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Dietary supplement

Sunflower Phosphatidyl Serine 100 mg Ingredients & Drug Interactions

by NOW

Sunflower Phosphatidyl Serine 100 mg label
See full label image
Softgel Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Sunflower Phosphatidyl Serine 100 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Sunflower Phosphatidyl Serine 100 mg is a dietary supplement by NOW with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, age-related cognitive decline, attention and focus (adhd).Based on those ingredients, 219 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Phosphatidyl Serine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Sunflower Phosphatidyl Serine 100 mg by NOW

Ask about any prescription or over-the-counter medication and we check it for interactions with Sunflower Phosphatidyl Serine 100 mg by NOW — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Sunflower Phosphatidyl Serine 100 mg by NOW

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: phosphatidylserine 100 mg per softgel. Phosphatidylserine is a naturally occurring fat-like compound found in cell membranes.

The softgel also contains inactive ingredients — sunflower oil, vegetarian softgel capsule material, silicon dioxide, and mixed tocopherols — that help deliver and preserve the active ingredient.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: memory and cognitive support.
  • We looked for evidence on: Age-related cognitive decline, Alzheimer disease, Attention deficit-hyperactivity disorder (ADHD), Cognitive function, Dementia, mental performance — and 1 related terms.
  • The strongest evidence on file: Phosphatidylserine is rated "Possibly Effective" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Phosphatidylserine is rated "Possibly Effective" for Alzheimer disease.
  • Also on file: Phosphatidylserine is rated "Insufficient Reliable Evidence To Rate" for Attention deficit-hyperactivity disorder (ADHD), Cognitive function, Dementia.

Phosphatidylserine is possibly effective for age-related cognitive decline and Alzheimer disease based on available evidence. For athletic performance, cognitive function, attention deficit-hyperactivity disorder (ADHD), and dementia, the evidence we hold is insufficient to make a reliable rating.

Talk with your doctor about what the research actually shows for your specific situation.

The evidence, ingredient by ingredient Phosphatidylserine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Phosphatidylserine is generally well tolerated in studies, though long-term safety isn't fully established. The most common side effects are flatulence, gastrointestinal upset, headache, insomnia, and nausea.

Insomnia is more likely at higher doses (around 600 mg), and gastrointestinal upset can occur at doses of 200–300 mg per day. There isn't enough safety data to know whether phosphatidylserine is safe during pregnancy or breastfeeding, so the advice is to avoid it if you're pregnant or nursing.

Talk with your doctor or pharmacist about your individual situation if you're considering this product and are pregnant, planning pregnancy, or breastfeeding.

Side effects, ingredient by ingredient Phosphatidylserine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Phosphatidylserine.
  • The most serious interaction on file is rated Moderate.
  • For scale: 219 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you use anticholinergic drugs (for overactive bladder, certain poisonings) or cholinergic drugs (for myasthenia gravis, Alzheimer disease, glaucoma). Phosphatidylserine may reduce anticholinergic effectiveness or add to cholinergic effects — both Moderate-severity risks.

Use the medication checker on this page with your exact drugs to be sure.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Phosphatidylserine may help with age-related memory loss or early Alzheimer disease, but the evidence is still limited. If you take anticholinergic or cholinergic medications, you'll want to check with your doctor or pharmacist first — this product could change how those drugs work.

Avoid it during pregnancy and breastfeeding unless your healthcare provider advises otherwise.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Sunflower Phosphatidyl Serine 100 mg, straight from the product label.

Brand NOW
Barcode (UPC) 733739023919
Net contents 60 Veggie Softgel(s)
Market status On market
Date entered into DSLD Mar 25, 2021
DSLD ID 245928
Product type Fat/fatty Acid
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Sunflower Phosphatidyl Serine 100 mg by NOW, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veggie Softgel(s)
Maximum serving Sizes:
1 Veggie Softgel(s)
Servings per container
60
UPC/BARCODE
733739023919
IngredientAmount% DV
Phosphatidyl Serine100 mg--

Other ingredients: Sunflower Oil, Vegetarian Softgel Capsule, Silicon Dioxide, Mixed Tocopherols

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Usage: Take 1 softgel 1 to 3 times daily with food.

Formulation

Phosphatidyl serine (PS) is a natural compound that's an important component of cell membranes, where it plays an essential role in communication and the transfer of nutrients between cells. Derived from non-GMO sunflower lecithin, NOW soy-free Sunflower Phosphatidyl Serine supports brain health, nervous system function, and the activity of neurotransmitters involved in learning, memory, and mood.

Natural color variation may occur in this product.

Brain health

Soy-free

Vegetarian/vegan

Non-GMO

Not manufactured with yeast, wheat, gluten, soy, milk, egg, fish or shellfish ingredients.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Caution: For adults only.

Consult physician if pregnant/nursing, taking medication, or have a medical condition.

Keep out of reach of children.

Not manufactured with yeast, wheat, gluten, soy, milk, egg, fish or shellfish ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Storage

Store in a cool, dry place after opening.

Formula

Sharp-PS GREEN

FDA Statement of Identity

A Dietary Supplement

General Statements

General health Family owned since 1968.

Brand IP Statement(s)

Sharp-PS is a registered trademark of Enzymotec Ltd.

Seals/Symbols

GMP Quality Assured

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Sunflower Phosphatidyl Serine 100 mg by NOW label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Sunflower Phosphatidyl Serine 100 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Sunflower Phosphatidyl Serine 100 mg by NOW

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Veggie Softgel(s) Dosage formSoftgel Capsule Servings per container60 Amounts shown are per serving.

