Adrenal Serenity Ingredients & Drug Interactions
by Natural Factors Stress-Relax
What is this page for?
First and foremost: checking Adrenal Serenity against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Adrenal Serenity is a dietary supplement by Natural Factors Stress-Relax with 4 active ingredients. Its ingredients are commonly taken for fatigue and low energy, stress and coping (adaptogen), mental performance and focus.Based on those ingredients, 1,499 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sensoril Ashwagandha extract, Rhodiola extract, Eleuthero extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Adrenal Serenity by Natural Factors Stress-Relax
Ask about any prescription or over-the-counter medication and we check it for interactions with Adrenal Serenity by Natural Factors Stress-Relax — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Adrenal Serenity by Natural Factors Stress-Relax
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Adrenal Serenity contains five active ingredients designed to support your stress response. You're getting Rhodiola extract, Sensoril Ashwagandha extract (with withanolides as its active component), Eleuthero extract (eleutheroside-containing), and Lavender extract.
The product also contains inactive ingredients — rice powder, a vegetarian capsule, and magnesium stearate — that help bind and deliver the actives.
Does it work?
Not established
The evidence for these ingredients varies widely, and most of it isn't fully established in our data. For lavender specifically, the research shows it may help with dysmenorrhea (period pain), but probably won't help cancer-related pain.
For pre-procedural anxiety, alopecia areata, and cancer-related fatigue, we don't have enough reliable evidence to say whether it works. The effectiveness of the other ingredients in this product — Rhodiola, Ashwagandha, and Eleuthero — isn't rated in our data.
How safe is it?
Well-documented data
Lavender is generally well tolerated when used in the approved forms in this product. The most common side effects are mild — breath odor, constipation, diarrhea, upset stomach, heartburn, and headache.
Allergic skin reactions can happen with lavender oil applied to skin. Serious side effects are rare.
One important caution: lavender essential oil is toxic if swallowed, though this capsule form shouldn't pose that risk. Safety data for the other ingredients in this product isn't well studied, so use it only with your healthcare provider's guidance.
If you're pregnant or breastfeeding, we don't have enough reliable data to know whether this product is safe — talk with your doctor or pharmacist about whether it's right for you.
Meds to double-check
Moderate interaction found
If you take CNS depressants — sedatives, sleep aids, anti-anxiety medications, pain relievers, antihistamines, or similar drugs — the lavender in this product may increase both their therapeutic and unwanted effects. Check your specific medications with the tool on this page before taking Adrenal Serenity.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
This is a multi-ingredient stress supplement built mainly around herbs with limited evidence. If you take any sedating medication — sleep aids, anti-anxiety drugs, pain relievers, or antihistamines — check with your pharmacist first because lavender might amplify their effects.
Otherwise, run your exact medications through the checker below before you start.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Adrenal Serenity, straight from the product label.
| Brand | Natural Factors Stress-Relax |
|---|---|
| Barcode (UPC) | 068958028347 |
| Net contents | 60 Vegetarian Capsule(s) |
| Market status | On market |
| Date entered into DSLD | May 22, 2020 |
| DSLD ID | 220461 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Adrenal Serenity by Natural Factors Stress-Relax, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Rhodiola extract | 75 mg | -- |
| Sensoril Ashwagandha extract | 250 mg | -- |
| Withanolides | 20 mg | -- |
| Eleuthero extract | 150 mg | -- |
| Eleutherosides | 1.2 mg | -- |
| Lavender extract | 150 mg | -- |
| Rosavins | 2.6 mg | -- |
| Salidrosides | 0.75 mg | -- |
Other ingredients: Rice powder, Vegetarian Capsule, Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols
isura Non-GMO - Mass Spec Documentation Lab tested
Purity & Potency Guaranteed
Suggested/Recommended/Usage/Directions
Suggested Usage: 1-2 capsules 2 times per day or as directed by a health professional.
Precautions
Cautions: As with any supplement, consult your health professional before use if you are pregnant, breastfeeding, or trying to conceive, or if you are taking medication, have a medical condition, or anticipate surgery.
