Interactions on record — worth a quick check against your medications. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

Stay Sharp Ingredients & Drug Interactions

by Estroven

Stay Sharp label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Stay Sharp against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Stay Sharp is a dietary supplement by Estroven with 3 active ingredients. Its ingredients are commonly taken for eye health, age-related macular degeneration, cataract prevention.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Zeaxanthin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Stay Sharp by Estroven

Ask about any prescription or over-the-counter medication and we check it for interactions with Stay Sharp by Estroven — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Stay Sharp by Estroven

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Estroven Stay Sharp contains 3 active ingredients: lutein, zeaxanthin, and docosahexaenoic acid (an omega-3 fat). Lutein and zeaxanthin are carotenoids — plant pigments that accumulate in the eye and are thought to help protect the retina.

Docosahexaenoic acid is a fatty acid naturally found in the brain and eyes. The softgel also contains inactive ingredients (gelatin, sunflower oil, glycerin, and others) that help deliver the actives.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: support concentration, focus, and eye health.
  • We looked for evidence on: Age-related macular degeneration (AMD), Asthenopia (eye strain), Cataracts, Cognitive function, presbyopia, visual acuity.
  • The strongest evidence on file: Lutein is rated "Possibly Effective" for Age-related macular degeneration (AMD) (Natural Medicines).
  • Also on file: Lutein is rated "Possibly Effective" for Cataracts.
  • Also on file: Zeaxanthin is rated "Possibly Effective" for Age-related macular degeneration (AMD).

Lutein is possibly effective for age-related macular degeneration (AMD) and cataracts — two common vision problems as we age — but the evidence falls short of being strong or definitive. Zeaxanthin is also possibly effective for AMD.

Evidence for zeaxanthin's use in age-related cognitive decline, Alzheimer disease, asthma, and breast cancer is insufficient — we simply don't have enough data to rate it either way. We could not check the effectiveness of docosahexaenoic acid from the data on file for this product.

The evidence, ingredient by ingredient Lutein Zeaxanthin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lutein from food and typical supplement doses is generally well tolerated. In trials, doses up to 20 mg daily caused no reported adverse effects.

Zeaxanthin is also generally well tolerated at typical supplement doses. For pregnancy and breastfeeding: both lutein and zeaxanthin carry a "Likely Safe" rating, though the data notes that supplement safety (as opposed to food sources) isn't as well studied in these settings.

If you're pregnant or nursing, talk with your doctor or pharmacist to weigh the limited data against your individual needs.

Side effects, ingredient by ingredient Lutein Zeaxanthin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Zeaxanthin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antidiabetes drugs (like metformin, sulfonylureas, or insulin), double-check them with the tool below — zeaxanthin may theoretically increase the risk of low blood sugar. No other medication interactions are documented for the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Stay Sharp may be worth considering if you're concerned about age-related eye health, especially AMD or cataracts — lutein and zeaxanthin have some evidence behind them for these conditions, even if it's not ironclad. If you take diabetes medications, check them against the interaction tool on this page first, then confirm with your doctor or pharmacist before starting.

For any other questions about your own health or medications, your pharmacist or doctor can give you personalized advice.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 13, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Stay Sharp, straight from the product label.

Brand Estroven
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Dec 13, 2022
DSLD ID 278648
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult Female (18 - 50 Years), Menopause, Seniors/Mature (>50 Years) - Women ONLY
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Stay Sharp by Estroven, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Softgel(s)
Maximum serving Sizes:
2 Softgel(s)
Servings per container
30
IngredientAmount% DV
Calories15 Calorie(s)--
Total Fat1 Gram(s)2%
Lutein10 mg--
Zeaxanthin2 mg--
Docosahexaenoic Acid400 mg--

Other ingredients: Gelatin, Water, Sunflower Oil, High Oleic, Glycerin, Titanium Dioxide, Riboflavin, Tocopherols, Ascorbyl Palmitate, Sunflower Lecithin, Natural Flavors

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

From the #1 Menopause brand

30 Day supply

Formula

During & after menopause

Formulation

Clinically proven ingredients Support concentration & Focus Help protect eye health vision Safe & drug free

Safe & drug free

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Suggested/Recommended/Usage/Directions

Directions: Take two (2) softgels daily with food. For best results, ongoing use is important.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Stay Sharp by Estroven label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Stay Sharp label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Stay Sharp by Estroven

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Softgel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Lutein

No known
interactions
10 mg per serving

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help...

Lutein monograph & interactions

Zeaxanthin

Interacts with
86 drugs
2 mg per serving

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The stron...

