KB Ingredients & Drug Interactions
by New Sun
What is this page for?
First and foremost: checking KB against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
KB is a dietary supplement by New Sun with 7 active ingredients. Its ingredients are commonly taken for water retention (diuretic), digestive upset and bloating, urinary tract support.Based on those ingredients, 2,179 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Marshmallow, Uva Ursi, Buchu. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against KB by New Sun
Ask about any prescription or over-the-counter medication and we check it for interactions with KB by New Sun — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
Ask the Pharmacist
A licensed pharmacist will answer your question by email — free, usually within 24 hours.
Got it — thank you!
A licensed pharmacist will answer within 24 hours. Keep an eye on your email (worth checking spam, just in case).
HelloPharmacist Scorecard of KB by New Sun
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
KB contains seven ingredients, six of which are herbal extracts: juniper, marshmallow, buchu, cornsilk, hydrangea, meadowsweet, and uva ursi. These are bundled in a proprietary blend and filled into gelatin capsules (the capsule itself is an inactive ingredient).
The product is marketed for urinary and kidney support, though the evidence supporting most of these herbs for specific conditions is limited to insufficient data or animal research.
Does it work?
Leans against
The evidence on these ingredients is sparse. Uva ursi is rated possibly ineffective for urinary tract infections (UTIs), the condition it's most often used for.
Juniper, marshmallow, buchu, hydrangea, and meadowsweet all carry ratings of insufficient reliable evidence — meaning there isn't solid clinical proof they work for their traditional uses like GERD, rheumatoid arthritis, wound healing, headache, or respiratory infections. We have no effectiveness data on file for cornsilk.
If you're taking this product for a specific health concern, the evidence backing these ingredients is weak.
How safe is it?
Well-documented data
Short-term use of these herbs is generally well tolerated in low doses, but safety data in humans are limited. Juniper can irritate the kidneys with long-term or high-dose use.
Uva ursi is well tolerated at low doses short-term but can cause nausea, vomiting, diarrhea, and stomach upset; very high doses (30 grams or more of the dried herb) have been reported as potentially fatal. Buchu and hydrangea also lack strong human safety data, and large or prolonged doses may cause unwanted effects.
Hydrangea may cause gastroenteritis, dizziness, or chest tightness. For pregnancy: juniper and buchu are rated likely or definitely unsafe, and meadowsweet is likely unsafe — these herbs may affect the uterus or lack safety data.
Marshmallow, hydrangea, and uva ursi all have insufficient safety information, so there isn't enough data to know if they're safe in pregnancy. None of these ingredients should be used in pregnancy without talking to your doctor.
For breastfeeding, there isn't enough reliable safety data on any of them, so it's best avoided.
Meds to double-check
Moderate interaction found
Before starting KB, check whether you take lithium (mood stabilizer), blood thinners or antiplatelet drugs (warfarin, aspirin, clopidogrel), medications metabolized by CYP2C19 or CYP3A4 enzymes, drugs that go through glucuronidation, or medications that acidify your urine. These are the drug types most likely to interact with the ingredients we checked — juniper, marshmallow, buchu, hydrangea, meadowsweet, and uva ursi.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with graded evidence leaning against its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
If you take lithium, blood thinners, or medications broken down by your liver's CYP2C19 or CYP3A4 pathways, talk to your pharmacist before using this product — the interaction risk is real and potentially serious. This product is not suitable during pregnancy or breastfeeding.
Even if you don't take those medications, the evidence that these herbs actually work for kidney or urinary health is weak, so know what you're paying for.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 6 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 24, 2012.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about KB, straight from the product label.
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for KB by New Sun, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Blend | 950 mg | -- |
| Juniper | 0 NP | -- |
| Marshmallow | 0 NP | -- |
| Buchu | 0 NP | -- |
| Cornsilk | 0 NP | -- |
| Hydrangea | 0 NP | -- |
| Meadowsweet | 0 NP | -- |
| Uva Ursi | 0 NP | -- |
Other ingredients: Gelatin
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions
KB should be used in children only with the guidance of a health care professional.
