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Dietary supplement

Complete Multi-Symptom Menopause Relief Ingredients & Drug Interactions

by Estroven

Complete Multi-Symptom Menopause Relief label
See full label image
Other (e.g. Tea Bag) Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Complete Multi-Symptom Menopause Relief against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Complete Multi-Symptom Menopause Relief is a dietary supplement by Estroven with 1 active ingredient. Its ingredients are commonly taken for constipation, digestive upset, menopausal symptoms.Based on those ingredients, 658 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Rhapontic Rhubarb root extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Complete Multi-Symptom Menopause Relief by Estroven

Ask about any prescription or over-the-counter medication and we check it for interactions with Complete Multi-Symptom Menopause Relief by Estroven — and tell you which ingredient is responsible.

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Computed from our clinical databases

HelloPharmacist Scorecard of Complete Multi-Symptom Menopause Relief by Estroven

Four independent checks of what is known — a summary of the available information, not a grade of the product itself.

Evidence for Intended Use
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

None of the active ingredients could be matched to our evidence database, so intended use can't be graded.

Why this rating?
  • None of the active ingredients could be matched to a HelloPharmacist monograph, so intended use can't be graded against our evidence data.
Ingredient Transparency
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • “Rhapontic Rhubarb root extract” is listed as a grouped ingredient — the label gives one combined amount (4 mg) without saying how much of each component you get.
Known Interaction Concern
Not assessable

None of the active ingredients could be matched to our interaction database.

Why this rating?
  • We couldn't match any ingredient to a HelloPharmacist monograph, so there was nothing to check interactions against.
Safety Information
Unable to assess

None of the active ingredients could be matched to our safety data.

Why this rating?
  • We couldn't match any ingredient to a HelloPharmacist monograph, so there was no safety data to measure.

HelloPharmacist summaryFully disclosed formula with no assessable stated purpose. Medication interactions could not be assessed, and safety information could not be assessed.

Assessment coverage: 0 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Complete Multi-Symptom Menopause Relief, straight from the product label.

Brand Estroven
Barcode (UPC) 092961040294
Net contents 28 Caplet(s)
Market status On market
Date entered into DSLD Jan 22, 2021
DSLD ID 242625
Product type Botanical
Supplement form Other (e.g. Tea Bag)
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult Female (18 - 50 Years), Menopause, Seniors/Mature (>50 Years) - Women ONLY
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Complete Multi-Symptom Menopause Relief by Estroven, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Caplet(s)
Maximum serving Sizes:
1 Caplet(s)
UPC/BARCODE
092961040294
IngredientAmount% DV
Rhaponticin2.2 mg--
Desoxyrhaponticin1 mg--
Rhapontic Rhubarb root extract4 mg--

Other ingredients: Dicalcium Phosphate, Microcrystalline Cellulose, Coating, Stearic Acid, Croscarmellose Sodium, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Safe & Effective Relief for All Stages of Menopause

Contains clinically proven, plant-based Rhapontic Rhubarb Root Extract, which has been trusted by physicians for over 20 years to relieve menopause symptoms.

Complete multi-symptom menopause relief

Formulation

Up to 90% reduction in hot flashes and night sweats Proven Effective for even severe menopause symptoms

Drug free, estrogen free and soy free

Estroven Complete multi-symptom Fast relief in as little as 28 days. Plant based Extract. Demonstrated long term safety 1 small caplet per day

Estroven does not contain synthetic, animal, or human derived hormones

Hot flashes Night sweats Sleeplessness Low energy Mood swings Mental & physical exhaustion Low sex drive Vaginal Dryness Anxiety Occasional Bladder leakage Daily stress Joint and muscular comfort Concentration

Up to 90% reduction in hot flashes and night sweats

Clinically proven and faster menopause relief Hot flashes Night sweats Sleeplessness Low energy Mood swings & More Relief of all major symptoms

Safe Estrogen and drug free

Country of origin: Germany

Precautions

For questions, concerns, or to report an adverse event, please call 1-877-ESTROVEN or visit www.estroven.com.

Tamper Evident: Product is sealed within blisters. Do not use if any part of the blister is torn, open or damaged.

As with any dietary supplement, please inform your healthcare professional before taking.

Do not take if pregnant, breastfeeding or intending to become pregnant.

Keep out of reach of children

General Statements

Compared to placebo per the Menopause Rating Scale (MRS). Based on clinical studies after 12 weeks of use. Faster vs.other Estroven products. Nielsen xAOC 52 weeks ending 12/21/2019 and #1 pharmacist recommended menopause brand based on Pharmacy Times OTC Survey, 2019.

4 week supply

#1 Brand of choice among women and pharmacists

Other leading menopause brands May take up to 90 days to work. Some formulas are based on synthesized chemicals including MSG and ammonium succinate. Some have no published long term studies demonstrating safety. Up to 2 capsules per day.

Brand IP Statement(s)

Estroven is a trademark of DSM. ERr 731 is a registered trademark of Chemisch-Pharmazeutische Fabrik Goppingen Carl Muller Apotheker GmbH & Co.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Suggested/Recommended/Usage/Directions

Only 1 caplet per day

Directions for Use: Take one caplet daily, at any time of day, with or without food. Results seen in as little as 28 days and improve with continued use. The enclosed blister cards include the days of the week on the back to help you stay on track with your regimen.

