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Dietary supplement

Sublingual B12 1000 mcg Cherry Ingredients & Drug Interactions

by Nature Made

Sublingual B12 1000 mcg Cherry label
See full label image
Lozenge Category: Vitamin
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Sublingual B12 1000 mcg Cherry against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Sublingual B12 1000 mcg Cherry is a dietary supplement by Nature Made with 1 active ingredient. Its ingredients are commonly taken for treating or preventing b12 deficiency, pernicious anemia, low energy and fatigue.Based on those ingredients, 20 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Vitamin B12. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Sublingual B12 1000 mcg Cherry by Nature Made

Ask about any prescription or over-the-counter medication and we check it for interactions with Sublingual B12 1000 mcg Cherry by Nature Made — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Sublingual B12 1000 mcg Cherry by Nature Made

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This lozenge contains one active ingredient: vitamin B12 (1000 mcg). B12 is an essential vitamin your body uses for nerve function, red blood cell formation, and DNA synthesis.

The remaining ingredients—mannitol, corn starch, crospovidone, stearic acid, silicon dioxide, magnesium stearate, sucralose, and cherry flavoring—are inactive and help shape and flavor the lozenge.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Support nervous system function and cellular energy.
  • We looked for evidence on: Peripheral neuropathy, Chemotherapy-induced peripheral neuropathy, Fatigue, Cognitive function, Vitamin B12 deficiency, Diabetic neuropathy — and 3 related terms.
  • The strongest evidence on file: Vitamin B12 is rated "Effective" for Vitamin B12 deficiency (Natural Medicines).
  • Also on file: Vitamin B12 is rated "Insufficient Reliable Evidence To Rate" for Chemotherapy-induced peripheral neuropathy, Cognitive function, Diabetic neuropathy, Fatigue, and more.

Vitamin B12 is effective for treating B12 deficiency and a rare genetic condition called Imerslund-Grasbeck disease. It's also likely effective for cyanide poisoning.

There is possibly effective evidence for canker sores and a nerve pain condition called postherpetic neuralgia, though the evidence is less established.

The evidence, ingredient by ingredient Vitamin B12

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

B12 is generally very well tolerated. Your body removes excess B12 through urine, so there's no established upper limit for how much you can safely take.

During pregnancy and breastfeeding, B12 is both needed and considered safe at recommended amounts—follow your provider's guidance on the right dose for you. Serious side effects are rare.

Allergic reactions like rash, itching, or hives can occur, and in very rare cases, correcting severe B12 deficiency has been linked to a dangerous drop in potassium (low blood potassium) levels—something your doctor would monitor if you had that condition. Injection site reactions are noted with shots, not lozenges.

Side effects, ingredient by ingredient Vitamin B12

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Vitamin B12.
  • The most serious interaction on file is rated Minor.
  • For scale: 20 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take metformin for diabetes, let your pharmacist know you're adding B12, since metformin can lower your B12 levels anyway. No other medication interactions are documented for the ingredients we could check, but always confirm your full medication list with the search tool on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

This product is a straightforward way to supplement B12 if you're deficient or at risk—especially if you take metformin. B12 is very safe and well tolerated.

If you're pregnant, breastfeeding, or take any medications, a quick check with your pharmacist will confirm there's nothing to worry about.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Sublingual B12 1000 mcg Cherry, straight from the product label.

