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Dietary supplement

Spinach Leaf Extract 750 mg Ingredients & Drug Interactions

by Swanson GreenFoods Formulas

Spinach Leaf Extract 750 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Spinach Leaf Extract 750 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Spinach Leaf Extract 750 mg is a dietary supplement by Swanson GreenFoods Formulas with 1 active ingredient. Its ingredients are commonly taken for general nutrition and antioxidant support, eye health, heart health and blood pressure.Based on those ingredients, 88 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Spinach extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Spinach Leaf Extract 750 mg by Swanson GreenFoods Formulas

Ask about any prescription or over-the-counter medication and we check it for interactions with Spinach Leaf Extract 750 mg by Swanson GreenFoods Formulas — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Spinach Leaf Extract 750 mg by Swanson GreenFoods Formulas

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: spinach extract at 750 mg per capsule. Spinach is a leafy green vegetable packed with nutrients.

The capsule also contains inactive ingredients — hypromellose, magnesium stearate, and brown rice flour — which are standard binders and fillers.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Spinach product and its label doesn't state a use — see Spinach's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for spinach extract isn't established yet for the conditions studied in our data. Proposed uses include nonalcoholic fatty liver disease, cognitive function, muscle strength, obesity, and polycystic ovary syndrome, but we don't have enough reliable research to rate any of them.

If you're considering this product for a specific health goal, talk with your pharmacist or doctor about what the current science actually supports.

The evidence, ingredient by ingredient Spinach

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Spinach as a food is well tolerated and safe for most people, including during pregnancy and while breastfeeding. Serious side effects are rare.

In infants under 4 months, methemoglobinemia (a blood condition affecting oxygen) has been reported, so this product is not appropriate for very young babies. Allergic reactions can occur in sensitive individuals.

Occupational exposure to spinach powder has been linked to asthma and lung inflammation in workers, though typical food or supplement use hasn't reported these issues.

Side effects, ingredient by ingredient Spinach

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Spinach.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 88 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your exact medications if you take warfarin (Coumadin) or any blood thinner — spinach raises vitamin K, which interferes with anticoagulation. Also flag any diabetes or blood-sugar medications, since spinach may lower glucose levels.

Run these through the checker on this page with your specific drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a straightforward spinach extract supplement. If you take warfarin or diabetes medications, you need to check with your pharmacist or doctor first — spinach can meaningfully affect both.

For most other people with no blood-thinning or glucose-control medications, spinach is nutritious and well tolerated.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Spinach Leaf Extract 750 mg, straight from the product label.

Brand Swanson GreenFoods Formulas
Barcode (UPC) 087614060620
Net contents 60 Veggie Cap(s)
Market status On market
Date entered into DSLD Apr 25, 2019
DSLD ID 188783
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Vegetarian, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Spinach Leaf Extract 750 mg by Swanson GreenFoods Formulas, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veggie Capsule(s)
Maximum serving Sizes:
1 Veggie Capsule(s)
UPC/BARCODE
087614060620
IngredientAmount% DV
Spinach extract750 mg--

Other ingredients: Hypromellose, Magnesium Stearate, Brown Rice Flour

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Phytonutient-Rich Green Foods Low-Temperature Water Extract 20:1

To reorder, call toll free 1-800-437-4148 or visit our website at www.swansonvitamins.com

Formulation

V Vegetarian formula

Seals/Symbols

V Vegetarian formula Guaranteed purity & potency

FDA Statement of Identity

Herbal Supplement

Precautions

Do not use if seal is broken.

Keep out of reach of children.

Storage

Store in a cool, dry place.

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take one veggie capsule per day with water.

General

SWR062 Rev 1 07 09 18

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Spinach Leaf Extract 750 mg by Swanson GreenFoods Formulas label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Spinach Leaf Extract 750 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Spinach Leaf Extract 750 mg by Swanson GreenFoods Formulas

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Veggie Capsule(s) Dosage formCapsule Amounts shown are per serving.

Spinach extract

Interacts with
88 drugs
750 mg per serving

Spinach is a nutrient-dense leafy green that is a healthy part of a balanced diet, providing vitamins, minerals, fiber, and antioxidants. While it is...

Spinach extract monograph & interactions

Other (inactive) ingredients: Hypromellose, Magnesium Stearate, Brown Rice Flour. These complete the product’s ingredient list but are not active constituents.

Interaction report

Spinach Leaf Extract 750 mg by Swanson GreenFoods Formulas Drug Interactions

Want to check YOUR meds against Spinach Leaf Extract 750 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
88Drugs
88 Moderate

Ingredients driving the most interactions

Spinach extract 88

Individual Drug Interactions

The ingredients in Spinach Leaf Extract 750 mg interact with 88 drugs. Click any drug to see the details.

