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Dietary supplement

Shepherd's Purse Ingredients & Drug Interactions

by Herb Pharm

Shepherd's Purse label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Shepherd's Purse against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Shepherd's Purse is a dietary supplement by Herb Pharm with 1 active ingredient. Its ingredients are commonly taken for heavy or prolonged menstrual bleeding, minor bleeding (nosebleeds, wounds), mild diuretic.Based on those ingredients, 264 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Shepherd's Purse flowering aerial parts (Capsella bursa-pastoris) extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Shepherd's Purse by Herb Pharm

Ask about any prescription or over-the-counter medication and we check it for interactions with Shepherd's Purse by Herb Pharm — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Shepherd's Purse by Herb Pharm

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Shepherd's Purse by Herb Pharm contains one active ingredient: Shepherd's Purse flowering aerial parts extract. The inactive ingredients are certified organic cane alcohol and distilled water — the liquid form uses alcohol as the extraction medium and preservative.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: support for menstrual and postpartum health.
  • We looked for evidence on: Menorrhagia, Postpartum complications, hemostasis, uterine bleeding.
  • The closest evidence on file: Shepherd's Purse is rated "Insufficient Reliable Evidence To Rate" for Postpartum complications (Natural Medicines).
  • Also on file: Shepherd's Purse is rated "Insufficient Reliable Evidence To Rate" for Menorrhagia.

The evidence for Shepherd's Purse is limited. For postpartum complications and heavy menstrual bleeding (menorrhagia), we don't have reliable data to rate whether it works.

That doesn't mean it's ineffective — it means the studies we have aren't strong enough to say one way or another.

The evidence, ingredient by ingredient Shepherd's Purse

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Shepherd's Purse is generally well tolerated in small amounts over the short term, though human safety data are sparse. Adverse effects traditionally linked to it include sedation, changes in blood pressure, abnormal heart rhythms, and irregular menstruation — though most people using small amounts short-term don't report problems.

Don't use it during pregnancy; it may stimulate the uterus and the safety data mark it as likely unsafe. Breastfeeding is also off-limits — there isn't enough safety information to know it's okay.

Side effects, ingredient by ingredient Shepherd's Purse

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Shepherd's Purse.
  • The most serious interaction on file is rated Moderate.
  • For scale: 264 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Shepherd's Purse, double-check any sedating medications you're on — sleep aids, anti-anxiety drugs, narcotic pain relievers — and any thyroid hormone replacement. Both carry documented Moderate-severity interactions with this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Shepherd's Purse is worth checking with your pharmacist if you're considering it, especially if you take sleep aids, anti-anxiety drugs, pain relievers, or thyroid medication. The evidence for what it's used for isn't established in our data.

Pregnancy and breastfeeding are contraindications — avoid it in both.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Shepherd's Purse, straight from the product label.

Brand Herb Pharm
Barcode (UPC) 090800000232
Net contents 1 fl. Oz.; 30 mL
Market status On market
Date entered into DSLD Feb 25, 2021
DSLD ID 242583
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Organic, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Shepherd's Purse by Herb Pharm, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.7 mL
Maximum serving Sizes:
0.7 mL
Servings per container
42
UPC/BARCODE
090800000232
IngredientAmount% DV
Shepherd's Purse flowering aerial parts (Capsella bursa-pastoris) extract654 mg--

Other ingredients: certified organic Cane Alcohol, distilled Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use Shake well before using Add 1 full squeeze of the dropper bulb to 2 oz. of water or juice, 2 to 5 times per day. Best taken between meals.

Precautions

Caution: Seek expert medical advice before taking during pregnancy.

Keep out of the reach of children

Storage

Store away from heat & light

Formula

Capsella bursa-pastoris

Shepherd's purse liquid extract

Formulation

Optimal well-being

Gluten-free

Fresh herb / menstruum ratio: 1 : 1.5

Certified organic by Organic Certifiers

Seals/Symbols

USDA Organic

General Statements

Herbal Supplement

FDA Disclaimer Statement

This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Shepherd's Purse by Herb Pharm label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Shepherd's Purse label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Shepherd's Purse by Herb Pharm

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.7 mL Dosage formLiquid Servings per container42 Amounts shown are per serving.