Keep out of the reach of children.
Sealed for your protection. Do not use if seal is broken.
Formula
Adrenal Serenity is a unique combination of herbal extract that helps the body cope with occasional stress and promote emotional well-being.
Ashwagandha, eleuthero, rhodiola complex & calming lavender
Formulation
Manufactured by Natural Factors to ensure safety and potency in accordance with Good Manufacturing Practices (GMP) of the FDA and Health Canada.
Contains no artificial colors, preservatives, or sweeteners; no dairy, sugar, wheat, gluten, yeast, soy, egg, fish, shellfish, animal products, salt, tree nuts, or GMOs.
Suitable for vegetarians/vegans.
Stress relief & mental focus
Storage
For freshness, store in a cool, dry place.
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
General Statements
Product of Canada. Recyclable container and label.
FDA Statement of Identity
Dietary Supplement
Brand IP Statement(s)
Sensoril is a trademark of Natreon, Inc. and is protected under U.S. Patent 6,153,198 & 7,318,938
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Adrenal Serenity by Natural Factors Stress-Relax label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Adrenal Serenity by Natural Factors Stress-Relax
These are the 4 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Rhodiola extract
Interacts with1,271 drugs
Rhodiola is an herb traditionally used to fight fatigue and help the body cope with stress. Some small studies suggest it may modestly reduce fatigue...
Rhodiola extract monograph & interactions- › Rosavins
- › Salidrosides
Sensoril Ashwagandha extract
Interacts with1,372 drugs
Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evid...
Sensoril Ashwagandha extract monograph & interactions- › Withanolides
Eleuthero extract
Interacts with1,140 drugs
Eleuthero is an herb traditionally used as an 'adaptogen' to fight fatigue, boost energy, and help the body handle stress. The scientific evidence beh...
Eleuthero extract monograph & interactions- › Eleutherosides
Lavender extract
Interacts with248 drugs
Lavender is a fragrant herb most popular for promoting relaxation, easing anxiety, and supporting sleep, with some encouraging evidence for a standard...
Lavender extract monograph & interactionsOther (inactive) ingredients: Rice powder, Vegetarian Capsule, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
Adrenal Serenity by Natural Factors Stress-Relax Drug Interactions
HelloPharmacist Interaction Report
Adrenal Serenity by Natural Factors Stress-Relax contains five active ingredients, and we've found documented interactions for one of them.
Lavender extract carries a Moderate interaction with CNS depressants (sedatives, sleep aids, anti-anxiety medications, pain relievers, antihistamines, and others). Lavender has sedative properties and may intensify both the helpful and unwanted effects of these drugs — though clinical studies of people taking lavender haven't reported serious problems.
Read the full breakdown — every affected drug type, severity by severity
The other four ingredients — Rhodiola extract, Sensoril Ashwagandha extract, Eleuthero extract, and their related compounds — are either blend containers whose individual parts we've listed separately, or ingredients we currently hold no interaction data for (Withanolides, Eleutherosides, Rosavins, Salidrosides). We couldn't check those four components.
Altogether, these interactions span 248 individual medications. To see if any of your own prescriptions or over-the-counter drugs fall into the CNS depressant category, use the medication checker on this page with your exact drug names.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Adrenal Serenity?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Adrenal Serenity interact with 1,499 drugs. Click any drug to see the details.
4 of the 4 ingredients in Adrenal Serenity interact with drugs. Each result below shows which ingredient is responsible. Sensoril Ashwagandha extract Rhodiola extract Eleuthero extract Lavender extract
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Adrenal Serenity — through 3 ingredients. Tap an ingredient for the detail:
Eleuthero ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, eleuthero might interfere with immunosuppressive drugs because of its immunostimulant activity.
Read the full Eleuthero Extract + 6-mercaptopurine interactionSensoril Ashwagandha ExtractHepatotoxic Drugs, Immunosuppressants Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Sensoril Ashwagandha Extract + 6-mercaptopurine interactionRhodiola ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, rhodiola use might interfere with immunosuppressive therapy.