FDA Statement of Identity

Dietary Supplement

Storage

Store at room temperature. Do not expose to excessive heat, humidity or direct sunlight.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Complete Multi-Symptom Menopause Relief by Estroven label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Complete Multi-Symptom Menopause Relief label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Complete Multi-Symptom Menopause Relief by Estroven

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Caplet(s) Dosage formOther (e.g. Tea Bag) Amounts shown are per serving.

Rhapontic Rhubarb root extract

Interacts with
658 drugs
4 mg per serving

Rhubarb root has a long history of use as a laxative and in traditional Chinese medicine, and its edible stalks are a common food. Most medicinal clai...

Rhapontic Rhubarb root extract monograph & interactions
  • › Rhaponticin
  • › Desoxyrhaponticin

Other (inactive) ingredients: Dicalcium Phosphate, Microcrystalline Cellulose, Coating, Stearic Acid, Croscarmellose Sodium, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Complete Multi-Symptom Menopause Relief by Estroven Drug Interactions

Complete Multi-Symptom Menopause Relief contains a single active ingredient, and it has known interactions with 658 medications. Here’s the picture, then you can look up your own drug.

Want to check YOUR meds against Complete Multi-Symptom Menopause Relief?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
658Drugs
658 Moderate

Ingredients driving the most interactions

Rhapontic Rhubarb root extract 658

Individual Drug Interactions

The ingredients in Complete Multi-Symptom Menopause Relief interact with 658 drugs. Click any drug to see the details.

1 of the 1 ingredient in Complete Multi-Symptom Menopause Relief interact with drugs. Each result below shows which ingredient is responsible. Rhapontic Rhubarb root extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Complete Multi-Symptom Menopause Relief with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Rhapontic Rhubarb root extract8 drug types · 658 drugs

Corticosteroids

Theoretically, frequent and high doses of rhubarb might increase the risk of hypokalemia when taken with corticosteroids.
Rhubarb has stimulant laxative effects. Overuse of rhubarb might compound corticosteroid-induced potassium loss.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically, taking rhubarb with cyclosporine might reduce cyclosporine levels.
Animal research shows that co-administration of rhubarb decoction 0.25 or 1 gram/kg with cyclosporine 2.5 mg/kg, decreases cyclosporine maximum plasma concentration and overall exposure levels when compared with taking cyclosporine alone. The authors theorize that rhubarb might reduce cyclosporine bioavailability by inducing of P-glycoprotein and/or cytochrome P450 3A4. However, since rhubarb was administered as a single oral dose and enzyme induction usually occurs after multiple doses, it is possible that cyclosporine absorption was actually reduced via rhubarb's stimulant laxative effects. Also, the composition of the rhubarb decoction was not described.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, overuse of rhubarb might increase the risk of adverse effects when taken with digoxin.
Rhubarb has stimulant laxative effects. Overuse of rhubarb might cause potassium depletion, increasing the risk of digoxin toxicity.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, frequent and high doses of rhubarb might increase the risk of hypokalemia.
Rhubarb has stimulant laxative effects. Overuse of rhubarb might cause potassium depletion and compound diuretic-induced potassium loss.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, concomitant use of rhubarb with potentially hepatotoxic drugs might increase the risk of developing liver damage.
Some animal research suggests that anthraquinones in rhubarb might have hepatotoxic effects. Also, rhubarb use has been linked to at least 24 cases of liver injury, although details on the dose of rhubarb and duration of use in these cases is unclear.

Likelihood Possible Evidence D
Nephrotoxic Drugs

Theoretically, long-term use of anthraquinones from rhubarb might increase the risk of nephrotoxicity when used with nephrotoxic drugs.
The anthraquinone constituents of rhubarb have been shown to induce nephrotoxicity in animal research. Additionally, in a case report, a 23-year old female presented with kidney failure after taking 6 tablets of a proprietary slimming agent (found to contain the anthraquinones emodin and aloe-emodin from rhubarb) daily for 6 weeks and then adding diclofenac 25 mg 4 times daily for 2 days. The authors postulate that the anthraquinone constituents of rhubarb contributed to the renal dysfunction, and the addition of diclofenac, a nephrotoxic drug, led to renal failure. Until more is known, advise patients to avoid taking rhubarb if they are taking other potentially nephrotoxic drugs.

Likelihood Possible Evidence D
Stimulant Laxatives

Theoretically, rhubarb might increase the risk for fluid and electrolyte loss when taken with other stimulant laxatives.
Rhubarb has stimulant laxative effects. Concomitant use with stimulant laxatives might compound fluid and electrolyte loss.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, excessive use of rhubarb might increase the risk of bleeding when taken with warfarin.
Rhubarb has stimulant laxative effects and can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding. Advise patients who take warfarin not to take excessive amounts of rhubarb.

Likelihood Possible Evidence D
Rhapontic Rhubarb root extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Complete Multi-Symptom Menopause Relief, from the product label.

