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Dietary supplement

Skullcap Extract 2,000 mg Alcohol-Free Ingredients & Drug Interactions

by Nature's Answer

Skullcap Extract 2,000 mg Alcohol-Free label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Skullcap Extract 2,000 mg Alcohol-Free against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Skullcap Extract 2,000 mg Alcohol-Free is a dietary supplement by Nature's Answer with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, trouble sleeping, nervous tension.Based on those ingredients, 248 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Skullcap Aerial Parts Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Skullcap Extract 2,000 mg Alcohol-Free by Nature's Answer

Ask about any prescription or over-the-counter medication and we check it for interactions with Skullcap Extract 2,000 mg Alcohol-Free by Nature's Answer — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Skullcap Extract 2,000 mg Alcohol-Free by Nature's Answer

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Skullcap Aerial Parts Extract at 2,000 mg per serving. It comes as an alcohol-free liquid, so you get the plant extract without the alcohol base.

The inactive ingredients are glycerin and purified water — simple excipients to keep the liquid stable and easy to dose.

Does it work?

No specific claim
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
General wellness

This Skullcap product is marketed for general wellness, not a specific health condition, so there's no single claim to grade — see Skullcap's own graded uses on its monograph.

Why this rating?
  • The label markets general wellness (“promotes overall health and wellbeing”), not a specific health condition, so there is no single claim to grade against clinical-evidence data.

The evidence for skullcap doesn't give us a clear answer yet. The data we hold rates its effectiveness as insufficient for epilepsy, stress relief, stroke recovery, spasticity, contact dermatitis, and premenstrual dysphoric disorder (PMDD).

That means the research so far hasn't established reliable proof that it works for any of these uses — not that it doesn't work, just that we don't have the data to say one way or the other.

The evidence, ingredient by ingredient Skullcap

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Skullcap is often used short-term, but safety data is limited and product quality varies, so use it with care. The most common side effects reported with oral use are cognitive impairment, digestive disturbances, and sedation.

Mild digestive disturbances showed up in around 9% of people taking 350 mg three times daily for 2 weeks. Higher doses — particularly 200 mg and above — are more likely to cause sedation and cognitive slowness.

Pregnancy and breastfeeding: There isn't enough safety data for pregnancy, so it's best avoided if you're pregnant. Safety while breastfeeding is unknown as well, so avoid it during that time too.

If you're planning pregnancy, pregnant, or nursing, talk with your doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient Skullcap

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Skullcap.
  • The most serious interaction on file is rated Moderate.
  • For scale: 248 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check whether you use any CNS depressants — medications that slow your nervous system, like sleep aids, anti-anxiety drugs, sedating pain relievers, or certain antidepressants. Combining skullcap with these carries a moderate risk of additive drowsiness and cognitive impairment.

Use the medication checker on this page to verify your exact prescriptions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula marketed for general wellness rather than one specific gradeable purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Skullcap extract might appeal to you if you're looking for a traditional herbal option, but the evidence for what it actually does isn't established yet. The main thing to watch is sedation and cognitive effects, especially if you take other medications that make you drowsy.

Before you start, check your medications with the tool on this page, and talk with your pharmacist about whether it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Skullcap Extract 2,000 mg Alcohol-Free, straight from the product label.

Brand Nature's Answer
Barcode (UPC) 083000006722
Net contents 1 Fluid Ounce(s); 30 mL
Market status On market
Date entered into DSLD Mar 25, 2025
DSLD ID 326753
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher, Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Skullcap Extract 2,000 mg Alcohol-Free by Nature's Answer, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 mL
Maximum serving Sizes:
2 mL
Servings per container
15
UPC/BARCODE
083000006722
IngredientAmount% DV
Skullcap Aerial Parts Extract665 mg--

Other ingredients: Glycerin, Water, Purified

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

Gluten Free

Promotes overall health & wellbeing

Gluten-Free Alcohol-Free Absolutely no preservatives

Our alcohol-free extracts are produced using our cold Bio-Chelated proprietary extraction process, yielding a Holistically Balanced Advanced Botanical Fingerprint extract in the same synergistic ratios as in the plant.

Bio-Chelated Cold Extract Process

Seals/Symbols

K Parve (Kosher)

Formula

K Parve (Kosher)

Scutellaria lateriflora Made from 2,000 mg Skullcap Herb per serving

Brand IP Statement(s)

Nature's Answer Since 1972 Discover Nature's Answer

Copyright 2018 Nature's Answer

FDA Statement of Identity

Herbal Supplement

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take 2 mL (56 drops) three (3) times a day in a small amount of water. Shake well.

Precautions

Keep out of reach of children.

Warning: Do not use if pregnant or nursing.

Do not use if safety seal is damaged or missing.

General Statements

For product information, call (800)439-2324

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Skullcap Extract 2,000 mg Alcohol-Free by Nature's Answer label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Skullcap Extract 2,000 mg Alcohol-Free label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Skullcap Extract 2,000 mg Alcohol-Free by Nature's Answer

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 mL Dosage formLiquid Servings per container15 Amounts shown are per serving.

