Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Super Lutein 444 Formula Ingredients & Drug Interactions

by VisiVite

Super Lutein 444 Formula label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Super Lutein 444 Formula against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Super Lutein 444 Formula is a dietary supplement by VisiVite with 2 active ingredients. Its ingredients are commonly taken for eye health, age-related macular degeneration, cataract prevention.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Zeaxanthin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Super Lutein 444 Formula by VisiVite

Ask about any prescription or over-the-counter medication and we check it for interactions with Super Lutein 444 Formula by VisiVite — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Super Lutein 444 Formula by VisiVite

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 2 active ingredients: lutein and zeaxanthin. Both are carotenoids — naturally occurring pigments found in leafy greens and colorful vegetables — that accumulate in the eye's macula and lens.

They're included here because they may help protect vision as you age.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: antioxidant protection for eyes.
  • We looked for evidence on: Age-related macular degeneration (AMD), Asthenopia (eye strain), Cataracts, Central serous retinopathy, Choroideremia, Diabetic retinopathy — and 4 related terms.
  • The strongest evidence on file: Lutein is rated "Possibly Effective" for Age-related macular degeneration (AMD) (Natural Medicines).
  • Also on file: Lutein is rated "Possibly Effective" for Cataracts.
  • Also on file: Zeaxanthin is rated "Possibly Effective" for Age-related macular degeneration (AMD).

Lutein is possibly effective for age-related macular degeneration (AMD) and cataracts. Zeaxanthin is also possibly effective for AMD.

For other conditions listed in the research — retinitis pigmentosa, retinopathy of prematurity, necrotizing enterocolitis, and bronchopulmonary dysplasia — the evidence suggests these ingredients are possibly ineffective. For zeaxanthin and cognitive decline, Alzheimer's disease, asthma, and breast cancer, there isn't enough reliable evidence to say one way or the other.

The evidence, ingredient by ingredient Lutein Zeaxanthin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lutein from food and typical supplement doses is generally well tolerated. Doses up to 20 mg daily in trials haven't caused adverse effects.

Zeaxanthin is also generally well tolerated at normal supplement amounts. Both are rated likely safe in pregnancy and lactation, though the data on higher supplement doses during these periods isn't as robust as for food sources — if you're pregnant or breastfeeding, talk with your doctor or pharmacist about whether this product is right for you.

Side effects, ingredient by ingredient Lutein Zeaxanthin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Zeaxanthin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antidiabetes drugs (such as insulin, metformin, or sulfonylureas), check with our medication checker before starting this product — zeaxanthin may theoretically affect blood sugar control, though the human risk isn't fully clear.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Super Lutein 444 Formula is a straightforward eye-health supplement for anyone concerned about age-related macular degeneration or cataracts. If you take diabetes medication, check your specific drugs with our interaction tool before starting.

If you're pregnant, breastfeeding, or have any health concerns, a quick conversation with your pharmacist will help you decide if it fits your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 24, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Super Lutein 444 Formula, straight from the product label.

Brand VisiVite
Barcode (UPC) 899205000423
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD May 24, 2023
DSLD ID 292319
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Super Lutein 444 Formula by VisiVite, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
Servings per container
30
UPC/BARCODE
899205000423
IngredientAmount% DV
Lutein44 mg--
Zeaxanthin4 mg--

Other ingredients: Cellulose, Purified, Modified Cellulose, Stearate, Non-Hydrogenated, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

VisiVite Super Lutein 444 Formula is a highly purified extract of nature's marigold flowers, containing 44 mg lutein plus 4 mg zeaxanthin in clear vegetarian capsules. Provides premium antioxidant protection for your eyes against blue and ultraviolet light.

Lutein 44 mg From Marigolds 4 mg Zeaxanthin

FDA Disclaimer Statement

These statements have not been evaluated by the food and drug administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Suggested/Recommended/Usage/Directions

Recommended Intake: Take one capsule daily with food.

Storage

Store at 15-30 degrees C (59-86 degrees F)

Precautions

Protect from heat, light and moisture. Do not use if outer seal is broken.

Formulation

Assembled in a GMP certified USA facility.

Contains No: GMO's, Soy, Gluten, Sugar, Egg, Milk Products, Albumin, Whey, Casein, Peanuts, Shellfish, or Fish Protein.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Super Lutein 444 Formula by VisiVite label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Super Lutein 444 Formula label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Super Lutein 444 Formula by VisiVite

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Lutein

No known
interactions
44 mg per serving Form: Marigold Flower Extract

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help...

Lutein monograph & interactions

Zeaxanthin

Interacts with
86 drugs
4 mg per serving Form: Marigold Flower Extract

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The stron...

