Major interaction on record — check this product against your medications before combining. Based on 3 of 5 ingredients. Check your meds →
Dietary supplement

Sleep SR Ingredients & Drug Interactions

by Kaged Muscle

Sleep SR label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Sleep SR against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Sleep SR is a dietary supplement by Kaged Muscle with 5 active ingredients. Its ingredients are commonly taken for sleep problems, low mood and depression, anxiety.Based on those ingredients, 1,495 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are MicroActive Melatonin, L-Tryptophan, Vitamin B6. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Sleep SR by Kaged Muscle

Ask about any prescription or over-the-counter medication and we check it for interactions with Sleep SR by Kaged Muscle — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Sleep SR by Kaged Muscle

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Sleep SR contains five active ingredients. L-tryptophan is an amino acid your body uses to make serotonin, a chemical linked to mood and sleep.

Vitamin B6 is a B vitamin that supports energy and nerve function. Folate (vitamin B9) helps with cell division and DNA.

MicroActive Melatonin is a form of melatonin, the hormone your body makes naturally to regulate sleep-wake cycles. Lactium is a milk-derived ingredient.

The product also contains inactive ingredients like cellulose, rice extract, and gum arabic as binders and fillers.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Fall asleep faster and stay asleep longer.
  • We looked for evidence on: Insomnia, Delayed sleep phase syndrome (DSPS), Jet lag, Non-24-hour sleep wake disorder, Beta blocker-induced insomnia, Benzodiazepine withdrawal — and 3 related terms.
  • The strongest evidence on file: Melatonin is rated "Likely Effective" for Delayed sleep phase syndrome (DSPS) (Natural Medicines).
  • Also on file: Melatonin is rated "Likely Effective" for Non-24-hour sleep wake disorder.
  • Also on file: Melatonin is rated "Possibly Effective" for Jet lag, Beta blocker-induced insomnia.

The evidence for Sleep SR's ingredients is mixed. Melatonin is likely effective for delayed sleep phase disorder and non-24-hour sleep-wake disorder, and possibly effective for pre-procedural anxiety.

L-tryptophan shows possibly ineffective evidence for depression and insufficient evidence for anxiety, athletic performance, and bruxism (teeth grinding). Vitamin B6 is effective for sideroblastic anemia, vitamin B6 deficiency, and pyridoxine-dependent epilepsy, and likely effective for high homocysteine levels—but we have no effectiveness data in our records for sleep or insomnia.

The evidence for folate and lactium for sleep support isn't established in the data we hold.

The evidence, ingredient by ingredient L-tryptophan Vitamin B6 Melatonin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-tryptophan is generally well tolerated but has a complicated history. Most common side effects are belching, diarrhea, drowsiness, dry mouth, flatulence, headache, heartburn, lightheadedness, nausea, and stomach pain.

In 1989, a contaminated batch from one Japanese manufacturer caused over 1,500 cases of eosinophilia-myalgia syndrome (EMS), a rare neurological disorder; since then, the FDA has restricted L-tryptophan imports. Pregnancy safety data for L-tryptophan is mixed—some evidence suggests it's likely safe, but other evidence marks it possibly unsafe, so talk with your doctor.

Avoid it while breastfeeding; safety data is not established. Vitamin B6 is well tolerated at normal doses but high doses taken long-term can cause nerve damage (sensory neuropathy).

Melatonin is generally well tolerated for short-term use, though long-term safety is less certain. Common side effects are dizziness, drowsiness, headache, and nausea.

Melatonin is possibly unsafe in pregnancy and should be avoided while breastfeeding. We hold no pregnancy or breastfeeding data for folate or lactium in this product.

Side effects, ingredient by ingredient L-tryptophan Vitamin B6 Melatonin

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — L-tryptophan, Vitamin B6, Melatonin.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; seizure medications; immunosuppressants / transplant drugs; diabetes medications; Parkinson's medications.
  • For scale: 1,496 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Sleep SR, double-check with your pharmacist if you take CNS depressants (sedatives, sleep aids, some pain relievers)—L-tryptophan could cause dangerous excess drowsiness. Also check if you're on serotonergic drugs like antidepressants or migraine medications, antihypertensives (blood pressure drugs), anticonvulsants or seizure medications, anticoagulants or antiplatelet drugs (blood thinners), diabetes medications, immunosuppressants, or amiodarone.