If you suffer from kidney disorders, acid urine, irritated digestive conditions, or inflammatory kidney disease, do not take this product without consulting your doctor. May cause green color in urine. Discontinue use if nausea or upset stomach occurs. Long-term (more than 2-3 weeks) use of Uva Ursi is not recommended.
If taking any medications or experiencing any health issues, consult your doctor before use.
Do not use if safety seal is missing or broken.
Keep out of reach of children.
Warning: Do not take if you are pregnant, nursing, or have high blood pressure.
Formulation
This product does not contain: yeast, corn, wheat, egg, starch, preservatives, artificial coloring or sweeteners.
General
Product No. 58-4 V5.0
Suggested/Recommended/Usage/Directions
Recommendation: As a dietary supplement, take two capsules two to three times daily.
Storage
Store in a cool, dry place.
FDA Disclaimer Statement
This product is not intended to diagnose, treat, cure, or prevent any disease.
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
KB by New Sun label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in KB by New Sun
These are the 7 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container50 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Blend
- › Juniper
- › Marshmallow
- › Buchu
- › Cornsilk
- › Hydrangea
- › Meadowsweet
- › Uva Ursi
Other (inactive) ingredients: Gelatin. These complete the product’s ingredient list but are not active constituents.
KB by New Sun Drug Interactions
HelloPharmacist Interaction Report
KB by New Sun contains seven ingredients, six of which we could check for drug interactions.
Several of these ingredients interact with medications, and the most serious concern involves uva ursi, which can slow how your body breaks down a large number of drugs — including medications metabolized by CYP2C19 and CYP3A4 enzymes, drugs cleared through glucuronidation, and P-glycoprotein substrates. This is a Moderate severity interaction that could raise drug levels unexpectedly.
Read the full breakdown — every affected drug type, severity by severity
You'll also need to watch out for lithium (a mood stabilizer). Four ingredients in this product — juniper, marshmallow, hydrangea, and uva ursi — are all thought to have diuretic effects and could theoretically interfere with lithium excretion, raising lithium levels to unsafe amounts.
Buchu carries the same Moderate risk. If you take lithium, this product is not a good match without close medical oversight.
Additionally, buchu may enhance the effects of blood thinners (anticoagulants) and antiplatelet drugs like aspirin and warfarin, raising bleeding risk (Moderate severity). Meadowsweet, which contains salicylates, could also add to the effects of aspirin-type drugs.
Marshmallow might interfere with how your body absorbs other oral medications, so you'd want to space doses 30–60 minutes apart (Minor severity). Uva ursi may also reduce the effectiveness of medications that acidify your urine.
We could not check cornsilk — we hold no interaction data for it. Altogether, these interactions span 2,156 individual medications.
Before you start this product, run your exact medications through the search tool on this page.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against KB?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in KB interact with 2,179 drugs. Click any drug to see the details.
6 of the 7 ingredients in KB interact with drugs. Each result below shows which ingredient is responsible. Marshmallow Uva Ursi Buchu Juniper Meadowsweet Hydrangea
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with KB — through 2 ingredients. Tap an ingredient for the detail:
BuchuHepatotoxic Drugs Moderate
Interaction Summary
Buchu contains pulegone, a known hepatotoxin.
Read the full Buchu + 6-mercaptopurine interactionMarshmallowOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow + 6-mercaptopurine interactionAdo-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with KB — through 1 ingredient. Tap an ingredient for the detail:
Uva UrsiCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
Read the full Uva Ursi + Ado-trastuzumab Emtansine interactionAbacavir Sulfate, Dolutegravir, LamivudineTriumeq
How Abacavir Sulfate, Dolutegravir, Lamivudine interacts with KB — through 2 ingredients. Tap an ingredient for the detail:
BuchuHepatotoxic Drugs Moderate
Interaction Summary
Buchu contains pulegone, a known hepatotoxin.
Read the full Buchu + Abacavir Sulfate, Dolutegravir, Lamivudine interactionMarshmallowOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow + Abacavir Sulfate, Dolutegravir, Lamivudine interactionAbacavir, LamivudineEpzicom
How Abacavir, Lamivudine interacts with KB — through 2 ingredients. Tap an ingredient for the detail:
BuchuHepatotoxic Drugs Moderate
Interaction Summary
Buchu contains pulegone, a known hepatotoxin.