Skullcap Aerial Parts Extract

Interacts with
248 drugs
665 mg per serving

American skullcap is an herb traditionally used to calm anxiety and promote relaxation, but solid human evidence is very limited. It is generally cons...

Skullcap Aerial Parts Extract monograph & interactions

Other (inactive) ingredients: Glycerin, Water, Purified. These complete the product’s ingredient list but are not active constituents.

Interaction report

Skullcap Extract 2,000 mg Alcohol-Free by Nature's Answer Drug Interactions

Want to check YOUR meds against Skullcap Extract 2,000 mg Alcohol-Free?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
248Drugs
248 Moderate

Ingredients driving the most interactions

Skullcap Aerial Parts Extract 248

Individual Drug Interactions

The ingredients in Skullcap Extract 2,000 mg Alcohol-Free interact with 248 drugs. Click any drug to see the details.

1 of the 1 ingredient in Skullcap Extract 2,000 mg Alcohol-Free interact with drugs. Each result below shows which ingredient is responsible. Skullcap Aerial Parts Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Skullcap Extract 2,000 mg Alcohol-Free with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Skullcap Aerial Parts Extract1 drug type · 248 drugs

Cns Depressants

Theoretically, skullcap can have additive effects when used with other CNS depressants.
Animal and clinical research suggests that skullcap can cause sedation and cognitive impairment.

Likelihood Possible Evidence D
Skullcap Aerial Parts Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Skullcap Extract 2,000 mg Alcohol-Free, from the product label.

Nature's Answer

See all Nature's Answer products
Name
Nature's Answer
Street Address
85 Commerce Drive
City
Hauppauge
State
NY
ZipCode
11788
Phone Number
(800) 439-2324
Web Address
www.naturesanswer.com
Pharmacist Counseling Corner

Skullcap Extract 2,000 mg Alcohol-Free by Nature's Answer: Common Questions

Does Skullcap Extract 2,000 mg Alcohol-Free by Nature's Answer interact with any medications?
Yes. Based on its ingredients, Skullcap Extract 2,000 mg Alcohol-Free has a known interaction with 248 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Skullcap Extract 2,000 mg Alcohol-Free contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What dose is safe to take?
The product is 2,000 mg per serving, but we don't have dosing guidelines in our data. What we do know is that 100 mg didn't cause obvious CNS effects in one study, while 200 mg and higher doses did trigger sedation and cognitive slowness. Start low, talk with your pharmacist about what's right for you, and don't exceed doses without guidance.
Will this make me drowsy?
Yes, sedation is one of the most common side effects of skullcap, especially at higher doses. If you're sensitive to sedating effects or need to stay sharp, this product may not be a good fit. If you do take it, avoid driving or operating machinery until you know how it affects you.
Is this safe during pregnancy or breastfeeding?
No — there isn't enough safety data for pregnancy, so it's best avoided if you're pregnant. Safety while breastfeeding is unknown too, so avoid it during that time. Talk with your doctor or pharmacist if you're planning pregnancy, pregnant, or nursing and wondering about herbal options.
What is skullcap used for?
Skullcap has been used traditionally for things like epilepsy, stress, stroke recovery, spasticity, skin irritation, and menstrual symptoms. However, the research we have doesn't yet establish reliable proof that it works for any of these — the evidence is insufficient to rate its effectiveness.
What side effects might I notice?
The most common ones are sedation, cognitive impairment (feeling foggy or slow), and digestive disturbances. Mild digestive upset showed up in about 9% of people taking 350 mg three times daily for 2 weeks. One person also reported vivid dreams at that dose, though it's not clear if skullcap was the cause.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Skullcap Extract 2,000 mg Alcohol-Free is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Skullcap Extract 2,000 mg Alcohol-Free label
Go deeper

The Full Monographs Behind Skullcap Extract 2,000 mg Alcohol-Free’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Skullcap

Interacts with 248 drugs

American skullcap is an herb traditionally used to calm anxiety and promote relaxation, but solid human evidence is very limited. It is generally considered relatively safe for short-term us...

Read the full Skullcap monograph →
Sources

Sources & How We Checked

Skullcap Extract 2,000 mg Alcohol-Free's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Skullcap 3 references
  1. Wolfson P, Hoffmann DL. An investigation into the efficacy of Scutellaria lateriflora in healthy volunteers. Altern Ther Health Med 2003;9:74-8.
  2. Awad, R., Arnason, J. T., Trudeau, V., Bergeron, C., Budzinski, J. W., Foster, B. C., and Merali, Z. Phytochemical and biological analysis of skullcap (Scutellaria lateriflora L.): a medicinal plant with anxiolytic properties. Phytomedicine. 2003;10(8):6 PubMed
  3. Brock C, Whitehouse J, Tewfik I, Towell T. American skullcap (Scutellaria lateriflora): a randomised, double-blind placebo-controlled crossover study of its effects on mood in healthy volunteers. Phytother Res 2014;28(5):692-8.

See these in context on the Skullcap monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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