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Dietary supplement

Sinus Support 310 mg Ingredients & Drug Interactions

by Eclectic Institute

Capsule Category: Botanical
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Sinus Support 310 mg is a dietary supplement by Eclectic Institute with 4 active ingredients. Its ingredients are commonly taken for sinus and respiratory congestion, urinary tract infections, digestive support.Based on those ingredients, 301 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Nettle, Elder Flower, Wildcrafted, Eyebright. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Sinus Support 310 mg by Eclectic Institute

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 4 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (310 mg) without saying how much of each component you get.

This product contains 4 active ingredients in a proprietary blend: horseradish, nettle (also called stinging nettle), eyebright, and elder flower (wildcrafted). The blend totals 310 mg per capsule.

Hypromellose, a capsule material, is the only inactive ingredient listed.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Sinus and upper respiratory health support.
  • We looked for evidence on: Allergic rhinitis (hay fever), Common cold, Conjunctivitis, Cough, Lower respiratory tract infections, Pharyngitis — and 4 related terms.
  • The closest evidence on file: Eyebright is rated "Insufficient Reliable Evidence To Rate" for Allergic rhinitis (hay fever) (Natural Medicines).
  • Also on file: Eyebright is rated "Insufficient Reliable Evidence To Rate" for Common cold, Cough, Pharyngitis, Rhinosinusitis, and more.
  • Also on file: Horseradish is rated "Insufficient Reliable Evidence To Rate" for Respiratory tract infections.

The evidence for what this product does isn't established in our data. Horseradish, nettle, eyebright, and elder flower all carry ratings of insufficient reliable evidence for the conditions they're traditionally used for—sinus and respiratory support, allergic rhinitis, and related concerns.

That doesn't mean they don't work; it means the clinical evidence we hold isn't strong enough to rate them.

The evidence, ingredient by ingredient Horseradish Stinging Nettle Eyebright Elderberry

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Horseradish is generally well tolerated in food amounts but can irritate your digestive tract and mucous membranes in larger supplement doses. In rare cases, large amounts have caused serious reactions like fainting.

Nettle is generally well tolerated when used as directed, though it can occasionally cause constipation or diarrhea, and direct contact with the fresh plant causes itching and stinging. Eyebright has been reported to cause confusion, headache, nausea, constipation, cough, and congestion.

Elder flower from properly cooked products is generally well tolerated, but raw or unripe berries and seeds can be toxic. Pregnant and breastfeeding women should not use horseradish (safety not established), nettle (likely unsafe in pregnancy; safety not established while breastfeeding), eyebright (safety not established), or elder flower (safety not established) without talking to their doctor.

Side effects, ingredient by ingredient Horseradish Stinging Nettle Eyebright Elderberry

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Eyebright, Horseradish, Elderberry, Stinging Nettle.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; lithium.
  • For scale: 301 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check with your doctor or pharmacist if you're on any of these: blood thinners (like warfarin), diabetes drugs, diuretics (water pills), lithium, thyroid hormone, immunosuppressants, or pazopanib. All carry Moderate interactions with one or more ingredients in this blend.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you take blood thinners, diabetes medications, diuretics, lithium, thyroid hormone, or immunosuppressants, you'll want to talk with your doctor or pharmacist before starting this product—the interactions are real and could affect how your medications work. Even if you're not on those drugs, if you're pregnant or breastfeeding, check with your doctor first.

The evidence for what this blend does for sinus support isn't established in our data, so know what you're trying it for.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Sinus Support 310 mg, straight from the product label.

Brand Eclectic Institute
Barcode (UPC) 023363324156
Net contents 45 Cap(s)
Market status On market
Date entered into DSLD Jan 23, 2023
DSLD ID 263805
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Sinus Support 310 mg by Eclectic Institute, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
45
UPC/BARCODE
023363324156
IngredientAmount% DV
Proprietary Blend310 mg--
Horseradish0 NP--
Nettle0 NP--
Eyebright0 NP--
Elder Flower, Wildcrafted0 NP--

Other ingredients: Hypromellose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Naturally Concentrated Organic/Wildcrafted Naturopathic Physician Formulated

Organic/Wildcrafted

Grain/Soy/Dairy-Free Non-GMO No Fillers

Vegan

Each capsule is made from 3.3 g of fresh herbs. Concentrate combinations are innovative, naturopathic physician-formulated freeze-dried compounds that delivery super-concentrated botanicals in a single capsule. We concentrate using only traditional processes of juicing and decocting, and then freeze-dry the concentrates onto whole herbs. 100% naturally concentrated with no additives, fillers or toxic solvent residues.

