Interactions on record — worth a quick check against your medications. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

Smart PS Green Phosphatidylserine Ingredients & Drug Interactions

by Nootropics Depot

Smart PS Green Phosphatidylserine label
See full label image
Softgel Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Oct 7, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Smart PS Green Phosphatidylserine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Smart PS Green Phosphatidylserine is a dietary supplement by Nootropics Depot with 3 active ingredients. Its ingredients are commonly taken for memory and cognitive support, age-related cognitive decline, attention and focus (adhd).Based on those ingredients, 219 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sharp-PS Green. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Smart PS Green Phosphatidylserine by Nootropics Depot

Ask about any prescription or over-the-counter medication and we check it for interactions with Smart PS Green Phosphatidylserine by Nootropics Depot — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Smart PS Green Phosphatidylserine by Nootropics Depot

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • “Sharp-PS Green” is listed as a grouped ingredient — the label gives one combined amount (556 mg) without saying how much of each component you get.

Smart PS Green Phosphatidylserine is a single-ingredient softgel: phosphatidylserine, a fat-like compound found in cell membranes. The product uses Sharp-PS Green, a branded form of this ingredient.

It's rounded out with standard capsule fillers — gelatin, glycerin, polyglycitol syrup, and purified water.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Phosphatidylserine's overall clinical evidence instead.

Moderate

Some clinical evidence supports Phosphatidylserine for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Age-related cognitive decline — rated "Possibly Effective" (Natural Medicines).
  • On file: Alzheimer disease — rated "Possibly Effective" (Natural Medicines).

Phosphatidylserine is possibly effective for age-related cognitive decline and Alzheimer disease based on the evidence we hold. For athletic performance, attention deficit-hyperactivity disorder (ADHD), general cognitive function, and dementia, the reliable evidence isn't established yet — we can't say whether it works for those uses.

The evidence, ingredient by ingredient Phosphatidylserine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Phosphatidylserine is generally well tolerated in studies, though long-term safety isn't fully established. The most common side effects are flatulence, gastrointestinal upset, headache, insomnia, and nausea — with gastrointestinal symptoms possible at doses of 200–300 mg/day and insomnia more likely at 600 mg or higher.

The safety data advises against use during pregnancy and while breastfeeding because there isn't enough information to say it's safe in either situation. Talk with your doctor or pharmacist about whether this product makes sense for you if you're pregnant, planning pregnancy, or nursing.

Side effects, ingredient by ingredient Phosphatidylserine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Phosphatidylserine.
  • The most serious interaction on file is rated Moderate.
  • For scale: 219 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Smart PS Green, double-check if you're on anticholinergic drugs or cholinergic medications (Moderate severity for both). Phosphatidylserine may interfere with how anticholinergics work or amplify cholinergic effects.

Your doctor or pharmacist can review your specific prescriptions against the full interaction list on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Smart PS Green may be worth considering if you're concerned about age-related cognitive decline or Alzheimer disease, since phosphatidylserine has some evidence behind it for those uses. If you take anticholinergic or cholinergic medications, check with your doctor or pharmacist first — the interactions are theoretical but worth discussing before you add this in.

Keep an eye out for nausea, headache, or sleep trouble, and don't expect results overnight.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Smart PS Green Phosphatidylserine, straight from the product label.

Brand Nootropics Depot
Net contents 120 Softgel(s)
Market status On market
Date entered into DSLD Aug 23, 2020
DSLD ID 232636
Product type Fat/fatty Acid
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Smart PS Green Phosphatidylserine by Nootropics Depot, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
120
IngredientAmount% DV
Total Carbohydrates61.33 mg1%
Total Fat411.44 mg1%
Saturated Fat411.44 mg1%
Protein169.47 mg1%
Total Calories4.63 Calorie(s)--
Phosphatidylserine100 mg--
Sharp-PS Green556 mg--

Other ingredients: Gelatin, Glycerin, Polyglycitol Syrup, purified Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Soy-free Softgels

FDA Statement of Identity

Dietary Supplement

Precautions

Disclaimer: Always consult with a qualified health physician before taking any new dietary supplement.

Warning: Keep out of reach of children. Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions, and/or taking prescription drug(s) or OTC medication(s).

Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions, and/or taking prescription drug(s) or OTC medication(s).

FDA Disclaimer Statement

This product is not intended to diagnose, treat, cure or prevent any diseases. These statements have not been evaluated by the Food & Drug Administration.

Storage

Suggested Use: As a dietary supplement, take 1 softgel daily.

Brand IP Statement(s)

Smart PS is a trademark of Soft Gel Technologies, Inc. Sharp PS is a registered trademark of Enzymotec Ltd.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Smart PS Green Phosphatidylserine by Nootropics Depot label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Smart PS Green Phosphatidylserine label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Smart PS Green Phosphatidylserine by Nootropics Depot

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container120 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Protein

169.47 mg per serving

Total Calories

4.63 Calorie(s) per serving

Sharp-PS Green

Interacts with
219 drugs
556 mg per serving

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinki...

