Major interaction on record — check this product against your medications before combining. Based on 8 of 11 ingredients. Check your meds →
Dietary supplement

Sport Ingredients & Drug Interactions

by Mannatech

Sport label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Sport against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Sport is a dietary supplement by Mannatech with 11 active ingredients. Its ingredients are commonly taken for bone health, joint and arthritis support, hormone (testosterone/estrogen) support.Based on those ingredients, 2,151 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Gum Tragacanth, Aloe vera, Chromium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Sport by Mannatech

Ask about any prescription or over-the-counter medication and we check it for interactions with Sport by Mannatech — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Sport by Mannatech

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 6 of its 10 active ingredients.
  • “Sterol Complex” is a proprietary blend — the label gives one combined amount (800 mg) without saying how much of each component you get.
  • “Ambrotose Complex” is a proprietary blend — the label gives one combined amount (5 mg) without saying how much of each component you get.

Sport contains 10 active ingredients. The minerals include boron and chromium, which support bone health and blood sugar control respectively.

Plant extracts include sarsaparilla, wild yam extract, and aloe vera — traditionally used for inflammation and joint function. The product also contains larch arabinogalactan (a soluble fiber), orchic extract (from beef testicular tissue), and two proprietary blends — Sterol Complex and Ambrotose Complex — whose specific components aren't listed separately on the label.

Binding and flow agents (gelatin, brown rice flour, silicon dioxide, and magnesium stearate) make up the inactive ingredients.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Chromium deficiency — rated "Likely Effective" (Chromium) (Natural Medicines).
  • On file: Boron deficiency — rated "Likely Effective" (Boron) (Natural Medicines).
  • On file: Oral submucous fibrosis — rated "Possibly Effective" (Aloe) (Natural Medicines).
  • On file: Diabetes — rated "Possibly Effective" (Chromium) (Natural Medicines).
  • On file: Vaginal candidiasis — rated "Possibly Effective" (Boron) (Natural Medicines).

Boron is likely effective for boron deficiency and possibly effective for yeast infections and radiation-related skin damage, though it's ineffective for athletic performance. Chromium is likely effective for chromium deficiency and possibly effective for type 2 diabetes, but doesn't appear to help prediabetes, schizophrenia, or high blood pressure.

For the other active ingredients — sarsaparilla, aloe vera, wild yam extract, and arabinogalactan — the evidence we hold shows insufficient reliability to rate their effectiveness for the conditions they're traditionally used for, like psoriasis, arthritis, or menopausal symptoms. The specific components of Sterol Complex and Ambrotose Complex aren't provided, so we can't assess their effectiveness.

The evidence, ingredient by ingredient Boron Chromium Sarsaparilla Orchic Extract Wild Yam Tragacanth Larch Arabinogalactan Aloe

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 8 of the 8 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 8 of 8.
  • General safety write-ups exist for 8 of 8.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Boron is generally well tolerated at low doses but can be toxic at high doses; avoid it entirely during pregnancy and while breastfeeding due to harm to the fetus and lack of safety data. Chromium is usually well tolerated at typical supplement doses, though high or long-term use carries risks; small amounts from food or prenatal vitamins are generally acceptable, but extra supplement doses should be avoided in pregnancy and lactation unless your doctor recommends them.

Sarsaparilla is likely low-risk in food amounts, but human data on supplement doses are limited; avoid it in pregnancy and while breastfeeding due to insufficient safety information. Aloe vera's topical gel is generally well tolerated, but oral aloe latex (the yellow substance under the plant's skin) can cause serious side effects — abdominal pain, diarrhea, and with long-term use, severe potassium loss and heart rhythm problems.

Avoid oral aloe during pregnancy because it may stimulate the uterus and act as a strong laxative, and avoid it while breastfeeding due to limited safety data. Wild yam extract is likely fine for short-term use in healthy adults but hasn't been well studied long-term; avoid it in pregnancy and while breastfeeding.

Gum tragacanth, arabinogalactan, and orchic extract have limited to no safety data in pregnancy and lactation — avoid medicinal amounts unless your doctor advises otherwise. Orchic extract, derived from raw bovine organs from slaughterhouses, carries concerns about contamination and quality.