Brand Nature Made
Barcode (UPC) 031604027179
Net contents 50 Microlozenge(s)
Market status On market
Date entered into DSLD Sep 22, 2022
DSLD ID 276573
Product type Vitamin
Supplement form Lozenge
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Sublingual B12 1000 mcg Cherry by Nature Made, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Lozenge(s)
Maximum serving Sizes:
1 Lozenge(s)
Servings per container
50
UPC/BARCODE
031604027179
IngredientAmount% DV
Vitamin B121000 mcg41667%

Other ingredients: Mannitol, Corn Starch, Crospovidone, Stearic Acid, Silicon Dioxide, Magnesium Stearate, Sucralose, natural and artificial Cherry flavor

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

#1 pharmacist recommended vitamin & supplement brand

Seals/Symbols

USP Verified Dietary Supplement

Formula

Cherry Natural & artificial flavor

Formulation

Helps support nervous system function Helps convert food into cellular energy

Important for vegetarians & vegans

No color added No preservatives

USP has tested and verified ingredients, potency, and manufacturing process. USP sets official standards for dietary supplements. www.uspverified.org. Based on a survey of pharmacists who recommend branded vitamins and supplements.

FDA Statement of Identity

Dietary Supplement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Suggested/Recommended/Usage/Directions

Suggested use: Adults, take 1 lozenge daily with a meal. Place lozenge under tongue until dissolved before swallowing.

Storage

Store tightly closed, in a cool, dry place, out of reach of children.

Precautions

Store tightly closed, in a cool, dry place, out of reach of children.

Do not use if imprinted seal under cap is broken or missing.

Caution: If you are taking medication, consult your physician before use.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Sublingual B12 1000 mcg Cherry by Nature Made label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Sublingual B12 1000 mcg Cherry label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Sublingual B12 1000 mcg Cherry by Nature Made

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Lozenge(s) Dosage formLozenge Servings per container50 Amounts shown are per serving.

Vitamin B12

Interacts with
20 drugs
1000 mcg per serving Form: Cyanocobalamin

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Vitamin B12 monograph & interactions

Other (inactive) ingredients: Mannitol, Corn Starch, Crospovidone, Stearic Acid, Silicon Dioxide, Magnesium Stearate, Sucralose, Natural and artificial Cherry flavor. These complete the product’s ingredient list but are not active constituents.

Interaction report

Sublingual B12 1000 mcg Cherry by Nature Made Drug Interactions

Want to check YOUR meds against Sublingual B12 1000 mcg Cherry?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
20Drugs
20 Minor

Ingredients driving the most interactions

Vitamin B12 20

Individual Drug Interactions

The ingredients in Sublingual B12 1000 mcg Cherry interact with 20 drugs. Click any drug to see the details.

1 of the 1 ingredient in Sublingual B12 1000 mcg Cherry interact with drugs. Each result below shows which ingredient is responsible. Vitamin B12

Each ingredient & the kinds of drugs it affects

For each ingredient in Sublingual B12 1000 mcg Cherry with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin B121 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Vitamin B12 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Sublingual B12 1000 mcg Cherry, from the product label.

Nature Made

See all Nature Made products
Name
Nature Made Nutritional Products
City
West Hills
State
CA
ZipCode
91309-9903
Phone Number
1-800-276-2878
Web Address
www.NatureMade.com
Pharmacist Counseling Corner

Sublingual B12 1000 mcg Cherry by Nature Made: Common Questions

Does Sublingual B12 1000 mcg Cherry by Nature Made interact with any medications?
Yes. Based on its ingredients, Sublingual B12 1000 mcg Cherry has a known interaction with 20 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Sublingual B12 1000 mcg Cherry contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will B12 cause any side effects?
B12 is very well tolerated by most people. Allergic reactions like rash or itching are possible but uncommon. In rare cases, when B12 corrects a severe deficiency, a dangerous drop in potassium can occur—your doctor would watch for this if you had that condition. Otherwise, any excess B12 just leaves your body in urine.
Is it safe to take B12 if I'm pregnant or breastfeeding?
Yes. B12 is actually needed during pregnancy and breastfeeding and is considered safe at recommended amounts. Follow your provider's advice on the right dose for you.
I take metformin for diabetes. Can I use this B12 supplement?
Yes, you can. In fact, metformin can lower your B12 levels over time, so supplementing may help. Talk to your doctor or pharmacist about whether this dose and timing work for your situation.
What is B12 used for in the body?
B12 is essential for nerve function, red blood cell formation, and DNA synthesis. Your body can't store much B12, so regular intake or supplementation is important if you're at risk for deficiency.
How does this lozenge work compared to a pill or injection?
This product is a sublingual lozenge, meaning it dissolves under your tongue and may be absorbed directly into the bloodstream rather than passing through your digestive system. The facts we have don't compare its effectiveness to other forms, so ask your pharmacist which form is best for your needs.
Are there any fillers or unnecessary ingredients?
The inactive ingredients are mannitol, corn starch, crospovidone, stearic acid, silicon dioxide, magnesium stearate, sucralose, and cherry flavoring. These are standard binders, thickeners, and flavorings to make the lozenge work and taste good—no unusual extras here.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Sublingual B12 1000 mcg Cherry is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Sublingual B12 1000 mcg Cherry label
Go deeper

