Super Digestive Enzymes Ingredients & Drug Interactions
by Herbadiet
What is this page for?
First and foremost: checking Super Digestive Enzymes against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Super Digestive Enzymes is a dietary supplement by Herbadiet with 2 active ingredients. Its ingredients are commonly taken for digestive upset and indigestion, constipation, wound and skin care (topical).Based on those ingredients, 92 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Papaya fruit extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Super Digestive Enzymes by Herbadiet
Ask about any prescription or over-the-counter medication and we check it for interactions with Super Digestive Enzymes by Herbadiet — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Super Digestive Enzymes by Herbadiet
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Super Digestive Enzymes contains 2 active ingredients: papaya fruit extract and pineapple fruit extract. Papaya contains papain, an enzyme that helps break down proteins during digestion.
Pineapple provides bromelain, another protein-digesting enzyme. The product has no inactive fillers listed.
Does it work?
Not established
We hold insufficient evidence to rate papaya for any of the digestive or health conditions the research covers — aging skin, hair loss, gallbladder cancer, colorectal cancer, and diabetes are all listed as having insufficient reliable evidence. The effectiveness data on file does not address digestive enzyme function or general digestive support, so we cannot tell you whether this product works for those purposes based on the information we have.
How safe is it?
Well-documented data
Ripe papaya fruit eaten as food is generally well tolerated. Papaya leaf extract seems to be generally well tolerated too, though some people report nausea and vomiting.
Papain from raw or unripe papaya can trigger allergic reactions — itchy watery eyes, runny nose, sneezing, stomach cramps, sweating, and diarrhea — especially in people with latex allergies. Serious allergic reactions are rare but possible.
Unripe papaya, papaya latex, and papaya seeds should be avoided. Concentrated supplements and large amounts are less well studied than ripe fruit, so eating moderate amounts of ripe papaya is likely safer than relying on supplements.
Meds to double-check
Moderate interaction found
Check with your doctor or pharmacist before taking this product if you use blood sugar medications (antidiabetes drugs), amiodarone (Cordarone) for heart rhythm, warfarin (Coumadin) or other blood thinners, or levothyroxine (Synthroid) for thyroid. These are the drug types where papaya fruit extract has documented Moderate interactions.
No interactions are documented in our data for pineapple fruit extract.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
This product may help with digestion if the enzyme content is active and effective, but we don't have solid evidence to confirm that. The bigger concern is that papaya extract can interact with blood sugar medications, heart rhythm drugs, blood thinners, and thyroid replacement — and with 92 individual medications documented to interact with papaya.
Before you start, talk with your doctor or pharmacist about whether it's safe to combine with your specific medications.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Super Digestive Enzymes, straight from the product label.
| Brand | Herbadiet |
|---|---|
| Barcode (UPC) | 5113339193981 |
| Net contents | 60 V-Cap(s) |
| Market status | On market |
| Date entered into DSLD | Mar 25, 2021 |
| DSLD ID | 244257 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Super Digestive Enzymes by Herbadiet, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Papaya fruit extract | 250 mg | -- |
| Pineapple fruit extract | 250 mg | -- |
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
If you are struggling with digestive issues such as bloating, gas, constipation, indigestion, or IBS we may have a natural solution for you.
Super Digestive Enzymes A Blend of Papain & Bromelain
Formulation
Herbadiet's Super Digestive Enzyme is a powerful supplement to ease and reduce gastrointestinal pains and discomforts. Don't let digestive problems hold you back. Take charge of your gut health today!
All Natural Gastrointestinal Support Enhances Absorption of Nutrients Improves Digestive Functions
100% Natural
Digestive Support Ayurvedic Proprietary Medicine
Vegan
Free of fillers, binders, artificial ingredients, dairy, soy, wheat, gluten, yeast
Suitable for vegetarians and vegans
Contains nothing other than listed ingredients
FDA Disclaimer Statement
These statement have not been evaluated by FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
Precautions
Keep out of reach of children.
Do not use if seal under the cap is broken or missing.
Caution: If you are pregnant, breast feeding, or taking medications, consult your doctor before use.
Discontinue use and consult your doctor if any adverse reactions occur.
Storage
Store in a dry place.
General Statements
Batch No: ARK-C48
Suggested/Recommended/Usage/Directions
Directions for use: Take one capsule twice a day, or as directed by your physician.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Super Digestive Enzymes by Herbadiet label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Super Digestive Enzymes by Herbadiet
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Papaya fruit extract
Interacts with92 drugs
Papaya is a tropical fruit that is nutritious and generally safe to eat as food, and it contains an enzyme called papain used as a digestive aid and m...
Papaya fruit extract monograph & interactionsPineapple fruit extract
Super Digestive Enzymes by Herbadiet Drug Interactions
HelloPharmacist Interaction Report
Super Digestive Enzymes by Herbadiet contains papaya fruit extract, which interacts with several medication types.