Phosphatidyl Serine

Interacts with
219 drugs
100 mg per serving Form: Sunflower Lecithin

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinki...

Phosphatidyl Serine monograph & interactions

Other (inactive) ingredients: Sunflower Oil, Vegetarian Softgel Capsule, Silicon Dioxide, Mixed Tocopherols. These complete the product’s ingredient list but are not active constituents.

Interaction report

Sunflower Phosphatidyl Serine 100 mg by NOW Drug Interactions

Want to check YOUR meds against Sunflower Phosphatidyl Serine 100 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
219Drugs
219 Moderate

Ingredients driving the most interactions

Phosphatidyl Serine 219

Individual Drug Interactions

The ingredients in Sunflower Phosphatidyl Serine 100 mg interact with 219 drugs. Click any drug to see the details.

1 of the 1 ingredient in Sunflower Phosphatidyl Serine 100 mg interact with drugs. Each result below shows which ingredient is responsible. Phosphatidyl Serine

Each ingredient & the kinds of drugs it affects

For each ingredient in Sunflower Phosphatidyl Serine 100 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Phosphatidyl Serine2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically interfere with the activity of anticholinergic agents.

Likelihood Possible Evidence B
Cholinergic Drugs

Theoretically, phosphatidylserine might have additive effects with cholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically lead to additive cholinergic effects when used with cholinergic drugs.

Likelihood Possible Evidence B
Phosphatidyl Serine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Sunflower Phosphatidyl Serine 100 mg, from the product label.

NOW

See all NOW products
Name
NOW Foods
Street Address
395 S. Glen Ellyn Rd.
City
Bloomingdale
State
IL
ZipCode
60108
Web Address
nowfoods.com
Pharmacist Counseling Corner

Sunflower Phosphatidyl Serine 100 mg by NOW: Common Questions

Does Sunflower Phosphatidyl Serine 100 mg by NOW interact with any medications?
Yes. Based on its ingredients, Sunflower Phosphatidyl Serine 100 mg has a known interaction with 219 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Sunflower Phosphatidyl Serine 100 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will phosphatidylserine actually help my memory?
It's possibly effective for age-related cognitive decline and Alzheimer disease based on current evidence, but the data isn't rock-solid yet. For other memory or focus concerns — like ADHD or general cognitive function — we don't have enough reliable evidence to say. Your doctor can discuss what the research actually shows for your specific situation.
What side effects should I watch for?
The most common ones are flatulence, stomach upset, headache, insomnia, and nausea. Insomnia is more likely if you take a higher dose around 600 mg, and stomach upset can show up at doses of 200–300 mg per day. At 100 mg per softgel, side effects tend to be mild, but everyone's different.
Is this safe if I'm pregnant or breastfeeding?
There isn't enough safety data either way, so the advice is to avoid it during pregnancy and while breastfeeding. If you're pregnant, planning pregnancy, or nursing and want to consider this supplement, talk with your doctor or pharmacist for guidance specific to you.
What exactly is phosphatidylserine?
It's a fat-like compound naturally found in cell membranes throughout your body. It's believed to play a role in nerve cell communication and brain function, which is why it's studied for memory and cognitive health.
Can I take this long-term?
It's generally well tolerated in studies, but long-term safety hasn't been fully established. If you're thinking about taking it regularly for months or longer, check in with your doctor to make sure it's right for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Sunflower Phosphatidyl Serine 100 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Sunflower Phosphatidyl Serine 100 mg label
Go deeper

The Full Monographs Behind Sunflower Phosphatidyl Serine 100 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Phosphatidylserine

Interacts with 219 drugs

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinking. Some research suggests possible bene...

Read the full Phosphatidylserine monograph →
Sources

Sources & How We Checked

Sunflower Phosphatidyl Serine 100 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Phosphatidylserine 9 references
  1. Crook T, Petrie W, Wells C, Massari DC. Effects of phosphatidylserine in Alzheimer's disease. Psychopharmacol Bull 1992;28:61-6.
  2. Pepping J. Phosphatidylserine. Am J Health-Syst Pharm 1999;56:2038,2043-4.
  3. Kidd PM. Phosphatidylserine; Membrane nutrient for memory. A clinical and mechanistic assessment. Altern Med Rev 1996;1:70-84.
  4. Kim HY, Akbar M, Lau A, et al. Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3). Role of phosphatidylserine in antiapoptotic effect. J Biol Chem 2000;275:35215-23.. PubMed
  5. Zanotti A, Valzelli L, Toffano G. Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats. Psychopharmacology (Berl) 1989;99:316-21.. PubMed
  6. Schreiber S, Kampf-Sherf O, Gorfine M, et al. An open trial of plant-source derived phosphatydilserine for treatment of age-related cognitive decline. Isr J Psychiatry Relat Sci 2000;37:302-7.
  7. Pepping, J. Phosphatidylserine. Am J Health Syst.Pharm. 10-15-1999;56(20):2038, 2043-2038, 2044.
  8. Monteverde, A., Gnemmi, P., Rossi, F., Monteverde, A., and Finali, G. C. Selegiline in the treatment of mild to moderate Alzheimer-type dementia. Clin.Ther 1990;12(4):315-322.
  9. Vakhapova V, Cohen T, Richter Y, Herzog Y, Kam Y, Korczyn AD. Phosphatidylserine containing omega-3 Fatty acids may improve memory abilities in nondemented elderly individuals with memory complaints: results from an open-label extension study. Dement Geri PubMed

See these in context on the Phosphatidylserine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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