixaban, or daily aspirin). All three drug types are documented to interact at Moderate severity.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Saw palmetto may be worth considering if you're exploring options for urinary or prostate concerns—though the evidence for common uses is limited or unclear. It's not for you if you take hormonal birth control, hormone replacement therapy, or blood thinners without first checking with your doctor or pharmacist, given the documented interaction risks.

Avoid it entirely during pregnancy and while breastfeeding. Have a conversation with your healthcare provider about whether saw palmetto makes sense for you before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Saw Palmetto 580 mg, straight from the product label.

Brand Solaray
Barcode (UPC) 076280015522
Net contents 360 VegCap(s)
Market status On market
Date entered into DSLD Sep 25, 2023
DSLD ID 296228
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Saw Palmetto 580 mg by Solaray, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 VegCap(s)
Maximum serving Sizes:
1 VegCap(s)
Servings per container
360
UPC/BARCODE
076280015522
IngredientAmount% DV
Saw Palmetto580 mg--

Other ingredients: Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Solaray Est. 1973 A brighter way 1973

A Brighter Way 1973

Formula

True Herbs

Dietary Supplement

Discussion: Native to the Florida peninsula, Saw Palmetto berries have been used traditionally for thousands of years. Saw Palmetto berries contain fatty acids and plant sterols. These phytonutrients have been clinically studied for healthy prostate function. Solaray Saw Palmetto Berries are wild-crafted in the United States.

Formulation

Urinary tract support

Non GMO Project Verified nongmoproject.org

Lab Verified

Vegan

Seals/Symbols

Non GMO Project Verified nongmoproject.org

General Statements

Since 1973, we've scoured the globe for the highest quality ingredients, connecting you with the most efficacious supplements that help you live brighter & embrace the moments that matter most.

California Residents Only Warning: Reproductive Harm - www.P65Warnings.ca.gov

100% PCR Bottles

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Saw Palmetto 580 mg by Solaray label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Saw Palmetto 580 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Saw Palmetto 580 mg by Solaray

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 VegCap(s) Dosage formCapsule Servings per container360 Amounts shown are per serving.

Saw Palmetto

Interacts with
174 drugs
580 mg per serving

Saw palmetto is a plant extract most often used for urinary symptoms linked to an enlarged prostate (BPH). The best research suggests it works no bett...

Saw Palmetto monograph & interactions

Other (inactive) ingredients: Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Saw Palmetto 580 mg by Solaray Drug Interactions

Want to check YOUR meds against Saw Palmetto 580 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
174Drugs
174 Moderate

Ingredients driving the most interactions

Saw Palmetto 174

Individual Drug Interactions

The ingredients in Saw Palmetto 580 mg interact with 174 drugs. Click any drug to see the details.

1 of the 1 ingredient in Saw Palmetto 580 mg interact with drugs. Each result below shows which ingredient is responsible. Saw Palmetto

Each ingredient & the kinds of drugs it affects

For each ingredient in Saw Palmetto 580 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Saw Palmetto3 drug types · 174 drugs

Anticoagulant/Antiplatelet Drugs

Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Saw palmetto is reported to prolong bleeding time. Theoretically, it might increase the risk of bleeding when used concomitantly with anticoagulant or antiplatelet drugs.

Likelihood Possible Evidence D
Contraceptive Drugs

Saw palmetto might reduce the effectiveness of contraceptive drugs.
Saw palmetto might have antiestrogenic effects. Theoretically, it might interfere with contraceptive drugs taken concomitantly.

Likelihood Possible Evidence B
Estrogens

Saw palmetto might reduce the effectiveness of estrogens.
Saw palmetto might have antiestrogenic effects. Theoretically, it might interfere with estrogens taken concomitantly.

Likelihood Possible Evidence B
Saw Palmetto full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Saw Palmetto 580 mg, from the product label.