Read the full Rhodiola Extract + 6-mercaptopurine interactionAbacavir Sulfate, Dolutegravir, LamivudineTriumeq
How Abacavir Sulfate, Dolutegravir, Lamivudine interacts with Adrenal Serenity — through 1 ingredient. Tap an ingredient for the detail:
Sensoril Ashwagandha ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Sensoril Ashwagandha Extract + Abacavir Sulfate, Dolutegravir, Lamivudine interactionAbacavir, LamivudineEpzicom
How Abacavir, Lamivudine interacts with Adrenal Serenity — through 1 ingredient. Tap an ingredient for the detail:
Sensoril Ashwagandha ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Sensoril Ashwagandha Extract + Abacavir, Lamivudine interactionAbciximabReoPro
How Abciximab interacts with Adrenal Serenity — through 1 ingredient. Tap an ingredient for the detail:
Eleuthero ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, eleuthero may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Eleuthero Extract + Abciximab interactionAbiraterone
How Abiraterone interacts with Adrenal Serenity — through 3 ingredients. Tap an ingredient for the detail:
Sensoril Ashwagandha ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Sensoril Ashwagandha Extract + Abiraterone interactionRhodiola ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.
Read the full Rhodiola Extract + Abiraterone interactionEleuthero ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP3A4.
Read the full Eleuthero Extract + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Adrenal Serenity — through 3 ingredients. Tap an ingredient for the detail:
Sensoril Ashwagandha ExtractHepatotoxic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Sensoril Ashwagandha Extract + Abiraterone Acetate interactionRhodiola ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.
Read the full Rhodiola Extract + Abiraterone Acetate interactionEleuthero ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP3A4.
Read the full Eleuthero Extract + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Adrenal Serenity — through 3 ingredients. Tap an ingredient for the detail:
Eleuthero ExtractAnticoagulant/antiplatelet Drugs, Immunosuppressants +1 Moderate
Interaction Summary
Theoretically, eleuthero may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Eleuthero Extract + Abrocitinib interactionSensoril Ashwagandha ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Read the full Sensoril Ashwagandha Extract + Abrocitinib interactionRhodiola ExtractImmunosuppressants, Cytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, rhodiola use might interfere with immunosuppressive therapy.
Read the full Rhodiola Extract + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Adrenal Serenity — through 3 ingredients. Tap an ingredient for the detail:
Rhodiola ExtractP-glycoprotein Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, rhodiola might increase levels of P-glycoprotein substrates.
Read the full Rhodiola Extract + Acalabrutinib interactionEleuthero ExtractCytochrome P450 3a4 (cyp3a4) Substrates, P-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP3A4.
Read the full Eleuthero Extract + Acalabrutinib interactionSensoril Ashwagandha ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Sensoril Ashwagandha Extract + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Adrenal Serenity — through 3 ingredients. Tap an ingredient for the detail:
Eleuthero ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, eleuthero might have additive effects when used with antidiabetes drugs.
Read the full Eleuthero Extract + Acarbose interactionRhodiola ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking rhodiola with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Rhodiola Extract + Acarbose interactionSensoril Ashwagandha ExtractAntidiabetes Drugs, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Sensoril Ashwagandha Extract + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Adrenal Serenity — through 2 ingredients. Tap an ingredient for the detail:
Sensoril Ashwagandha ExtractHepatotoxic Drugs, Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Sensoril Ashwagandha Extract + Acebutolol interactionRhodiola ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking rhodiola with antihypertensive drugs might increase the risk of hypotension.
Read the full Rhodiola Extract + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Adrenal Serenity — through 1 ingredient. Tap an ingredient for the detail:
Eleuthero ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, eleuthero may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Eleuthero Extract + Acenocoumarol interactionAcepromazineAtravet
How Acepromazine interacts with Adrenal Serenity — through 3 ingredients. Tap an ingredient for the detail:
Sensoril Ashwagandha ExtractCns Depressants Moderate
Interaction Summary
Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Read the full Sensoril Ashwagandha Extract + Acepromazine interactionLavender ExtractCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Lavender Extract + Acepromazine interactionRhodiola ExtractCns Depressants Minor
Interaction Summary
Theoretically, rhodiola might increase the risk of adverse effects when taken with CNS depressants.
