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Dietary supplement

Cohealon Ingredients & Drug Interactions

by Cardiovascular Research

Cohealon label
See full label image
Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Cohealon against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Cohealon is a dietary supplement by Cardiovascular Research with 1 active ingredient. Its ingredients are commonly taken for peripheral artery disease and leg pain, heart and circulation support, energy and exercise performance.Based on those ingredients, 19 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Propionyl-L-Carnitine Hydrochloride. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Cohealon by Cardiovascular Research

Ask about any prescription or over-the-counter medication and we check it for interactions with Cohealon by Cardiovascular Research — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Cohealon by Cardiovascular Research

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Cohealon contains one active ingredient: propionyl-L-carnitine hydrochloride, a form of carnitine that your body uses to help cells produce energy. The tablet also includes inactive ingredients—microcrystalline cellulose, dicalcium phosphate, stearic acid, and L-leucine—which are fillers and binders.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: heart and circulation support.
  • We looked for evidence on: Angina, Cardiovascular disease (CVD), Congestive heart failure (CHF), Intermittent claudication, Erectile dysfunction (ED), peripheral artery disease — and 2 related terms.
  • The strongest evidence on file: Propionyl-l-carnitine is rated "Possibly Effective" for Angina (Natural Medicines).
  • Also on file: Propionyl-l-carnitine is rated "Possibly Effective" for Cardiovascular disease (CVD), Congestive heart failure (CHF), Intermittent claudication.
  • Also on file: Propionyl-l-carnitine is rated "Insufficient Reliable Evidence To Rate" for Erectile dysfunction (ED).

Propionyl-L-carnitine is possibly effective for several heart and digestive conditions. The evidence supports its use for congestive heart failure (weakened heart), angina (chest pain from reduced blood flow), ulcerative colitis (inflammatory bowel disease), and cardiovascular disease more broadly.

That said, 'possibly effective' means the studies are promising but not definitive — talk to your doctor about whether it's right for your specific situation.

The evidence, ingredient by ingredient Propionyl-l-carnitine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Orally, propionyl-L-carnitine is generally well tolerated for short-term use, but check with your healthcare provider before starting. The most common side effects are diarrhea, stomach pain, nausea, and vomiting.

Some people report a fishy odor in their urine, breath, or sweat. In clinical trials, bronchitis and back pain were reported more often than with placebo.

Safety hasn't been established in pregnancy, so it should be avoided then. There isn't enough data on breastfeeding safety, so avoid it while nursing.

Side effects, ingredient by ingredient Propionyl-l-carnitine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Propionyl-l-carnitine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 19 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start Cohealon, double-check if you take any blood thinners (warfarin, acenocoumarol, or similar drugs) — propionyl-L-carnitine may strengthen their effect, raising bleeding risk. Also check if you're on thyroid hormone replacement therapy — this ingredient may weaken how well it works.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Cohealon may help if you have heart failure, angina, or cardiovascular disease, but it's not for everyone. If you take blood thinners or thyroid medication, you need to check with your pharmacist before adding this supplement — the interactions are real.

Talk to your doctor about whether the benefits fit your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Cohealon, straight from the product label.

Brand Cardiovascular Research
Barcode (UPC) 696859131752
Net contents 90 Tablet(s)
Market status On market
Date entered into DSLD Mar 22, 2024
DSLD ID 304359
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Cohealon by Cardiovascular Research, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
2 Tablet(s)
Servings per container
90
UPC/BARCODE
696859131752
IngredientAmount% DV
Propionyl-L-Carnitine Hydrochloride333 mg--

Other ingredients: Microcrystalline Cellulose, Dicalcium Phosphate, Stearic Acid, L-Leucine

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

A Dietary Supplement

Dietary Supplement

Formula

Cohealon is a scientifically designed dietary supplement which contains Propionyl L-Carnitine, the physiologic active form of L-Carnitine.

Propionyl-L-Carnitine HCl 333 mg

Formulation

This product is specially formulated to provide targeted delivery of PLC to receptors in the gastrointestinal tract.