Side effects, ingredient by ingredient Boron Chromium Sarsaparilla Orchic Extract Wild Yam Tragacanth Larch Arabinogalactan Aloe

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 6 of the 8 matched ingredients can interact with medications — Sarsaparilla, Aloe, Tragacanth, Chromium, Wild Yam, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; heart-rhythm medications; lithium.
  • For scale: 2,152 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Sport, double-check if you use heart medications like digoxin or warfarin (due to Major and Moderate bleeding/toxicity risks), insulin or antidiabetes drugs (low blood sugar risk), levothyroxine for thyroid function (absorption reduction), lithium for mood (level interference), blood thinners or antiplatelet drugs, diuretics (water pills), stimulant laxatives, or nonsteroidal anti-inflammatory drugs like ibuprofen. If you take any of these, talk with your doctor or pharmacist about whether this product is right for you.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with strong clinical evidence behind its ingredients' uses. Major medication interactions have been identified, and safety information is well characterized.

This product is designed for active adults seeking joint and metabolic support, but the multiple drug interactions — especially with heart, blood-sugar, and blood-thinning medications — mean you'll need to clear it with your own doctor or pharmacist before starting. If you're pregnant, breastfeeding, or take any prescription medications, don't start this without talking it over first.

The evidence for most ingredients beyond boron and chromium isn't well established.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 8 of 10 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Sport, straight from the product label.

Brand Mannatech
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Jul 25, 2014
DSLD ID 34896
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Sport by Mannatech, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
IngredientAmount% DV
Protein1 Gram(s)--
Cholesterol5 mg2%
Boron2 mg--
Chromium200 mcg167%
Sarsaparilla200 mg--
Ghatti Gum0 NP--
Gum Tragacanth0 NP--
Arabinogalactan0 NP--
Orchic Substance400 mg--
Wild Yam extract200 mg--
Aloe vera0 NP--
Sterol Complex800 mg--
Ambrotose Complex5 mg--
standardized to 12.5% Diosgenin25 mg--

Other ingredients: Gelatin, Brown Rice Flour, Silicon Dioxide, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

WARNING: If you are pregnant, nursing, taking medication, have a health condition, or are planning a medical procedure, consult your healthcare professional before use.

Discontinue use and consult your doctor if any adverse reaction occurs.

Do not use if inner seal is missing or broken.

Keep out of reach of children.

Keep bottle tightly closed.

Storage

Store in a cool, dry place.

Keep out of reach of children.

Brand IP Statement(s)

Mannatech, Stylized M Design, Sport and Ambrotose are trademarks of Mannatech, Incorporated. (C) 2014 Mannatech, Incorporated. All rights reserved.

General

Product Number 12101 US.12101.14.011

FDA Statement of Identity

DIETARY SUPPLEMENT

Seals/Symbols

M(SM)

General Statements

SPORT

Suggested/Recommended/Usage/Directions

Recommended Adult Use: Take two capsules with 8 fl oz of water or other liquid immediately following exercise.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Sport by Mannatech label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Sport label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Sport by Mannatech

These are the 11 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Protein

1 Gram(s) per serving

Boron

No known
interactions
2 mg per serving Form: Boron Citrate

Boron is a trace mineral found in many plant foods and sold as a supplement, mainly promoted for bone, joint, and hormone health. The human evidence f...

Boron monograph & interactions

Chromium

Interacts with
178 drugs
200 mcg per serving Form: Chromium Picolinate

Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control i...

Chromium monograph & interactions

Sterol Complex

800 mg per serving

Ambrotose Complex

5 mg per serving

Other (inactive) ingredients: Gelatin, Brown Rice Flour, Silicon Dioxide, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Sport by Mannatech Drug Interactions

Want to check YOUR meds against Sport?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,151Drugs
1 Major 2,143 Moderate 7 Minor

Ingredients driving the most interactions

Gum Tragacanth 2,022
Aloe vera 461
Chromium 178
Arabinogalactan 121
Wild Yam extract 41

Individual Drug Interactions

The ingredients in Sport interact with 2,151 drugs. Click any drug to see the details.

6 of the 11 ingredients in Sport interact with drugs. Each result below shows which ingredient is responsible. Gum Tragacanth Aloe vera Chromium Arabinogalactan Wild Yam extract Sarsaparilla

Each ingredient & the kinds of drugs it affects

For each ingredient in Sport with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Gum Tragacanth1 drug type · 2,022 drugs

Oral Drugs

Theoretically, tragacanth might alter absorption of oral drugs.
Tragacanth contains hydrocolloidal fiber which can decrease, increase, or not affect oral drug absorption. To avoid changes in absorption, take tragacanth 30-60 minutes after oral medications.

