Interactions on record — worth a quick check against your medications. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

Phyto-Gen Renal-gen Ingredients & Drug Interactions

by Genestra Brands

Phyto-Gen Renal-gen label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Phyto-Gen Renal-gen against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Phyto-Gen Renal-gen is a dietary supplement by Genestra Brands with 3 active ingredients. Its ingredients are commonly taken for water retention (diuretic), digestive upset and bloating, urinary tract support.Based on those ingredients, 291 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Corn (Zea mays) root bark extract, Juniper (Juniperus communis) young shoot extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Phyto-Gen Renal-gen by Genestra Brands

Ask about any prescription or over-the-counter medication and we check it for interactions with Phyto-Gen Renal-gen by Genestra Brands — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Phyto-Gen Renal-gen by Genestra Brands

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Phyto-Gen Renal-gen contains three active plant extracts in liquid form: elm bud extract, juniper young shoot extract, and corn root bark extract. The product also contains purified water, ethanol, and glycerin as inactive ingredients.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: kidney and urinary tract support.
  • We looked for evidence on: Urinary tract infections (UTIs), Kidney stones (nephrolithiasis), Prostatitis, Nocturnal enuresis, Bladder health, Fluid retention — and 1 related terms.
  • The closest evidence on file: Corn Silk is rated "Insufficient Reliable Evidence To Rate" for Kidney stones (nephrolithiasis) (Natural Medicines).
  • Also on file: Corn Silk is rated "Insufficient Reliable Evidence To Rate" for Prostatitis, Urinary tract infections (UTIs), Nocturnal enuresis.
  • Also on file: Juniper is rated "Insufficient Reliable Evidence To Rate" for Kidney stones (nephrolithiasis), Urinary tract infections (UTIs).

The effectiveness evidence for Phyto-Gen Renal-gen is not established in our data. All uses listed for its individual ingredients—including kidney stones, urinary tract infections, GERD, rheumatoid arthritis, and others—carry a rating of insufficient reliable evidence.

This means the research either doesn't exist, isn't strong enough, or is too limited to draw a conclusion about whether this product works for any of those purposes.

The evidence, ingredient by ingredient Juniper Corn Silk

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Juniper extract is generally well tolerated when used short-term in low doses, but medicinal doses may irritate the kidneys and shouldn't be used long-term. Topically, juniper can cause skin irritation, allergies, and in rare cases, burn-like lesions—especially with sun exposure.

Corn root bark extract is generally well tolerated for short-term use, though human safety data are limited; prolonged use may cause low potassium. Both ingredients carry specific cautions in pregnancy and breastfeeding (see below).

Do not use this product during pregnancy—juniper is considered unsafe, and there isn't enough safety data for corn root bark. While breastfeeding, juniper is best avoided; corn root bark is possibly safe, but only if your doctor or pharmacist approves.

Elm bud extract safety information is not on file.

Side effects, ingredient by ingredient Juniper Corn Silk

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Corn Silk, Juniper.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium.
  • For scale: 291 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, have your pharmacist or doctor check whether you're on antidiabetes drugs, antihypertensive medications (blood pressure–lowering drugs), corticosteroids, diuretics, or warfarin. Each of these can have Moderate-severity interactions with the juniper or corn root bark in this formula.

Also check if you take lithium, which can interact with juniper at a Minor severity level.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you take blood pressure medications, diabetes medications, diuretics, corticosteroids, or warfarin, you'll want to check with your doctor or pharmacist before starting this product. Even people without those drugs should discuss it with their own healthcare provider, since the effectiveness evidence for its intended uses isn't established.

Avoid it during pregnancy; if you're breastfeeding, get personalized advice from your pharmacist or doctor before taking it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Phyto-Gen Renal-gen, straight from the product label.

Brand Genestra Brands
Barcode (UPC) 883196127504
Net contents 0.5 fl. Oz.; 15 mL
Market status On market
Date entered into DSLD Jul 23, 2020
DSLD ID 231120
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Phyto-Gen Renal-gen by Genestra Brands, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.28 mL
Maximum serving Sizes:
0.28 mL
Servings per container
53
UPC/BARCODE
883196127504
IngredientAmount% DV
Elm (Ulmus campestris) bud extract0.09 mL--
Juniper (Juniperus communis) young shoot extract0.09 mL--
Corn (Zea mays) root bark extract0.09 mL--

Other ingredients: purified Water, Ethanol, Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Recommended Dose: Take 10 drops once daily or as recommended by your health professional. Invert bottle to 45 degrees and shake lightly allowing drops to fall directly into mouth or in 1/4 oz of water.

