Shred Research Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Shred Research against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Shred Research is a dietary supplement by Sarms Pharm (SP) with 3 active ingredients. Its ingredients are commonly taken for muscle building, strength gains, fat loss / body recomposition.Based on those ingredients, 612 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Ostarine MK-2866, Andarine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Shred Research by Sarms Pharm (SP)
Ask about any prescription or over-the-counter medication and we check it for interactions with Shred Research by Sarms Pharm (SP) — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Shred Research by Sarms Pharm (SP)
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Shred Research contains three active ingredients, each a selective androgen receptor modulator (SARM) or related research compound: Andarine (S-4), Stenabolic SR-9009, and Ostarine MK-2866. These are investigational drugs designed to affect how your body builds and uses muscle, but none are approved by the FDA and none are legal to sell as dietary supplements.
The product contains no inactive ingredients listed.
Does it work?
Couldn't assess
The evidence supporting these ingredients is not established. For Andarine, Stenabolic, and Ostarine, the data we hold shows insufficient reliable evidence to rate their effectiveness for athletic performance, weight management, muscle wasting, or any other claimed use.
These are research compounds without proven benefit in humans.
How safe is it?
Well-documented data
This product carries serious safety warnings. Andarine and Ostarine are unapproved investigational drugs with known risks: both may damage the liver, increase markers of liver injury, and raise the risk of heart attack or stroke according to FDA warnings.
Ostarine has caused abdominal pain, nausea, diarrhea, and in clinical trials, increases in liver enzymes in a meaningful portion of users. Stenabolic is an untested research chemical with no human safety data at all.
None of these ingredients should be used during pregnancy—Andarine and Ostarine affect hormone pathways, and Stenabolic is rated possibly unsafe with no safety information. Breastfeeding is also contraindicated for all three due to lack of safety data.
Meds to double-check
Moderate interaction found
Before taking this product, check with your doctor or pharmacist if you take androgens (androgenic drugs), hepatotoxic medications, drugs that induce or inhibit CYP3A4 metabolism, probenecid, rifampin, or substrates of CYP2C9. The moderate-severity interactions with androgens and liver-toxic drugs are the most serious concerns.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Shred Research is not a legal supplement; it contains three unapproved research compounds with significant gaps in human safety data and documented risks to your liver and heart. The evidence supporting their effectiveness is insufficient.
If you're considering this product, talk with your doctor or pharmacist first—do not start it without personalized medical guidance, and be honest with them about any medications you take, since the interactions are substantial.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 26, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Shred Research, straight from the product label.
| Brand | Sarms Pharm (SP) |
|---|---|
| Net contents | 90 Cap(s) |
| Market status | On market |
| Date entered into DSLD | Dec 26, 2020 |
| DSLD ID | 242059 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | No Claim |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Shred Research by Sarms Pharm (SP), sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Andarine | 50 mg | -- |
| Stenabolic SR-9009 | 30 mg | -- |
| Ostarine MK-2866 | 30 mg | -- |
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Research Product
90 Caps / 30 mg / 30 mg / 50 mg per 3 Caps
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Shred Research by Sarms Pharm (SP) label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Shred Research by Sarms Pharm (SP)
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size0 Not Present Dosage formCapsule Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Andarine
Interacts with9 drugs
Andarine (S-4) is a synthetic selective androgen receptor modulator (SARM) that is not approved by the FDA for human use and is banned in sports. It i...
Andarine monograph & interactionsStenabolic SR-9009
No knowninteractions
Stenabolic (also called SR9009) is an experimental research chemical, not a true dietary supplement, herb, or approved drug. It is sold online for fat...
Stenabolic SR-9009 monograph & interactionsOstarine MK-2866
Interacts with611 drugs
Ostarine (also called MK-2866 or enobosarm) is an experimental, unapproved drug known as a SARM (selective androgen receptor modulator), not a true di...
Ostarine MK-2866 monograph & interactionsShred Research by Sarms Pharm (SP) Drug Interactions
HelloPharmacist Interaction Report
Shred Research by Sarms Pharm contains three active ingredients—Andarine, Stenabolic SR-9009, and Ostarine MK-2866—two of which carry documented interactions with medications.