Solaray

See all Solaray products
Name
Solaray
City
Park City
State
UT
ZipCode
84098
Phone Number
800-538-5888
Web Address
www.solaray.com
Pharmacist Counseling Corner

Saw Palmetto 580 mg by Solaray: Common Questions

Does Saw Palmetto 580 mg by Solaray interact with any medications?
Yes. Based on its ingredients, Saw Palmetto 580 mg has a known interaction with 174 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Saw Palmetto 580 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will saw palmetto make my birth control less effective?
Possibly. Saw palmetto has antiestrogenic properties—it may interfere with estrogens in your body—and theoretically could reduce how well hormonal contraceptives work. This is a Moderate-severity interaction. Talk to your doctor or pharmacist before adding saw palmetto to your routine if you're on any form of hormonal birth control.
Can I take saw palmetto if I'm on a blood thinner?
Not without checking first. Saw palmetto may prolong bleeding time, which could increase your risk of bleeding if you're on anticoagulants or antiplatelet drugs like warfarin or aspirin. This is a Moderate-severity interaction. Run it by your doctor or pharmacist before you start.
Is saw palmetto safe during pregnancy?
No. Saw palmetto is rated likely unsafe in pregnancy because of possible hormonal effects and lack of safety data. Do not use it if you're pregnant or trying to become pregnant. Talk to your doctor if you're considering it.
What side effects might I experience?
Saw palmetto is generally well tolerated, but mild and infrequent side effects can include abdominal pain, constipation, diarrhea, dizziness, fatigue, headache, nausea, and decreased libido. Skin reactions and heart rhythm changes have been reported very rarely. Stop and tell your doctor if you have any unusual symptoms.
Does saw palmetto actually work for prostate problems?
The evidence is limited. It's rated possibly ineffective for benign prostatic hyperplasia (BPH), the most common prostate concern. For transurethral resection of the prostate (TURP), it's rated possibly effective, but overall the data doesn't strongly support its use. Talk to your doctor about what the evidence shows for your specific situation.
Is there anything in this capsule besides saw palmetto?
The capsule contains cellulose as an inactive ingredient—a common filler and binding agent. The active ingredient is the 580 mg of saw palmetto extract itself.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Saw Palmetto 580 mg label
Go deeper

The Full Monographs Behind Saw Palmetto 580 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Saw Palmetto

Interacts with 174 drugs

Saw palmetto is a plant extract most often used for urinary symptoms linked to an enlarged prostate (BPH). The best research suggests it works no better than a placebo for most men, though i...

