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Dietary supplement

Super Formula #1 OC-Classic Ingredients & Drug Interactions

by Physician's Signature

Super Formula #1 OC-Classic label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Super Formula #1 OC-Classic against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Super Formula #1 OC-Classic is a dietary supplement by Physician's Signature with 5 active ingredients. Its ingredients are commonly taken for treating or preventing b12 deficiency, pernicious anemia, low energy and fatigue.Based on those ingredients, 481 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Alpha-Lipoic Acid, Rose Hip Extract, Royal Jelly. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Super Formula #1 OC-Classic by Physician's Signature

Ask about any prescription or over-the-counter medication and we check it for interactions with Super Formula #1 OC-Classic by Physician's Signature — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Super Formula #1 OC-Classic by Physician's Signature

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Super Formula #1 OC-Classic contains five active ingredients. Vitamin B12 supports energy and nerve function; royal jelly is a bee product believed to support wellness; alpha-lipoic acid is an antioxidant; bee pollen is another bee product; and rose hip extract comes from the fruit of rose plants.

The softgel also contains inactive ingredients including soybean oil, gelatin, glycerin, silica, and several others that act as fillers, binders, and capsule materials.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: support for the cardiovascular system.
  • We looked for evidence on: Cardiovascular disease (CVD), Atherosclerosis, Heart failure, Atrial fibrillation, Coronary artery bypass graft (CABG) surgery, Anthracycline cardiotoxicity — and 3 related terms.
  • The closest evidence on file: Royal Jelly is rated "Insufficient Reliable Evidence To Rate" for Atherosclerosis (Natural Medicines).
  • Also on file: Alpha-lipoic Acid is rated "Insufficient Reliable Evidence To Rate" for Atrial fibrillation, Cardiovascular disease (CVD), Heart failure, Coronary artery bypass graft (CABG) surgery, and more.
  • Also on file: Vitamin B12 is rated "Insufficient Reliable Evidence To Rate" for Atherosclerosis.

Evidence for these ingredients is mixed. Vitamin B12 is effective for B12 deficiency and a rare condition called Imerslund-Grasbeck disease; it's also likely effective for cyanide poisoning and possibly effective for canker sores and a nerve pain condition called postherpetic neuralgia.

Alpha-lipoic acid is possibly effective for diabetic nerve damage and high cholesterol, and possibly effective for weight management. Rose hip extract is possibly effective for pain after surgery and osteoarthritis.

Royal jelly is possibly effective for menopausal symptoms but possibly ineffective for hay fever and physical performance. Bee pollen shows insufficient evidence for most uses tested, with one effectiveness rating showing it's possibly ineffective for athletic performance.

The evidence, ingredient by ingredient Vitamin B12 Royal Jelly Alpha-lipoic Acid Bee Pollen Rose Hip

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin B12 is generally very well tolerated with no established upper limit; it's needed in pregnancy and breastfeeding at normal recommended amounts. Royal jelly is generally well tolerated but can trigger serious allergic reactions—including anaphylaxis and death—in people with a history of asthma or atopy (allergic tendency).

The data advises against royal jelly in pregnancy and breastfeeding due to insufficient safety information. Alpha-lipoic acid is generally well tolerated in most adults but can lower blood sugar and is best used under medical guidance; avoid it in pregnancy and breastfeeding due to insufficient data.

Bee pollen is generally tolerated but can cause serious allergic reactions, sometimes severe, in people with pollen allergies; the data advises against it in pregnancy due to concern it may stimulate the uterus, and avoid it while breastfeeding. Rose hip is generally well tolerated as a food but supplement safety is less studied; food amounts are likely fine, but concentrated supplements should be used only with doctor approval, and there isn't enough data on supplement doses in pregnancy or breastfeeding.

Most common side effects across these ingredients are headache, nausea, and mild gastrointestinal upset; serious reactions are rare but include allergic responses and liver inflammation.

Side effects, ingredient by ingredient Vitamin B12 Royal Jelly Alpha-lipoic Acid Bee Pollen Rose Hip

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Bee Pollen, Royal Jelly, Alpha-lipoic Acid, Rose Hip, Vitamin B12.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; cancer treatments; diabetes medications; lithium.
  • For scale: 481 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take warfarin or other blood thinners (anticoagulants or antiplatelet drugs), do not start this product without checking with your pharmacist—royal jelly, bee pollen, and alpha-lipoic acid all pose Moderate bleeding risks. If you take diabetes medications, antihypertensive drugs (blood pressure medications), thyroid hormone drugs, or any chemotherapy medications (alkylating agents or antitumor antibiotics), check your specific drugs first.