The most serious concern is Andarine's moderate-severity interaction with androgens (other androgenic drugs), which may increase the risk of androgenic side effects including masculinization, virilization, acne, hair loss, increased libido, and aggression.
Read the full breakdown — every affected drug type, severity by severity
Ostarine interacts with several drug types. It may increase the risk of liver damage (hepatotoxicity) when used alongside hepatotoxic drugs.
It can also be affected by CYP3A4 inducers (such as rifampin), which may reduce ostarine's effectiveness, and by probenecid, which may raise ostarine levels and increase both its effects and side effects. CYP3A4 inhibitors and CYP2C9 substrates carry minor-severity interactions with ostarine, though clinical significance is limited.
Stenabolic SR-9009 has no documented interactions in our data. Altogether, these interactions span 613 individual medications.
Because this product contains unapproved research compounds with significant safety gaps, you should discuss it with your doctor or pharmacist before considering use, and run your exact medications through the checker below if you do.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Shred Research?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Shred Research interact with 612 drugs. Click any drug to see the details.
2 of the 3 ingredients in Shred Research interact with drugs. Each result below shows which ingredient is responsible. Ostarine MK-2866 Andarine
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.
Read the full Ostarine Mk-2866 + 6-mercaptopurine interactionAbacavir Sulfate, Dolutegravir, LamivudineTriumeq
How Abacavir Sulfate, Dolutegravir, Lamivudine interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.
Read the full Ostarine Mk-2866 + Abacavir Sulfate, Dolutegravir, Lamivudine interactionAbacavir, LamivudineEpzicom
How Abacavir, Lamivudine interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.
Read the full Ostarine Mk-2866 + Abacavir, Lamivudine interactionAbiraterone
How Abiraterone interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Cytochrome P450 3a4 (cyp3a4) Inhibitors, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of ostarine with CYP3A4 inhibitors could increase the effects and adverse effects of ostarine, although this is unlikely to be clinically significant.
Read the full Ostarine Mk-2866 + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.
Read the full Ostarine Mk-2866 + Abiraterone Acetate interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.
Read the full Ostarine Mk-2866 + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.
Read the full Ostarine Mk-2866 + Acebutolol interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.
Read the full Ostarine Mk-2866 + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.
Read the full Ostarine Mk-2866 + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.
Read the full Ostarine Mk-2866 + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.
Read the full Ostarine Mk-2866 + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.
Read the full Ostarine Mk-2866 + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.
Read the full Ostarine Mk-2866 + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.
Read the full Ostarine Mk-2866 + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.
Read the full Ostarine Mk-2866 + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.
Read the full Ostarine Mk-2866 + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.
Read the full Ostarine Mk-2866 + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.
Read the full Ostarine Mk-2866 + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.
Read the full Ostarine Mk-2866 + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.
Read the full Ostarine Mk-2866 + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.
Read the full Ostarine Mk-2866 + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.
Read the full Ostarine Mk-2866 + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.
Read the full Ostarine Mk-2866 + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.
Read the full Ostarine Mk-2866 + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.
Read the full Ostarine Mk-2866 + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.
Read the full Ostarine Mk-2866 + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.
Read the full Ostarine Mk-2866 + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.
Read the full Ostarine Mk-2866 + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.
Read the full Ostarine Mk-2866 + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.
Read the full Ostarine Mk-2866 + Acetaminophen, Chlorpheniramine, Phenylephrine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Shred Research with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Ostarine MK-2866
Cytochrome P450 3A4 (Cyp3A4) Inducers
Theoretically, concomitant use of ostarine with CYP3A4 inducers could decrease the clinical effects of ostarine.
Ostarine is partially metabolized by CYP3A4. Clinical research shows that taking rifampin, a potent inducer of CYP3A4, reduces the maximum plasma concentration of ostarine by 23% and the area under the curve by 43%.
Hepatotoxic Drugs
Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.
Some clinical research shows that ostarine can increase alanine aminotransferase, a marker of liver damage, in some patients. Additionally, the U.S. Food and Drug Administration warns that supplements containing SARMs, such as ostarine, have been associated with reports of liver toxicity and there are at least two reports of drug-induced liver injury attributed to the use of ostarine.
