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Dietary supplement

Shepherd's Purse Ingredients & Drug Interactions

by Herbalist & Alchemist

Shepherd's Purse label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Shepherd's Purse against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Shepherd's Purse is a dietary supplement by Herbalist & Alchemist with 1 active ingredient. Its ingredients are commonly taken for heavy or prolonged menstrual bleeding, minor bleeding (nosebleeds, wounds), mild diuretic.Based on those ingredients, 264 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are fresh Shepherd's Purse whole plant extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Shepherd's Purse by Herbalist & Alchemist

Ask about any prescription or over-the-counter medication and we check it for interactions with Shepherd's Purse by Herbalist & Alchemist — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Shepherd's Purse by Herbalist & Alchemist

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: fresh Shepherd's Purse whole plant extract. The liquid is made with distilled water and ethyl alcohol as inactive ingredients.

Shepherd's Purse is a traditional herb that has been used for certain women's health concerns, though the evidence for its effectiveness is limited.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Shepherd's Purse's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Supports healthy coagulation of blood.
  • We looked for evidence on: Menorrhagia, Postpartum complications, Hemostasis, Bleeding disorders.
  • The closest evidence on file: Shepherd's Purse is rated "Insufficient Reliable Evidence To Rate" for Postpartum complications (Natural Medicines).
  • Also on file: Shepherd's Purse is rated "Insufficient Reliable Evidence To Rate" for Menorrhagia.

The data we hold doesn't establish that Shepherd's Purse reliably works for postpartum bleeding (postpartum complications) or heavy menstrual bleeding (menorrhagia) — both are rated as having insufficient reliable evidence. That doesn't mean it doesn't work; it means the research isn't solid enough yet for us to say it does.

The evidence, ingredient by ingredient Shepherd's Purse

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Shepherd's Purse seems to be generally well tolerated when you use a small amount short-term, but human safety data are limited. Adverse effects that have been reported historically include sedation, changes in blood pressure, heart palpitations, abnormal thyroid function, and irregular menstruation — though these aren't guaranteed to occur.

During pregnancy, the safety data advise against use because the herb may stimulate the uterus. During breastfeeding, there isn't enough safety information, so avoid it then too.

If you're pregnant, planning to become pregnant, or breastfeeding, talk with your doctor or pharmacist before considering this product.

Side effects, ingredient by ingredient Shepherd's Purse

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Shepherd's Purse.
  • The most serious interaction on file is rated Moderate.
  • For scale: 264 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with us before adding this product if you take CNS depressants (sedatives, sleep aids, anxiety medications) or thyroid hormone replacement therapy — both carry Moderate-severity interaction risk. These are the main medication types to watch.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Shepherd's Purse might interest someone exploring traditional herbal support for women's health, but the evidence for it is thin. If you take medications for sleep, anxiety, or thyroid problems, you need to check your exact drugs before starting — and it's off-limits during pregnancy and breastfeeding.

Chat with your pharmacist before you use it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 23, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Shepherd's Purse, straight from the product label.

Brand Herbalist & Alchemist
Barcode (UPC) 667056125660
Net contents 2 fl. Oz.; 60 mL
Market status On market
Date entered into DSLD Mar 23, 2018
DSLD ID 174623
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher, Organic
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Shepherd's Purse by Herbalist & Alchemist, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
2 mL
Servings per container
30
UPC/BARCODE
667056125660
IngredientAmount% DV
fresh Shepherd's Purse whole plant extract2 mL--

Other ingredients: distilled Water, Ethyl Alcohol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Capsella bursa-pastoris

OK

General Statements

Supports healthy coagulation of blood

Herbal Supplement

Botanical preparation ratio 1:2

Suggested/Recommended/Usage/Directions

Suggested Use: 20-40 drops (1-2 mL) in juice or water. Take 4 times per day. Shake well before using.

Precautions

Contraindications: Do not use during pregnancy unless otherwise directed by a qualified expert.

Use cautiously if you have a history of oxalate kidney stones.