Likelihood Possible Evidence D
Gum Tragacanth full monograph & interactions

Aloe vera7 drug types · 461 drugs

Digoxin (Lanoxin)

Theoretically, aloe latex might increase the risk of adverse effects when taken with cardiac glycosides.
Overuse of aloe latex can increase the risk of adverse effects from cardiac glycoside drugs, such as digoxin, due to potassium depletion. Overuse of aloe, along with cardiac glycoside drugs, can increase the risk of toxicity.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that aloe gel can inhibit platelet aggregation. This inhibition was greater than that seen with celecoxib, but less than that seen with aspirin.

Likelihood Possible Evidence D
Antidiabetes Drugs

Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Preliminary clinical research suggests aloe gel might lower blood glucose levels and have additive effects when used with antidiabetes drugs. Monitor blood glucose levels closely.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Overuse of aloe latex might compound diuretic-induced potassium loss, increasing the risk of hypokalemia.

Likelihood Possible Evidence D
Stimulant Laxatives

Theoretically, aloe latex might increase the risk for fluid and electrolyte loss when taken with stimulant laxatives.
Due to cathartic laxative effects of aloe latex, concomitant use with other stimulant laxatives might compound fluid and electrolyte loss.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, aloe latex might increase the risk of bleeding when taken with warfarin.
Aloe latex has stimulant laxative effects. In some people aloe latex can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding. Advise patients who take warfarin not to take excessive amounts of aloe vera.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, aloe might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that aloe extract induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Aloe vera full monograph & interactions

Chromium5 drug types · 178 drugs

Antidiabetes Drugs

Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Some research shows that taking chromium might lower blood glucose levels, especially in patients with poorly controlled type 2 diabetes.

Likelihood Possible Evidence A
Insulin

Theoretically, concomitant use of chromium and insulin might increase the risk of hypoglycemia.
In clinical research, chromium has been shown to increase insulin sensitivity,

Likelihood Possible Evidence B
Levothyroxine (Synthroid, Others)

Chromium might bind levothyroxine in the intestinal tract and decrease levothyroxine absorption.
Clinical research in healthy volunteers shows that taking chromium picolinate 1000 mcg with levothyroxine 1 mg decreases serum levels of levothyroxine by 17% when compared to taking levothyroxine alone. Advise patients to take levothyroxine at least 30 minutes before or 3-4 hours after taking chromium.

Likelihood Probable Evidence B
Aspirin

Theoretically, aspirin might increase chromium absorption.
Animal research suggests that aspirin may increase chromium absorption and chromium levels in the blood.

Likelihood Possible Evidence D
Nonsteroidal Anti-Inflammatory Drugs (Nsaids)

NSAIDs might increase chromium levels in the body.
Drugs that are prostaglandin inhibitors, such as NSAIDs, seem to increase chromium absorption and retention.

Likelihood Possible Evidence D
Chromium full monograph & interactions

Arabinogalactan1 drug type · 121 drugs

Immunosuppressants

Theoretically, larch arabinogalactan might interfere with immunosuppression therapy due to immunostimulant effects. Immunosuppressant drugs include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), corticosteroids (glucocorticoids), and other drugs.

Likelihood Possible Evidence D
Arabinogalactan full monograph & interactions

Wild Yam extract1 drug type · 41 drugs

Estrogens

Theoretically, wild yam might increase or decrease the effects of estrogen.
Wild yam root shows estrogenic and anti-estrogenic effects in vitro. Theoretically, wild yam might interfere with hormone therapy.

Likelihood Possible Evidence D
Wild Yam extract full monograph & interactions

Sarsaparilla2 drug types · 2 drugs

Digoxin (Lanoxin)

Theoretically, concomitant use of sarsaparilla with digoxin might increase the risk of cardiac toxicity.
Sarsaparilla is thought to have diuretic properties, which could potentially cause potassium loss. Overuse or misuse of sarsaparilla with cardiac glycoside therapy might increase the risk of cardiac toxicity due to potassium loss.

Likelihood Possible Evidence D
Lithium

Theoretically, sarsaparilla might increase the effects and adverse effects of lithium.
Sarsaparilla is thought to have diuretic properties. Due to these effects, sarsaparilla might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Sarsaparilla full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Sport, from the product label.