The Full Monographs Behind Sublingual B12 1000 mcg Cherry’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph →
Sources

Sources & How We Checked

Sublingual B12 1000 mcg Cherry's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 30 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B12 30 references
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  2. Hartman TJ, Woodson K, Stolzenberg-Solomon R, et al. Association of the B-vitamins pyridoxal 5'-phosphate (B6), B12, and folate with lung cancer risk in older men. Am J Epidemiol 2001;153:688-94.. DOI
  3. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  4. Lange H, Suryapranata H, De Luca G, et al. Folate therapy and in-stent restenosis after coronary stenting. N Engl J Med 2004;350:2673-81. PubMed
  5. Collin, S. M., Metcalfe, C., Refsum, H., Lewis, S. J., Zuccolo, L., Smith, G. D., Chen, L., Harris, R., Davis, M., Marsden, G., Johnston, C., Lane, J. A., Ebbing, M., Bonaa, K. H., Nygard, O., Ueland, P. M., Grau, M. V., Baron, J. A., Donovan, J. L., Nea
  6. Geissbuhler, P., Mermillod, B., and Rapin, C. H. Elevated serum vitamin B12 levels associated with CRP as a predictive factor of mortality in palliative care cancer patients: a prospective study over five years. J.Pain Symptom.Manage. 2000;20(2):93-103. PubMed
  7. Salles, N., Herrmann, F., Sakbani, K., Rapin, C. H., and Sieber, C. High vitamin B12 level: a strong predictor of mortality in elderly inpatients. J Am Geriatr.Soc 2005;53(5):917-918.
  8. Looker, H. C., Fagot-Campagna, A., Gunter, E. W., Pfeiffer, C. M., Sievers, M. L., Bennett, P. H., Nelson, R. G., Hanson, R. L., and Knowler, W. C. Homocysteine and vitamin B(12) concentrations and mortality rates in type 2 diabetes. Diabetes Metab Res R
  9. Uhl, W., Nolting, A., Golor, G., Rost, K. L., and Kovar, A. Safety of hydroxocobalamin in healthy volunteers in a randomized, placebo-controlled study. Clin Toxicol (Phila) 2006;44 Suppl 1:17-28. PubMed
  10. Borron, S. W., Baud, F. J., Barriot, P., Imbert, M., and Bismuth, C. Prospective study of hydroxocobalamin for acute cyanide poisoning in smoke inhalation. Ann Emerg.Med 2007;49(6):794-801, 801. PubMed
  11. Borron, S. W., Baud, F. J., Megarbane, B., and Bismuth, C. Hydroxocobalamin for severe acute cyanide poisoning by ingestion or inhalation. Am J Emerg.Med 2007;25(5):551-558. PubMed
  12. Lewis, J. G. Gout, Steatorrhoea, and Megaloblastic Anaemia. Ann Rheum.Dis 1962;21(3):284-286. PubMed
  13. Tal, S., Shavit, Y., Stern, F., and Malnick, S. Association between vitamin B12 levels and mortality in hospitalized older adults. J Am Geriatr.Soc 2010;58(3):523-526. PubMed
  14. Baztan, J. J., Gavidia, J. J., Gomez-Pavon, J., Esteve, A., and Ruiperez, I. High vitamin B12 levels and in-hospital mortality. J Am Geriatr.Soc 2010;58(11):2237-2238. PubMed
