Medication interaction hub

What Supplements Interact with Acetaminophen, Butalbital, Caffeine, Codeine?

Acetaminophen, Butalbital, Caffeine, Codeine brand names: Esgic with Codeine, Fioricet w/ Codeine. Every interaction below applies to the brands too.

305 Interactions 15 Major 245 Moderate 45 Minor
Curated & coded by · Clinical Pharmacist · Updated September 27, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Acetaminophen, Butalbital, Caffeine, Codeine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Acetaminophen, Butalbital, Caffeine, Codeine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

305 supplements and herbal ingredients have interactions with Acetaminophen, Butalbital, Caffeine, Codeine on file in the HelloPharmacist interaction database — 15 rated major, 245 moderate, and 45 minor. The most serious involve Beer, Grapefruit, Siberian Cocklebur, Wine and 1,4-butanediol.

Our assessment: with 15 major-rated interactions on the list, this one deserves real attention — know the major entries before combining anything with Acetaminophen, Butalbital, Caffeine, Codeine.

Major 15 Moderate 245 Minor 45 No known interaction 1,147

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Acetaminophen, Butalbital, Caffeine, Codeine: Top Interactions at a Glance

The Acetaminophen, Butalbital, Caffeine, Codeine supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 305 interacting ingredients — plus 1,147 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Acetaminophen, Butalbital, Caffeine, Codeine Combinations Today

The Acetaminophen, Butalbital, Caffeine, Codeine + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Probable Vitamin C + Acetaminophen, Butalbital, Caffeine, Codeinei

High-dose vitamin C might slightly prolong the clearance of acetaminophen.

Read the full interaction Minor Likelihood Possible Vitamin D + Acetaminophen, Butalbital, Caffeine, Codeinei

Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.

Read the full interaction Moderate Likelihood Probable Caffeine + Acetaminophen, Butalbital, Caffeine, Codeinei

Theoretically, concomitant use might increase stimulant adverse effects.

Read the full interaction Moderate Likelihood Possible Beet + Acetaminophen, Butalbital, Caffeine, Codeinei

Theoretically, beet might increase the levels of CYP3A4 substrates.

Read the full interaction Moderate Likelihood Possible Vitamin A + Acetaminophen, Butalbital, Caffeine, Codeinei

Theoretically, taking high doses of vitamin A in combination with other potentially hepatotoxic drugs might increase the risk of liver disease.

Read the full interaction Moderate Likelihood Possible Ashwagandha + Acetaminophen, Butalbital, Caffeine, Codeinei

Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.

Read the full interaction
The complete list

Every Supplement Checked Against Acetaminophen, Butalbital, Caffeine, Codeine

All 1,452 ingredients in our database, ranked by severity — 305 with a Acetaminophen, Butalbital, Caffeine, Codeine interaction on file and 1,147 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Acetaminophen, Butalbital, Caffeine, Codeine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Vitamin C with Acetaminophen, Butalbital, Caffeine, Codeine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. High-dose vitamin C might slightly prolong the clearance of acetaminophen.

Full Vitamin C + Acetaminophen, Butalbital, Caffeine, Codeine answer

Can you take Vitamin D with Acetaminophen, Butalbital, Caffeine, Codeine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.

Full Vitamin D + Acetaminophen, Butalbital, Caffeine, Codeine answer

Can you take Caffeine with Acetaminophen, Butalbital, Caffeine, Codeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Caffeine + Acetaminophen, Butalbital, Caffeine, Codeine answer

Can you take Beet with Acetaminophen, Butalbital, Caffeine, Codeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, beet might increase the levels of CYP3A4 substrates.

Full Beet + Acetaminophen, Butalbital, Caffeine, Codeine answer

Can you take Vitamin A with Acetaminophen, Butalbital, Caffeine, Codeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking high doses of vitamin A in combination with other potentially hepatotoxic drugs might increase the risk of liver disea...