These are documented interactions at Moderate or Major severity.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

Sleep SR may help if you have a delayed sleep phase disorder or non-24-hour sleep-wake disorder, but evidence for general insomnia or sleep support isn't established in our data. If you take any CNS depressants, serotonergic drugs, blood pressure medications, seizure medications, blood thinners, or diabetes drugs, check with your pharmacist before starting—the interactions are real and could matter.

Talk to your doctor or pharmacist about whether this product fits your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Sleep SR, straight from the product label.

Brand Kaged Muscle
Barcode (UPC) 050015107320
Net contents 30 Veggie Capsule(s)
Market status On market
Date entered into DSLD Feb 23, 2025
DSLD ID 323468
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Sleep SR by Kaged Muscle, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
050015107320
IngredientAmount% DV
L-Tryptophan275 mg--
Vitamin B610 mg588%
Folate200 mcg DFE50%
MicroActive Melatonin2 mg--
Lactium150 mg--

Other ingredients: Cellulose, Rice extract, Rice, Gum Arabic, Sunflower Oil, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Fall asleep faster Stay asleep longer Reduce stress Wake up refreshed

Optimize your evening ritual Sleep SR is a 7 hour sustained release sleep and relaxation formula.

For relief of occasional sleeplessness

Formula

Premium ingredients like B6, folic acid, tryptophan, and lactium support stress relief and relaxation. Sleep SR provides the perfect amount of melatonin throughout the night, so you wake up feeling refreshed and energized. Quaetrefolic Lactium

Seals/Symbols

Informed Sport We Test - You Trust Banned Substance Tested Every Batch

General Statements

Never Stop Evolving

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Precautions

Contains: Milk.

Warning: Not intended for people with medical conditions affecting sleep.

Consult your physician prior to using this product if you are pregnant, nursing, under 18 years of age, take medication or have a medical condition.

Immediately discontinue use and contact your physician if any adverse reactions occur. Do not drive or operate heavy machinery after use.

Consult your physician prior to using this product if you are pregnant, nursing, under 18 years of age, take medication or have a medical condition. Keep out of reach of children.

This product contains a silica gel pack. Do not eat.

Suggested/Recommended/Usage/Directions

Directions: Take 1 capsule 30-60 minutes before bed for relief of occasional sleeplessness.

Storage

Store in a cool, dry place, avoid direct sunlight, humidity and high temperatures. Replace lid after use.

Brand IP Statement(s)

Copyright 2022 Kaged Muscle LLC. Quatrefolic is a registered trademark of Gnosis S.p.A. U.S. Patent No. 7,947,662. MicroActive Melatonin is a registered trademark of Bioactives LLC.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Sleep SR by Kaged Muscle label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Sleep SR label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Sleep SR by Kaged Muscle

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Tryptophan

Interacts with
394 drugs
275 mg per serving

L-tryptophan is an essential amino acid the body uses to make serotonin and melatonin, and people take it to support sleep and mood. The evidence for...

L-Tryptophan monograph & interactions

Vitamin B6

Interacts with
210 drugs
10 mg per serving Form: Pyridoxal 5-Phosphate

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B6 monograph & interactions

Folate

200 mcg DFE per serving Form: Quatrefolic

MicroActive Melatonin

Interacts with
1,461 drugs
2 mg per serving Form: Melatonin

Melatonin is a hormone your body makes naturally to help control your sleep-wake cycle, and the supplement form is widely used to help with sleep timi...

MicroActive Melatonin monograph & interactions

Lactium

150 mg per serving

Other (inactive) ingredients: Cellulose, Rice extract, Rice, Gum Arabic, Sunflower Oil, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Sleep SR by Kaged Muscle Drug Interactions

Want to check YOUR meds against Sleep SR?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,495Drugs
248 Major 937 Moderate 310 Minor

Ingredients driving the most interactions

MicroActive Melatonin 1,461
L-Tryptophan 394
Vitamin B6 210

Individual Drug Interactions

The ingredients in Sleep SR interact with 1,495 drugs. Click any drug to see the details.

3 of the 5 ingredients in Sleep SR interact with drugs. Each result below shows which ingredient is responsible. MicroActive Melatonin L-Tryptophan Vitamin B6

Each ingredient & the kinds of drugs it affects

For each ingredient in Sleep SR with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

MicroActive Melatonin18 drug types · 1,461 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, melatonin may have anticoagulant effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
There are isolated case reports of minor bleeding and decreased prothrombin activity in people taking melatonin with warfarin (Coumadin). The mechanism, if any, of this interaction is unknown. Taking melatonin orally seems to decrease coagulation activity within one hour of dosing in healthy men.