  15. Omboni, E., Checchini, M., and Longoni, F. [Hypopotassemia and megaloblastic anemia. Presentation of a case]. Minerva Med 8-31-1987;78(16):1255-1257.
  16. Aalfs As, Scholvinck LH, Horvath B. Acneiform eruption in a 5-year old due to vitamin B12 supplementation. Eur J Dermatol 2013;23(5):726-7. PubMed
  17. Balta I, Ozuguz P. Vitamin B12-induced acneiform eruption. Cutan Ocul Toxicol 2014;33(2):94-5. PubMed
  18. Carman KB, Belgemen T, Yis U. Involuntary movements misdiagnosed as seizure during vitamin B12 treatment. Pediatr Emerg Care 2013;29(11):1223-4. PubMed
  19. Djuric V, Bogic M, Popadic AP, et al. Anaphylactic reaction to hydroxycobalamin with tolerance to cyanocobalamin. Ann Allergy Asthma Immunol 2012;108(3):207-8. PubMed
  20. Kartel O, Gulec M, Demirel F, et al. Vitamin B12 allergy and successful desensitization with cyanocobalamin: A case report. Allergol Immunopath (Madr) 2012;40(5):324-5.
  21. Patiroglu T, Unal E, Yildirim S. Infantile tremor syndrome associated with cobalamin therapy: A case report. Clin Neurol Neurosurg 2013;115(9):1903-5. PubMed
  22. Schulte S, Barkema LW, Kardaun SH. Long-lasting atypical acneiform eruption with prominent comedones induced by hydroxocobalamin (vitamin B12). J Dtsch Dermatol Ges 2014;12(6):502-3.
  23. Zanus C, Alberini E, Costa P, et al. Involuntary movements after correction of vitamin B12 deficiency: A video-case report. Epileptic Disord 2012;14(2):174-80. PubMed
  24. Fanidi A, Carreras-Torres R, Larose TL, et al. Is high vitamin B12 status a cause of lung cancer? Int J Cancer. 2019 Sep 15;145(6):1499-1503. PubMed
  25. Fujita Y, Mizukami T, Maya Y, et al. Vitamin B12 allergy manifesting as lymphomatoid contact dermatitis. Eur J Dermatol. 2020;30(3):304-305. PubMed
  26. Dépret F, Hoffmann C, Daoud L, et al. Association between hydroxocobalamin administration and acute kidney injury after smoke inhalation: a multicenter retrospective study. Crit Care. 2019;23(1):421. PubMed
  27. Khairan P, Sobue T, Eshak ES, et al. Association of dietary intakes of vitamin B12, vitamin B6, folate, and methionine with the risk of esophageal cancer: the Japan Public Health Center-based (JPHC) prospective study. BMC Cancer 2021;21(1):982. PubMed
  28. Evans J, Pandya A, Ding Y, Qunibi WY. Hydroxocobalamin-Induced Oxalate Nephropathy in a Patient With Smoke Inhalation. Kidney Int Rep 2021;6(8):2228-2231. PubMed
  29. Lacombe V, Chabrun F, Lacout C, et al. Persistent elevation of plasma vitamin B12 is strongly associated with solid cancer. Sci Rep 2021;11(1):13361. PubMed
  30. Pegalajar-García MD, Cebolla-Verdugo M, Prados-Carmona Á, Llamas-Segura C, Navarro-Triviño FJ. Systemic allergic dermatitis to cobalt present in cyanocobalamin supplementation. Contact Dermatitis 2023;89(3):203-205. PubMed

See these in context on the Vitamin B12 monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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