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Dietary supplement

Serrapeptase Ingredients & Drug Interactions

by Healthy Directions

Serrapeptase label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Serrapeptase against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Serrapeptase is a dietary supplement by Healthy Directions with 1 active ingredient. Its ingredients are commonly taken for inflammation and swelling, sinus and respiratory congestion, pain after surgery or injury.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Serrapeptase. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Serrapeptase by Healthy Directions

Ask about any prescription or over-the-counter medication and we check it for interactions with Serrapeptase by Healthy Directions — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Serrapeptase by Healthy Directions

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains a single active ingredient: serrapeptase, an enzyme that works by breaking down fibrin — a protein involved in inflammation and clot formation. The capsule also includes inactive ingredients (rice flour, hypromellose, and stearic acid) that serve as fillers and binders.

Does it work?

No specific claim
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
General wellness

This Serrapeptase product is marketed for general wellness, not a specific health condition, so there's no single claim to grade — see Serrapeptase's own graded uses on its monograph.

Why this rating?
  • The label markets general wellness (“Daily wellness”), not a specific health condition, so there is no single claim to grade against clinical-evidence data.

The evidence for serrapeptase isn't established in the data we hold. For chronic bronchitis, asthma, atherosclerosis, back pain, and osteoporosis — conditions it's sometimes marketed for — the reliability of evidence is insufficient to rate whether it works.

You'll want to talk with your doctor about whether this is the right choice for your specific health goals.

The evidence, ingredient by ingredient Serrapeptase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Serrapeptase is generally well tolerated when taken short-term. The most common side effects are epigastric pain (discomfort in the upper abdomen), gastrointestinal upset, and nausea — though these appear to occur at rates similar to placebo in trial settings.

A rare serious side effect, bullous pemphigoid (a blistering skin condition), has been reported. Long-term safety hasn't been well studied, so caution is warranted with extended use.

During pregnancy, there isn't enough safety data, so it's best avoided. While breastfeeding, reliable safety information is lacking — talk with your doctor or pharmacist before use.

Side effects, ingredient by ingredient Serrapeptase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Serrapeptase.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking serrapeptase, double-check any blood thinners (anticoagulants) or antiplatelet drugs you're on — this is a Moderate severity interaction. The combined effect could increase bleeding and bruising risk.

If you're unsure whether your medication falls into this category, use the interaction checker below or ask your pharmacist.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula marketed for general wellness rather than one specific gradeable purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Serrapeptase may appeal to you if you're exploring options for inflammation or clotting-related conditions, but the evidence for its effectiveness isn't established in our data. If you take any blood thinner or antiplatelet medication, check with your pharmacist first — the interaction risk is real.

Long-term safety is unknown, and it should be avoided in pregnancy and while breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Serrapeptase, straight from the product label.

Brand Healthy Directions
Barcode (UPC) 810047391449
Net contents 60 Vegan Capsule(s)
Market status On market
Date entered into DSLD Nov 22, 2024
DSLD ID 316992
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Serrapeptase by Healthy Directions, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegan Capsule(s)
Maximum serving Sizes:
1 Vegan Capsule(s)
Servings per container
60
UPC/BARCODE
810047391449
IngredientAmount% DV
Serrapeptase55 mg--

Other ingredients: Rice Flour, Hypromellose, Stearic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Questions? Call 1-866-599-9491 www.healthydirections.com

60-day supply

Formulation

Unconditionally guaranteed for purity and labeled potency.

Daily wellness

Vegan

Gluten free

Storage

To preserve quality and freshness, store bottle with cap tightly closed in a cool, dry place.

Precautions

Precautions: Consult a health care practitioner if you are pregnant or nursing, have a serious medical condition, or use any medications.

Keep out of reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula

Serrapeptase 120,000 SPU/serving

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: Take 1 vegan capsule once daily with a meal.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Serrapeptase by Healthy Directions label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Serrapeptase label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Serrapeptase by Healthy Directions

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Vegan Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Serrapeptase

Interacts with
122 drugs
55 mg per serving

Serrapeptase is an enzyme marketed to reduce inflammation, swelling, pain, and mucus, but the human evidence is limited and mostly low quality. If you...

Serrapeptase monograph & interactions

Other (inactive) ingredients: Rice Flour, Hypromellose, Stearic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Serrapeptase by Healthy Directions Drug Interactions

Want to check YOUR meds against Serrapeptase?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

Serrapeptase 122

Individual Drug Interactions

The ingredients in Serrapeptase interact with 122 drugs. Click any drug to see the details.

1 of the 1 ingredient in Serrapeptase interact with drugs. Each result below shows which ingredient is responsible. Serrapeptase

Each ingredient & the kinds of drugs it affects

For each ingredient in Serrapeptase with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Serrapeptase1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking serrapeptase with drugs that have antiplatelet or anticoagulant effects might increase the risk of bruising and bleeding.
In vitro research shows that serrapeptase has fibrinolytic activity.

Likelihood Possible Evidence D
Serrapeptase full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Serrapeptase, from the product label.

Healthy Directions

See all Healthy Directions products
Name
Healthy Directions
City
Bethesda
State
MD
ZipCode
20817
Phone Number
1-800-304-1708
Web Address
healthydirections.com
Pharmacist Counseling Corner

Serrapeptase by Healthy Directions: Common Questions

Does Serrapeptase by Healthy Directions interact with any medications?
Yes. Based on its ingredients, Serrapeptase has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Serrapeptase contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take serrapeptase if I'm on a blood thinner like warfarin or aspirin?
Not without checking with your pharmacist first. Serrapeptase can increase bleeding risk when combined with blood thinners or antiplatelet drugs — it's a Moderate severity interaction. Your pharmacist can review your specific medication and dose to help you decide.
What side effects should I expect?
The most common ones are stomach discomfort, nausea, and gastrointestinal upset — though they occur about as often as placebo in studies. A rare serious side effect, a blistering skin condition, has been reported. Stop and call your doctor if you develop unusual skin symptoms.
Is it safe to take serrapeptase long-term?
Long-term safety hasn't been well studied, so caution is warranted if you're considering it for months or longer. Short-term use appears generally tolerated, but we don't have solid data on extended use.
Can I take serrapeptase while pregnant or breastfeeding?
No — the safety data advises against it in both cases. During pregnancy, there's not enough information to know whether it's safe. While breastfeeding, reliable safety information is lacking. Talk with your doctor or pharmacist for personalized guidance.
Does serrapeptase really work for back pain or asthma?
The evidence we have is insufficient to rate whether it works for those conditions or for chronic bronchitis, atherosclerosis, or osteoporosis. You'll want to discuss other options with your doctor.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Serrapeptase is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Serrapeptase label
Go deeper

The Full Monographs Behind Serrapeptase’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Serrapeptase

Interacts with 122 drugs

Serrapeptase is an enzyme marketed to reduce inflammation, swelling, pain, and mucus, but the human evidence is limited and mostly low quality. If you want to try it, choose an enteric-coate...

Read the full Serrapeptase monograph →
Sources

Sources & How We Checked

Serrapeptase's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Serrapeptase 2 references
  1. Tachibana M, Mizukoshi O, Harada Y, et al. A multi-centre, double-blind study of serrapeptase versus placebo in post-antrotomy buccal swelling. Pharmatherapeutica 1984;3:526-30..
  2. Mazzone A, Catalani M, Costanzo M, et al. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res 1990;18:379-88.. PubMed

See these in context on the Serrapeptase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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