Likelihood Possible Evidence B
Anticonvulsants

Theoretically, melatonin may reduce the effects of anticonvulsants. Some clinical research suggests that melatonin may increase the frequency of seizures in certain patients, particularly children with neurological impairment.

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, taking melatonin with antidiabetes drugs might increase the risk of hypoglycemia.
Some clinical research shows that melatonin reduces levels of fasting blood glucose and improves glycemic control. However, other research suggests that melatonin might impair glucose utilization and increase insulin resistance, while other research has found no effect on glucose levels. Until more is known, use melatonin cautiously in combination with antidiabetes drugs.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking melatonin with antihypertensive drugs might increase the risk of hypotension or hypertension.
Some clinical research suggests that taking melatonin decreases blood pressure in healthy adults. Also, melatonin seems to lower systolic and diastolic blood pressure in individuals with high blood pressure at nighttime or untreated essential hypertension. However, melatonin seems to worsen blood pressure in patients who are taking antihypertensive medications. Immediate-release melatonin 5 mg at night in combination with nifedipine GITS (Procardia XL) increases systolic blood pressure an average of 6.5 mmHg, diastolic blood pressure by an average of 4.9 mmHg, and heart rate by 3.9 bpm. Also, results from animal research suggest that melatonin reduces the effectiveness of certain antihypertensive drugs, including methoxamine and clonidine.

Likelihood Possible Evidence A
Caffeine

Theoretically, taking caffeine with melatonin might increase levels of melatonin.
Some evidence suggests that caffeine consumption can decrease endogenous melatonin levels, while other evidence suggests that caffeine increases endogenous melatonin levels. When administered in combination with melatonin supplements, caffeine seems to increase melatonin effects and levels. The reason for this discrepancy is not completely clear. Part of the discrepancy may result from the fact that caffeine can inhibit melatonin synthesis as well as inhibit melatonin metabolism. By functioning as an adenosine receptor antagonist, caffeine may indirectly inhibit the synthesis of melatonin. Conversely, because melatonin and caffeine are both metabolized by cytochrome P450 1A2 (CYP1A2) enzyme, concomitant use of melatonin and caffeine may reduce the metabolism of melatonin, resulting in higher serum levels.

Likelihood Probable Evidence B
Cns Depressants

Theoretically, taking melatonin might increase the sedative effects of CNS depressants.
Melatonin has sedative effects. Theoretically, concomitant use of melatonin with alcohol, benzodiazepines, or other sedative drugs might cause additive sedation.

Likelihood Possible Evidence D
Contraceptive Drugs

Theoretically, taking contraceptive drugs with melatonin might increase the effects and adverse effects of melatonin.
Contraceptive drugs can increase the levels of endogenous melatonin. Theoretically, these drugs may increase the effects and adverse effects of oral melatonin.

Likelihood Probable Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, melatonin might increase levels of drugs metabolized by CYP1A2. Also, other CYP1A2 substrates might decrease the metabolism of melatonin, increasing melatonin levels.
Melatonin is metabolized in the liver primarily by the CYP2C19 and CYP1A2 enzymes. Theoretically, combined administration of melatonin with drugs metabolized by the CYP1A2 enzyme might reduce the metabolism of these drugs, resulting in increased serum levels. Conversely, some drugs metabolized by CYP1A2 may inhibit the metabolism of melatonin, resulting in increased serum levels of melatonin. Until more is known, use melatonin cautiously in patients taking drugs metabolized by these enzymes.

Likelihood Probable Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, melatonin might increase levels of drugs metabolized by CYP2C19. Also, other CYP2C19 substrates might decrease the metabolism of melatonin, increasing melatonin levels.
Melatonin is metabolized in the liver primarily by the CYP2C19 and CYP1A2 enzymes. Theoretically, combined administration of melatonin with certain drugs metabolized by the CYP2C19 enzyme may reduce the metabolism of these drugs, resulting in increased serum levels. Conversely, some drugs metabolized by CYP2C19 may inhibit the metabolism of melatonin, resulting in increased serum levels of melatonin. Until more is known, use melatonin cautiously in patients taking drugs metabolized by these enzymes.