Read the full Rhodiola Extract + Acepromazine interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Adrenal Serenity — through 3 ingredients. Tap an ingredient for the detail:
Eleuthero ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
Read the full Eleuthero Extract + Acetaminophen interactionSensoril Ashwagandha ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Sensoril Ashwagandha Extract + Acetaminophen interactionRhodiola ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.
Read the full Rhodiola Extract + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Adrenal Serenity — through 3 ingredients. Tap an ingredient for the detail:
Sensoril Ashwagandha ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Sensoril Ashwagandha Extract + Acetaminophen, Aspirin interactionEleuthero ExtractAnticoagulant/antiplatelet Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, eleuthero may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Eleuthero Extract + Acetaminophen, Aspirin interactionRhodiola ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.
Read the full Rhodiola Extract + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Adrenal Serenity — through 3 ingredients. Tap an ingredient for the detail:
Eleuthero ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs +1 Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
Read the full Eleuthero Extract + Acetaminophen, Aspirin, Caffeine interactionSensoril Ashwagandha ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Sensoril Ashwagandha Extract + Acetaminophen, Aspirin, Caffeine interactionRhodiola ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.
Read the full Rhodiola Extract + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Adrenal Serenity — through 3 ingredients. Tap an ingredient for the detail:
Eleuthero ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
Read the full Eleuthero Extract + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionSensoril Ashwagandha ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Sensoril Ashwagandha Extract + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionRhodiola ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.
Read the full Rhodiola Extract + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Adrenal Serenity — through 3 ingredients. Tap an ingredient for the detail:
Sensoril Ashwagandha ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Sensoril Ashwagandha Extract + Acetaminophen, Butalbital interactionEleuthero ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
Read the full Eleuthero Extract + Acetaminophen, Butalbital interactionRhodiola ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.
Read the full Rhodiola Extract + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Adrenal Serenity — through 3 ingredients. Tap an ingredient for the detail:
Eleuthero ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
Read the full Eleuthero Extract + Acetaminophen, Butalbital, Caffeine interactionSensoril Ashwagandha ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Sensoril Ashwagandha Extract + Acetaminophen, Butalbital, Caffeine interactionRhodiola ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.
Read the full Rhodiola Extract + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Adrenal Serenity — through 4 ingredients. Tap an ingredient for the detail:
Lavender ExtractCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Lavender Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionSensoril Ashwagandha ExtractHepatotoxic Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Sensoril Ashwagandha Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionEleuthero ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
Read the full Eleuthero Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionRhodiola ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Minor
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.
Read the full Rhodiola Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Adrenal Serenity — through 4 ingredients. Tap an ingredient for the detail:
Sensoril Ashwagandha ExtractCns Depressants, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Read the full Sensoril Ashwagandha Extract + Acetaminophen, Butalbital, Codeine interactionLavender ExtractCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Lavender Extract + Acetaminophen, Butalbital, Codeine interactionEleuthero ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP2D6.
Read the full Eleuthero Extract + Acetaminophen, Butalbital, Codeine interactionRhodiola ExtractCns Depressants, Cytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rhodiola might increase the risk of adverse effects when taken with CNS depressants.
Read the full Rhodiola Extract + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Adrenal Serenity — through 4 ingredients. Tap an ingredient for the detail:
Eleuthero ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
Read the full Eleuthero Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionSensoril Ashwagandha ExtractHepatotoxic Drugs, Cns Depressants +1 Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Sensoril Ashwagandha Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionLavender ExtractCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Lavender Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionRhodiola ExtractCns Depressants, Cytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rhodiola might increase the risk of adverse effects when taken with CNS depressants.