Read the full Buchu + Abacavir, Lamivudine interactionMarshmallowOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow + Abacavir, Lamivudine interactionAbciximabReoPro
How Abciximab interacts with KB — through 2 ingredients. Tap an ingredient for the detail:
BuchuAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Buchu may have antiplatelet effects.
Read the full Buchu + Abciximab interactionMarshmallowOral Drugs, Anticoagulant/antiplatelet Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with KB — through 2 ingredients. Tap an ingredient for the detail:
Uva UrsiCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
Read the full Uva Ursi + Abemaciclib interactionMarshmallowOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow + Abemaciclib interactionAbiraterone
How Abiraterone interacts with KB — through 3 ingredients. Tap an ingredient for the detail:
BuchuHepatotoxic Drugs Moderate
Interaction Summary
Buchu contains pulegone, a known hepatotoxin.
Read the full Buchu + Abiraterone interactionUva UrsiCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
Read the full Uva Ursi + Abiraterone interactionMarshmallowOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with KB — through 3 ingredients. Tap an ingredient for the detail:
BuchuHepatotoxic Drugs Moderate
Interaction Summary
Buchu contains pulegone, a known hepatotoxin.
Read the full Buchu + Abiraterone Acetate interactionUva UrsiCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
Read the full Uva Ursi + Abiraterone Acetate interactionMarshmallowOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with KB — through 3 ingredients. Tap an ingredient for the detail:
BuchuAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Buchu may have antiplatelet effects.
Read the full Buchu + Abrocitinib interactionUva UrsiCytochrome P450 2c19 (cyp2c19) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may decrease the metabolism of CYP2C19 substrates.
Read the full Uva Ursi + Abrocitinib interactionMarshmallowOral Drugs, Anticoagulant/antiplatelet Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with KB — through 2 ingredients. Tap an ingredient for the detail:
Uva UrsiCytochrome P450 3a4 (cyp3a4) Substrates, P-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
Read the full Uva Ursi + Acalabrutinib interactionMarshmallowOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with KB — through 3 ingredients. Tap an ingredient for the detail:
JuniperAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking juniper berry with antidiabetes medications might cause additive hypoglycemia.
Read the full Juniper + Acarbose interactionBuchuHepatotoxic Drugs Moderate
Interaction Summary
Buchu contains pulegone, a known hepatotoxin.
Read the full Buchu + Acarbose interactionMarshmallowOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with KB — through 2 ingredients. Tap an ingredient for the detail:
BuchuHepatotoxic Drugs Moderate
Interaction Summary
Buchu contains pulegone, a known hepatotoxin.
Read the full Buchu + Acebutolol interactionMarshmallowOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with KB — through 2 ingredients. Tap an ingredient for the detail:
BuchuAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Buchu may have antiplatelet effects.
Read the full Buchu + Acenocoumarol interactionMarshmallowOral Drugs, Anticoagulant/antiplatelet Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow + Acenocoumarol interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with KB — through 3 ingredients. Tap an ingredient for the detail:
BuchuHepatotoxic Drugs Moderate
Interaction Summary
Buchu contains pulegone, a known hepatotoxin.
Read the full Buchu + Acetaminophen interactionUva UrsiGlucuronidated Drugs Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Uva Ursi + Acetaminophen interactionMarshmallowOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with KB — through 4 ingredients. Tap an ingredient for the detail:
Uva UrsiGlucuronidated Drugs Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Uva Ursi + Acetaminophen, Aspirin interactionMeadowsweetAspirin Moderate
Interaction Summary
Theoretically, meadowsweet might have an additive effect with other salicylate-containing drugs, such as aspirin.
Read the full Meadowsweet + Acetaminophen, Aspirin interactionBuchuHepatotoxic Drugs, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Buchu contains pulegone, a known hepatotoxin.
Read the full Buchu + Acetaminophen, Aspirin interactionMarshmallowOral Drugs, Anticoagulant/antiplatelet Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with KB — through 4 ingredients. Tap an ingredient for the detail:
BuchuAnticoagulant/antiplatelet Drugs, Hepatotoxic Drugs Moderate
Interaction Summary
Buchu may have antiplatelet effects.