Probenecid (Benemid)
Theoretically, concomitant use of ostarine with probenecid could increase the effects and adverse effects of ostarine.
Clinical research shows that probenecid increases ostarine levels and slows the clearance of ostarine, likely via inhibition of UDP-glucuronosyltransferase (UGT). Ostarine is partially metabolized by UGT.
Rifampin (Rifadin)
Theoretically, concomitant use of ostarine with rifampin could decrease the clinical effects of ostarine.
Clinical research shows that taking rifampin with ostarine reduces the maximum plasma concentration of ostarine by 23% and the area under the curve by 43%. Ostarine is partially metabolized by cytochrome P450 3A4 (CYP3A4), and rifampin is a potent CYP3A4 inducer.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, ostarine might increase levels of drugs metabolized by CYP2C9, although clinical research suggests this is not clinically relevant.
Although in vitro research suggests that ostarine inhibits CYP2C9, more robust clinical research shows that ostarine does not significantly affect CYP2C9.
Cytochrome P450 3A4 (Cyp3A4) Inhibitors
Theoretically, concomitant use of ostarine with CYP3A4 inhibitors could increase the effects and adverse effects of ostarine, although this is unlikely to be clinically significant.
Ostarine is partially metabolized by CYP3A4. However, clinical research shows that taking itraconazole, a potent inhibitor of CYP3A4, had minimal effects on the levels of ostarine in the body.
Andarine
Androgens
Due to its androgenic properties, Andarine (S-4) may theoretically interact with other androgenic drugs, potentially increasing the risk of side effects associated with androgenic activity (source: https://pubmed.ncbi.nlm.nih.gov/12604714/). These side effects can include masculinization, virilization, acne, hair loss, increased libido, aggression, mood changes, and liver toxicity.
Brand information
Manufacturer and brand details for Shred Research, from the product label.
Shred Research by Sarms Pharm (SP): Common Questions
Does Shred Research by Sarms Pharm (SP) interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is this product legal to buy?
Can I take this if I'm pregnant or breastfeeding?
What are the main side effects I should know about?
Does this product actually work for muscle building or fat loss?
What happens if these ingredients affect my liver?
Should I have my liver checked if I take this?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Shred Research is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Shred Research’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Andarine
Interacts with 9 drugsAndarine (S-4) is a synthetic selective androgen receptor modulator (SARM) that is not approved by the FDA for human use and is banned in sports. It is not a legal dietary supplement ingredi...
Read the full Andarine monograph → Herb & supplement monographStenabolic
Stenabolic (also called SR9009) is an experimental research chemical, not a true dietary supplement, herb, or approved drug. It is sold online for fat loss and endurance, but it has never be...
Read the full Stenabolic monograph → Herb & supplement monographOstarine
Interacts with 611 drugsOstarine (also called MK-2866 or enobosarm) is an experimental, unapproved drug known as a SARM (selective androgen receptor modulator), not a true dietary supplement. It is not approved by...
Read the full Ostarine monograph →Sources & How We Checked
Shred Research's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 12 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Andarine 1 reference
- FDA. FDA Warns against using SARMs in body building products. October 2017. Available at: https://www.fda.gov/newsevents/newsroom/fdainbrief/ucm583021.htm.
Stenabolic 1 reference
- What Should Tested Athletes Know About GW1516? Education, Spirit of Sport. U.S. Anti-Doping Agency (USADA). September 24, 2019. Available at: https://www.usada.org/spirit-of-sport/education/what-should-athletes-know-gw1516/
Ostarine 10 references
- Warning Letter: Ironmag Labs 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm582464.htm Accessed: November 1, 2017
- Warning Letter: Panther Sports Nutrition 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm581630.htm. Accessed: November 1, 2017
- Warning Letter: Infantry Labs LLC 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm582685.htm. Accessed: November 1, 2017
- Dobs AS, Boccia RV, Croot CC, et al. Effects of enobosarm on muscle wasting and physical function in patients with cancer: a double-blind, randomised controlled phase 2 trial. Lancet Oncol 2013;14(4):335-45. PubMed
- Dalton JT, Barnette KG, Bohl CE, et al. The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double-blind, placebo-controlled phase II tri
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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