Read the full Rhodiola Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Adrenal Serenity — through 4 ingredients. Tap an ingredient for the detail:
Lavender ExtractCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Lavender Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionEleuthero ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP2D6.
Read the full Eleuthero Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionSensoril Ashwagandha ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants +2 Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Sensoril Ashwagandha Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionRhodiola ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Minor
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.
Read the full Rhodiola Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Adrenal Serenity — through 4 ingredients. Tap an ingredient for the detail:
Sensoril Ashwagandha ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Hepatotoxic Drugs +2 Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Sensoril Ashwagandha Extract + Acetaminophen, Caffeine, Codeine interactionEleuthero ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
Read the full Eleuthero Extract + Acetaminophen, Caffeine, Codeine interactionLavender ExtractCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Lavender Extract + Acetaminophen, Caffeine, Codeine interactionRhodiola ExtractCns Depressants, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Minor
Interaction Summary
Theoretically, rhodiola might increase the risk of adverse effects when taken with CNS depressants.
Read the full Rhodiola Extract + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Adrenal Serenity — through 4 ingredients. Tap an ingredient for the detail:
Eleuthero ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP3A4.
Read the full Eleuthero Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionSensoril Ashwagandha ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Sensoril Ashwagandha Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionLavender ExtractCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Lavender Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionRhodiola ExtractCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Minor
Interaction Summary
Theoretically, rhodiola might increase the risk of adverse effects when taken with CNS depressants.
Read the full Rhodiola Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Adrenal Serenity — through 4 ingredients. Tap an ingredient for the detail:
Lavender ExtractCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Lavender Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionEleuthero ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP2D6.
Read the full Eleuthero Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionSensoril Ashwagandha ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants +2 Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Sensoril Ashwagandha Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionRhodiola ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Minor
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.
Read the full Rhodiola Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Adrenal Serenity — through 3 ingredients. Tap an ingredient for the detail:
Sensoril Ashwagandha ExtractHepatotoxic Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Sensoril Ashwagandha Extract + Acetaminophen, Caffeine, Isometheptene interactionEleuthero ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
Read the full Eleuthero Extract + Acetaminophen, Caffeine, Isometheptene interactionRhodiola ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.
Read the full Rhodiola Extract + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Adrenal Serenity — through 3 ingredients. Tap an ingredient for the detail:
Eleuthero ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP3A4.
Read the full Eleuthero Extract + Acetaminophen, Caffeine, Pyrilamine interactionSensoril Ashwagandha ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Sensoril Ashwagandha Extract + Acetaminophen, Caffeine, Pyrilamine interactionRhodiola ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.
Read the full Rhodiola Extract + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Adrenal Serenity — through 3 ingredients. Tap an ingredient for the detail:
Sensoril Ashwagandha ExtractSerotonergic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors.
Read the full Sensoril Ashwagandha Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionEleuthero ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
Read the full Eleuthero Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionRhodiola ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.
Read the full Rhodiola Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Adrenal Serenity — through 4 ingredients. Tap an ingredient for the detail:
Sensoril Ashwagandha ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cns Depressants +3 Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Sensoril Ashwagandha Extract + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionEleuthero ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
Read the full Eleuthero Extract + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionLavender ExtractCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Lavender Extract + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionRhodiola ExtractCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Minor
Interaction Summary
Theoretically, rhodiola might increase the risk of adverse effects when taken with CNS depressants.
Read the full Rhodiola Extract + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Adrenal Serenity — through 3 ingredients. Tap an ingredient for the detail:
Eleuthero ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP3A4.
Read the full Eleuthero Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionSensoril Ashwagandha ExtractSerotonergic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors.
Read the full Sensoril Ashwagandha Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionRhodiola ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.
Read the full Rhodiola Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Adrenal Serenity with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Sensoril Ashwagandha extract
Antidiabetes Drugs
Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
There is preliminary clinical evidence suggesting that ashwagandha might lower blood glucose levels. Theoretically, ashwagandha might have additive effects when used with antidiabetes drugs and increase the risk of hypoglycemia.