1 of the 1 ingredient in Spinach Leaf Extract 750 mg interact with drugs. Each result below shows which ingredient is responsible. Spinach extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Spinach Leaf Extract 750 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Spinach extract2 drug types · 88 drugs

Antidiabetes Drugs

There are claims that spinach leaves have hypoglycemic effects. Evidence from clinical research suggests that consumption of a spinach-rich meal reduces post-meal blood glucose levels. Theoretically, spinach might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia. Monitor blood glucose levels closely. Dose adjustments might be necessary. Some antidiabetes drugs include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), and others.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Spinach contains vitamin K, which can interfere with the activity of warfarin.
In human research, although eating spinach with one meal does not result in coagulation test results outside the therapeutic range, daily consumption for one week necessitates dose adjustment of warfarin. Individuals using anticoagulants should consume a consistent daily amount of spinach to maintain the effect of anticoagulant therapy.

Likelihood Possible Evidence D
Spinach extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Spinach Leaf Extract 750 mg, from the product label.

Swanson GreenFoods Formulas

See all Swanson GreenFoods Formulas products
Name
Swanson Health Products
City
Fargo
State
ND
ZipCode
58104
Phone Number
1-800-437-4148
Web Address
www.swansonvitamins.com
Pharmacist Counseling Corner

Spinach Leaf Extract 750 mg by Swanson GreenFoods Formulas: Common Questions

Does Spinach Leaf Extract 750 mg by Swanson GreenFoods Formulas interact with any medications?
Yes. Based on its ingredients, Spinach Leaf Extract 750 mg has a known interaction with 88 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Spinach Leaf Extract 750 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant or breastfeeding?
Yes — spinach as a food is considered likely safe during both pregnancy and lactation. This supplement is just concentrated spinach extract, so the same safety profile applies.
Will spinach extract lower my blood sugar?
There's evidence that spinach can reduce blood glucose levels after meals. If you take diabetes medication, this additive effect could increase the risk of low blood sugar, so your dose may need adjusting. Talk to your doctor about it.
I'm on warfarin — can I take this?
Not without adjustment. Spinach contains vitamin K, which counteracts warfarin. One meal with spinach won't throw off your test results, but daily use will require your doctor to adjust your warfarin dose. Keep intake consistent and let them know you're taking it.
Does this product have any fillers or extra ingredients?
The capsule contains hypromellose, magnesium stearate, and brown rice flour — standard inactive ingredients used as binders. The active ingredient is just spinach extract.
Is spinach extract proven to work for fatty liver disease or cognitive function?
Not yet. We don't have enough reliable research to say it works for those conditions. If you're looking to treat a specific health issue, ask your doctor what the evidence actually supports.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Spinach Leaf Extract 750 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Spinach Leaf Extract 750 mg label
Go deeper

The Full Monographs Behind Spinach Leaf Extract 750 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Spinach

Interacts with 88 drugs

Spinach is a nutrient-dense leafy green that is a healthy part of a balanced diet, providing vitamins, minerals, fiber, and antioxidants. While it is very safe as a food, concentrated supple...

Read the full Spinach monograph →
Sources

Sources & How We Checked

Spinach Leaf Extract 750 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Spinach 6 references
  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  2. Karlson, B., Leijd, B., and Hellstrom, K. On the influence of vitamin K-rich vegetables and wine on the effectiveness of warfarin treatment. Acta Med Scand. 1986;220(4):347-350. PubMed
  3. Roller, E., Meller, S., Homey, B., Ruzicka, T., and Neumann, N. J. [Contact dermatitis caused by spinach, hedge mustard and chives]. Hautarzt 2003;54(4):374-375.
  4. Schuller, A., Morisset, M., Maadi, F., Kolopp Sarda, M. N., Fremont, S., Parisot, L., Kanny, G., and Moneret-Vautrin, D. A. Occupational asthma due to allergy to spinach powder in a pasta factory. Allergy 2005;60(3):408-409. PubMed
  5. Gustafsson, K., Asp, N. G., Hagander, B., and Nyman, M. Satiety effects of spinach in mixed meals: comparison with other vegetables. Int.J.Food Sci.Nutr. 1995;46(4):327-334. PubMed
  6. Schreiber, J., Muller, E., Becker, W. M., Zabel, P., Schlaak, M., and Amthor, M. [Spinach powder-induced exogenous allergic alveolitis]. Pneumologie 1998;52(1):61-65.

See these in context on the Spinach monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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