The most serious documented concern is a Moderate interaction with blood sugar medications (antidiabetes drugs), where papaya may add to their effect and lower blood sugar further — though this has mainly been seen with fermented papaya preparations in a small study. Papaya extract may also delay how your body absorbs and processes amiodarone (a heart rhythm medication), theoretically raising its levels in your blood.
Read the full breakdown — every affected drug type, severity by severity
Papaya may increase the blood-thinning effects of warfarin, raising your bleeding risk. There's also a theoretical concern that eating large amounts of papaya could reduce how well levothyroxine (thyroid replacement) works.
Altogether, these interactions span 92 individual medications. We have no interaction data on file for pineapple fruit extract, so we cannot assess whether it poses additional risks.
If you take any of these drug types — or any prescription medication — use the search tool below to check your exact medications before starting this product. Your doctor or pharmacist can tell you whether it's safe to combine with what you're already taking.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Super Digestive Enzymes?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Super Digestive Enzymes interact with 92 drugs. Click any drug to see the details.
1 of the 2 ingredients in Super Digestive Enzymes interact with drugs. Each result below shows which ingredient is responsible. Papaya fruit extract
AcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Super Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract + Acarbose interactionAcetohexamideDymelor
How Acetohexamide interacts with Super Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract + Acetohexamide interactionAlbiglutideTanzeum
How Albiglutide interacts with Super Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract + Albiglutide interactionAlogliptinNesina
How Alogliptin interacts with Super Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Super Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Super Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract + Alogliptin, Pioglitazone interactionAmiodaroneCordarone, Pacerone
How Amiodarone interacts with Super Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit ExtractAmiodarone (cordarone) Moderate
Interaction Summary
Theoretically, papaya extract may increase the levels and clinical effects of amiodarone.
Read the full Papaya Fruit Extract + Amiodarone interactionAntidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
How Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interacts with Super Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionCanagliflozinInvokana
How Canagliflozin interacts with Super Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract + Canagliflozin interactionCanagliflozin, MetforminInvokamet
How Canagliflozin, Metformin interacts with Super Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract + Canagliflozin, Metformin interactionCanagliflozin, Metformin HydrochlorideInvokamet XR
How Canagliflozin, Metformin Hydrochloride interacts with Super Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract + Canagliflozin, Metformin Hydrochloride interactionChlorpropamideChlorpropam, Diabinese
How Chlorpropamide interacts with Super Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract + Chlorpropamide interactionDapagliflozinFarxiga
How Dapagliflozin interacts with Super Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract + Dapagliflozin interactionDapagliflozin Propanediol, MetforminXigduo XR
How Dapagliflozin Propanediol, Metformin interacts with Super Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract + Dapagliflozin Propanediol, Metformin interactionDapagliflozin Propanediol, Saxagliptin HydrochlorideQtern
How Dapagliflozin Propanediol, Saxagliptin Hydrochloride interacts with Super Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract + Dapagliflozin Propanediol, Saxagliptin Hydrochloride interactionDapagliflozin, Metformin Hydrochloride, Saxagliptin HydrochlorideQternmet XR
How Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interacts with Super Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionDasiglucagon HydrochlorideZegalogue
How Dasiglucagon Hydrochloride interacts with Super Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract + Dasiglucagon Hydrochloride interactionDulaglutideTrulicity
How Dulaglutide interacts with Super Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract + Dulaglutide interactionEmpagliflozinJardiance
How Empagliflozin interacts with Super Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract + Empagliflozin interactionEmpagliflozin, Linagliptin, Metformin HydrochlorideTrijardy XR
How Empagliflozin, Linagliptin, Metformin Hydrochloride interacts with Super Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract + Empagliflozin, Linagliptin, Metformin Hydrochloride interactionEmpagliflozin, MetforminSynjardy
How Empagliflozin, Metformin interacts with Super Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract + Empagliflozin, Metformin interactionEmpagliflozin, Metformin HydrochlorideSynjardy XR
How Empagliflozin, Metformin Hydrochloride interacts with Super Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract + Empagliflozin, Metformin Hydrochloride interactionErtugliflozinSteglatro
How Ertugliflozin interacts with Super Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract + Ertugliflozin interactionErtugliflozin, Metformin HydrochlorideSegluromet
How Ertugliflozin, Metformin Hydrochloride interacts with Super Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract + Ertugliflozin, Metformin Hydrochloride interactionExenatideBydureon, Byetta
How Exenatide interacts with Super Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract + Exenatide interactionExenatide SyntheticBydureon BCISE
How Exenatide Synthetic interacts with Super Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract + Exenatide Synthetic interactionGliclazideDiamicron
How Gliclazide interacts with Super Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract + Gliclazide interactionGlimepirideAmaryl
How Glimepiride interacts with Super Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract + Glimepiride interactionGlipizideGlucotrol, Glucotrol XL
How Glipizide interacts with Super Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract + Glipizide interactionGlipizide, MetforminMetaglip
How Glipizide, Metformin interacts with Super Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract + Glipizide, Metformin interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Super Digestive Enzymes with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Papaya fruit extract
Amiodarone (Cordarone)
Theoretically, papaya extract may increase the levels and clinical effects of amiodarone.