Keep out of children's reach

FDA Disclaimer Statement

This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

General

NO. SHP-2 1738WE

Seals/Symbols

OK

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Shepherd's Purse by Herbalist & Alchemist label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Shepherd's Purse label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Shepherd's Purse by Herbalist & Alchemist

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 mL Dosage formLiquid Servings per container30 Amounts shown are per serving.

Fresh Shepherd's Purse whole plant extract

Interacts with
264 drugs
2 mL per serving

Shepherd's purse is a traditional herb most often used to help slow heavy menstrual bleeding and other minor bleeding, but solid human research is ver...

Fresh Shepherd's Purse whole plant extract monograph & interactions

Other (inactive) ingredients: Distilled Water, Ethyl Alcohol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Shepherd's Purse by Herbalist & Alchemist Drug Interactions

Want to check YOUR meds against Shepherd's Purse?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
264Drugs
264 Moderate

Ingredients driving the most interactions

fresh Shepherd's Purse whole plant extract 264

Individual Drug Interactions

The ingredients in Shepherd's Purse interact with 264 drugs. Click any drug to see the details.

1 of the 1 ingredient in Shepherd's Purse interact with drugs. Each result below shows which ingredient is responsible. fresh Shepherd's Purse whole plant extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Shepherd's Purse with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

fresh Shepherd's Purse whole plant extract2 drug types · 264 drugs

Cns Depressants

Theoretically, concomitant use with drugs with sedative properties may cause additive effects and side effects.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, concomitant use may interfere with thyroid dysfunction therapy.

Likelihood Possible Evidence D
fresh Shepherd's Purse whole plant extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Shepherd's Purse, from the product label.

Herbalist & Alchemist

See all Herbalist & Alchemist products
Name
Herbalist & Alchemist, Inc.
City
Washington
State
NJ
ZipCode
07882
Phone Number
800-611-8235
Web Address
www.herbalist-alchemist.com
Pharmacist Counseling Corner

Shepherd's Purse by Herbalist & Alchemist: Common Questions

Does Shepherd's Purse by Herbalist & Alchemist interact with any medications?
Yes. Based on its ingredients, Shepherd's Purse has a known interaction with 264 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Shepherd's Purse contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant or breastfeeding?
No — the safety data advise against use during pregnancy because the herb may stimulate the uterus, and there isn't enough safety information for breastfeeding either. If you're pregnant, planning pregnancy, or nursing, talk with your doctor or pharmacist.
Does Shepherd's Purse actually work for heavy periods?
The research we hold is insufficient to say it does reliably. That's the honest answer — it doesn't mean it won't help you, just that the evidence isn't solid yet.
What side effects might I notice?
Small amounts used short-term are generally well tolerated. Historically, drowsiness, blood pressure changes, heart palpitations, and irregular periods have been reported — though they're not guaranteed.
Why does this product interact with so many medications?
The 264 medications come from two main categories: CNS depressants (sleep aids, sedatives, anxiety drugs) and thyroid hormones. One herb can interact with multiple individual drugs in each category because they all work through similar pathways.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Shepherd's Purse is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Shepherd's Purse label
Go deeper

The Full Monographs Behind Shepherd's Purse’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Shepherd's Purse

Interacts with 264 drugs

Shepherd's purse is a traditional herb most often used to help slow heavy menstrual bleeding and other minor bleeding, but solid human research is very limited. Because it may affect blood c...

Read the full Shepherd's Purse monograph →
Sources

Sources & How We Checked

Shepherd's Purse's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Shepherd's Purse 4 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Naafe M, Kariman N, Keshavarz Z, et al. Effect of hydroalcoholic extracts of Capsella bursa-pastoris on heavy menstrual bleeding: A randomized clinical trial. J Altern Complement Med. 2018;24(7):694-700. PubMed
  4. Ghalandari S, Kariman N, Sheikhan Z, et al. Effect of hydroalcoholic extract of Capsella bursa pastoris on early postpartum hemorrhage: A clinical trial study. J Altern Complement Med. 2017;23(10):794-799.

See these in context on the Shepherd's Purse monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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