Shepherd's Purse - Acetaminophen, Butalbital, Caffeine, Codeine Interaction
Herbal: Shepherd's Purse
Also Known As: Capsella bursa-pastoris, Blind Weed, Bolsa del Pastor, Bolsa-de-Pastor, Bourse à Berger, Bourse-à-Pasteur, Bourse de Capucin, Boursette, Bursae Pastoris Herba, Capsella, Capselle, Capselle a Pasteur, Capselle Bourse-à-Pasteur, Caseweed, Cocowort, Corne de Lion, Erva-Do-B
Drug: Acetaminophen, Butalbital, Caffeine, Codeine
Brand names:
Esgic with Codeine, Fioricet w/ Codeine

Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 04, 2025
Interaction Details
Acetaminophen, Butalbital, Caffeine, Codeine is classified as belonging to the following category: Cns Depressants
Theoretically, concomitant use with drugs with sedative properties may cause additive effects and side effects.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
Shepherd's Purse Overview

Shepherd's Purse - More Interactions
Shepherd's Purse interacts with 263 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
Unknown | No interactions have been reported or no interaction data is currently available. |
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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Drug descriptions are provided by MedlinePlus.