Read the full Buchu + Acetaminophen, Aspirin, Caffeine interactionUva UrsiGlucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Uva Ursi + Acetaminophen, Aspirin, Caffeine interactionMeadowsweetAspirin Moderate
Interaction Summary
Theoretically, meadowsweet might have an additive effect with other salicylate-containing drugs, such as aspirin.
Read the full Meadowsweet + Acetaminophen, Aspirin, Caffeine interactionMarshmallowAnticoagulant/antiplatelet Drugs, Oral Drugs Minor
Interaction Summary
Theoretically, marshmallow flower might have antiplatelet effects.
Read the full Marshmallow + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with KB — through 3 ingredients. Tap an ingredient for the detail:
BuchuHepatotoxic Drugs Moderate
Interaction Summary
Buchu contains pulegone, a known hepatotoxin.
Read the full Buchu + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionUva UrsiGlucuronidated Drugs Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Uva Ursi + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionMarshmallowOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with KB — through 3 ingredients. Tap an ingredient for the detail:
Uva UrsiGlucuronidated Drugs Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Uva Ursi + Acetaminophen, Butalbital interactionBuchuHepatotoxic Drugs Moderate
Interaction Summary
Buchu contains pulegone, a known hepatotoxin.
Read the full Buchu + Acetaminophen, Butalbital interactionMarshmallowOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with KB — through 3 ingredients. Tap an ingredient for the detail:
BuchuHepatotoxic Drugs Moderate
Interaction Summary
Buchu contains pulegone, a known hepatotoxin.
Read the full Buchu + Acetaminophen, Butalbital, Caffeine interactionUva UrsiGlucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Uva Ursi + Acetaminophen, Butalbital, Caffeine interactionMarshmallowOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with KB — through 3 ingredients. Tap an ingredient for the detail:
BuchuHepatotoxic Drugs Moderate
Interaction Summary
Buchu contains pulegone, a known hepatotoxin.
Read the full Buchu + Acetaminophen, Butalbital, Caffeine, Codeine interactionUva UrsiCytochrome P450 3a4 (cyp3a4) Substrates, Glucuronidated Drugs Moderate
Interaction Summary
Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
Read the full Uva Ursi + Acetaminophen, Butalbital, Caffeine, Codeine interactionMarshmallowOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with KB — through 3 ingredients. Tap an ingredient for the detail:
Uva UrsiGlucuronidated Drugs Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Uva Ursi + Acetaminophen, Butalbital, Codeine interactionBuchuHepatotoxic Drugs Moderate
Interaction Summary
Buchu contains pulegone, a known hepatotoxin.
Read the full Buchu + Acetaminophen, Butalbital, Codeine interactionMarshmallowOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with KB — through 3 ingredients. Tap an ingredient for the detail:
BuchuHepatotoxic Drugs Moderate
Interaction Summary
Buchu contains pulegone, a known hepatotoxin.
Read the full Buchu + Acetaminophen, Butalbital, Codeine Phosphate interactionUva UrsiGlucuronidated Drugs Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Uva Ursi + Acetaminophen, Butalbital, Codeine Phosphate interactionMarshmallowOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with KB — through 3 ingredients. Tap an ingredient for the detail:
Uva UrsiGlucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Uva Ursi + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionBuchuHepatotoxic Drugs Moderate
Interaction Summary
Buchu contains pulegone, a known hepatotoxin.
Read the full Buchu + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionMarshmallowOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with KB — through 3 ingredients. Tap an ingredient for the detail:
Uva UrsiCytochrome P450 3a4 (cyp3a4) Substrates, Glucuronidated Drugs Moderate
Interaction Summary
Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
Read the full Uva Ursi + Acetaminophen, Caffeine, Codeine interactionBuchuHepatotoxic Drugs Moderate
Interaction Summary
Buchu contains pulegone, a known hepatotoxin.
Read the full Buchu + Acetaminophen, Caffeine, Codeine interactionMarshmallowOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with KB — through 3 ingredients. Tap an ingredient for the detail:
Uva UrsiGlucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Uva Ursi + Acetaminophen, Caffeine, Codeine, Salicylamide interactionBuchuHepatotoxic Drugs Moderate
Interaction Summary
Buchu contains pulegone, a known hepatotoxin.