Antihypertensive Drugs
Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Animal research suggests that ashwagandha might lower systolic and diastolic blood pressure. Theoretically, ashwagandha might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Benzodiazepines
Theoretically, taking ashwagandha might increase the sedative effects of benzodiazepines.
There is preliminary evidence that ashwagandha might have an additive effect with diazepam (Valium) and clonazepam (Klonopin). This may also occur with other benzodiazepines.
Cns Depressants
Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Ashwagandha seems to have sedative effects. Theoretically, this may potentiate the effects of barbiturates, other sedatives, and anxiolytics.
Hepatotoxic Drugs
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Ashwagandha has been linked to cases of acute hepatitis, liver failure, hepatic encephalopathy, autoimmune hepatitis, the need for liver transplantation, and death due to liver failure.
Immunosuppressants
Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Ashwagandha has demonstrated immunostimulant effects in humans. Animal research has shown that ashwagandha can attenuate the immunosuppression caused by cyclophosphamide.
Thyroid Hormone
Ashwagandha might increase the effects and adverse effects of thyroid hormone.
Concomitant use of ashwagandha with thyroid hormones may cause additive therapeutic and adverse effects. Preliminary clinical research and animal studies suggest that ashwagandha boosts thyroid hormone synthesis and secretion. In one clinical study, ashwagandha increased triiodothyronine (T3) and thyroxine (T4) levels by 41.5% and 19.6%, respectively, and reduced serum TSH levels by 17.4% from baseline in adults with subclinical hypothyroidism.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that ashwagandha extract induces CYP1A2 enzymes.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that ashwagandha extract induces CYP3A4 enzymes.
Serotonergic Drugs
Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors. However, there is no evidence to suggest that ashwagandha increases the risk of serotonin-related effects, and there have been no published case reports of serotonin syndrome when combined with other serotonergic drugs. Nevertheless, due to the lack of extensive studies on the matter and the fact that ashwagandha appears to affect serotonergic pathways, it would be prudent to exercise caution when combining it with drugs that affect serotonin. [References: - Effects of Withania somnifera (Ashwaga ndha) on Stress and the Stress-Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia. Curr Neuropharmacol. 2021 Sep 14; 19: 1468–1495. - A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/]
Rhodiola extract
Antidiabetes Drugs
Theoretically, taking rhodiola with antidiabetes drugs might increase the risk of hypoglycemia.
In vitro and animal research shows that rhodiola extract can decrease blood glucose due to alpha-glucosidase activity.
Antihypertensive Drugs
Theoretically, taking rhodiola with antihypertensive drugs might increase the risk of hypotension.
In vitro and animal research shows that rhodiola extract inhibits angiotensin-converting enzyme (ACE) and might lower blood pressure.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, rhodiola might increase levels of drugs metabolized by CYP2C9.
In vitro research shows that rhodiola inhibits CYP2C9. This effect is highly variable and appears to be dependent on the rhodiola product studied. Also, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days reduces the metabolism of losartan, a CYP2C9 substrate, by 21% after 4 hours.
Immunosuppressants
Theoretically, rhodiola use might interfere with immunosuppressive therapy.
In vitro and animal research show that rhodiola has immunostimulatory effects.
Losartan (Cozaar)
Rhodiola might increase the levels and adverse effects of losartan.
A clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days reduces the metabolism of losartan, a CYP2C9 substrate, by 21% after 4 hours.
P-Glycoprotein Substrates
Theoretically, rhodiola might increase levels of P-glycoprotein substrates.
In vitro research shows that rhodiola inhibits P-glycoprotein. Theoretically, using rhodiola with P-glycoprotein substrates might increase drug levels and potentially increase the risk of adverse effects.
Antidepressant Drugs
Theoretically, rhodiola might increase the risk of adverse effects when taken with antidepressants.
A review of adverse event reports in Poland identified cases of tachyarrhythmias, myalgia, arthralgia, gum pain, restless leg syndrome, swallowing disorders, and changes in consciousness when rhodiola was taken in combination with paroxetine, escitalopram, fluoxetine, sertraline, trazodone, and/or duloxetine.