Sharp-PS Green monograph & interactions

Other (inactive) ingredients: Gelatin, Glycerin, Polyglycitol Syrup, Purified Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Smart PS Green Phosphatidylserine by Nootropics Depot Drug Interactions

Want to check YOUR meds against Smart PS Green Phosphatidylserine?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
219Drugs
219 Moderate

Ingredients driving the most interactions

Sharp-PS Green 219

Individual Drug Interactions

The ingredients in Smart PS Green Phosphatidylserine interact with 219 drugs. Click any drug to see the details.

1 of the 3 ingredients in Smart PS Green Phosphatidylserine interact with drugs. Each result below shows which ingredient is responsible. Sharp-PS Green

Each ingredient & the kinds of drugs it affects

For each ingredient in Smart PS Green Phosphatidylserine with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Sharp-PS Green2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically interfere with the activity of anticholinergic agents.

Likelihood Possible Evidence B
Cholinergic Drugs

Theoretically, phosphatidylserine might have additive effects with cholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically lead to additive cholinergic effects when used with cholinergic drugs.

Likelihood Possible Evidence B
Sharp-PS Green full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Smart PS Green Phosphatidylserine, from the product label.

Nootropics Depot

See all Nootropics Depot products
Name
Nootropics Depot
Street Address
8380 S. Kyrene Rd. Ste. 110
City
Tempe
State
AZ
ZipCode
85284
Web Address
nootropicsdepot.com
Pharmacist Counseling Corner

Smart PS Green Phosphatidylserine by Nootropics Depot: Common Questions

Does Smart PS Green Phosphatidylserine by Nootropics Depot interact with any medications?
Yes. Based on its ingredients, Smart PS Green Phosphatidylserine has a known interaction with 219 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Smart PS Green Phosphatidylserine contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
The safety data advises against it. There isn't enough information to say phosphatidylserine is safe during pregnancy or while breastfeeding. Talk with your doctor or pharmacist about your situation — they can help you decide if it's right for you.
What are the most common side effects?
Flatulence, gastrointestinal upset, headache, insomnia, and nausea. GI symptoms can show up at doses around 200–300 mg/day, and insomnia is more likely at 600 mg or higher. Most people tolerate it fine in studies, though.
Does phosphatidylserine actually work for brain health?
For age-related cognitive decline and Alzheimer disease, it's possibly effective based on the evidence we hold. For ADHD, general cognitive function, athletic performance, and dementia, the evidence isn't solid enough yet for us to say whether it works.
How long does it take to work?
The product facts don't specify a timeframe. Talk with your doctor or pharmacist about realistic timelines for your particular reason for taking it.
Is there anything else in this besides phosphatidylserine?
Just the inactive ingredients that make up the capsule — gelatin, glycerin, polyglycitol syrup, and purified water. It's a straightforward single-ingredient formula.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Smart PS Green Phosphatidylserine is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Smart PS Green Phosphatidylserine label
Go deeper

The Full Monographs Behind Smart PS Green Phosphatidylserine’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Phosphatidylserine

Interacts with 219 drugs

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinking. Some research suggests possible bene...

Read the full Phosphatidylserine monograph →
Sources

Sources & How We Checked

Smart PS Green Phosphatidylserine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Phosphatidylserine 9 references
  1. Crook T, Petrie W, Wells C, Massari DC. Effects of phosphatidylserine in Alzheimer's disease. Psychopharmacol Bull 1992;28:61-6.
  2. Pepping J. Phosphatidylserine. Am J Health-Syst Pharm 1999;56:2038,2043-4.
  3. Kidd PM. Phosphatidylserine; Membrane nutrient for memory. A clinical and mechanistic assessment. Altern Med Rev 1996;1:70-84.
  4. Kim HY, Akbar M, Lau A, et al. Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3). Role of phosphatidylserine in antiapoptotic effect. J Biol Chem 2000;275:35215-23.. PubMed
  5. Zanotti A, Valzelli L, Toffano G. Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats. Psychopharmacology (Berl) 1989;99:316-21.. PubMed
  6. Schreiber S, Kampf-Sherf O, Gorfine M, et al. An open trial of plant-source derived phosphatydilserine for treatment of age-related cognitive decline. Isr J Psychiatry Relat Sci 2000;37:302-7.
  7. Pepping, J. Phosphatidylserine. Am J Health Syst.Pharm. 10-15-1999;56(20):2038, 2043-2038, 2044.
  8. Monteverde, A., Gnemmi, P., Rossi, F., Monteverde, A., and Finali, G. C. Selegiline in the treatment of mild to moderate Alzheimer-type dementia. Clin.Ther 1990;12(4):315-322.
  9. Vakhapova V, Cohen T, Richter Y, Herzog Y, Kam Y, Korczyn AD. Phosphatidylserine containing omega-3 Fatty acids may improve memory abilities in nondemented elderly individuals with memory complaints: results from an open-label extension study. Dement Geri PubMed

See these in context on the Phosphatidylserine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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