Mannatech

See all Mannatech products
Name
Mannatech, Incorporated
Street Address
600 S. Royal Ln., Ste. 200
City
Coppell
State
TX
ZipCode
75019
Web Address
mannatech.com
Pharmacist Counseling Corner

Sport by Mannatech: Common Questions

Does Sport by Mannatech interact with any medications?
Yes. Based on its ingredients, Sport has a known interaction with 2,151 medications, including 1 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Sport contains 11 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant?
No. Multiple ingredients — boron, chromium (extra supplement doses), sarsaparilla, aloe latex, wild yam, gum tragacanth, arabinogalactan, and orchic extract — have safety warnings against use in pregnancy. Boron is possibly unsafe at higher doses, and the others lack sufficient safety data. Talk with your doctor or pharmacist before taking any supplement while pregnant.
What's orchic substance, and why is it in here?
Orchic extract is derived from raw bovine testicular tissue, traditionally used in sports supplements for hormone and athletic support. However, human safety and effectiveness data are very limited, and animal-tissue products carry quality and contamination concerns — including the theoretical risk of contamination with diseased tissue. If you're concerned, discuss it with your doctor or pharmacist.
Is boron safe at the dose in this product?
Boron is generally safe in small amounts from food and typical low-dose supplements. The product facts note that doses below the tolerable upper intake level of 20 mg are well tolerated. If you have questions about the specific dose in Sport, check the label or ask your pharmacist.
Will this help my athletic performance?
According to the evidence we hold, boron is possibly ineffective for athletic performance, and the effectiveness of the other active ingredients for that purpose isn't established in our data. If you're an athlete looking for performance support, talk with your doctor or sports medicine provider about what actually works.
Can I take this while breastfeeding?
No. Several ingredients — boron, chromium (extra supplement doses), sarsaparilla, aloe, wild yam, gum tragacanth, arabinogalactan, and orchic extract — should be avoided while breastfeeding due to limited or no safety data. Talk with your doctor or pharmacist before using this product if you're nursing.
What are Sterol Complex and Ambrotose Complex?
These are proprietary ingredient blends on the product label, but their specific components aren't listed in the product facts we have. For details on what's in them, check the manufacturer's website or contact Mannatech directly.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Sport label
Go deeper

The Full Monographs Behind Sport’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Boron

Boron is a trace mineral found in many plant foods and sold as a supplement, mainly promoted for bone, joint, and hormone health. The human evidence for most of these uses is limited or prel...

Read the full Boron monograph → Herb & supplement monograph

Chromium

Interacts with 178 drugs

Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control in certain people with type 2 diabetes, b...

Read the full Chromium monograph → Herb & supplement monograph

Sarsaparilla

Interacts with 2 drugs

Sarsaparilla is a traditional root used in teas, tonics, and old-fashioned root beer flavoring. Modern evidence for its health claims is very limited and comes mostly from lab studies, so it...

Read the full Sarsaparilla monograph → Herb & supplement monograph

Orchic Extract

Orchic extract is a glandular supplement made from the testicle tissue of animals, usually cattle. It is marketed for testosterone and male vitality, but there is essentially no reliable hum...

Read the full Orchic Extract monograph → Herb & supplement monograph

Wild Yam

Interacts with 41 drugs

Wild yam is a root traditionally used for menopausal symptoms, cramps, and as a so-called 'natural' hormone supplement, but solid human evidence for these uses is lacking. Despite popular cl...

Read the full Wild Yam monograph → Herb & supplement monograph

Tragacanth

Interacts with 2,022 drugs

Tragacanth is a plant gum used mainly as a thickener and emulsifier in foods, cosmetics, and medicines, and traditionally to soothe the throat and gut. There is very little solid human resea...

Read the full Tragacanth monograph → Herb & supplement monograph

Larch Arabinogalactan

Interacts with 121 drugs

Larch arabinogalactan is a soluble fiber from larch trees that is mainly used as a prebiotic and for immune support. Early research is interesting but limited, and most claims are not yet fi...

Read the full Larch Arabinogalactan monograph → Herb & supplement monograph

Aloe

Interacts with 461 drugs

Aloe vera gel is widely used on the skin for minor burns and irritation, and some research suggests it may help. Aloe latex (the yellow part) is a strong laxative that can cause cramping and...