Likelihood Probable Evidence D
Fluvoxamine (Luvox)

Theoretically, taking fluvoxamine with melatonin might increase levels of melatonin.
Fluvoxamine can significantly increase melatonin levels. In some cases, fluvoxamine might increase bioavailability of exogenously administered melatonin by up to 20 times. Some researchers think this might be a beneficial interaction and be potentially useful for cases of refractory insomnia. However, this interaction might also cause unwanted excessive drowsiness and possibly other adverse effects. Fluvoxamine is known to increase endogenous melatonin secretion. It seems to increase serum levels of exogenously administered melatonin possibly by decreasing melatonin metabolism by inhibiting cytochrome P450 (CYP450) 1A2 and 2C19 or by inhibiting melatonin elimination. This effect has been found in healthy people taking fluvoxamine 50-75 mg and melatonin 5 mg.

Likelihood Probable Evidence B
Immunosuppressants

Theoretically, melatonin might interfere with immunosuppressive therapy.
Melatonin can stimulate immune function. Theoretically, melatonin might interfere with immunosuppressive therapy.

Likelihood Possible Evidence B
Methamphetamine (Desoxyn)

Theoretically, taking melatonin with methamphetamine may increase the adverse effects of methamphetamine.
Animal research suggests that melatonin exacerbates the adverse effects of methamphetamine, resulting in greater depression of tryptophan hydroxylase (TPH) and tyrosine hydroxylase (TH) activity, as well as a significant reduction in dopamine levels. This has not been shown in humans.

Likelihood Possible Evidence D
Nifedipine Gits (Procardia Xl)

Theoretically, taking melatonin with extended release nifedipine reduces the effects of nifedipine.
Melatonin can decrease the effectiveness of extended release nifedipine (GITS). Immediate-release melatonin 5 mg at night in combination with nifedipine GITS 30-60 mg daily increases systolic and blood pressure by an average of 6.5 mmHg and 4.9 mmHg, respectively. Concomitant use with melatonin also increases heart rate by 3.9 bpm. The mechanism of this interaction is not known.

Likelihood Probable Evidence B
Seizure Threshold Lowering Drugs

Theoretically, taking melatonin with drugs that lower the seizure threshold might increase the risk of seizure activity.
Some clinical evidence suggests that melatonin may increase the frequency of seizures in certain patients, particularly children with neurological disabilities.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, melatonin may have antiplatelet effects and may increase the risk of bleeding with warfarin.
Three cases of increased prothrombin time have been reported for patients aged 48-72 years who took melatonin orally in combination with warfarin. However, three cases of decreased prothrombin time have also been reported for patients aged 51-84 years who took melatonin orally in combination with warfarin. Until more is known, use melatonin cautiously in patients taking warfarin.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, melatonin might increase levels of drugs metabolized by CYP2D6.
Laboratory research suggests that certain lots of melatonin inhibit CYP2D6. Theoretically, combined administration of melatonin with certain drugs metabolized by the CYP2D6 enzyme may reduce the metabolism of these drugs, resulting in increased serum levels. Until more is known, use melatonin cautiously in patients taking drugs metabolized by these enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, melatonin might increase levels of drugs metabolized by CYP3A4.
Laboratory research shows that certain lots of melatonin inhibit CYP3A4. Theoretically, combined administration of melatonin with certain drugs metabolized by CYP3A4 may reduce the metabolism of these drugs, resulting in increased serum levels. Until more is known, use melatonin cautiously in patients taking drugs metabolized by these enzymes.

Likelihood Possible Evidence D
Flumazenil (Romazicon)

Theoretically, taking flumazenil with melatonin might reduce the effects of melatonin.
Animal research shows that flumazenil may inhibit the effect of melatonin.

Likelihood Possible Evidence D
MicroActive Melatonin full monograph & interactions

L-Tryptophan2 drug types · 394 drugs

Cns Depressants

Theoretically, concomitant use of L-tryptophan with CNS depressants might cause additive sedative effects.
Clinical research shows that L-tryptophan can cause fatigue and drowsiness.

Likelihood Probable Evidence B
Serotonergic Drugs

Theoretically, combining L-tryptophan with serotonergic drugs might cause additive serotonergic effects.
L-tryptophan is a precursor to serotonin. Theoretically, combining serotonergic drugs with L-tryptophan might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders.