Those on hormone therapy, including oral contraceptives, lithium, or aspirin should also verify with a pharmacist.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help with B12 deficiency, nerve pain, high cholesterol, and postherpetic neuralgia, but blood-thinner users and people on diabetes, thyroid, or chemotherapy medications should check their exact drugs with a pharmacist first. Anyone with a history of asthma, pollen allergies, or severe allergies should be cautious, especially with royal jelly and bee pollen.

Talk to your pharmacist or doctor before starting, especially if you take any regular medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Super Formula #1 OC-Classic, straight from the product label.

Brand Physician's Signature
Barcode (UPC) 854755007247
Net contents 180 Softgel(s)
Market status On market
Date entered into DSLD Aug 22, 2024
DSLD ID 316964
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Super Formula #1 OC-Classic by Physician's Signature, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
180
UPC/BARCODE
854755007247
IngredientAmount% DV
Vitamin B123 mcg125%
Royal Jelly45 mg--
Alpha-Lipoic Acid5 mg--
Bee Pollen0.4 mg--
Rose Hip Extract25 mg--

Other ingredients: Soybean Oil, Sodium Alginate, Yellow Beeswax, Lecithin, Disodium Edetate, Maltodextrin, Dicalcium Phosphate, Silica, Microcrystalline Cellulose, Gelatin, Glycerin, Water, Caramel, Titanium Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Super Formula #1 offers excellent support for the cardiovascular system by providing Vitamin B12 along with targeted ingredients such as Alpha Lipoic Acid, Rosehips extract, chelating agents like Royal Jelly, sodium alginate, and EDTA.

Super Formula #1 OC-Classic with royal jelly

Suggested/Recommended/Usage/Directions

Suggested Use: Take one softgel capsule, twice daily or as directed by a healthcare professional.

Precautions

Caution: Consult your physician prior to using this product if you are pregnant, nursing, or have any pre-existing medical conditions.

Keep out of the reach of children

Do not use if seal is broken

Contains: soy.

Formulation

Note: The color, taste, and texture of this product may vary due to its natural ingredients and/or seasonal changes.

Storage

Store in a cool, dry place

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

Rawleigh A Friend of the Family since 1889 Physician's Signature By W.T. Rawleigh

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Super Formula #1 OC-Classic by Physician's Signature label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Super Formula #1 OC-Classic label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Super Formula #1 OC-Classic by Physician's Signature

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container180 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin B12

Interacts with
20 drugs
3 mcg per serving Form: Cyanocobalamin

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Vitamin B12 monograph & interactions

Royal Jelly

Interacts with
174 drugs
45 mg per serving

Royal jelly is a nutrient-rich substance made by worker bees to feed the queen bee. People take it for menopause symptoms, energy, skin, and immune su...

Royal Jelly monograph & interactions

Alpha-Lipoic Acid

Interacts with
263 drugs
5 mg per serving

Alpha-lipoic acid (ALA) is an antioxidant made naturally by the body and found in small amounts in foods. It is most studied for diabetic nerve pain,...

Alpha-Lipoic Acid monograph & interactions

Bee Pollen

Interacts with
2 drugs
0.4 mg per serving

Bee pollen is a nutrient-rich product collected by bees and marketed as a 'superfood' for energy and immune support, but solid human evidence for most...

Bee Pollen monograph & interactions

Rose Hip Extract

Interacts with
213 drugs
25 mg per serving

Rose hip is the vitamin C–rich fruit of the wild rose, used traditionally for colds and joint pain. A standardized rose hip powder has some research s...

Rose Hip Extract monograph & interactions

Other (inactive) ingredients: Soybean Oil, Sodium Alginate, Yellow Beeswax, Lecithin, Disodium Edetate, Maltodextrin, Dicalcium Phosphate, Silica, Microcrystalline Cellulose, Gelatin, Glycerin, Water, Caramel, Titanium Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Super Formula #1 OC-Classic by Physician's Signature Drug Interactions

Want to check YOUR meds against Super Formula #1 OC-Classic?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
481Drugs
395 Moderate 86 Minor

Ingredients driving the most interactions

Alpha-Lipoic Acid 263
Rose Hip Extract 213
Royal Jelly 174
Vitamin B12 20
Bee Pollen 2

Individual Drug Interactions

The ingredients in Super Formula #1 OC-Classic interact with 481 drugs. Click any drug to see the details.