Animal research in rats shows that a single oral dose of papaya extract, as well as multiple doses of papaya extract daily over 14 days, prior to a single dose of amiodarone delays the time to maximum amiodarone concentration. However, only the 14-day papaya extract regimen increases systemic amiodarone exposure by 60% to 70%. This interaction has not been reported in humans.
Antidiabetes Drugs
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects. It is unclear if other forms of papaya have the same effect.
A small low-quality clinical study in patients with type 2 diabetes who are taking glibenclamide shows that taking a fermented papaya preparation 3 grams daily for 2 months decreases fasting and postprandial blood glucose levels when compared to baseline. Additionally, of the 25 patients in the study, 9 required a reduction in glibenclamide dose.
Levothyroxine (Synthroid, Others)
Theoretically, consuming large quantities of papaya fruit can reduce the clinical effects of levothyroxine.
In one case-report, a 37-year-old male with a history of thyroidectomy who was stabilized on levothyroxine for 5 years presented with hypothyroidism after consuming 5-6 papaya fruits daily for 14 days during vacation. In a controlled re-challenge test involving 5-6 papayas daily, the patient remained euthyroid for 7 days, but developed mild hypothyroidism after 14 days. Both times, thyroid levels normalized 40-45 days after discontinuing papaya.
Warfarin (Coumadin)
Theoretically, concomitant use of warfarin with papain-containing papaya extract might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.
Brand information
Manufacturer and brand details for Super Digestive Enzymes, from the product label.
Herbadiet
See all Herbadiet products- Name
- Arkure Health Care
- Street Address
- 11, Sector - 14
- City
- Rohtak
- State
- Haryana
- ZipCode
- 124001
- Web Address
- www.herbadiet.in
Super Digestive Enzymes by Herbadiet: Common Questions
Does Super Digestive Enzymes by Herbadiet interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is papaya fruit extract safe during pregnancy?
Can I take this if I'm breastfeeding?
What are the most common side effects?
Why does this product say it has digestive enzymes if the evidence isn't proven?
Should I avoid this product if I'm allergic to latex?
Is unripe papaya safe in this supplement?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Super Digestive Enzymes is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Super Digestive Enzymes’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Super Digestive Enzymes's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 14 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Papaya 14 references
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
- Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
- Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
- Blanco C, Diaz-Perales A, Collada C, et al. Class I chitinases as potential panallergens involved in the latex-fruit syndrome. J Allergy Clin Immunol 1999;103(3 Pt 1):507-13. PubMed
- Diaz-Perales A, Collada C, Blanco C, et al. Cross-reactions in the latex-fruit syndrome: A relevant role of chitinases but not of complex asparagine-linked glycans. J Allergy Clin Immunol 1999;104:681-7. PubMed
- Castillo, R., Delgado, J., Quiralte, J., Blanco, C., and Carrillo, T. Food hypersensitivity among adult patients: epidemiological and clinical aspects. Allergol.Immunopathol.(Madr.) 1996;24(3):93-97.
- Oderinde, O., Noronha, C., Oremosu, A., Kusemiju, T., and Okanlawon, O. A. Abortifacient properties of aqueous extract of Carica papaya (Linn) seeds on female Sprague-Dawley rats. Niger.Postgrad.Med J 2002;9(2):95-98. DOI
- Danese, C., Esposito, D., D'Alfonso, V., Cirene, M., Ambrosino, M., and Colotto, M. Plasma glucose level decreases as collateral effect of fermented papaya preparation use. Clin Ter. 2006;157(3):195-198.
- Iliev, D. and Elsner, P. Generalized drug reaction due to papaya juice in throat lozenges. Dermatology 1997;194(4):364-366. PubMed
- Andersen HA, Bernatz PE, Grindlay JH. Perforation of the esophagus after use of a digestant agent: report of case and experimental study. Ann Otol Rhinol Laryngol 1959;68:890-6. PubMed
- Deiana L, Marini S, Mariotti S. Ingestion of large amounts of papaya fruit and impaired effectiveness of levothyroxine therapy. Endocr Pract 2012;18(1):98-100. PubMed
- Rodrigues M, Alves G, Francisco J, Fortuna A, Falcão A. Herb-drug pharmacokinetic interaction between Carica papaya extract and amiodarone in rats. J Pharm Pharm Sci 2014;17(3):302-15. PubMed
- Rajapakse S, de Silva NL, Weeratunga P, Rodrigo C, Sigera C, Fernando SD. Carica papaya extract in dengue: a systematic review and meta-analysis. BMC Complement Altern Med. 2019;19(1):265. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC