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Dietary supplement

Spm-gen Ingredients & Drug Interactions

by Genestra Brands

Spm-gen label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Spm-gen against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Spm-gen is a dietary supplement by Genestra Brands with 3 active ingredients. Its ingredients are commonly taken for water retention (diuretic), digestive upset and bloating, urinary tract support.Based on those ingredients, 162 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Juniper (Juniperus communis) young shoot extract, Silver Linden (Tilia tomentosa) bud extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Spm-gen by Genestra Brands

Ask about any prescription or over-the-counter medication and we check it for interactions with Spm-gen by Genestra Brands — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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Computed from our clinical databases

HelloPharmacist Scorecard of Spm-gen by Genestra Brands

Four independent checks of what is known — a summary of the available information, not a grade of the product itself.

Evidence for Intended Use
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

The stated purpose hasn't been mapped to our evidence data yet.

Why this rating?
  • We haven't mapped this product's purpose to our evidence data yet — it'll be graded on the next content refresh.
Ingredient Transparency
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.
Known Interaction Concern
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Linden, Juniper.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; lithium.
  • For scale: 162 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.
Safety Information
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

HelloPharmacist summaryFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 22, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Spm-gen, straight from the product label.

Brand Genestra Brands
Barcode (UPC) 88319612151
Net contents 0.5 fl. Oz.; 15 mL
Market status Off market
Date entered into DSLD Sep 22, 2016
DSLD ID 64530
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Children 4 or More Years of Age, Vegan, Vegetarian, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Spm-gen by Genestra Brands, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.28 mL
Maximum serving Sizes:
0.28 mL
Servings per container
53
UPC/BARCODE
88319612151
IngredientAmount% DV
Juniper (Juniperus communis) young shoot extract0.09 mL--
Silver Linden (Tilia tomentosa) bud extract0.09 mL--
English Holly (Ilex aquifolium) young shoot extract0.09 mL--

Other ingredients: purified Water, Ethanol, Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Recommended Dose: Adults and Children (over 12 years): Take 10 drops once daily, or as recommended by your healthcare practitioner.

Invert bottle to 45(0) and shake lightly allowing drops to fall directly into mouth or in 1/4 oz. of water.

Precautions

For risk information, see outer box. Do not use if seal is missing or broken.

Risk Information: If you are pregnant or breastfeeding, do not use, unless directed by your healthcare practitioner.

If symptoms persist or worsen, consult your healthcare practitioner.

Quality Assurance: Safety-sealed for your protection and for product freshness. Do not use if inner seal is missing or broken.

General

910

General Statements

Phyto-Gen

V1.0 910

Formula

- Juniper - Silver Linden - English Holly

FDA Statement of Identity

Herbal Supplement

Formulation

Guaranteed to contain no added starch, yeast, corn, soy, sodium, sugar, artificial coloring or flavoring, dairy or animal products.

Ideal for vegans.

Storage

Store in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Spm-gen by Genestra Brands label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Spm-gen label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Spm-gen by Genestra Brands

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size0.28 mL Dosage formLiquid Servings per container53 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Juniper (Juniperus communis) young shoot extract

Interacts with
162 drugs
0.09 mL per serving

Juniper berry is a traditional herb best known for flavoring gin and for its folk use as a diuretic and digestive aid. Solid human evidence for its he...

Juniper (Juniperus communis) young shoot extract monograph & interactions

Silver Linden (Tilia tomentosa) bud extract

Interacts with
1 drug
0.09 mL per serving

Linden (also called lime flower) is a traditional herbal tea long used to calm nerves, ease cold symptoms, and support restful sleep. Strong human evi...

Silver Linden (Tilia tomentosa) bud extract monograph & interactions

English Holly (Ilex aquifolium) young shoot extract

No known
interactions
0.09 mL per serving

Holly (Ilex aquifolium) is a common ornamental shrub whose bright red berries are poisonous and should never be eaten. There is very little reliable h...