Full Vitamin A + Acetaminophen, Butalbital, Caffeine, Codeine answer

Can you take Galphimia Glauca with Acetaminophen, Butalbital, Caffeine, Codeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Galphimia glauca with CNS depressants may increase the risk of sedation.

Full Galphimia Glauca + Acetaminophen, Butalbital, Caffeine, Codeine answer

Can you take Gamma Butyrolactone (gbl) with Acetaminophen, Butalbital, Caffeine, Codeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of GBL with CNS depressants may potentiate respiratory and CNS depression.

Full Gamma Butyrolactone (gbl) + Acetaminophen, Butalbital, Caffeine, Codeine answer

Can you take Garcinia with Acetaminophen, Butalbital, Caffeine, Codeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.

Full Garcinia + Acetaminophen, Butalbital, Caffeine, Codeine answer

Can you take Genistein Combined Polysaccharide with Acetaminophen, Butalbital, Caffeine, Codeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, genistein combined polysaccharide might reduce the clearance of caffeine.

Full Genistein Combined Polysaccharide + Acetaminophen, Butalbital, Caffeine, Codeine answer

Can you take German Chamomile with Acetaminophen, Butalbital, Caffeine, Codeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, German chamomile might have additive effects when used with CNS depressants.

Full German Chamomile + Acetaminophen, Butalbital, Caffeine, Codeine answer

Can you take Ginger with Acetaminophen, Butalbital, Caffeine, Codeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Ginger might increase or decrease the levels of CYP3A4 substrates.

Full Ginger + Acetaminophen, Butalbital, Caffeine, Codeine answer

Can you take Ginkgo with Acetaminophen, Butalbital, Caffeine, Codeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ginkgo with drugs that lower the seizure threshold might increase the risk for convulsions.

Full Ginkgo + Acetaminophen, Butalbital, Caffeine, Codeine answer

Can you take Goji with Acetaminophen, Butalbital, Caffeine, Codeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, goji berry might inhibit CYP2D6 and reduce metabolism of CYP2D6 substrates.

Full Goji + Acetaminophen, Butalbital, Caffeine, Codeine answer

Can you take Goldthread with Acetaminophen, Butalbital, Caffeine, Codeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There's very preliminary evidence that berberine, a constituent of goldthread, might inhibit cytochrome P450 3A4 (CYP3A4) enzyme.

Full Goldthread + Acetaminophen, Butalbital, Caffeine, Codeine answer

Can you take Gotu Kola with Acetaminophen, Butalbital, Caffeine, Codeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking gotu kola might increase the sedative effects of CNS depressants.

Full Gotu Kola + Acetaminophen, Butalbital, Caffeine, Codeine answer

Can you take Grape with Acetaminophen, Butalbital, Caffeine, Codeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, grape seed extract may increase the levels of CYP2D6 substrates.

Full Grape + Acetaminophen, Butalbital, Caffeine, Codeine answer

Can you take Greater Celandine with Acetaminophen, Butalbital, Caffeine, Codeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Research in vitro shows that chelidonine, a constituent of greater celandine, inhibits cytochrome P450 2D6 (CYP2D6) enzyme activity.

Full Greater Celandine + Acetaminophen, Butalbital, Caffeine, Codeine answer

Can you take Griffonia Simplicifolia with Acetaminophen, Butalbital, Caffeine, Codeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Griffonia simplicifolia seed extract with CNS depressants might increase the risk of additive CNS depression.

Full Griffonia Simplicifolia + Acetaminophen, Butalbital, Caffeine, Codeine answer

Can you take Guar Gum with Acetaminophen, Butalbital, Caffeine, Codeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.

Full Guar Gum + Acetaminophen, Butalbital, Caffeine, Codeine answer

Can you take Guarana with Acetaminophen, Butalbital, Caffeine, Codeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Guarana + Acetaminophen, Butalbital, Caffeine, Codeine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Acetaminophen, Butalbital, Caffeine, Codeine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Acetaminophen, Butalbital, Caffeine, Codeine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Acetaminophen, Butalbital, Caffeine, Codeine sits in 18 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Acetaminophen, Butalbital, Caffeine, Codeine through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Acetaminophen, Butalbital, Caffeine, Codeine through this category.