Shepherd's Purse flowering aerial parts (Capsella bursa-pastoris) extract

Interacts with
264 drugs
654 mg per serving

Shepherd's purse is a traditional herb most often used to help slow heavy menstrual bleeding and other minor bleeding, but solid human research is ver...

Shepherd's Purse flowering aerial parts (Capsella bursa-pastoris) extract monograph & interactions

Other (inactive) ingredients: Certified organic Cane Alcohol, Distilled Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Shepherd's Purse by Herb Pharm Drug Interactions

Want to check YOUR meds against Shepherd's Purse?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
264Drugs
264 Moderate

Ingredients driving the most interactions

Shepherd's Purse flowering aerial parts (Capsella bursa-pastoris) extract 264

Individual Drug Interactions

The ingredients in Shepherd's Purse interact with 264 drugs. Click any drug to see the details.

1 of the 1 ingredient in Shepherd's Purse interact with drugs. Each result below shows which ingredient is responsible. Shepherd's Purse flowering aerial parts (Capsella bursa-pastoris) extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Shepherd's Purse with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Shepherd's Purse flowering aerial parts (Capsella bursa-pastoris) extract2 drug types · 264 drugs

Cns Depressants

Theoretically, concomitant use with drugs with sedative properties may cause additive effects and side effects.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, concomitant use may interfere with thyroid dysfunction therapy.

Likelihood Possible Evidence D
Shepherd's Purse flowering aerial parts (Capsella bursa-pastoris) extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Shepherd's Purse, from the product label.

Herb Pharm

See all Herb Pharm products
Name
Herb Pharm
City
Williams
State
OR
ZipCode
97544
Phone Number
800-348-4372
Web Address
www.herb-pharm.com
Pharmacist Counseling Corner

Shepherd's Purse by Herb Pharm: Common Questions

Does Shepherd's Purse by Herb Pharm interact with any medications?
Yes. Based on its ingredients, Shepherd's Purse has a known interaction with 264 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Shepherd's Purse contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Shepherd's Purse if I'm pregnant or breastfeeding?
No. During pregnancy, it may stimulate the uterus and is rated likely unsafe. While breastfeeding, there isn't enough safety data, so it's best avoided. Talk to your pharmacist or doctor for alternatives if you need support during these times.
What is Shepherd's Purse actually used for?
Traditionally it's used for postpartum complications and heavy menstrual bleeding, but we don't have reliable evidence to confirm it works for either. The data we hold on effectiveness is insufficient.
Will Shepherd's Purse make me drowsy?
It can theoretically add to the sedative effects of sleep aids and other sedating drugs, making drowsiness worse if you combine them. On its own in small amounts short-term, most people tolerate it without problems, though sedation has been traditionally linked to it.
Is there alcohol in this product?
Yes. The liquid extract uses certified organic cane alcohol as the extraction medium. If you need to avoid alcohol, ask your pharmacist about alternative forms or products.
How long can I safely take Shepherd's Purse?
The data support short-term use only. Human safety data are limited, so this isn't something to take long-term without talking to your pharmacist or doctor first.
Does this interact with thyroid medication?
Yes. Shepherd's Purse theoretically interferes with thyroid hormone replacement therapy. If you take levothyroxine or another thyroid drug, check with your pharmacist before starting this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Shepherd's Purse label
Go deeper

The Full Monographs Behind Shepherd's Purse’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Shepherd's Purse

Interacts with 264 drugs

Shepherd's purse is a traditional herb most often used to help slow heavy menstrual bleeding and other minor bleeding, but solid human research is very limited. Because it may affect blood c...

Read the full Shepherd's Purse monograph →
Sources

Sources & How We Checked

Shepherd's Purse's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Shepherd's Purse 4 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Naafe M, Kariman N, Keshavarz Z, et al. Effect of hydroalcoholic extracts of Capsella bursa-pastoris on heavy menstrual bleeding: A randomized clinical trial. J Altern Complement Med. 2018;24(7):694-700. PubMed
  4. Ghalandari S, Kariman N, Sheikhan Z, et al. Effect of hydroalcoholic extract of Capsella bursa pastoris on early postpartum hemorrhage: A clinical trial study. J Altern Complement Med. 2017;23(10):794-799.

See these in context on the Shepherd's Purse monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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