Read the full Buchu + Acetaminophen, Caffeine, Codeine, Salicylamide interactionMarshmallowOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with KB — through 3 ingredients. Tap an ingredient for the detail:
Uva UrsiGlucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Uva Ursi + Acetaminophen, Caffeine, Dihydrocodeine interactionBuchuHepatotoxic Drugs Moderate
Interaction Summary
Buchu contains pulegone, a known hepatotoxin.
Read the full Buchu + Acetaminophen, Caffeine, Dihydrocodeine interactionMarshmallowOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with KB — through 3 ingredients. Tap an ingredient for the detail:
BuchuHepatotoxic Drugs Moderate
Interaction Summary
Buchu contains pulegone, a known hepatotoxin.
Read the full Buchu + Acetaminophen, Caffeine, Isometheptene interactionUva UrsiGlucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Uva Ursi + Acetaminophen, Caffeine, Isometheptene interactionMarshmallowOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with KB — through 4 ingredients. Tap an ingredient for the detail:
Uva UrsiCytochrome P450 3a4 (cyp3a4) Substrates, Glucuronidated Drugs Moderate
Interaction Summary
Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
Read the full Uva Ursi + Acetaminophen, Caffeine, Pyrilamine interactionBuchuHepatotoxic Drugs Moderate
Interaction Summary
Buchu contains pulegone, a known hepatotoxin.
Read the full Buchu + Acetaminophen, Caffeine, Pyrilamine interactionMarshmallowOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow + Acetaminophen, Caffeine, Pyrilamine interactionJuniperDiuretic Drugs Minor
Interaction Summary
Theoretically, juniper berry might increase the risk of adverse effects from diuretic drugs.
Read the full Juniper + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with KB — through 3 ingredients. Tap an ingredient for the detail:
Uva UrsiGlucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Uva Ursi + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionBuchuHepatotoxic Drugs Moderate
Interaction Summary
Buchu contains pulegone, a known hepatotoxin.
Read the full Buchu + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionMarshmallowOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with KB — through 3 ingredients. Tap an ingredient for the detail:
Uva UrsiGlucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Uva Ursi + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionBuchuHepatotoxic Drugs Moderate
Interaction Summary
Buchu contains pulegone, a known hepatotoxin.
Read the full Buchu + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionMarshmallowOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in KB with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Marshmallow
Lithium
Theoretically, due to potential diuretic effects, marshmallow might reduce excretion and increase levels of lithium.
Marshmallow is thought to have diuretic properties. To avoid lithium toxicity, the dose of lithium might need to be decreased when used with marshmallow.
Anticoagulant/Antiplatelet Drugs
Theoretically, marshmallow flower might have antiplatelet effects.
Animal research suggests that marshmallow flower extract has antiplatelet effects. However, the root and leaf of marshmallow, not the flower, are the plant parts most commonly found in dietary supplements. Theoretically, use of marshmallow flower with anticoagulant/antiplatelet drugs can have additive effects, and might increase the risk for bleeding in some patients.
Oral Drugs
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Marshmallow contains mucilage which can affect oral drug absorption. To avoid changes in absorption, take marshmallow 30-60 minutes after oral medications.
Uva Ursi
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, uva ursi may decrease the metabolism of CYP2C19 substrates.
In vitro, uva ursi appears to inhibit cytochrome CYP2C19. This effect has not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
In vitro, uva ursi appears to inhibit CYP3A4. This effect has not been reported in humans.
Glucuronidated Drugs
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
In vitro, uva ursi extract appears to strongly inhibit UDP-glucuronosyltransferase (UGT) 1A1 (UGT1A1). However, uva ursi extract does not appear to inhibit UGT1A1 in animal models. This effect has not been reported in humans.
Lithium
Theoretically, uva ursi may increase lithium levels, necessitating a decrease in dose.
Uva ursi may have diuretic properties. Diuretics may increase lithium reabsorption with sodium in the proximal tubule of the kidney. Theoretically, uva ursi might reduce excretion and increase levels of lithium.