Zeaxanthin monograph & interactions

Docosahexaenoic Acid

400 mg per serving Form: Algal Oil

Other (inactive) ingredients: Gelatin, Water, Sunflower Oil, High Oleic, Glycerin, Titanium Dioxide, Riboflavin, Tocopherols, Ascorbyl Palmitate, Sunflower Lecithin, Natural Flavors. These complete the product’s ingredient list but are not active constituents.

Interaction report

Stay Sharp by Estroven Drug Interactions

Want to check YOUR meds against Stay Sharp?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Zeaxanthin 86

Individual Drug Interactions

The ingredients in Stay Sharp interact with 86 drugs. Click any drug to see the details.

1 of the 3 ingredients in Stay Sharp interact with drugs. Each result below shows which ingredient is responsible. Zeaxanthin

Each ingredient & the kinds of drugs it affects

For each ingredient in Stay Sharp with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Zeaxanthin1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking zeaxanthin with antidiabetes drugs might increase the risk of hypoglycemia.
In an animal diabetic model, zeaxanthin has hypoglycemic effects. However, population research has found that increasing intake of dietary zeaxanthin plus lutein does not decrease the risk of developing type 2 diabetes.

Likelihood Possible Evidence D
Zeaxanthin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Stay Sharp, from the product label.

Estroven

See all Estroven products
Name
Estroven
Street Address
Not Present
Pharmacist Counseling Corner

Stay Sharp by Estroven: Common Questions

Does Stay Sharp by Estroven interact with any medications?
Yes. Based on its ingredients, Stay Sharp has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Stay Sharp contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this product safe to take while pregnant or breastfeeding?
Both lutein and zeaxanthin carry a "Likely Safe" rating for pregnancy and breastfeeding. That said, the safety data on supplement doses (as opposed to getting these nutrients from food) isn't as thorough in these situations. Talk with your doctor or pharmacist — they can help you decide whether this product is right for you right now.
What are lutein and zeaxanthin, and why are they in an eye supplement?
Lutein and zeaxanthin are carotenoids — plant pigments that naturally build up in the retina (the light-sensitive part of the eye). Research suggests they may help protect against age-related macular degeneration and cataracts by filtering damaging light and acting as antioxidants.
Does lutein cause side effects?
Dietary and supplemental lutein is generally well tolerated. In studies, doses up to 20 mg daily did not produce adverse effects. Zeaxanthin is also well tolerated at typical supplement doses.
Can this product help with AMD or cataracts?
Both lutein and zeaxanthin are possibly effective for age-related macular degeneration and possibly effective for cataracts — meaning there's some evidence, but it's not conclusive. They're not a substitute for regular eye exams or medical treatment if you have these conditions.
What is docosahexaenoic acid and why is it in this product?
Docosahexaenoic acid (DHA) is an omega-3 fatty acid naturally found in the brain and eyes. It's included in eye-support formulas because of its role in eye and brain health, though we don't have specific effectiveness data on file for this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Stay Sharp is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Stay Sharp label
Go deeper

The Full Monographs Behind Stay Sharp’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lutein

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help slow progression of age-related macular...

Read the full Lutein monograph → Herb & supplement monograph

Zeaxanthin

Interacts with 86 drugs

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The strongest evidence relates to slowing progres...

Read the full Zeaxanthin monograph →
Sources

Sources & How We Checked

Stay Sharp's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lutein 2 references
  1. Brown L, Rimm EB, Seddon JM, et al. A prospective study of carotenoid intake and risk of cataract extraction in US men. Am J Clin Nutr 1999;70:517-24. PubMed
  2. Chasan-Taber L, Willett WC, Seddon JM, et al. A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. Am J Clin Nutr 1999;70:509-16. PubMed

See these in context on the Lutein monograph →

Zeaxanthin 4 references
  1. Montonen J, Knekt P, Jarvinen R, Reunanen A. Dietary antioxidant intake and risk of type 2 diabetes. Diabetes Care 2004;27:362-6. PubMed
  2. Leermakers ET, Darweesh SK, Baena CP, et al. The effects of lutein on cardiometabolic health across the life course: a systematic review and meta-analysis. Am J Clin Nutr 2016;103(2):481-94. PubMed
  3. Kou L, Du M, Zhang C, Dai Z, Li X, Zhang B. The Hypoglycemic, Hypolipidemic, and Anti-Diabetic Nephritic Activities of Zeaxanthin in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats. Appl Biochem Biotechnol 2017;182(3):944-955. PubMed
  4. Xu X, Zhao X, Berde Y, Low YL, Kuchan MJ. Milk and Plasma Lutein and Zeaxanthin Concentrations in Chinese Breast-Feeding Mother-Infant Dyads With Healthy Maternal Fruit and Vegetable Intake. J Am Coll Nutr 2019;38(2):179-184. PubMed

See these in context on the Zeaxanthin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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