5 of the 5 ingredients in Super Formula #1 OC-Classic interact with drugs. Each result below shows which ingredient is responsible. Alpha-Lipoic Acid Rose Hip Extract Royal Jelly Vitamin B12 Bee Pollen

Each ingredient & the kinds of drugs it affects

For each ingredient in Super Formula #1 OC-Classic with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Alpha-Lipoic Acid5 drug types · 263 drugs

Alkylating Agents

Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of alkylating agents.
The use of antioxidants like alpha-lipoic acid during chemotherapy is controversial. There are concerns that antioxidants could reduce the activity of chemotherapy drugs that generate free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as alpha-lipoic acid have on chemotherapy. Advise patients to consult their oncologist before using alpha-lipoic acid.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, alpha-lipoic acid may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro, alpha-lipoic acid inhibits platelet aggregation.

Likelihood Possible Evidence D
Antitumor Antibiotics

Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of antitumor antibiotics.
The use of antioxidants like alpha-lipoic acid during chemotherapy is controversial. There are concerns that antioxidants could reduce the activity of antitumor antibiotic drugs, which work by generating free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as alpha-lipoic acid have on chemotherapy involving antitumor antibiotics. Advise patients to consult their oncologist before using alpha-lipoic acid.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, alpha-lipoic acid might decrease the effects of thyroid hormone drugs.
Animal research suggests that co-administration of thyroxine with alpha-lipoic acid reduces conversion into the active T3 form.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking alpha-lipoic acid with antidiabetes drugs might increase the risk of hypoglycemia.
Although some small clinical studies have suggested that alpha-lipoic acid can lower blood glucose levels, larger clinical studies in patients with diabetes have shown no clinically meaningful effect. Additionally, co-administration of single doses of alpha-lipoic acid and glyburide or acarbose did not cause detectable drug interactions in healthy volunteers.

Likelihood Unlikely Evidence B
Alpha-Lipoic Acid full monograph & interactions

Rose Hip Extract8 drug types · 213 drugs

Alkylating Agents

Theoretically, the antioxidant effects of rose hip might reduce the effectiveness of alkylating agents but might also reduce the oxidative damage caused by certain alkylating agents.
Rose hip contains vitamin C. The use of antioxidants like vitamin C during chemotherapy is controversial. There is concern that antioxidants could reduce the activity of chemotherapy drugs that generate free radicals, such as cyclophosphamide, chlorambucil, carmustine, busulfan, and thiotepa. In contrast, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. Further, some animal research suggests that the antioxidant effects of rose hip might attenuate cyclophosphamide-induced testicular toxicity. More evidence is needed to determine what effect, if any, antioxidants found in rose hip, such as vitamin C, have on the effectiveness and adverse effects of chemotherapy.

Likelihood Possible Evidence D
Aluminum

Theoretically, rose hip might increase the amount of aluminum absorbed from aluminum compounds.
Rose hip contains vitamin C. Theoretically, vitamin C increases the absorption of aluminum. Concomitant use might increase aluminum absorption, but the clinical significance of this is unknown. Administer rose hip two hours before or four hours after antacids.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, rose hip might reduce the effectiveness of anticoagulant or antiplatelet drugs.
In vitro and animal research suggests that a constituent of rose hip, rugosin E, can induce platelet aggregation. This has not been shown in humans. Theoretically, concomitant use of rose hip might reduce the effectiveness of antiplatelet or anticoagulant drugs.

Likelihood Possible Evidence D
Antitumor Antibiotics

Theoretically, the antioxidant effects of rose hip might reduce the effectiveness of antitumor antibiotics.
Rose hip contains the antioxidant vitamin C. There is concern that antioxidants might reduce the activity of chemotherapy drugs that generate free radicals, such as antitumor antibiotics. In contrast, other researchers theorize that antioxidants might make antitumor antibiotic chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effects, if any, antioxidants such as vitamin C have on antitumor antibiotic chemotherapy.

Likelihood Possible Evidence D
Estrogens

Theoretically, rose hip might increase blood levels of estrogens.
Rose hip contains vitamin C. Increases in plasma estrogen levels of up to 55% have occured under some circumstances when vitamin C is taken concurrently with oral contraceptives or hormone replacement therapy, including topical products. It is suggested that vitamin C prevents oxidation of estrogen in the tissues, regenerates oxidized estrogen, and reduces sulfate conjugation of estrogen in the gut wall. When tissue levels of vitamin C are high, these processes are already maximized and supplemental vitamin C does not have any effect on estrogen levels. However, increases in plasma estrogen levels may occur when women who are deficient in vitamin C take supplements.