Cns Depressants
Theoretically, rhodiola might increase the risk of adverse effects when taken with CNS depressants.
A review of adverse event reports in Poland identified cases of excessive sedation, myoclonus, hypotension, and hallucinations when rhodiola was taken with haloperidol, diazepam, or alprazolam.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.
In vitro research shows that rhodiola inhibits CYP1A2. This effect is highly variable and appears to be dependent on the rhodiola product studied. However, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days does not inhibit the metabolism of caffeine, a CYP1A2 substrate.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.
In vitro research shows that rhodiola inhibits CYP3A4. This effect is highly variable and appears to be dependent on the rhodiola product studied. However, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days does not inhibit the metabolism of midazolam, a CYP3A4 substrate.
Eleuthero extract
Anticoagulant/Antiplatelet Drugs
Theoretically, eleuthero may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research shows that a constituent of eleuthero, dihydroxybenzoic acid, appears to inhibit platelet aggregation. Concomitant use with anticoagulant or antiplatelet drugs might increase the risk of bleeding. This effect has not been reported in humans.
Antidiabetes Drugs
Theoretically, eleuthero might have additive effects when used with antidiabetes drugs.
Animal research suggests that certain constituents of eleuthero have hypoglycemic activity in both healthy and diabetic animals. A small study in adults with type 2 diabetes also shows that taking eleuthero for 3 months can lower blood glucose levels. However, one very small study in healthy individuals shows that taking powdered eleuthero 3 grams, 40 minutes prior to a 75-gram oral glucose tolerance test, significantly increases postprandial blood glucose levels when compared with placebo. These contradictory findings might be due to patient-specific variability and variability in active ingredient ratios.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
In vitro and animal research suggest that standardized extracts of eleuthero inhibit CYP1A2. This effect has not been reported in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, eleuthero might increase levels of drugs metabolized by CYP2C9.
In vitro and animal research suggest that standardized extracts of eleuthero might inhibit CYP2C9. This effect has not been reported in humans.
Digoxin (Lanoxin)
Eleuthero might increase serum digoxin levels and increase the risk of side effects.
In one case report, a 74-year-old male who was stabilized on digoxin presented with an elevated serum digoxin level after starting an eleuthero supplement, without symptoms of toxicity. After stopping the supplement, serum digoxin levels returned to normal. It is not clear whether this was due to a pharmacokinetic interaction or to interference with the digoxin assay. Although the product was found to be free of digoxin and digitoxin, it was not tested for other contaminants.
Immunosuppressants
Theoretically, eleuthero might interfere with immunosuppressive drugs because of its immunostimulant activity.
Animal and in vitro research shows that eleuthero extracts have immunomodulatory effects, including increasing cellular and humoral activity.
P-Glycoprotein Substrates
Theoretically, eleuthero might increase levels of P-glycoprotein substrates.
In vitro research suggests that eleuthero can inhibit the multi-drug transporter protein, P-glycoprotein. However, it is too soon to tell if this is clinically important. This interaction has not been reported in humans.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, eleuthero might increase levels of drugs metabolized by CYP2D6.
In vitro and animal research suggest that standardized extracts of eleuthero might inhibit CYP2D6. However, research in healthy human volunteers has found that taking eleuthero 485 mg twice daily for 14 days does not inhibit CYP2D6 drug metabolism.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, eleuthero might increase levels of drugs metabolized by CYP3A4.
In vitro and animal research suggest that standardized extracts of eleuthero might inhibit CYP3A4. However, research in healthy human volunteers has found that taking eleuthero 485 mg twice daily for 14 days does not inhibit CYP3A4 drug metabolism.
Organic Anion-Transporting Polypeptide Substrates (Oatp)
Theoretically, eleuthero might decrease levels of drugs metabolized by OATP.
In vitro research suggests that eleuthero inhibits OATP2B1, which might reduce the bioavailability of oral drugs that are substrates of OATP2B1. Due to the weak inhibitory effect identified in this study, this interaction is not likely to be clinically significant.