Estroven

See all Estroven products
Name
i-Health, Inc.
Street Address
55 Sebethe Drive
City
Cromwell
State
CT
ZipCode
06416
Phone Number
1-877-378-7683
Web Address
www.estroven.com
Pharmacist Counseling Corner

Complete Multi-Symptom Menopause Relief by Estroven: Common Questions

Does Complete Multi-Symptom Menopause Relief by Estroven interact with any medications?
Yes. Based on its ingredients, Complete Multi-Symptom Menopause Relief has a known interaction with 658 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Complete Multi-Symptom Menopause Relief contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Complete Multi-Symptom Menopause Relief label
Go deeper

The Full Monographs Behind Complete Multi-Symptom Menopause Relief’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Rhubarb

Interacts with 658 drugs

Rhubarb root has a long history of use as a laxative and in traditional Chinese medicine, and its edible stalks are a common food. Most medicinal claims are backed by limited or low-quality...

Read the full Rhubarb monograph →
Sources

Sources & How We Checked

Complete Multi-Symptom Menopause Relief's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 20 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Rhubarb 20 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  4. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  5. Nusko G, Schneider B, Schneider I, et al. Anthranoid laxative use is not a risk factor for colorectal neoplasia: results of a prospective case control study. Gut 2000;46:651-5. PubMed
  6. Kwan TH, Tong MK, Leung KT, et al. Acute renal failure associated with prolonged intake of slimming pills containing anthraquinones. Hong Kong Med J 2006;12:394-7.
  7. Fairbairn JW. The anthraquinone laxatives. Biological assay and its relation to chemical structure. Pharmacology 1976;14:48-61. PubMed
  8. Siegers, C. P., Hertzberg-Lottin, E., Otte, M., and Schneider, B. Anthranoid laxative abuse--a risk for colorectal cancer? Gut 1993;34(8):1099-1101. PubMed
  9. Fan, J. G. Evaluating the efficacy and safety of Danning Pian in the short-term treatment of patients with non-alcoholic fatty liver disease: a multicenter clinical trial. Hepatobiliary.Pancreat.Dis.Int 2004;3(3):375-380.
  10. Yan, M., Zhang, L. Y., Sun, L. X., Jiang, Z. Z., and Xiao, X. H. Nephrotoxicity study of total rhubarb anthraquinones on Sprague Dawley rats using DNA microarrays. J Ethnopharmacol. 4-15-2006; PubMed
  11. Zhang, J. H., Li, L. S., and Zhang, M. Clinical effects of rheum and captopril on preventing progression of chronic renal failure. Chin Med J (Engl.) 1990;103(10):788-793.
  12. Mitsuma, T., Yokozawa, T., Oura, H., and Terasawa, K. [Rhubarb therapy in patients with chronic renal failure (Part 2)]. Nippon Jinzo Gakkai Shi 1987;29(2):195-207.
  13. Wu, C. X. [A preliminary study on the effect of a single Rheum officinale in heavy doses in the treatment of acute icteric hepatitis]. Zhong.Xi.Yi.Jie.He.Za Zhi.(Chinese Journal of Modern Developments in Traditional Medicine) 1984;4(2):88-89.
  14. Jiao, D. H. [Clinical research on the hemostatic effect of rhubarb on peptic ulcer with acute bleeding]. Zhong.Xi.Yi.Jie.He.Za Zhi.(Chinese Journal of Modern Developments in Traditional Medicine) 1984;4(10):597-600, 579.
  15. Jiao, D. H., Ma, Y. H., Chen, S. J., Liu, C. T., Shu, H. N., and Chu, C. M. Resume of 400 cases of acute upper digestive tract bleeding treated by rhubarb alone. Pharmacology 1980;20 Suppl 1:128-130.
  16. Zhang, JH, Yao, XD, Song, Y, and et al. [Long-term treating effects of rhubarb and captopril in delaying the progression of renal failure]. Chinese Kidney Disease Journal 1993;9(4):197-201.
  17. Rehman H, Begum W, Anjum F, Tabasum H, Zahid S. Effect of rhubarb (Rheum emodi) in primary dysmenorrhoea: a single-blind randomized controlled trial. J Complement Integr Med. 2015 Mar;12(1):61-9.
  18. Yu CP, Lin HJ, Lin SP, Shia CS, Chang PH, Hou YC, Hsieh YW. Rhubarb decreased the systemic exposure of cyclosporine, a probe substrate of P-glycoprotein and CYP 3A. Xenobiotica. 2016 Aug;46(8):677-82. PubMed
  19. Byeon JH, Kil JH, Ahn YC, Son CG. Systematic review of published data on herb induced liver injury. J Ethnopharmacol 2019;233:190-6. PubMed
  20. Zhao D, Feng SX, Zhang HJ, et al. Pharmacokinetics, tissue distribution and excretion of five rhubarb anthraquinones in rats after oral administration of effective fraction of anthraquinones from rheum officinale. Xenobiotica. 2021;51(8):916-925. PubMed

See these in context on the Rhubarb monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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