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Dietary supplement

Skullcap Ingredients & Drug Interactions

by Nature's Answer

Skullcap label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Skullcap against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Skullcap is a dietary supplement by Nature's Answer with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, trouble sleeping, nervous tension.Based on those ingredients, 248 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Skullcap (Scutellaria lateriflora) aerial parts extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Skullcap by Nature's Answer

Ask about any prescription or over-the-counter medication and we check it for interactions with Skullcap by Nature's Answer — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Skullcap by Nature's Answer

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Skullcap by Nature's Answer contains one active ingredient: an extract from the aerial parts (leaves and stems) of Scutellaria lateriflora, commonly known as skullcap. The extract is delivered in a liquid form using purified water, vegetable glycerin, and a small amount of certified organic alcohol as a base.

Does it work?

No specific claim
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
General wellness

This Skullcap product is marketed for general wellness, not a specific health condition, so there's no single claim to grade — see Skullcap's own graded uses on its monograph.

Why this rating?
  • The label markets general wellness (“promotes overall health and wellbeing”), not a specific health condition, so there is no single claim to grade against clinical-evidence data.

The evidence for skullcap's effectiveness is not established in our data. It's been used traditionally for epilepsy, stress, stroke recovery, spasticity, contact dermatitis, and premenstrual dysphoric disorder (PMDD), but reliable research backing these uses is insufficient.

If you're considering it for a specific condition, talk with your doctor about what the current evidence shows and whether it's a reasonable option for you.

The evidence, ingredient by ingredient Skullcap

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Skullcap is generally well tolerated at lower doses — a single 100 mg dose showed no adverse CNS effects in research — but higher doses carry risks. At 200 mg or more, sedation and cognitive impairment can occur; one person taking 350 mg three times daily reported vivid dreams.

Around 9% of patients in a short-term trial experienced mild digestive disturbances at that higher dose. Because safety data is limited and product quality varies, use skullcap with care and stick to short-term use.

The safety data advises against use during pregnancy and breastfeeding, so talk with your doctor or pharmacist if you're pregnant, planning pregnancy, or nursing.

Side effects, ingredient by ingredient Skullcap

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Skullcap.
  • The most serious interaction on file is rated Moderate.
  • For scale: 248 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check this product with your doctor or pharmacist if you take CNS depressants — sedating medications like sleep aids (benzodiazepines, zolpidem), anti-anxiety drugs, antidepressants with sedating effects, opioids, or muscle relaxants. Skullcap may strengthen their drowsiness and impair your thinking.

If you're on any of these, make sure your provider knows before you add skullcap.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula marketed for general wellness rather than one specific gradeable purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Skullcap may help some people, but the evidence isn't solid yet. Its main risk is adding to the sedating effects of sleep aids, anxiety medications, and similar drugs — a Moderate concern worth checking before you start.

If you're pregnant, breastfeeding, or taking any CNS depressants, confirm with your doctor or pharmacist that it's appropriate for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 7, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Skullcap, straight from the product label.

Brand Nature's Answer
Barcode (UPC) 083000004995
Net contents 1 fl. Oz.; 30 mL
Market status On market
Date entered into DSLD Jan 7, 2019
DSLD ID 185204
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Skullcap by Nature's Answer, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
2 mL
Servings per container
15
UPC/BARCODE
083000004995
IngredientAmount% DV
Skullcap (Scutellaria lateriflora) aerial parts extract450 mg--

Other ingredients: purified Water, Vegetable Glycerin, 12-15% certified organic Alcohol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Gluten Free

K Parve

Bio-Chelated Cold Extraction Process

Formula

K Parve

Scutellaria lateriflora Made From 1,600 mg Skullcap

Low Alcohol

General

9293 Rev. 717 1143

General Statements

Since 1972 Promotes Overall Health & Wellbeing

Brand IP Statement(s)

Discover Nature's Answer

Our alcohol extracts are produced using our cold Bio-Chelated proprietary extraction process, yielding a Holistically Balanced Advanced Botanical Fingerprint extract in the same synergistic ratios as in the plant.

2017 Nature's Answer

Formulation

Gluten-free

FDA Statement of Identity

Herbal Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 1-2 mL (28-56 drops) three (3) times a day in a small amount of water. Shake well.

Precautions

Keep out of reach of children.

Warning: Do you use if pregnant or nursing.