Free of corn, yeast, wheat and gluten.

Gluten free, casein free

Suggested/Recommended/Usage/Directions

Directions Take one or two tablets per day, or as directed by a physician.

FDA Disclaimer Statement

This product has not been evaluated by the FDA. This product is not intended to diagnose, cure, treat or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Cohealon by Cardiovascular Research label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Cohealon label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Cohealon by Cardiovascular Research

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container90 Amounts shown are per serving.

Propionyl-L-Carnitine Hydrochloride

Interacts with
19 drugs
333 mg per serving

Propionyl-l-carnitine is a form of the amino acid derivative carnitine that the body uses to help turn fat into energy, and it is studied mostly for c...

Propionyl-L-Carnitine Hydrochloride monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Dicalcium Phosphate, Stearic Acid, L-Leucine. These complete the product’s ingredient list but are not active constituents.

Interaction report

Cohealon by Cardiovascular Research Drug Interactions

Want to check YOUR meds against Cohealon?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
19Drugs
19 Moderate

Ingredients driving the most interactions

Propionyl-L-Carnitine Hydrochloride 19

Individual Drug Interactions

The ingredients in Cohealon interact with 19 drugs. Click any drug to see the details.

1 of the 1 ingredient in Cohealon interact with drugs. Each result below shows which ingredient is responsible. Propionyl-L-Carnitine Hydrochloride

Each ingredient & the kinds of drugs it affects

For each ingredient in Cohealon with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Propionyl-L-Carnitine Hydrochloride3 drug types · 19 drugs

Acenocoumarol (Sintrom)

Theoretically, propionyl-L-carnitine might increase the anticoagulant effects of acenocoumarol.
L-carnitine, the parent compound of propionyl-L-carnitine, might enhance the anticoagulant effects of acenocoumarol, an oral anticoagulant similar to warfarin, but shorter-acting. There are at least two case reports of INR elevation when L-carnitine was taken with acenocoumarol. In one case, a 33-year-old male with a previously stable INR had an elevated INR of 4.65 after L-carnitine was started and continued for 10 weeks. INR normalized after discontinuation of the L-carnitine-containing product. It is unclear if such an interaction would also occur with propionyl-L-carnitine.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, acetyl-L-carnitine might decrease the effectiveness of thyroid hormone replacement.
L-carnitine appears to act as a peripheral thyroid hormone antagonist by inhibiting entry of thyroid hormone into the nucleus of cells. Taking L-carnitine also seems to diminish some of the symptoms of hyperthyroidism. It is unclear if such an interaction would occur with propionyl-L-carnitine.

Likelihood Possible Evidence B
Warfarin (Coumadin)

Theoretically, propionyl-L-carnitine might increase the anticoagulant effects of warfarin.
L-carnitine, the parent compound of propionyl-L-carnitine, might increase the anticoagulant effects of acenocoumarol, a shorter-acting oral anticoagulant similar to warfarin. There is not enough information to know whether this interaction occurs with propionyl-L-carnitine and warfarin.

Likelihood Possible Evidence D
Propionyl-L-Carnitine Hydrochloride full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Cohealon, from the product label.

Cardiovascular Research

See all Cardiovascular Research products
Name
Cardiovascular Research, LTD.
Street Address
1061-B Shary Circle
City
Concord
State
CA
ZipCode
94518
Pharmacist Counseling Corner