100% naturally concentrated with no additives, fillers or toxic solvent residues.

Naturally concentrated 10.6x

Raw Fresh Freeze-Dried

Supports Nasal Health

Suggested/Recommended/Usage/Directions

Suggested use: Up to 3 capsules per day.

Precautions

Discontinue use if unusual symptoms occur.

Consult your health care advisor regarding the use of this product during pregnancy, with infants or with prescription drugs.

Consult your health care advisor regarding the use of this product during pregnancy, with infants or with prescription drugs.

Keep out of reach of children.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Brand IP Statement(s)

Eclectic Institute - Since 1982

FDA Statement of Identity

Dietary Supplement

Formula

100% Kosher.

See for yourself

Sinus Support 310 mg by Eclectic Institute label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Sinus Support 310 mg by Eclectic Institute

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container45 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

310 mg per serving

Other (inactive) ingredients: Hypromellose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Sinus Support 310 mg by Eclectic Institute Drug Interactions

Want to check YOUR meds against Sinus Support 310 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
301Drugs
301 Moderate

Ingredients driving the most interactions

Nettle 164

Each ingredient & the kinds of drugs it affects

For each ingredient in Sinus Support 310 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Nettle4 drug types · 164 drugs

Antidiabetes Drugs

Theoretically, stinging nettle might have additive effects with antidiabetes drugs.
Clinical research shows that stinging nettle might decrease blood glucose levels in patients with diabetes.

Likelihood Possible Evidence B
Diuretic Drugs

Theoretically, combining stinging nettle with diuretic drugs may have additive effects.
Animal research suggests that the above ground parts and roots of stinging nettle may have a diuretic effect.

Likelihood Possible Evidence D
Lithium

Theoretically, stinging nettle might reduce excretion and increase levels of lithium.
Animal research suggests that stinging nettle has diuretic and natriuretic properties, which could alter the excretion of lithium. The dose of lithium might need to be decreased.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is some concern that stinging nettle might decrease the effects of anticoagulant drugs such as warfarin.
Stinging nettle contains a significant amount of vitamin K. When taken in large quantities, this might interfere with the activity of warfarin.

Likelihood Possible Evidence D

Elder Flower, Wildcrafted2 drug types · 121 drugs

Immunosuppressants

Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Elderberry has immunostimulant activity, increasing the production of cytokines, including interleukin and tumor necrosis factor.

Likelihood Possible Evidence B
Pazopanib (Votrient)

Theoretically, elderberry might interact with pazopanib, potentially increasing the risk of adverse effects.
In one case, a 65-year-old patient taking pazopanib for 4 weeks for soft-tissue sarcoma developed severe nausea, loose stools, and elevated alanine transaminase and aspartate transaminase levels and was diagnosed with grade 3 liver injury. The patient reported taking elderberry supplements for 2 years, dose unspecified, and was also taking a multivitamin and a calcium supplement. The patient's symptoms and liver enzyme levels improved upon discontinuation of pazopanib and all supplements. Pazopanib treatment was re-initiated, at a lower dose, with no further evidence of liver injury. It was unclear in this case report if the elderberry supplements were derived from the berry, the flower, or the combination.

Likelihood Possible Evidence D

Eyebright1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, eyebright might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research suggests that eyebright lowers blood glucose levels.

Likelihood Possible Evidence D

Horseradish1 drug type · 16 drugs

Thyroid Hormone

Theoretically, horseradish might interfere with the effects of thyroid hormone.
Horseradish and other members of the cabbage and mustard family are associated with depressed thyroid function.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Sinus Support 310 mg, from the product label.