Zeaxanthin monograph & interactions

Other (inactive) ingredients: Cellulose, Purified, Modified Cellulose, Stearate, Non-Hydrogenated, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Super Lutein 444 Formula by VisiVite Drug Interactions

Want to check YOUR meds against Super Lutein 444 Formula?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Zeaxanthin 86

Individual Drug Interactions

The ingredients in Super Lutein 444 Formula interact with 86 drugs. Click any drug to see the details.

1 of the 2 ingredients in Super Lutein 444 Formula interact with drugs. Each result below shows which ingredient is responsible. Zeaxanthin

Each ingredient & the kinds of drugs it affects

For each ingredient in Super Lutein 444 Formula with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Zeaxanthin1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking zeaxanthin with antidiabetes drugs might increase the risk of hypoglycemia.
In an animal diabetic model, zeaxanthin has hypoglycemic effects. However, population research has found that increasing intake of dietary zeaxanthin plus lutein does not decrease the risk of developing type 2 diabetes.

Likelihood Possible Evidence D
Zeaxanthin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Super Lutein 444 Formula, from the product label.

VisiVite

See all VisiVite products
Name
Vitamin Science, Inc.
City
Huntington
State
NY
ZipCode
11743
Phone Number
1-800-427-7660
Web Address
www.visivite.com
Pharmacist Counseling Corner

Super Lutein 444 Formula by VisiVite: Common Questions

Does Super Lutein 444 Formula by VisiVite interact with any medications?
Yes. Based on its ingredients, Super Lutein 444 Formula has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Super Lutein 444 Formula contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What exactly are lutein and zeaxanthin?
They're carotenoids — pigments your body naturally gets from foods like spinach, kale, and egg yolks. They settle in your eye's macula and lens, where they may help shield them from age-related damage.
Will this help my cataracts or macular degeneration?
The research suggests both lutein and zeaxanthin are possibly effective for age-related macular degeneration (AMD) and lutein for cataracts. That means there's promise, but it's not proven beyond doubt. Talk with your eye doctor about whether supplementing makes sense for your specific situation.
Are there any side effects?
Lutein at typical doses hasn't caused adverse effects in trials. Zeaxanthin is also generally well tolerated at supplement amounts. Neither ingredient typically causes problems when used as directed.
Is it safe to take while pregnant or breastfeeding?
Both lutein and zeaxanthin are rated likely safe in pregnancy and lactation. That said, most of the safety data come from food sources — supplement safety at higher doses during these times isn't as well studied. Check with your doctor or pharmacist for personalized advice.
What are the inactive ingredients?
The capsule contains cellulose, modified cellulose, non-hydrogenated stearate, and silica — standard binders and fillers that help hold the capsule together and keep the contents stable.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Super Lutein 444 Formula is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Super Lutein 444 Formula label
Go deeper

The Full Monographs Behind Super Lutein 444 Formula’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lutein

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help slow progression of age-related macular...

Read the full Lutein monograph → Herb & supplement monograph

Zeaxanthin

Interacts with 86 drugs

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The strongest evidence relates to slowing progres...

Read the full Zeaxanthin monograph →
Sources

Sources & How We Checked

Super Lutein 444 Formula's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lutein 2 references
  1. Brown L, Rimm EB, Seddon JM, et al. A prospective study of carotenoid intake and risk of cataract extraction in US men. Am J Clin Nutr 1999;70:517-24. PubMed
  2. Chasan-Taber L, Willett WC, Seddon JM, et al. A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. Am J Clin Nutr 1999;70:509-16. PubMed

See these in context on the Lutein monograph →

Zeaxanthin 4 references
  1. Montonen J, Knekt P, Jarvinen R, Reunanen A. Dietary antioxidant intake and risk of type 2 diabetes. Diabetes Care 2004;27:362-6. PubMed
  2. Leermakers ET, Darweesh SK, Baena CP, et al. The effects of lutein on cardiometabolic health across the life course: a systematic review and meta-analysis. Am J Clin Nutr 2016;103(2):481-94. PubMed
  3. Kou L, Du M, Zhang C, Dai Z, Li X, Zhang B. The Hypoglycemic, Hypolipidemic, and Anti-Diabetic Nephritic Activities of Zeaxanthin in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats. Appl Biochem Biotechnol 2017;182(3):944-955. PubMed
  4. Xu X, Zhao X, Berde Y, Low YL, Kuchan MJ. Milk and Plasma Lutein and Zeaxanthin Concentrations in Chinese Breast-Feeding Mother-Infant Dyads With Healthy Maternal Fruit and Vegetable Intake. J Am Coll Nutr 2019;38(2):179-184. PubMed

See these in context on the Zeaxanthin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team