Likelihood Possible Evidence D
Lithium

Theoretically, rose hip might increase blood levels of lithium.
Rose hip is thought to have diuretic properties. Theoretically, due to these potential diuretic effects, rose hip might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Aspirin

Theoretically, rose hip might reduce the clearance of aspirin; however, its vitamin C content is likely too low to produce clinically significant effects.
Rose hip contains vitamin C. It has been suggested that acidification of the urine by vitamin C can decrease the urinary excretion of salicylates, increasing plasma salicylate levels. However, short-term use of up to 6 grams daily of vitamin C does not seem to affect urinary pH or salicylate excretion. The vitamin C content of rose hip is typically about 500 mg per 100 grams. Thus, a clinically significant interaction between rose hip and aspirin is unlikely.

Likelihood Unlikely Evidence B
Warfarin (Coumadin)

Theoretically, rose hip might reduce the effectiveness of warfarin; however, its vitamin C content is likely too low to produce clinically significant effects.
Rose hip contains vitamin C. High doses of vitamin C may reduce the response to warfarin, possibly by causing diarrhea and reducing warfarin absorption. This occurred in two people who took up to 16 grams daily of vitamin C, and resulted in decreased prothrombin time. Lower doses of 5-10 grams daily of vitamin C can also reduce warfarin absorption, but this does not seem to be clinically significant. The vitamin C content of rose hip is typically about 500 mg per 100 grams. Thus, a clinically significant interaction between rose hip and warfarin is unlikely.

Likelihood Unlikely Evidence D
Rose Hip Extract full monograph & interactions

Royal Jelly2 drug types · 174 drugs

Antihypertensive Drugs

Theoretically, royal jelly might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research suggests that royal jelly might lower blood pressure.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Royal jelly might increase the risk of bleeding when taken with warfarin.
In one case, an 87-year-old male who was previously stabilized on warfarin developed hematuria and was found to have an INR of 7.29 after taking a royal jelly supplement for one week.

Likelihood Possible Evidence D
Royal Jelly full monograph & interactions

Vitamin B121 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Vitamin B12 full monograph & interactions

Bee Pollen1 drug type · 2 drugs

Warfarin (Coumadin)

There is some concern that bee pollen might interact with warfarin and increase the risk of bleeding.
In one case report, a patient on warfarin had a stable international normalized ratio (INR) of 1.9-3.3 for 9 months. The patient's INR was found to be 7.1 after starting bee pollen granules one teaspoon twice daily for approximately one month. The patient's warfarin dose was decreased by approximately 11% in order to return the INR to the therapeutic range while continuing the bee pollen supplement.

Likelihood Possible Evidence D
Bee Pollen full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Super Formula #1 OC-Classic, from the product label.

Physician's Signature

See all Physician's Signature products
Name
Vitamins Direct (USA), Inc.
City
West Palm Beach
State
FL
ZipCode
33407
Phone Number
866-354-8384
Web Address
www.wtrawleigh.com
Pharmacist Counseling Corner

Super Formula #1 OC-Classic by Physician's Signature: Common Questions

Does Super Formula #1 OC-Classic by Physician's Signature interact with any medications?
Yes. Based on its ingredients, Super Formula #1 OC-Classic has a known interaction with 481 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Super Formula #1 OC-Classic contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product have any serious side effects?
Serious side effects are rare overall, but they do occur. Royal jelly and bee pollen can cause anaphylaxis and death in people with asthma or pollen allergies. Vitamin B12 rarely causes severe low potassium when correcting certain anemias. Alpha-lipoic acid has raised rare concerns about insulin autoimmune syndrome. Rose hip and bee pollen have each caused acute liver inflammation in isolated cases.
Can I take this if I'm pregnant?
It depends on the ingredient. Vitamin B12 is considered safe in pregnancy at normal amounts. Royal jelly, alpha-lipoic acid, and bee pollen all lack enough safety data—the data advises against them in pregnancy. Rose hip doesn't have enough reliable data for pregnancy either. Talk with your doctor or pharmacist for personalized advice.
Can I take this while breastfeeding?
Vitamin B12 is considered safe during breastfeeding at recommended amounts. Royal jelly and bee pollen are best avoided due to insufficient safety data. Alpha-lipoic acid and rose hip also lack enough reliable data. Check with your pharmacist or doctor about your individual situation.
Will this help my arthritis pain?
Rose hip extract is possibly effective for osteoarthritis pain. The other ingredients in this formula don't have strong evidence for arthritis. If you're considering it specifically for joint pain, rose hip is the one with the most support, though results vary.
What should I do if I'm allergic to pollen?
Be cautious with bee pollen and royal jelly—both can trigger serious allergic reactions in people with pollen allergies, especially those sensitive to ragweed, daisies, or related plants. If you have seasonal allergies or asthma, talk with your pharmacist before taking this product.
Does this product contain any fillers?
Yes. The softgel contains several inactive ingredients including soybean oil, gelatin, silica, microcrystalline cellulose, and others that serve as fillers, binders, and capsule materials.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Super Formula #1 OC-Classic label
Go deeper

