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Dietary supplement

Serraflazyme Ingredients & Drug Interactions

by Cardiovascular Research

Serraflazyme label
See full label image
Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Serraflazyme against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Serraflazyme is a dietary supplement by Cardiovascular Research with 1 active ingredient. Its ingredients are commonly taken for inflammation and swelling, sinus and respiratory congestion, pain after surgery or injury.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Serrapeptase. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Serraflazyme by Cardiovascular Research

Ask about any prescription or over-the-counter medication and we check it for interactions with Serraflazyme by Cardiovascular Research — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Serraflazyme by Cardiovascular Research

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Serraflazyme contains one active ingredient: serrapeptase, an enzyme derived from silkworm cocoons. It's designed to help break down certain proteins in your body.

The product also contains inactive ingredients (microcrystalline cellulose, calcium phosphate, hydroxypropyl methylcellulose, silicon dioxide, magnesium stearate, sodium alginate, stearic acid, ethylcellulose, ammonium hydroxide, medium chain triglycerides, and oleic acid), which are standard excipients that give the tablet its form and help it dissolve.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Serrapeptase product and its label doesn't state a use — see Serrapeptase's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for serrapeptase isn't established in the data we hold. Studies show insufficient reliable evidence for chronic bronchitis, asthma, atherosclerosis, back pain, and osteoporosis—the conditions it's often marketed for.

That doesn't mean it doesn't work; it means the research hasn't yet proven it does in a way that meets the standard for reliability.

The evidence, ingredient by ingredient Serrapeptase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Serrapeptase is generally well tolerated in the short term, but long-term safety isn't well studied, so we don't know how it behaves over months or years. The most common side effects reported in trials—epigastric pain (upper stomach discomfort), gastrointestinal upset, and nausea—occurred at about the same rate as placebo, suggesting they're mild when they do occur.

A rare serious side effect (bullous pemphigoid, a blistering skin condition) has been reported. During pregnancy, there isn't enough safety data, so it's best avoided.

While breastfeeding, no reliable safety information exists, so it should be avoided as well. If you're pregnant or breastfeeding, talk with your doctor or pharmacist before considering this product.

Side effects, ingredient by ingredient Serrapeptase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Serrapeptase.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Serraflazyme, check with your doctor or pharmacist if you take any blood thinners or antiplatelet drugs (such as warfarin, aspirin, clopidogrel, or similar medications). Serrapeptase may increase your risk of bruising and bleeding when combined with these drugs—a Moderate interaction—so your provider may need to adjust your plan or monitor you more closely.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Serraflazyme might appeal to people looking for a natural enzyme supplement, but the evidence that it actually works for its claimed uses isn't solid yet. If you take blood thinners or antiplatelet drugs (like aspirin or warfarin), you need to check with your doctor or pharmacist before starting it—the interaction risk is real.

Avoid it if you're pregnant or breastfeeding. Have the full conversation with your own healthcare provider about whether it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Serraflazyme, straight from the product label.

Brand Cardiovascular Research
Net contents 100 Tablet(s)
Market status On market
Date entered into DSLD Jun 25, 2013
DSLD ID 22999
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Serraflazyme by Cardiovascular Research, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
4 Tablet(s)
Servings per container
100
IngredientAmount% DV
Serrapeptase5 mg--

Other ingredients: Microcrystalline Cellulose, Calcium Phosphate, Hydroxypropyl Methylcellulose, Silicon Dioxide, Magnesium Stearate, Sodium Alginate, Stearic Acid, Ethylcellulose, Ammonium Hydroxide, Medium Chain Triglycerides, Oleic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Serrapeptase Enzyme (Serratio Peptidase)

SERRAFLAZYME contains 5 mg of the purified enzyme, Serratio Peptidase, in an enterically-coated tablet.

FDA Statement of Identity

Dietary Supplement

A DIETARY SUPPLEMENT

Suggested/Recommended/Usage/Directions

DIRECTIONS Take one to four tablets daily, preferably before meals, or as directed by a physician.

FDA Disclaimer Statement

This product has not been evaluated by the FDA. This product is not intended to diagnose, cure, treat or prevent any disease.