Do not use if safety seal is damaged or missing.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Skullcap by Nature's Answer label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Skullcap label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Skullcap by Nature's Answer

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 mL Dosage formLiquid Servings per container15 Amounts shown are per serving.

Skullcap (Scutellaria lateriflora) aerial parts extract

Interacts with
248 drugs
450 mg per serving

American skullcap is an herb traditionally used to calm anxiety and promote relaxation, but solid human evidence is very limited. It is generally cons...

Skullcap (Scutellaria lateriflora) aerial parts extract monograph & interactions

Other (inactive) ingredients: Purified Water, Vegetable Glycerin, 12-15% certified organic Alcohol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Skullcap by Nature's Answer Drug Interactions

Want to check YOUR meds against Skullcap?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
248Drugs
248 Moderate

Ingredients driving the most interactions

Skullcap (Scutellaria lateriflora) aerial parts extract 248

Individual Drug Interactions

The ingredients in Skullcap interact with 248 drugs. Click any drug to see the details.

1 of the 1 ingredient in Skullcap interact with drugs. Each result below shows which ingredient is responsible. Skullcap (Scutellaria lateriflora) aerial parts extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Skullcap with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Skullcap (Scutellaria lateriflora) aerial parts extract1 drug type · 248 drugs

Cns Depressants

Theoretically, skullcap can have additive effects when used with other CNS depressants.
Animal and clinical research suggests that skullcap can cause sedation and cognitive impairment.

Likelihood Possible Evidence D
Skullcap (Scutellaria lateriflora) aerial parts extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Skullcap, from the product label.

Nature's Answer

See all Nature's Answer products
Name
Nature's Answer
Street Address
85 Commerce Drive
City
Hauppauge
State
NY
ZipCode
11788
Phone Number
(800) 439-2324
Web Address
www.naturesanswer.com
Pharmacist Counseling Corner

Skullcap by Nature's Answer: Common Questions

Does Skullcap by Nature's Answer interact with any medications?
Yes. Based on its ingredients, Skullcap has a known interaction with 248 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Skullcap contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Skullcap if I'm pregnant or breastfeeding?
The safety data advises against use during pregnancy and breastfeeding because there isn't enough information to know it's safe. If you're pregnant, planning pregnancy, or nursing, talk with your doctor or pharmacist before taking it.
What are the most common side effects?
Sedation, cognitive impairment (trouble thinking clearly), and digestive disturbances are the most commonly reported. At higher doses like 200 mg or above, sedation and cognitive problems become more likely. About 9% of people in a trial at 350 mg three times daily had mild stomach issues.
Is there good evidence that skullcap works for stress or anxiety?
The evidence isn't established yet. Skullcap has been used traditionally for stress and other conditions, but reliable research backing these uses is insufficient. If you're considering it, ask your doctor what the current data shows.
What's in the liquid besides skullcap?
The liquid is made with purified water, vegetable glycerin, and a small amount of certified organic alcohol as a preservative base.
Can I take this with sleep aids or anti-anxiety medication?
Not without checking first. Skullcap can add to the sedating effects of these drugs, which may increase drowsiness and impair your thinking. Talk with your doctor or pharmacist before combining them.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Skullcap is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Skullcap label
Go deeper

The Full Monographs Behind Skullcap’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Skullcap

Interacts with 248 drugs

American skullcap is an herb traditionally used to calm anxiety and promote relaxation, but solid human evidence is very limited. It is generally considered relatively safe for short-term us...

Read the full Skullcap monograph →
Sources

Sources & How We Checked

Skullcap's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Skullcap 3 references
  1. Wolfson P, Hoffmann DL. An investigation into the efficacy of Scutellaria lateriflora in healthy volunteers. Altern Ther Health Med 2003;9:74-8.
  2. Awad, R., Arnason, J. T., Trudeau, V., Bergeron, C., Budzinski, J. W., Foster, B. C., and Merali, Z. Phytochemical and biological analysis of skullcap (Scutellaria lateriflora L.): a medicinal plant with anxiolytic properties. Phytomedicine. 2003;10(8):6 PubMed
  3. Brock C, Whitehouse J, Tewfik I, Towell T. American skullcap (Scutellaria lateriflora): a randomised, double-blind placebo-controlled crossover study of its effects on mood in healthy volunteers. Phytother Res 2014;28(5):692-8.

See these in context on the Skullcap monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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