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Acetaminophen, Butalbital, Caffeine, Codeine through this category.

Cytochrome P450 2D6 (Cyp2D6) Substrates 60 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

60 of the supplement ingredients on this page reach Acetaminophen, Butalbital, Caffeine, Codeine through this category.

Stimulant Drugs 44 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

44 of the supplement ingredients on this page reach Acetaminophen, Butalbital, Caffeine, Codeine through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Acetaminophen, Butalbital, Caffeine, Codeine through this category.

Cytochrome P450 2E1 (Cyp2E1) Substrates 24 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

24 of the supplement ingredients on this page reach Acetaminophen, Butalbital, Caffeine, Codeine through this category.

Caffeine 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Acetaminophen, Butalbital, Caffeine, Codeine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Acetaminophen, Butalbital, Caffeine, Codeine through this category.

Glucuronidated Drugs 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Acetaminophen, Butalbital, Caffeine, Codeine through this category.

Acetaminophen (Tylenol, Others) 8 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

8 of the supplement ingredients on this page reach Acetaminophen, Butalbital, Caffeine, Codeine through this category.

Barbiturates 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Acetaminophen, Butalbital, Caffeine, Codeine through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Acetaminophen, Butalbital, Caffeine, Codeine through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Acetaminophen, Butalbital, Caffeine, Codeine through this category.

Methylxanthines 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Acetaminophen, Butalbital, Caffeine, Codeine through this category.

Narcotic Drugs 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Acetaminophen, Butalbital, Caffeine, Codeine through this category.

Codeine 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Acetaminophen, Butalbital, Caffeine, Codeine through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Acetaminophen, Butalbital, Caffeine, Codeine through this category.

Related: does Acetaminophen, Butalbital, Caffeine, Codeine deplete any nutrients?

Acetaminophen, Butalbital, Caffeine, Codeine has 4 reported nutrient associations in the research literature — see the Acetaminophen, Butalbital, Caffeine, Codeine nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Acetaminophen, Butalbital, Caffeine, Codeine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Acetaminophen, Butalbital, Caffeine, Codeine.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

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Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

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Prefer typing? The interaction checker looks up products by name too.

Pharmacist Counseling Corner

Acetaminophen, Butalbital, Caffeine, Codeine & Supplements: Common Questions

What supplements interact with Acetaminophen, Butalbital, Caffeine, Codeine?
Our database currently documents 305 ingredients with a known Acetaminophen, Butalbital, Caffeine, Codeine interaction (15 major, 245 moderate, 45 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 305. The highest-ranked right now: Beer, Grapefruit, Siberian Cocklebur.
Which Acetaminophen, Butalbital, Caffeine, Codeine supplement interactions are the most serious?
Focus on the major group: Beer, Grapefruit, Siberian Cocklebur, Wine and 1,4-butanediol, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Acetaminophen, Butalbital, Caffeine, Codeine?
Plenty of supplements coexist fine with Acetaminophen, Butalbital, Caffeine, Codeine; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Esgic with Codeine have the same supplement interactions as Acetaminophen, Butalbital, Caffeine, Codeine?
Yes — Esgic with Codeine, Fioricet w/ Codeine all contain Acetaminophen, Butalbital, Caffeine, Codeine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Acetaminophen, Butalbital, Caffeine, Codeine deplete any vitamins or nutrients?
It might — Acetaminophen, Butalbital, Caffeine, Codeine has 4 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Acetaminophen, Butalbital, Caffeine, Codeine nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Acetaminophen, Butalbital, Caffeine, Codeine and my other medications?
This page covers Acetaminophen, Butalbital, Caffeine, Codeine against supplements and herbal ingredients. Checking Acetaminophen, Butalbital, Caffeine, Codeine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 27, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.