Seals/Symbols

ECOLOGICAL FORMULAS

General Statements

10090891 EXP0913

This preparation is scientifically designed for maximal absorption.

Formulation

Free of yeast, corn, wheat, sugar, starch, phenols, egg, milk, and other common food and chemical allergens.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Serraflazyme by Cardiovascular Research label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Serraflazyme label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Serraflazyme by Cardiovascular Research

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container100 Amounts shown are per serving.

Serrapeptase

Interacts with
122 drugs
5 mg per serving

Serrapeptase is an enzyme marketed to reduce inflammation, swelling, pain, and mucus, but the human evidence is limited and mostly low quality. If you...

Serrapeptase monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Calcium Phosphate, Hydroxypropyl Methylcellulose, Silicon Dioxide, Magnesium Stearate, Sodium Alginate, Stearic Acid, Ethylcellulose, Ammonium Hydroxide, Medium Chain Triglycerides, Oleic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Serraflazyme by Cardiovascular Research Drug Interactions

Want to check YOUR meds against Serraflazyme?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

Serrapeptase 122

Individual Drug Interactions

The ingredients in Serraflazyme interact with 122 drugs. Click any drug to see the details.

1 of the 1 ingredient in Serraflazyme interact with drugs. Each result below shows which ingredient is responsible. Serrapeptase

Each ingredient & the kinds of drugs it affects

For each ingredient in Serraflazyme with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Serrapeptase1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking serrapeptase with drugs that have antiplatelet or anticoagulant effects might increase the risk of bruising and bleeding.
In vitro research shows that serrapeptase has fibrinolytic activity.

Likelihood Possible Evidence D
Serrapeptase full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Serraflazyme, from the product label.

Cardiovascular Research

See all Cardiovascular Research products
Name
CARDIOVASCULAR RESEARCH, LTD.
Street Address
1061-B SHARY CIRCLE
City
CONCORD
State
CA
ZipCode
94518
Pharmacist Counseling Corner

Serraflazyme by Cardiovascular Research: Common Questions

Does Serraflazyme by Cardiovascular Research interact with any medications?
Yes. Based on its ingredients, Serraflazyme has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Serraflazyme contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this with my blood thinner?
Not without checking first with your doctor or pharmacist. Serrapeptase can theoretically increase bleeding risk when combined with blood thinners or antiplatelet drugs. Your provider needs to know you're considering it and may need to monitor you or adjust your regimen.
What are the common side effects?
The most common reports are epigastric pain (upper stomach discomfort), gastrointestinal upset, and nausea—but these occurred at about the same rate as placebo in trials, so they're generally mild. A rare serious side effect, bullous pemphigoid (a blistering skin condition), has been reported.
Is it safe to take long-term?
Serrapeptase is generally well tolerated in the short term, but long-term safety hasn't been well studied. If you're considering using it beyond a few weeks, talk it over with your doctor or pharmacist.
Can I take this while pregnant or breastfeeding?
No—there isn't enough safety data during pregnancy, so it's best avoided. While breastfeeding, there's no reliable safety information either, so it should be avoided. Talk with your doctor or pharmacist about your options.
Does serrapeptase actually work for the conditions it claims to treat?
The evidence isn't solid yet. We don't have reliable proof that it works for chronic bronchitis, asthma, atherosclerosis, back pain, osteoporosis, or other uses it's commonly marketed for—that doesn't mean it's ineffective, just that the research hasn't established it yet.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Serraflazyme is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Serraflazyme label
Go deeper

The Full Monographs Behind Serraflazyme’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Serrapeptase

Interacts with 122 drugs

Serrapeptase is an enzyme marketed to reduce inflammation, swelling, pain, and mucus, but the human evidence is limited and mostly low quality. If you want to try it, choose an enteric-coate...

Read the full Serrapeptase monograph →
Sources

Sources & How We Checked

Serraflazyme's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Serrapeptase 2 references
  1. Tachibana M, Mizukoshi O, Harada Y, et al. A multi-centre, double-blind study of serrapeptase versus placebo in post-antrotomy buccal swelling. Pharmatherapeutica 1984;3:526-30..
  2. Mazzone A, Catalani M, Costanzo M, et al. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res 1990;18:379-88.. PubMed

See these in context on the Serrapeptase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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