Cohealon by Cardiovascular Research: Common Questions

Does Cohealon by Cardiovascular Research interact with any medications?
Yes. Based on its ingredients, Cohealon has a known interaction with 19 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Cohealon contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is propionyl-L-carnitine and what does it do?
It's a form of carnitine, a compound your body naturally makes and uses to help cells produce energy. Propionyl-L-carnitine is the form used in Cohealon and may support heart health and circulation.
What side effects should I expect?
The most common ones are diarrhea, stomach pain, nausea, and vomiting. Some people notice a fishy smell in their urine, breath, or sweat. Bronchitis and back pain were also reported more often in trials than with placebo, though they're not common.
Can I take Cohealon if I'm pregnant or breastfeeding?
No — safety hasn't been established in pregnancy, so it should be avoided then. There also isn't enough data on breastfeeding safety, so avoid it while nursing. Talk to your doctor if you need heart support during these times.
Does propionyl-L-carnitine really work for heart problems?
The evidence says it's possibly effective for congestive heart failure, angina, and cardiovascular disease. That means studies are encouraging but not conclusive. Ask your doctor whether it makes sense for your condition.
Is there a fishy smell side effect permanent?
The facts don't say. That metabolite-related odor is listed as a reported adverse effect, but we don't have data on whether it goes away after you stop taking it. Ask your pharmacist if you're concerned.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Cohealon label
Go deeper

The Full Monographs Behind Cohealon’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Propionyl-l-carnitine

Interacts with 19 drugs

Propionyl-l-carnitine is a form of the amino acid derivative carnitine that the body uses to help turn fat into energy, and it is studied mostly for circulation problems like peripheral arte...

Read the full Propionyl-l-carnitine monograph →
Sources

Sources & How We Checked

Cohealon's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Propionyl-l-carnitine 12 references
  1. Cherchi A, Lai C, Onnis E, et al. Propionyl carnitine in stable effort angina. Cardiovasc Drugs Ther 1990;4:481-6. PubMed
  2. Bartels GL, Remme WJ, den Hartog FR, et al. Additional anti-ischemic effects of long-term L-propionylcarnitine in anginal patients treated with conventional antianginal therapy. Cardiovasc Drugs Ther 1995;9:749-53.
  3. Caponnetto S, Canale C, Masperone MA, et al. Efficacy of L-propionylcarnitine treatment in patients with left ventricular dysfunction. Eur Heart J 1994;15:1267-73. PubMed
  4. Benvenga S, Ruggeri RM, Russo A, et al. Usefulness of L-carnitine, a naturally occurring peripheral antagonist of thyroid hormone action, in iatrogenic hyperthyroidism: a randomized, double-blind, placebo-controlled clinical trial. J Clin Endocrinol Meta
  5. Martinez E, Domingo P, Roca-Cusachs A. Potentiation of acenocoumarol action by L-carnitine. J Intern Med 1993;233:94.
  6. Bachmann HU, Hoffmann A. Interaction of food supplement L-carnitine with oral anticoagulant acenocoumarol. Swiss Med Wkly 2004;134:385. PubMed
  7. Gentile V, Vicini P, Prigiotti G, et al. Preliminary observations on the use of propionyl-L-carnitine in combination with sildenafil in patients with erectile dysfunction and diabetes. Curr Med Res Opin 2004;20:1377-84. PubMed
  8. 12761 Benvenga S, Amato A, Calvani M, Trimarchi F. Effects of carnitine on thyroid hormone action. Ann N Y Acad Sci 2004;1033:158-67. PubMed
  9. Brass EP, Koster D, Hiatt WR, Amato A. A systematic review and meta-analysis of propionyl-L-carnitine effects on exercise performance in patients with claudication. Vasc Med 2013;18:3-12.
  10. Hiatt WR, Creager MA, Amato A, Brass EP. Effect of propionyl-L-carnitine on a background of monitored exercise in patients with claudication secondary to peripheral artery disease. J Cardiopulm Rehabil Prev 2011;31:125-32. PubMed
  11. Jacobs PL, Goldstein ER, Blackburn W, et al. Glycine propionyl-L-carnitine produces enhanced anaerobic work capacity with reduced lactate accumulation in resistance trained males. J Int Soc Sports Nutr 2009;6:9. PubMed
  12. Jacobs PL, Goldstein ER. Long-term glycine propionyl-l-carnitine supplementation and paradoxical effects on repeated anaerobic sprint performance. J Int Soc Sports Nutr 2010;7:35.

See these in context on the Propionyl-l-carnitine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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