General Statements

For warnings and additional information, see outer box.

Contents may not fill package in order to accommodate required labeling. Please rely on stated quantity.

Scan to learn about our quality excellence

Precautions

Keep out of the reach of children.

Use only if safety seal is intact.

Warning: If you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.

This product was sealed for your protection. Do not use if box or contents are open or damaged.

Storage

Store in a cool, dry place.

FDA Statement of Identity

Dietary Supplement

Formula

Juniper Elm Corn

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Phyto-Gen Renal-gen by Genestra Brands label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Phyto-Gen Renal-gen label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Phyto-Gen Renal-gen by Genestra Brands

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size0.28 mL Dosage formLiquid Servings per container53 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Elm (Ulmus campestris) bud extract

0.09 mL per serving

Juniper (Juniperus communis) young shoot extract

Interacts with
162 drugs
0.09 mL per serving

Juniper berry is a traditional herb best known for flavoring gin and for its folk use as a diuretic and digestive aid. Solid human evidence for its he...

Juniper (Juniperus communis) young shoot extract monograph & interactions

Corn (Zea mays) root bark extract

Interacts with
290 drugs
0.09 mL per serving

Corn silk is a traditional herbal remedy taken as a tea or extract, mostly for urinary and mild fluid-related complaints. High-quality human evidence...

Corn (Zea mays) root bark extract monograph & interactions

Other (inactive) ingredients: Purified Water, Ethanol, Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Phyto-Gen Renal-gen by Genestra Brands Drug Interactions

Want to check YOUR meds against Phyto-Gen Renal-gen?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
291Drugs
290 Moderate 1 Minor

Ingredients driving the most interactions

Corn (Zea mays) root bark extract 290
Juniper (Juniperus communis) young shoot extract 162

Individual Drug Interactions

The ingredients in Phyto-Gen Renal-gen interact with 291 drugs. Click any drug to see the details.

2 of the 3 ingredients in Phyto-Gen Renal-gen interact with drugs. Each result below shows which ingredient is responsible. Corn (Zea mays) root bark extract Juniper (Juniperus communis) young shoot extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Phyto-Gen Renal-gen with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Corn (Zea mays) root bark extract5 drug types · 290 drugs

Antidiabetes Drugs

Theoretically, taking corn silk with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research in diabetic mice shows that taking corn silk extract lowers fasting blood glucose levels.

Likelihood Possible Evidence D
Antihypertensive Drugs

Taking corn silk extract with antihypertensive drugs might increase the risk of hypotension.
Clinical research in both hypertensive and normotensive adults shows that taking corn silk extract lowers systolic and diastolic blood pressure.

Likelihood Possible Evidence D
Corticosteroids

Taking corn silk with corticosteroids might increase the risk of hypokalemia.
Clinical research shows that taking corn silk extract increases the urinary excretion of potassium.

Likelihood Possible Evidence D
Diuretic Drugs

Taking corn silk with diuretic drugs might increase the risk of adverse effects such as hyponatremia and hypokalemia.
Clinical research shows that taking corn silk extract increases urine volume and promotes the urinary excretion of sodium and potassium. Some patients may require electrolyte supplementation.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, suddenly stopping, starting, or changing corn silk treatment may alter the effects of warfarin.
Corn silk contains vitamin K. Individuals taking warfarin should consume a consistent daily amount of corn silk to maintain consistent anticoagulation.

Likelihood Likely Evidence D
Corn (Zea mays) root bark extract full monograph & interactions

Juniper (Juniperus communis) young shoot extract3 drug types · 162 drugs

Antidiabetes Drugs

Theoretically, taking juniper berry with antidiabetes medications might cause additive hypoglycemia.
Animal research shows that juniper berry can lower blood glucose.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, juniper berry might increase the risk of adverse effects from diuretic drugs.
Juniper berry is thought to have mild diuretic effects.

Likelihood Possible Evidence D
Lithium

Theoretically, juniper berry might reduce lithium excretion and increase serum levels of lithium.
Juniper berry is thought to have mild diuretic effects.

Likelihood Possible Evidence D
Juniper (Juniperus communis) young shoot extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Phyto-Gen Renal-gen, from the product label.