Likelihood Possible Evidence D
L-Tryptophan full monograph & interactions

Vitamin B65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
Vitamin B6 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Sleep SR, from the product label.

Kaged Muscle

See all Kaged Muscle products
Name
Kaged
Street Address
17872 Gillette Ave, #475
City
Irvine
State
CA
ZipCode
92614
Phone Number
844.445.2433
Web Address
Kaged.com
Pharmacist Counseling Corner

Sleep SR by Kaged Muscle: Common Questions

Does Sleep SR by Kaged Muscle interact with any medications?
Yes. Based on its ingredients, Sleep SR has a known interaction with 1,495 medications, including 248 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Sleep SR contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Sleep SR if I'm pregnant?
The safety data for the ingredients in this product are mixed or insufficient for pregnancy. L-tryptophan has conflicting evidence—some data suggests it's likely safe, but other data marks it possibly unsafe. Melatonin is rated possibly unsafe in pregnancy. Talk with your doctor or midwife before taking it; they know your full health picture and can advise on whether it's right for you.
Is it safe to breastfeed while taking this?
No. L-tryptophan safety while breastfeeding is not established, so you should avoid it. Melatonin safety while breastfeeding hasn't been established either. If you're nursing and considering a sleep aid, talk with your doctor or pharmacist first.
What are the most common side effects?
From L-tryptophan: belching, diarrhea, drowsiness, dry mouth, flatulence, headache, heartburn, lightheadedness, nausea, and stomach pain. From melatonin: dizziness, drowsiness, headache, and nausea. From vitamin B6: headache, nausea, and loss of appetite. Most people tolerate these ingredients well, but if you notice any bothersome effects, let your pharmacist know.
Will Sleep SR work for regular insomnia?
Melatonin in this product is backed by evidence for delayed sleep phase disorder and non-24-hour sleep-wake disorder—specific sleep conditions. For general insomnia, the effectiveness evidence in our data is not established. Talk with your doctor about whether this product matches your sleep issue.
Is there any concern about L-tryptophan safety?
L-tryptophan is generally well tolerated, but there's important history: in 1989, a contaminated batch caused over 1,500 cases of a serious neurological disorder called eosinophilia-myalgia syndrome. The FDA now restricts L-tryptophan imports. Modern products are much safer, but this is why it's important to check with your pharmacist before starting.
Can high-dose vitamin B6 in this product harm my nerves?
Vitamin B6 is safe at normal dietary amounts and standard supplement doses. High doses taken long-term can cause sensory neuropathy (nerve damage), especially doses over 1,000 mg daily. Sleep SR's dose isn't specified on the facts provided, so ask your pharmacist whether the amount in this product poses any concern for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Sleep SR is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Sleep SR label
Go deeper

The Full Monographs Behind Sleep SR’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

L-tryptophan

Interacts with 394 drugs

L-tryptophan is an essential amino acid the body uses to make serotonin and melatonin, and people take it to support sleep and mood. The evidence for supplement use is limited and mixed, and...

Read the full L-tryptophan monograph → Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph → Herb & supplement monograph

Melatonin

Interacts with 1,461 drugs

Melatonin is a hormone your body makes naturally to help control your sleep-wake cycle, and the supplement form is widely used to help with sleep timing problems and jet lag. The evidence is...

Read the full Melatonin monograph →
Sources

Sources & How We Checked

Sleep SR's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 168 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

L-tryptophan 18 references
  1. Messiha FS. Fluoxetine: adverse effects and drug-drug interactions. J Toxicol Clin Toxicol 1993;31:603-30. PubMed
  2. Devoe LD, Castillo RA, Searle NS. Maternal dietary substrates and human fetal biophysical activity. The effects of tryptophan and glucose on fetal breathing movements. Am J Obstet Gynecol 1986;155:135-9. DOI
  3. Lieberman HR, Corkin S, Spring BJ. The effects of dietary neurotransmitter precursors on human behavior. Am J Clin Nutr 1985;42:366-70. PubMed
  4. U. S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Nutritional Products, Labeling, and Dietary Supplements. Information Paper on L-Tryptophan and 5-hydroxy-L-tryptophan, February 2001.
  5. Sullivan EA, Kamb ML, Jones JL, et al. The natural history of eosinophilia-myalgia syndrome in a tryptophan-exposed cohort in South Carolina. Arch Intern Med 1996;156:973-9. DOI
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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