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Dietary supplement

SpectraZyme Metagest Ingredients & Drug Interactions

by Metagenics

SpectraZyme Metagest label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking SpectraZyme Metagest against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

SpectraZyme Metagest is a dietary supplement by Metagenics with 2 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.Based on those ingredients, 36 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Betain HCl. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against SpectraZyme Metagest by Metagenics

Ask about any prescription or over-the-counter medication and we check it for interactions with SpectraZyme Metagest by Metagenics — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of SpectraZyme Metagest by Metagenics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

SpectraZyme Metagest has 2 active ingredients: pepsin and betaine hydrochloride. Pepsin is a proteolytic enzyme—a protein-digesting enzyme that works in the stomach to break down food.

Betaine hydrochloride is a compound that increases stomach acid to support digestion. The product also contains several inactive ingredients like microcrystalline cellulose, stearic acid, and silica, which help form and coat the tablet.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: digestive support and stomach acid complement.
  • We looked for evidence on: Dyspepsia, indigestion, bloating, protein digestion.
  • The closest evidence on file: Betaine Hydrochloride is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia (Natural Medicines).

The evidence on both ingredients is sparse. For betaine hydrochloride, there is insufficient reliable evidence to rate its use for indigestion (dyspepsia), low thyroid function, diarrhea, rheumatoid arthritis, food allergies, or hay fever.

No effectiveness ratings are on file for pepsin in our data.

The evidence, ingredient by ingredient Proteolytic Enzymes (proteases) Betaine Hydrochloride

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pepsin is generally well tolerated for most adults but may cause digestive upset or allergic reactions. In rare cases, occupational exposure to airborne pepsin has caused allergic rhinitis or asthma symptoms.

Betaine hydrochloride may irritate the stomach and is not safe if you have ulcers, gastritis, or true acid reflux; it can theoretically irritate or slow the healing of ulcers and may cause heartburn. The safety data advises against both ingredients during pregnancy.

For breastfeeding, there is little safety data on pepsin—use is not recommended without medical advice—and betaine hydrochloride should be avoided because safety has not been established.

Side effects, ingredient by ingredient Proteolytic Enzymes (proteases) Betaine Hydrochloride

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Betaine Hydrochloride.
  • The most serious interaction on file is rated Minor.
  • For scale: 36 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take SpectraZyme Metagest, double-check if you're on H2-blockers, antacids, or proton pump inhibitors (PPIs)—betaine hydrochloride may reduce how well these medications work. Use the search tool on this page to verify your exact drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Only minor medication interactions are documented, and safety information is well characterized.

This product is intended to support protein digestion and stomach acid. It's not right for anyone with ulcers, gastritis, or acid reflux.

If you take acid-reducing medications or have a history of stomach problems, talk to your pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about SpectraZyme Metagest, straight from the product label.

Brand Metagenics
Barcode (UPC) 755571939661
Net contents 270 Tablet(s)
Market status On market
Date entered into DSLD Mar 24, 2020
DSLD ID 216257
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for SpectraZyme Metagest by Metagenics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Tablet(s)
Maximum serving Sizes:
2 Tablet(s)
Servings per container
135
UPC/BARCODE
755571939661
IngredientAmount% DV
Pepsin90 mg--
Betain HCl1.3 Gram(s)--

Other ingredients: silicified Microcrystalline Cellulose, Stearic Acid, Cellulose, Silica, Magnesium Stearate, Coating

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

SpectraZyme Metagest features betaine HCl combined with pepsin - a proteolytic enzyme - to complement the natural production of digestive agents in the stomach.

Features Betaine HCI & Pepsin

Suggested/Recommended/Usage/Directions

Directions: Take two tablets with each meal, or as directed by your healthcare practitioner.

Formulation

This product is non-GMO and gluten free.

Stomach Acid Support

Precautions

Caution: If stomach discomfort occurs after administration, discontinue use and consult your healthcare practitioner. Do not use if there is a prior history of or a current peptic or duodenal ulcer.

Consult your healthcare practitioner if pregnant or nursing, or if taking other nutritional supplements or medications.

Keep out of the reach of children.

Storage

Storage: Keep tightly closed in a cool, dry place. Do not refrigerate.