Read the full Saw Palmetto monograph →
Sources

Sources & How We Checked

Saw Palmetto 580 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 22 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Saw Palmetto 22 references
  1. Wilt TJ, Ishani A, Stark G, et al. Saw palmetto extracts for treatment of benign prostatic hyperplasia: a systematic review. JAMA 1998;280:1604-9. PubMed
  2. Carraro JC, Raynaud JP, Koch G, et al. Comparison of phytotherapy (Permixon) with finasteride in the treatment of benign prostate hyperplasia: a randomized international study of 1,098 patients. Prostate 1996;29:231-40. DOI
  3. Di Silverio F, D'Eramo G, Lubrano C, et al. Evidence that Serenoa repens extract displays an antiestrogenic activity in prostatic tissue of benign prostatic hypertrophy patients. Eur Urol 1992;21:309-14. PubMed
  4. Stepanov VN, Siniakova LA, Sarrazin B, Raynaud JP. Efficacy and tolerability of the lipidosterolic extract of Serenoa repens (Permixon) in benign prostatic hyperplasia: a double-blind comparison of two dosage regimens. Adv Ther 1999;16:231-41.
  5. Cheema P, El-Mefty O, Jazieh AR. Intraoperative haemorrhage associated with the use of extract of Saw Palmetto herb: a case report and review of literature. J Intern Med 2001;250:167-9. PubMed
  6. Jibrin I, Erinle A, Saidi A, Aliyu ZY. Saw palmetto-induced pancreatitis. South Med J 2006;99:611-2. PubMed
  7. Prager N, Bickett K, French N, Marcovici G. A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia. J Altern Complement Med 2002
  8. Avins AL, Bent S, Staccone S, et al. A detailed safety assessment of a saw palmetto extract. Complement Ther Med 2008;16:147-54. PubMed
  9. Morgia, G., Mucciardi, G., Gali, A., Madonia, M., Marchese, F., Di, Benedetto A., Romano, G., Bonvissuto, G., Castelli, T., Macchione, L., and Magno, C. Treatment of chronic prostatitis/chronic pelvic pain syndrome category IIIA with Serenoa repens plus
  10. Aliaev, IuG, Vinarov, A. Z., Lokshin, K. L., and Spivak, L. G. [Efficiency and safety of prostamol-Uno in patients with chronic abacterial prostatitis]. Urologiia. 2006;(1):47-50.
  11. Agbabiaka, T. B., Pittler, M. H., Wider, B., and Ernst, E. Serenoa repens (saw palmetto): a systematic review of adverse events. Drug Saf 2009;32(8):637-647. PubMed
  12. Wargo, K. A., Allman, E., and Ibrahim, F. A possible case of saw palmetto-induced pancreatitis. South.Med.J. 2010;103(7):683-685. PubMed
  13. Lapi, F., Gallo, E., Giocaliere, E., Vietri, M., Baronti, R., Pieraccini, G., Tafi, A., Menniti-Ippolito, F., Mugelli, A., Firenzuoli, F., and Vannacci, A. Acute liver damage due to Serenoa repens: a case report. Br.J.Clin.Pharmacol. 2010;69(5):558-560.
  14. Mantovani, F. Serenoa repens in benign prostatic hypertrophy: analysis of 2 Italian studies. Minerva Urol.Nefrol. 2010;62(4):335-340.
  15. Hanaka, M., Yoshii, C., Yatera, K., Ito, C., Chojin, Y., Nagata, S., Yamasaki, K., Nishida, C., Kawanami, T., Kawanami, Y., Ishimoto, H., and Mukae, H. [A case of rhabdomyolysis caused by saw palmetto of healthy foods]. J.UOEH. 6-1-2012;34(2):193-199. PubMed
  16. Miroddi, M., Carni, A., Mannucci, C., Moleti, M., Navarra, M., and Calapai, G. Hot flashes in a young girl: a wake-up call concerning Serenoa repens use in children. Pediatrics 2012;130(5):e1374-e1376.
  17. Braeckman J. The extract of Serenoa repens in the treatment of benign prostatic hyperplasia: a multicenter open study. Current Therapeutic Research 1994;55(7):776-785. DOI
  18. Jipescu D, Patel A, Bohra H, Pientka A. Rare case of saw palmetto induced heart block. JACC 2017;69(11) supplement:2310.
  19. Morabito P, Miroddi M, Giovinazzo S, Spina E, Calapai G. Serenoa repens as an endocrine disruptor in a 10-year-Old young girl: a new case report. Pharmacology. 2015;96(1-2):41-3. doi: 10.1159/000431327.
  20. Gammoudi R, Ameur K, Ouni B, et al. Fixed drug eruption to Serenoa repens: first case report and consideration of the use of herbal medicine. Dermatol Ther 2020 Aug 29:e14247.
  21. Paulis G, Paulis A, Perletti G. Serenoa repens and its effects on male sexual function. A systematic review and meta-analysis of clinical trials. Arch Ital Urol Androl 2021;93(4):475-480. PubMed
  22. Venkateswaran S, Declet-Bauzo R, Shodeinde M, Gilford P. Postoperative Retroperitoneal Hematoma: A Case of Saw Palmetto and the Importance of Primary Care Intervention. HCA Healthc J Med 2020;1(5):279-282. PubMed

See these in context on the Saw Palmetto monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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