Urinary Acidifying Agents
Effects of uva ursi in the urinary tract may be reduced by urinary acidifying agents.
Uva ursi seems to work best in alkaline urine. Theoretically, taking uva ursi with medications known to acidify the urine may decrease any effects of uva ursi on the urinary tract.
P-Glycoprotein Substrates
Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.
In vitro, uva ursi appears to inhibit the multi-drug transporter protein, P-glycoprotein. This effect has not been reported in humans.
Buchu
Anticoagulant/Antiplatelet Drugs
Buchu may have antiplatelet effects. Theoretically, buchu may enhance the effects of anticoagulant or antiplatelet drugs and increase the risk of bleeding in some patients. Some anticoagulant or antiplatelet drugs include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.
Hepatotoxic Drugs
Buchu contains pulegone, a known hepatotoxin. There is some concern that buchu may adversely affect the liver, especially when the leaf is used in large doses or the oil is ingested. Theoretically, concomitant use with hepatotoxic drugs might increase the risk of liver damage. Some of these drugs include acarbose (Precose, Prandase), amiodarone (Cordarone), atorvastatin (Lipitor), azathioprine (Imuran), carbamazepine (Tegretol), cerivastatin (Baycol), diclofenac (Voltaren), felbamate (Felbatol), fenofibrate (Tricor), fluvastatin (Lescol), gemfibrozil (Lopid), isoniazid, itraconazole, (Sporanox), ketoconazole (Nizoral), leflunomide (Arava), lovastatin (Mevacor), methotrexate (Rheumatrex), nevirapine (Viramune), niacin, nitrofurantoin (Macrodantin), pioglitazone (Actos), pravastatin (Pravachol), pyrazinamide, rifampin (Rifadin), ritonavir (Norvir), rosiglitazone (Avandia), simvastatin (Zocor), tacrine (Cognex), tamoxifen, terbinafine (Lamisil), valproic acid, and zileuton (Zyflo)
Lithium
Buchu is thought to have diuretic properties. Theoretically, buchu might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.
Juniper
Antidiabetes Drugs
Theoretically, taking juniper berry with antidiabetes medications might cause additive hypoglycemia.
Animal research shows that juniper berry can lower blood glucose.
Diuretic Drugs
Theoretically, juniper berry might increase the risk of adverse effects from diuretic drugs.
Juniper berry is thought to have mild diuretic effects.
Lithium
Theoretically, juniper berry might reduce lithium excretion and increase serum levels of lithium.
Juniper berry is thought to have mild diuretic effects.
Meadowsweet
Aspirin
Theoretically, meadowsweet might have an additive effect with other salicylate-containing drugs, such as aspirin.
Meadowsweet contains salicin, a plant salicylate; however, salicin doesn't seem to have the antiplatelet effects of aspirin.
Choline Magnesium Trisalicylate (Trilisate)
Theoretically, meadowsweet might have an additive effect with other salicylate-containing drugs, such as choline magnesium trisalicylate.
Meadowsweet contains salicin, a plant salicylate.
Salsalate (Disalcid)
Theoretically, meadowsweet might have an additive effect with other salicylate-containing drugs such as salsalate.
Meadowsweet contains salicin, a plant salicylate.
Hydrangea
Lithium
Hydrangea is thought to have diuretic properties. Theoretically, due to these potential diuretic effects, hydrangea might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.
Brand information
Manufacturer and brand details for KB, from the product label.
New Sun
See all New Sun products- Name
- New Sun, Inc.
- City
- Hendersonville
- State
- NC
- ZipCode
- 28792
- Phone Number
- 1-800-544-0777
- Web Address
- www.newsun.net
KB by New Sun: Common Questions
Does KB by New Sun interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this during pregnancy or while breastfeeding?
What's this product supposed to do?
Is uva ursi safe to take long-term?
Can I space this out with my other medications if it affects absorption?
What are the most common side effects?
What's the proprietary blend, and why don't I know how much of each ingredient is in here?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if KB is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind KB’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Juniper
Interacts with 162 drugsJuniper berry is a traditional herb best known for flavoring gin and for its folk use as a diuretic and digestive aid. Solid human evidence for its health benefits is limited, and it can irr...