Genestra Brands

Name
Seroyal USA
City
Pittsburgh
State
PA
ZipCode
15275
Phone Number
1-888-737-6925
Web Address
seroyal.com
Pharmacist Counseling Corner

Phyto-Gen Renal-gen by Genestra Brands: Common Questions

Does Phyto-Gen Renal-gen by Genestra Brands interact with any medications?
Yes. Based on its ingredients, Phyto-Gen Renal-gen has a known interaction with 291 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Phyto-Gen Renal-gen contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take if I'm pregnant or breastfeeding?
No—do not use during pregnancy; juniper is considered unsafe. While breastfeeding, juniper is best avoided. Corn root bark is possibly safe if breastfeeding, but only with your doctor's or pharmacist's approval. Talk it over with your own healthcare provider to figure out what's right for you.
What does each ingredient in this product do?
The product contains elm bud extract, juniper young shoot extract, and corn root bark extract, but the evidence for what they actually accomplish isn't established in our data. All the uses we have on file for these ingredients—kidney stones, urinary tract infections, wound healing, and others—lack sufficient reliable research.
Can juniper extract cause side effects?
When used short-term in low doses, juniper is generally well tolerated, but a full safety evaluation hasn't been done. Applied topically, it can cause skin irritation, allergies, or even burn-like blistering—worse with sun exposure. It shouldn't be used long-term because medicinal doses may irritate the kidneys.
What's the concern with corn root bark and my blood pressure or blood sugar?
Corn root bark extract can lower blood pressure and blood sugar, so combining it with blood pressure or diabetes medications might cause them to drop too far. It also increases the amount of potassium and sodium you lose in urine, which can be a problem if you're on diuretics or corticosteroids. Your pharmacist or doctor can help you decide if it's safe for you.
I take warfarin. Can I use this product?
Corn root bark contains vitamin K, which affects how warfarin works. If you start, stop, or change how much of this product you take, it could shift your warfarin's effects. Talk with your doctor or pharmacist before using it—they may want to monitor your blood clotting more closely if you do take it.
What about the elm extract—does it interact with anything?
We don't have interaction data on file for elm bud extract, so we couldn't check it. That doesn't mean it's safe with all medications—it just means we have no monograph for it. Run your full medication list through the search tool on this page to be sure.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Phyto-Gen Renal-gen is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Phyto-Gen Renal-gen label
Go deeper

The Full Monographs Behind Phyto-Gen Renal-gen’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Juniper

Interacts with 162 drugs

Juniper berry is a traditional herb best known for flavoring gin and for its folk use as a diuretic and digestive aid. Solid human evidence for its health benefits is limited, and it can irr...

Read the full Juniper monograph → Herb & supplement monograph

Corn Silk

Interacts with 290 drugs

Corn silk is a traditional herbal remedy taken as a tea or extract, mostly for urinary and mild fluid-related complaints. High-quality human evidence for these uses is limited, so it should...

Read the full Corn Silk monograph →
Sources

Sources & How We Checked

Phyto-Gen Renal-gen's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Juniper 7 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Robbers JE, Tyler VE. Tyler's Herbs of Choice: The Therapeutic Use of Phytomedicinals. New York, NY: The Haworth Herbal Press, 1999.
  5. Sanchez de Medina F, Gamez MJ, Jimenez I, et al. Hypoglycemic activity of juniper "berries." Planta Med 1994;60:197-200. PubMed
  6. Swanston-Flatt SK, Day C, Bailey CJ, Flatt PR. Traditional plant treatments for diabetes. Studies in normal and streptozotocin diabetic mice. Diabetologia 1990;33:462-4. PubMed
  7. Tammaro A, Adebanjo GAR, Chello C, et al. Bullous dermatitis caused by common juniper. Contact Dermatitis. 2020. PubMed

See these in context on the Juniper monograph →

Corn Silk 4 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. George GO, Idu FK. Corn silk aqueous extracts and intraocular pressure of systemic and non-systemic hypertensive subjects. Clin Exp Optom. 2015 Mar;98(2):138-49. PubMed
  4. Sheng L, Chen Q, Di L, Li N. Evaluation of anti-diabetic potential of corn silk in high-fat diet/streptozotocin- induced type 2 diabetes mice model. Endocr Metab Immune Disord Drug Targets. 2020. PubMed

See these in context on the Corn Silk monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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