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Dietary supplement

Gut Eze Ingredients & Drug Interactions

by Physician's Signature

Gut Eze label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Gut Eze against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Gut Eze is a dietary supplement by Physician's Signature with 3 active ingredients. Its ingredients are commonly taken for digestive health and regularity, infant colic and gut support, diarrhea (including antibiotic-related).Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bifidobacterium breve SD-5206. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Gut Eze by Physician's Signature

Ask about any prescription or over-the-counter medication and we check it for interactions with Gut Eze by Physician's Signature — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Gut Eze by Physician's Signature

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.
  • “Proprietary Probiotic Blend” is a proprietary blend — the label gives one combined amount (20 mg) without saying how much of each component you get.

Gut Eze contains three active probiotic ingredients: Lactobacillus casei subsp. casei SD-5842, Bifidobacterium breve SD-5206, and Bifidobacterium infantis SD-6669. Probiotics are live beneficial bacteria meant to support your gut health.

The capsule itself is made with microcrystalline cellulose, hydroxypropyl methylcellulose, magnesium stearate, and silicon dioxide as inactive ingredients.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Bifidobacterium Breve's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: promote short chain fatty acids for gut and immune health.
  • We looked for evidence on: Antibiotic-associated diarrhea, Colic, Constipation, Irritable bowel syndrome (IBS), Clostridioides difficile infection, Ulcerative colitis — and 4 related terms.
  • The closest evidence on file: Bifidobacterium Breve is rated "Insufficient Reliable Evidence To Rate" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Bifidobacterium Breve is rated "Insufficient Reliable Evidence To Rate" for Constipation, Rotaviral diarrhea, Ulcerative colitis, Irritable bowel syndrome (IBS), and more.

The evidence for these probiotics is mixed. For Bifidobacterium breve specifically, the data shows it's possibly ineffective for age-related cognitive decline and sepsis, and there isn't enough reliable evidence yet to rate it for hay fever, antibiotic-associated diarrhea, or atopic disease.

The effectiveness ratings for the other two probiotic strains in this product aren't established in our data.

The evidence, ingredient by ingredient Bifidobacterium Breve

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bifidobacterium breve is generally well tolerated in healthy people, but caution is needed if you're very ill or immunocompromised — talk with your doctor first. Probiotics in general are often considered low-risk, but safety data are limited, so use this product only under your healthcare provider's guidance.

Rare cases of bacterial bloodstream infections (bacteremia) related to probiotic use have been reported in critically ill infants and adults, including some linked to B. breve in preterm infants. Bloating and flatulence have been reported with probiotic use generally, though not specifically documented with B. breve.

Side effects, ingredient by ingredient Bifidobacterium Breve

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Bifidobacterium Breve.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take Gut Eze, check if you're on antibiotic drugs — Bifidobacterium breve can lose its effectiveness if you take them at the same time. We don't have interaction data for the other two probiotic strains, so ask your pharmacist to search your full medication list.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Gut Eze is a three-strain probiotic intended to support digestive health. If you're on antibiotics, you'll need to space them apart from this product so the live bacteria aren't killed.

Anyone who's very ill, immunocompromised, a preterm infant, or a young child should check with their doctor before starting. Run your medications through the checker below.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Gut Eze, straight from the product label.

Brand Physician's Signature
Net contents 30 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jul 23, 2020
DSLD ID 229521
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Gut Eze by Physician's Signature, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
IngredientAmount% DV
Lactobacillus casei subsp. casei SD-58420 NP--
Bifidobacterium breve SD-52060 NP--
Bifidobacterium infantis SD-66690 NP--
Proprietary Probiotic Blend20 mg--

Other ingredients: Microcrystalline Cellulose, Hydroxypropyl Methylcellulose, Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Intended to promote production of short chain fatty acids (SFCAs) to maintain gut integrity, lipid metabolism, appetite regularity and immune integrity.

Suitable for Vegetarians

Suggested/Recommended/Usage/Directions

Directions: Take one capsule daily preferably with a meal.

Precautions

Caution: Consult your physician prior to using this product if you are pregnant, nursing, or have any pre-existing medical conditions.

Keep out of the reach of children.