The Full Monographs Behind Super Formula #1 OC-Classic’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph → Herb & supplement monograph

Royal Jelly

Interacts with 174 drugs

Royal jelly is a nutrient-rich substance made by worker bees to feed the queen bee. People take it for menopause symptoms, energy, skin, and immune support, but solid human evidence is limit...

Read the full Royal Jelly monograph → Herb & supplement monograph

Alpha-lipoic Acid

Interacts with 263 drugs

Alpha-lipoic acid (ALA) is an antioxidant made naturally by the body and found in small amounts in foods. It is most studied for diabetic nerve pain, where some evidence suggests it may help...

Read the full Alpha-lipoic Acid monograph → Herb & supplement monograph

Bee Pollen

Interacts with 2 drugs

Bee pollen is a nutrient-rich product collected by bees and marketed as a 'superfood' for energy and immune support, but solid human evidence for most of these claims is lacking. It can caus...

Read the full Bee Pollen monograph → Herb & supplement monograph

Rose Hip

Interacts with 213 drugs

Rose hip is the vitamin C–rich fruit of the wild rose, used traditionally for colds and joint pain. A standardized rose hip powder has some research support for easing osteoarthritis symptom...

Read the full Rose Hip monograph →
Sources

Sources & How We Checked

Super Formula #1 OC-Classic's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 131 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B12 30 references
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  2. Hartman TJ, Woodson K, Stolzenberg-Solomon R, et al. Association of the B-vitamins pyridoxal 5'-phosphate (B6), B12, and folate with lung cancer risk in older men. Am J Epidemiol 2001;153:688-94.. DOI
  3. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  4. Lange H, Suryapranata H, De Luca G, et al. Folate therapy and in-stent restenosis after coronary stenting. N Engl J Med 2004;350:2673-81. PubMed
  5. Collin, S. M., Metcalfe, C., Refsum, H., Lewis, S. J., Zuccolo, L., Smith, G. D., Chen, L., Harris, R., Davis, M., Marsden, G., Johnston, C., Lane, J. A., Ebbing, M., Bonaa, K. H., Nygard, O., Ueland, P. M., Grau, M. V., Baron, J. A., Donovan, J. L., Nea
  6. Geissbuhler, P., Mermillod, B., and Rapin, C. H. Elevated serum vitamin B12 levels associated with CRP as a predictive factor of mortality in palliative care cancer patients: a prospective study over five years. J.Pain Symptom.Manage. 2000;20(2):93-103. PubMed
  7. Salles, N., Herrmann, F., Sakbani, K., Rapin, C. H., and Sieber, C. High vitamin B12 level: a strong predictor of mortality in elderly inpatients. J Am Geriatr.Soc 2005;53(5):917-918.
  8. Looker, H. C., Fagot-Campagna, A., Gunter, E. W., Pfeiffer, C. M., Sievers, M. L., Bennett, P. H., Nelson, R. G., Hanson, R. L., and Knowler, W. C. Homocysteine and vitamin B(12) concentrations and mortality rates in type 2 diabetes. Diabetes Metab Res R
  9. Uhl, W., Nolting, A., Golor, G., Rost, K. L., and Kovar, A. Safety of hydroxocobalamin in healthy volunteers in a randomized, placebo-controlled study. Clin Toxicol (Phila) 2006;44 Suppl 1:17-28. PubMed
  10. Borron, S. W., Baud, F. J., Barriot, P., Imbert, M., and Bismuth, C. Prospective study of hydroxocobalamin for acute cyanide poisoning in smoke inhalation. Ann Emerg.Med 2007;49(6):794-801, 801. PubMed
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Royal Jelly 14 references
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Alpha-lipoic Acid 48 references
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Bee Pollen 15 references
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See these in context on the Bee Pollen monograph →

Rose Hip 24 references
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See these in context on the Rose Hip monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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