Seals/Symbols

GF Certified Gluten-free

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

General Statements

Practitioner exclusive

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

SpectraZyme Metagest by Metagenics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

SpectraZyme Metagest label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in SpectraZyme Metagest by Metagenics

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Tablet(s) Dosage formTablet Or Pill Servings per container135 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Pepsin

No known
interactions
90 mg per serving Form: Porcine

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Pepsin monograph & interactions

Betain HCl

Interacts with
36 drugs
1.3 Gram(s) per serving

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is l...

Betain HCl monograph & interactions

Other (inactive) ingredients: Silicified Microcrystalline Cellulose, Stearic Acid, Cellulose, Silica, Magnesium Stearate, Coating. These complete the product’s ingredient list but are not active constituents.

Interaction report

SpectraZyme Metagest by Metagenics Drug Interactions

Want to check YOUR meds against SpectraZyme Metagest?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
36Drugs
36 Minor

Ingredients driving the most interactions

Betain HCl 36

Individual Drug Interactions

The ingredients in SpectraZyme Metagest interact with 36 drugs. Click any drug to see the details.

1 of the 2 ingredients in SpectraZyme Metagest interact with drugs. Each result below shows which ingredient is responsible. Betain HCl

Each ingredient & the kinds of drugs it affects

For each ingredient in SpectraZyme Metagest with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Betain HCl3 drug types · 36 drugs

Antacids

Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
In human research, betaine hydrochloride increases stomach acidity. Antacids are taken to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with antacids might decrease the effects of the antacids.

Likelihood Possible Evidence D
H2-Blockers

Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.
In human research, betaine hydrochloride increases stomach acidity. H2-blockers are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with H2-blockers might decrease the effects of H2-blockers.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
In human research, betaine hydrochloride increases stomach acidity. PPIs are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with PPIs might decrease the effects of PPIs

Likelihood Possible Evidence D
Betain HCl full monograph & interactions
The maker

Brand information

Manufacturer and brand details for SpectraZyme Metagest, from the product label.

Metagenics

See all Metagenics products
Name
Metagenics
City
Gig Harbor
State
WA
ZipCode
98332
Phone Number
800 692 9400
Web Address
metagenics.com
Pharmacist Counseling Corner

SpectraZyme Metagest by Metagenics: Common Questions

Does SpectraZyme Metagest by Metagenics interact with any medications?
Yes. Based on its ingredients, SpectraZyme Metagest has a known interaction with 36 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
SpectraZyme Metagest contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant?
No. The safety data advises against both pepsin and betaine hydrochloride during pregnancy. Talk with your doctor or pharmacist about whether this product is right for you.
Is it safe to breastfeed while taking SpectraZyme Metagest?
The safety data does not support use while breastfeeding. Pepsin has little safety data during breastfeeding, and betaine hydrochloride should be avoided. Ask your pharmacist or doctor before taking it.
I have acid reflux. Is this product safe for me?
No. Betaine hydrochloride increases stomach acid and is not safe for people with true acid reflux. This product could make your symptoms worse. Talk to your pharmacist about a safer option.
What if I have a stomach ulcer?
Do not take this product. Betaine hydrochloride is not safe for people with ulcers; the added acid it produces could irritate or slow the healing of an ulcer. Check with your doctor first.
Can this cause an allergic reaction?
Pepsin can rarely cause allergic reactions. Occupational exposure to airborne pepsin has triggered allergic rhinitis or asthma in some workers. If you have a known sensitivity to proteases or asthma, talk to your pharmacist before taking it.
Does this actually work for digestion?
The evidence is not established in the data we hold. No reliable evidence supports pepsin or betaine hydrochloride for indigestion or other conditions listed in our files.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if SpectraZyme Metagest is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

SpectraZyme Metagest label
Go deeper

The Full Monographs Behind SpectraZyme Metagest’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Betaine Hydrochloride

Interacts with 36 drugs

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is limited and mostly based on tradition rat...

Read the full Betaine Hydrochloride monograph →
Sources

Sources & How We Checked

SpectraZyme Metagest's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Betaine Hydrochloride 2 references
  1. Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014 PubMed
  2. Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 4;10(11):4032-7. PubMed

See these in context on the Betaine Hydrochloride monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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