Eclectic Institute

See all Eclectic Institute products
Name
Eclectic Institute, Inc.
Street Address
12960 SE Ten Eyck Rd
City
Sandy
State
Oregon
ZipCode
97055
Phone Number
503-668-4120
Web Address
www.eclecticherb.com
Pharmacist Counseling Corner

Sinus Support 310 mg by Eclectic Institute: Common Questions

Does Sinus Support 310 mg by Eclectic Institute interact with any medications?
Yes. Based on its ingredients, Sinus Support 310 mg has a known interaction with 301 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Sinus Support 310 mg contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
The safety data advises against this product during pregnancy and breastfeeding. Horseradish is best avoided in pregnancy because safety hasn't been established, nettle is likely unsafe in pregnancy and not well studied while breastfeeding, eyebright safety is not established at either time, and elder flower supplements aren't recommended during either period. Talk with your doctor before using.
What does horseradish do in this blend?
Horseradish has been traditionally used for respiratory tract infections and other conditions, but the evidence we hold is insufficient to rate how well it works. It's included for its traditional sinus-support role.
Can this product cause side effects?
Yes. Horseradish can irritate your digestive tract and mucous membranes in large amounts; nettle can cause constipation or diarrhea; eyebright has been reported to cause confusion, headache, nausea, and cough; and improperly prepared elder flower (raw or unripe) can cause nausea, vomiting, and severe diarrhea. If you notice any of these, stop and talk to your pharmacist.
Does this product actually help with sinus issues?
The evidence we hold for all four ingredients—horseradish, nettle, eyebright, and elder flower—shows insufficient reliable evidence to rate their effectiveness for sinus support or related respiratory conditions. That means the clinical data isn't strong enough for us to say whether it works.
What's the inactive ingredient in this product?
Hypromellose, which is the material used to make the capsule itself.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Sinus Support 310 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Sinus Support 310 mg label
Sources

Sources & How We Checked

Sinus Support 310 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 39 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Horseradish 6 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  3. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  4. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  5. Panter, K. E. and James, L. F. Natural plant toxicants in milk: a review. J Anim Sci 1990;68(3):892-904. PubMed
  6. Lehmann CU, Puckett AL, Betz BO. 56-year-old man - increased heart rate - weakness - intense sweating - horseradish consumption - Dx?. J Fam Pract 2022;71(7):317-321. PubMed