Lavender extract
Cns Depressants
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Laboratory research suggests that lavender has sedative effects. However, clinical studies in patients taking oral lavender oil (Silexan) 160 mg for 10 weeks or taking lavender flower powder 1 gram daily for 2 months have not reported side effects of drowsiness, sedation, or sleepiness. There is still some concern that higher doses or different preparations of lavender might have additive effects with CNS depressant medications.
Brand information
Manufacturer and brand details for Adrenal Serenity, from the product label.
Natural Factors Stress-Relax
See all Natural Factors Stress-Relax products- Name
- Natural Factors Canada
Adrenal Serenity by Natural Factors Stress-Relax: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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The Full Monographs Behind Adrenal Serenity’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Rhodiola
Interacts with 1,271 drugsRhodiola is an herb traditionally used to fight fatigue and help the body cope with stress. Some small studies suggest it may modestly reduce fatigue and improve mood, but the evidence is li...
Read the full Rhodiola monograph → Herb & supplement monographAshwagandha
Interacts with 1,372 drugsAshwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evidence is still limited. It is generally w...
Read the full Ashwagandha monograph → Herb & supplement monographEleuthero
Interacts with 1,140 drugsEleuthero is an herb traditionally used as an 'adaptogen' to fight fatigue, boost energy, and help the body handle stress. The scientific evidence behind these uses is limited and mixed, so...
Read the full Eleuthero monograph → Herb & supplement monographLavender
Interacts with 248 drugsLavender is a fragrant herb most popular for promoting relaxation, easing anxiety, and supporting sleep, with some encouraging evidence for a standardized oral lavender oil product for anxie...
Read the full Lavender monograph →Sources & How We Checked
Adrenal Serenity's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 89 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Rhodiola 13 references
- Kim SH, Hyun SH, Choung SY. Antioxidative effects of Cinnamomi cassiae and Rhodiola rosea extracts in liver of diabetic mice. Biofactors 2006;26:209-19.
- Kwon YI, Jang HD, Shetty K. Evaluation of Rhodiola crenulata and Rhodiola rosea for management of type II diabetes and hypertension. Asia Pac J Clin Nutr 2006;15:425-32.
- Bystritsky A, Kerwin L, Feusner JD. A pilot study of Rhodiola rosea (Rhodax) for generalized anxiety disorder (GAD). J Altern Complement Med 2008;14:175-80.
- Shevtsov VA, Zholus BI, Shervarly VI, et al. A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work. Phytomedicine 2003;10:95-105. PubMed
- Apostolidis E, Kwon YI, Shetty K. Potential of cranberry-based herbal synergies for diabetes and hypertension management. Asia Pac J Clin Nutr 2006;15:433-41.
- Hellum BH, Tosse A, Hoybakk K, et al. Potent in vitro inhibition of CYP3A4 and P-glycoprotein by Rhodiola rosea. Planta Med 2010;76:331-8.
- Skopriska-Rozewska E, Wojcik R, Siwicki AK, et al. The effect of Rhodiola quadrifida extracts on cellular immunity in mice and rats. Pol J Vet Sci 2008;11:105-11.
- Mishra KP, Chanda S, Shukla K, Ganju L. Adjuvant effect of aqueous extract of Rhodiola imbricate rhizome on the immune responses to tetanus toxoid and ovalbumin in rats. Immunopharmacol Immunotoxicol 2010;32:141-6.
- Li HX, Sze SC, Tong Y, Ng TB. Production of Th1- and Th2-dependent cytokines induced by the Chinese medicine herb, Rhodiola algida, on human peripheral blood monocytes. J Ethnopharmacol 2009;123:257-66. PubMed
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- Thu OK, Nilsen OG, Hellum B. In vitro inhibition of cytochrome P-450 activities and quantification of constituents in a selection of commercial Rhodiola rosea products. Pharm Bio. 2016 Dec;54(12):3249-3256.
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