Read the full Aloe monograph →
Sources

Sources & How We Checked

Sport's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 122 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Boron 6 references
  1. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  3. Thai L, Hart LL. Boric acid vaginal suppositories. Ann Pharmacother 1993;27:1355-7.
  4. Acs N, Banhidy F, Puho E, Czeizel AE. Teratogenic effects of vaginal boric acid treatment during pregnancy. Int J Gynaecol Obstet 2006;93:55-6. PubMed
  5. Garabrant, D. H., Bernstein, L., Peters, J. M., and Smith, T. J. Respiratory and eye irritation from boron oxide and boric acid dusts. J Occup Med 1984;26(8):584-586. PubMed
  6. Hjelm C, Harari F, Vahter M. Pre- and postnatal environmental boron exposure and infant growth: results from a mother-child cohort in northern Argentina. Environ Res 2019;171:60-8. PubMed

See these in context on the Boron monograph →

Chromium 53 references
  1. Cerulli J, Grabe DW, Gauthier I, et al. Chromium picolinate toxicity. Ann Pharmacother 1998;32:428-31. PubMed
  2. Urberg M, Zemel MB. Evidence for synergism between chromium and nicotinic acid in the control of glucose tolerance in elderly humans. Metabolism 1987;36:896-9. PubMed
  3. Mohamedshah FY, Moser-Veillon PB, Yamini S, et al. Distribution of a stable isotope of chromium (53Cr) in serum, urine, and breast milk in lactating women. Am J Clin Nutr 1998;67:1250-5. PubMed
  4. Wasser WG, Feldman NS, D'Agati VD. Chronic renal failure after ingestion of over-the-counter chromium picolinate. [letter]. Ann Intern Med 1997;126:410. PubMed
  5. Mertz W. Interaction of chromium with insulin: a progress report. Nutr Rev 1998;56:174-7. PubMed
  6. Anderson RA. Chromium, glucose intolerance and diabetes. J Am Coll Nutr 1998;17:548-55. PubMed
  7. McLeod MN, Gaynes BN, Golden RN. Chromium potentiation of antidepressant pharmacotherapy for dysthymic disorder in 5 patients. J Clin Psych 1999;60:237-40. PubMed
  8. Fowler JF Jr. Systemic contact dermatitis caused by oral chromium picolinate. Cutis 2000;65:116. DOI
  9. Trent LK, Thieding-Cancel D. Effects of chromium picolinate on body composition. J Sports Med Phys Fitness 1995;35:273-80.
  10. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  11. Rabinovitz H, Friedensohn A, Leibovitz A, et al. Effect of chromium supplementation on blood glucose and lipid levels in type 2 diabetes mellitus elderly patients. Int J Vitam Nutr Res 2004;74:178-82. PubMed
  12. Lanca S, Alves A, Vieira AI, et al. Chromium-induced toxic hepatitis. Eur J Intern Med 2002;13:518-20. PubMed
  13. Kockler DR, McCarthy MW, Lawson CL. Seizure activity and unresponsiveness after hydroxycut ingestion. Pharmacotherapy 2001;21:647-51.. PubMed
  14. Davidson JR, Abraham K, Connor KM, McLeod MN. Effectiveness of chromium in atypical depression: a placebo-controlled trial. Biol Psychiatry 2003;53:261-4.. PubMed
  15. Food Standards Agency. Medicines and Healthcare products Regulatory Agency (MHRA). Expert Group on Vitamins and Minerals. Available at: http://cot.food.gov.uk/sites/default/files/vitmin2003.pdf.
  16. Mouser JF, Hak EB, Helms RA, et al. Chromium and zinc concentrations in pediatric patients receiving long-term parenteral nutrition. Am J Health Syst Pharm 1999;56:1950-6. PubMed
  17. Stevens T, Qadri A, Zein NN. Two patients with acute liver injury associated with use of the herbal weight-loss supplement hydroxycut. Ann Intern Med 2005;142:477-8. PubMed
  18. Wani S, Weskamp C, Marple J, Spry L. Acute tubular necrosis associated with chromium picolinate-containing dietary supplement. Ann Pharmacother 2006;40:563-6. PubMed
  19. Kleefstra N, Houweling ST, Jansman FG, et al. Chromium treatment has no effect in patients with poorly controlled, insulin-treated type 2 diabetes in an obese Western population: a randomized, double-blind, placebo-controlled trial. Diabetes Care 2006;29: PubMed
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Sarsaparilla 3 references
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Aloe 41 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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