See these in context on the Horseradish monograph →

Stinging Nettle 23 references
  1. Monographs on the medicinal uses of plant drugs. Exeter, UK: European Scientific Co-op Phytother, 1997.
  2. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  3. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  4. Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
  5. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  6. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  7. Mittman P. Randomized, double-blind study of freeze-dried Urtica dioica in the treatment of allergic rhinitis. Planta Med 1990;56:44-7.
  8. Vontobel HP, Herzog R, Rutishauser G, Kres H. [Results of a double-blind study on the effectiveness of ERU (extractum radicis Urticae) capsules in conservative treatment of benign prostatic hyperplasia]. (Abstract). Urologe A 1985;24:49-51.
  9. Randall C, Randall H, Dobbs F, et al. Randomized controlled trial of nettle sting for treatment of base-of-thumb pain. J R Soc Med 2000;93:305-9. PubMed
  10. Caliskaner Z, Karaayvaz M, Ozturk S. Misuse of a herb: stinging nettle (Urtica urens) induced severe tongue oedema. Complement Ther Med 2004;12:57-8. PubMed
  11. Krzeski, T., Kazon, M., Borkowski, A., Witeska, A., and Kuczera, J. Combined extracts of Urtica dioica and Pygeum africanum in the treatment of benign prostatic hyperplasia: double-blind comparison of two doses. Clin Ther 1993;15(6):1011-1020.
  12. Randall, C., Meethan, K., Randall, H., and Dobbs, F. Nettle sting of Urtica dioica for joint pain--an exploratory study of this complementary therapy. Complement Ther Med 1999;7(3):126-131. PubMed
  13. Tahri, A., Yamani, S., Legssyer, A., Aziz, M., Mekhfi, H., Bnouham, M., and Ziyyat, A. Acute diuretic, natriuretic and hypotensive effects of a continuous perfusion of aqueous extract of Urtica dioica in the rat. J Ethnopharmacol 2000;73(1-2):95-100. PubMed
  14. Sahin, M., Yilmaz, H., Gursoy, A., Demirel, A. N., Tutuncu, N. B., and Guvener, N. D. Gynaecomastia in a man and hyperoestrogenism in a woman due to ingestion of nettle (Urtica dioica). N.Z.Med.J. 2007;120(1265):U2803.
  15. Randall, C., Dickens, A., White, A., Sanders, H., Fox, M., and Campbell, J. Nettle sting for chronic knee pain: a randomised controlled pilot study. Complement Ther.Med. 2008;16(2):66-72. PubMed
  16. Rayburn, K., Fleischbein, E., Song, J., Allen, B., Kundert, M., Leiter, C., and Bush, T. Stinging nettle cream for osteoarthritis. Altern.Ther.Health Med. 2009;15(4):60-61.
  17. Oliver, F., Amon, E. U., Breathnach, A., Francis, D. M., Sarathchandra, P., Black, A. K., and Greaves, M. W. Contact urticaria due to the common stinging nettle (Urtica dioica)-- histological, ultrastructural and pharmacological studies. Clin Exp Dermato PubMed
  18. Kulze, A. and Greaves, M. Contact urticaria caused by stinging nettles. Br.J Dermatol. 1988;119(2):269-270. PubMed
  19. Patten G. Medicinal plant review: Urtica. Aust J Med Herbalism 1993;5(1):5-13.
  20. Maor D, Little M. Skin contact with a stinging tree requiring intensive care unit admission. Contact Dermatitis. 2017 Nov;77(5):335-37. PubMed
  21. Easton L, Vaid S, Nagel AK, Venci JV, Fortuna RJ. Stinging Nettle (Urtica dioica): An Unusual Case of Galactorrhea. Am J Case Rep 2021;22:e933999. PubMed
  22. Niazi B, Ahmed K, Ahmed M, Ali S, Song K, Elias S. Drug-Induced Liver Injury from Herbal Liver Detoxification Tea. Case Rep Gastroenterol 2022;16(3):612-617. PubMed
  23. Nnamani I, Tolu-Akinnawo O, Dufera RR, Akintunde A, Maliakkal B. Tinospora cordifolia (Guduchi/Giloy)-Induced Liver Injury: A Case Review. Cureus 2023;15(5):e39793. PubMed

See these in context on the Stinging Nettle monograph →

Eyebright 4 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Wichtl MW. Herbal Drugs and Phytopharmaceuticals. Ed. N.M. Bisset. Stuttgart: Medpharm GmbH Scientific Publishers, 1994.
  3. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  4. Porchezhian, E., Ansari, S. H., and Shreedharan, N. K. Antihyperglycemic activity of Euphrasia officinale leaves. Fitoterapia 2000;71(5):522-526. PubMed

See these in context on the Eyebright monograph →

Elderberry 6 references
  1. Barak V, Halperin T, Kalickman I. The effect of Sambucol, a black elderberry-based, natural product, on the production of human cytokines: I. Inflammatory cytokines. Eur Cytokine Netw 2001;12:290-6..
  2. Elderberry (Sambucus species). The Poison Plant Patch, Novia Scotia Museum, 2007. Available at: http://museum.gov.ns.ca/poison/?section=species&id=117 (Accessed 16 October 2009).
  3. European elder. Canadian Poisonous Plants Information System. Available at: http://www.cbif.gc.ca/pls/pp/ppack.jump?p_null=all&p_psn=121&p_type=all&p_sci=comm&p_x=px (Accessed 16 October 2009).
  4. Raus K, Pleschka S, Klein P, Schoop R, Fisher P. Effect of an echinacea-based hot drink versus oseltamivir in Influenza treatment: a randomized, double-blind, double-dummy, multicenter, noninferiority clinical trial. . Curr Ther Res Clin Exp. 2015;20;77:6 PubMed
  5. Ramachandran A, Antala D, Pudasainee P, Panginikkod S, Gupta H. A Plausible Association Between the Use of Elderberry and Autoimmune Hepatitis. Cureus 2022;14(4):e24250. PubMed
  6. Agarwal N, Mangla A. Elderberry interaction with pazopanib in a patient with soft-tissue sarcoma: A case report and literature review. Mol Clin Oncol 2024;20(5):36. PubMed

See these in context on the Elderberry monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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