English Holly (Ilex aquifolium) young shoot extract monograph & interactions

Other (inactive) ingredients: Purified Water, Ethanol, Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Spm-gen by Genestra Brands Drug Interactions

Spm-gen contains 3 ingredients, and 2 of them have known drug interactions. Altogether they interact with 162 medications. Here’s the picture, then you can look up your own drug.

Want to check YOUR meds against Spm-gen?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
162Drugs
87 Moderate 75 Minor

Ingredients driving the most interactions

Juniper (Juniperus communis) young shoot extract 162
Silver Linden (Tilia tomentosa) bud extract 1

Individual Drug Interactions

The ingredients in Spm-gen interact with 162 drugs. Click any drug to see the details.

2 of the 3 ingredients in Spm-gen interact with drugs. Each result below shows which ingredient is responsible. Juniper (Juniperus communis) young shoot extract Silver Linden (Tilia tomentosa) bud extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Spm-gen with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Juniper (Juniperus communis) young shoot extract3 drug types · 162 drugs

Antidiabetes Drugs

Theoretically, taking juniper berry with antidiabetes medications might cause additive hypoglycemia.
Animal research shows that juniper berry can lower blood glucose.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, juniper berry might increase the risk of adverse effects from diuretic drugs.
Juniper berry is thought to have mild diuretic effects.

Likelihood Possible Evidence D
Lithium

Theoretically, juniper berry might reduce lithium excretion and increase serum levels of lithium.
Juniper berry is thought to have mild diuretic effects.

Likelihood Possible Evidence D
Juniper (Juniperus communis) young shoot extract full monograph & interactions

Silver Linden (Tilia tomentosa) bud extract1 drug type · 1 drug

Lithium

Theoretically, due to its potential diuretic effects, linden might increase the effects and adverse effects of lithium.
Linden is thought to have diuretic properties. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Silver Linden (Tilia tomentosa) bud extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Spm-gen, from the product label.

Genestra Brands

Name
Seroyal USA
City
Wood Dale
State
Illinois
ZipCode
60191
Phone Number
1-888-737-6925
Pharmacist Counseling Corner

Spm-gen by Genestra Brands: Common Questions

Does Spm-gen by Genestra Brands interact with any medications?
Yes. Based on its ingredients, Spm-gen has a known interaction with 162 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Spm-gen contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Spm-gen is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Spm-gen label
Go deeper

The Full Monographs Behind Spm-gen’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Juniper

Interacts with 162 drugs

Juniper berry is a traditional herb best known for flavoring gin and for its folk use as a diuretic and digestive aid. Solid human evidence for its health benefits is limited, and it can irr...

Read the full Juniper monograph → Herb & supplement monograph

Linden

Interacts with 1 drug

Linden (also called lime flower) is a traditional herbal tea long used to calm nerves, ease cold symptoms, and support restful sleep. Strong human evidence for these uses is lacking, but the...

Read the full Linden monograph → Herb & supplement monograph

Holly

Holly (Ilex aquifolium) is a common ornamental shrub whose bright red berries are poisonous and should never be eaten. There is very little reliable human evidence supporting any health bene...

Read the full Holly monograph →
Sources

Sources & How We Checked

Spm-gen's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Juniper 7 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Robbers JE, Tyler VE. Tyler's Herbs of Choice: The Therapeutic Use of Phytomedicinals. New York, NY: The Haworth Herbal Press, 1999.
  5. Sanchez de Medina F, Gamez MJ, Jimenez I, et al. Hypoglycemic activity of juniper "berries." Planta Med 1994;60:197-200. PubMed
  6. Swanston-Flatt SK, Day C, Bailey CJ, Flatt PR. Traditional plant treatments for diabetes. Studies in normal and streptozotocin diabetic mice. Diabetologia 1990;33:462-4. PubMed
  7. Tammaro A, Adebanjo GAR, Chello C, et al. Bullous dermatitis caused by common juniper. Contact Dermatitis. 2020. PubMed

See these in context on the Juniper monograph →

Linden 2 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.

See these in context on the Linden monograph →

Holly 2 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

See these in context on the Holly monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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