Do not use if seal is broken

Storage

Store in a cool, dry place

General Statements

Rawleigh A friend of the family since 1889

By W.T. Rawleigh

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

Probiotic blend 1 billion CFU

1 billion CFU (colony forming units) per capsule at expiry.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Gut Eze by Physician's Signature label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Gut Eze label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Gut Eze by Physician's Signature

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Probiotic Blend

20 mg per serving

Other (inactive) ingredients: Microcrystalline Cellulose, Hydroxypropyl Methylcellulose, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Gut Eze by Physician's Signature Drug Interactions

Want to check YOUR meds against Gut Eze?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Bifidobacterium breve SD-5206 182

Individual Drug Interactions

The ingredients in Gut Eze interact with 182 drugs. Click any drug to see the details.

1 of the 3 ingredients in Gut Eze interact with drugs. Each result below shows which ingredient is responsible. Bifidobacterium breve SD-5206

Each ingredient & the kinds of drugs it affects

For each ingredient in Gut Eze with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Bifidobacterium breve SD-52061 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B. breve.
Since B. breve preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. breve preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium breve SD-5206 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Gut Eze, from the product label.

Physician's Signature

See all Physician's Signature products
Name
Vitamins Direct (USA), Inc.
City
West Palm Beach
State
FL
ZipCode
33407
Phone Number
866-354-8384
Web Address
www.wtrawleigh.com
Pharmacist Counseling Corner

Gut Eze by Physician's Signature: Common Questions

Does Gut Eze by Physician's Signature interact with any medications?
Yes. Based on its ingredients, Gut Eze has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Gut Eze contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Gut Eze while I'm on antibiotics?
You can take both, but timing matters. Antibiotics can kill the live bacteria in this product and make it less effective. Ask your pharmacist to help you space them out — usually a few hours apart works well.
What does Bifidobacterium breve do?
It's a type of beneficial bacteria that's meant to support gut health as part of a probiotic blend. Our data show it's likely ineffective for age-related cognitive decline and sepsis, but we don't have enough evidence yet to rate whether it helps with other conditions like hay fever or antibiotic-related diarrhea.
Are there any side effects I should know about?
Probiotics are generally well tolerated, but bloating and flatulence have been reported with probiotic use. Rare cases of bacterial bloodstream infections have occurred in very ill or immunocompromised people, so let your doctor know if you fall into that group.
Is Gut Eze safe if I'm very ill or immunocompromised?
Caution is needed if you're very ill or have a weakened immune system — talk with your doctor or pharmacist first. Some serious infections have been rarely reported in critically ill people taking probiotics.
Can I take Gut Eze while pregnant or breastfeeding?
We don't have pregnancy and breastfeeding safety data on file for these ingredients. Talk with your doctor or pharmacist for personalized advice based on your situation.
Does Gut Eze have any fillers?
Yes, the capsule contains inactive ingredients like microcrystalline cellulose, hydroxypropyl methylcellulose, magnesium stearate, and silicon dioxide.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Gut Eze label
Go deeper

The Full Monographs Behind Gut Eze’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bifidobacterium Breve

Interacts with 182 drugs

Bifidobacterium breve is a 'friendly' gut bacterium taken as a probiotic, most often to support digestion and balance the gut microbiome. Some studies suggest possible benefits for certain d...

Read the full Bifidobacterium Breve monograph →
Sources

Sources & How We Checked

Gut Eze's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bifidobacterium Breve 9 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  4. Ohishi A, Takahashi S, Ito Y, et al. Bifidobacterium septicemia associated with postoperative probiotic therapy in a neonate with omphalocele. J Pediatr. 2010;156(4):679-81. PubMed
  5. Sakurai Y, Watanabe T, Miura Y, et al. Clinical and bacteriologic characteristics of six cases of Bifidobacterium breve bacteremia due to probiotic administration in the neonatal intensive care unit. Pediatr Infect Dis J 2022;41(1):62-65. PubMed
  6. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
  7. Wakabayashi Y, Nakayama S, Yamamoto A, et al. First case of necrotizing fasciitis and bacteremia caused by Bifidobacteriumbreve. Anaerobe 2022;76:102613.
  8. Takeda Y, Ota K, Kondo A, et al. A case of necrotizing fasciitis caused by Bifidobacterium breve. IDCases 2022;31:e01667. PubMed
  9. Suwantarat N, Romagnoli M, Wakefield T, Carroll KC. Ventriculoperitoneal shunt infection caused by Bifidobacterium breve. Anaerobe 2014;28:1-3. PubMed

See these in context on the Bifidobacterium Breve monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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