Read the full Juniper monograph → Herb & supplement monographMarshmallow
Interacts with 2,040 drugsMarshmallow root is a traditional herb rich in soothing, gel-like fibers called mucilage, which is why it has long been used for coughs, sore throats, and stomach irritation. Evidence for th...
Read the full Marshmallow monograph → Herb & supplement monographBuchu
Interacts with 481 drugsBuchu is a fragrant South African shrub whose leaves are traditionally used for urinary and bladder complaints and as a diuretic. Solid human studies are lacking, so its benefits are largely...
Read the full Buchu monograph → Herb & supplement monographHydrangea
Interacts with 1 drugHydrangea root has a long history in folk medicine, mainly for urinary and kidney stone complaints, but there is very little modern human research to confirm it works for any condition. Beca...
Read the full Hydrangea monograph → Herb & supplement monographMeadowsweet
Interacts with 39 drugsMeadowsweet is a traditional European herb that contains natural salicylates (aspirin-like compounds) and is used mainly for digestive upset, colds, and minor aches. High-quality human studi...
Read the full Meadowsweet monograph → Herb & supplement monographUva Ursi
Interacts with 803 drugsUva ursi is a traditional herb used mainly for urinary tract infections, and its leaves contain a compound called arbutin that may have antimicrobial effects in the urine. Evidence in people...
Read the full Uva Ursi monograph →Sources & How We Checked
KB's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 27 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Juniper 7 references
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Robbers JE, Tyler VE. Tyler's Herbs of Choice: The Therapeutic Use of Phytomedicinals. New York, NY: The Haworth Herbal Press, 1999.
- Sanchez de Medina F, Gamez MJ, Jimenez I, et al. Hypoglycemic activity of juniper "berries." Planta Med 1994;60:197-200. PubMed
- Swanston-Flatt SK, Day C, Bailey CJ, Flatt PR. Traditional plant treatments for diabetes. Studies in normal and streptozotocin diabetic mice. Diabetologia 1990;33:462-4. PubMed
- Tammaro A, Adebanjo GAR, Chello C, et al. Bullous dermatitis caused by common juniper. Contact Dermatitis. 2020. PubMed
Marshmallow 5 references
- Monographs on the medicinal uses of plant drugs. Exeter, UK: European Scientific Co-op Phytother, 1997.
- Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Hage-Sleiman R, Mroueh M, Daher CF. Pharmacological evaluation of aqueous extract of Althaea officinalis flower grown in Lebanon. Pharm Biol 2011;49(3):327-33.
Buchu 3 references
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- Fetrow CW, Avila JR. Professional's Handbook of Complementary & Alternative Medicines. 1st ed. Springhouse, PA: Springhouse Corp., 1999.
- Moolla A, Viljoen AM. 'Buchu' - Agathosma betulina and Agathosma crenulata (Retaceae): a review. J Ethnopharmacol 2008;119(3):413-9.
Hydrangea 1 reference
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
Meadowsweet 3 references
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Uva Ursi 8 references
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Wang L, Del Priore LV. Bull's-eye maculopathy secondary to herbal toxicity from uva ursi. Am J Ophthalmol 2004;137:1135-7. PubMed
- Beaux, D., Fleurentin, J., and Mortier, F. Effect of extracts of Orthosiphon stamineus Benth, Hieracium pilosella L., Sambucus nigra L. and Arctostaphylos uva-ursi (L.) Spreng. in rats. Phytother.Res 1999;13(3):222-225.
- de Arriba SG, Naser B, Nolte KU. Risk assessment of free hydroquinone derived from Arctostaphylos Uva-ursi folium herbal preparations. Int J Toxicol. 2013;32(6):442-453.
- Park JB, Kim D, Min JS, et al. Identification and characterization of in vitro inhibitors against UDP-glucuronosyltransferase 1A1 in uva-ursi extracts and evaluation of in vivo uva-ursi-drug interactions. Food Chem Toxicol. 2018;120:651-661. PubMed
- Chauhan B, Yu C, Krantis A, et al. In vitro activity of uva-ursi against cytochrome P450 isoenzymes and P-glycoprotein. Can J Physiol Pharmacol. 2007;85(11):1099-107.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC