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Dietary supplement

Super Probiotic Acidophilus Ingredients & Drug Interactions

by Windmill

Super Probiotic Acidophilus label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Super Probiotic Acidophilus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Super Probiotic Acidophilus is a dietary supplement by Windmill with 2 active ingredients. Its ingredients are commonly taken for lactose intolerance, gas and bloating after dairy, diarrhea from dairy foods.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus acidophilus. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Super Probiotic Acidophilus by Windmill

Ask about any prescription or over-the-counter medication and we check it for interactions with Super Probiotic Acidophilus by Windmill — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Super Probiotic Acidophilus by Windmill

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains two active ingredients: Lactase and Lactobacillus acidophilus. Lactase is an enzyme that helps your body break down lactose, the natural sugar in milk and dairy products.

Lactobacillus acidophilus is a live, beneficial bacterium (probiotic) intended to support gut health. The capsule also contains several inactive ingredients: calcium sulfate, maltodextrin, cellulose, silicon dioxide, stearic acid, and magnesium stearate — these are fillers, binders, and other excipients that make up the capsule itself.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: immune system and intestinal health support.
  • We looked for evidence on: Antibiotic-associated diarrhea, Bacterial vaginosis, Clostridioides difficile infection, Inflammatory bowel disease (IBD), Irritable bowel syndrome (IBS), Lactose intolerance — and 4 related terms.
  • The strongest evidence on file: Lactase is rated "Effective" for Lactose intolerance (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea, Bacterial vaginosis, Irritable bowel syndrome (IBS).
  • Also on file: Lactobacillus Acidophilus is rated "Insufficient Reliable Evidence To Rate" for Respiratory tract infections, Inflammatory bowel disease (IBD), Lactose intolerance.

Lactase is rated effective for lactose intolerance — if you have trouble digesting dairy, this ingredient is backed by evidence. For colic and prematurity, the evidence isn't established in the data we hold.

Lactobacillus acidophilus is rated possibly effective for irritable bowel syndrome (IBS), possibly effective for Helicobacter pylori (a stomach bacterium), possibly effective for antibiotic-associated diarrhea, and possibly effective for bacterial vaginosis. For atopic disease (like eczema and asthma), it's rated possibly ineffective.

For acute respiratory distress syndrome, evidence isn't established.

The evidence, ingredient by ingredient Lactase Lactobacillus Acidophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactase is generally well tolerated when used as directed. Rarely, people can develop an allergic reaction to lactase itself — allergic rhinoconjunctivitis (nasal and eye symptoms) and contact dermatitis have been reported in occupational settings with powdered lactase exposure.

Lactobacillus acidophilus is generally well tolerated in healthy adults and children. Gastrointestinal side effects like stomach discomfort, bloating, gas, diarrhea, and burping can occur, but they're uncommon.

There's a theoretical concern that L. acidophilus might cause infection in some patients — cases of bacteremia and other serious infections have been documented, though most are thought to involve bacteria from other body locations, not from the probiotic itself. For pregnancy, lactase is rated possibly safe.

Lactobacillus acidophilus is rated possibly safe in pregnancy, but data are limited. For breastfeeding, limited data exist for lactase; pregnancy/lactation data on file for Lactobacillus acidophilus don't specify lactation.

Talk with your doctor or pharmacist before regular use during pregnancy or while breastfeeding.

Side effects, ingredient by ingredient Lactase Lactobacillus Acidophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Lactobacillus Acidophilus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take antibiotic drugs. Taking them at the same time as this product (Moderate severity) may reduce how well the probiotic works — your healthcare provider can help you space them out properly.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product might help if you have lactose intolerance or are dealing with IBS, antibiotic-associated diarrhea, or bacterial vaginosis — though the probiotic evidence is modest. The big thing to watch: if you're on an antibiotic, don't take this at the same time, because the antibiotic will kill the live organisms in the probiotic and make it less effective.

Check your exact medications with your doctor or pharmacist before you start, especially if you take antibiotics.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Super Probiotic Acidophilus, straight from the product label.

Brand Windmill
Barcode (UPC) 035046001025
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Jun 25, 2015
DSLD ID 46708
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Super Probiotic Acidophilus by Windmill, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetable Capsule(s)
Maximum serving Sizes:
1 Vegetable Capsule(s)
UPC/BARCODE
035046001025
IngredientAmount% DV
Lactase15 mg--
Lactobacillus acidophilus2000000000 CFU--

Other ingredients: Calcium Sulfate, Maltodextrin, Cellulose, Silicon Dioxide, Stearic Acid, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General

ITEM: 102/TC: 106210N2

General Statements

TRUSTED SINCE 1972

Natural Vitamins

(2 BILLION ACTIVE CULTURES)

Pharmacist Recommended

Helps Protect Immune System Helps Support Intestinal Health

MADE IN THE U.S.A.

FDA Statement of Identity

DIETARY SUPPLEMENT

Formulation

NO SUGAR, STARCH, YEAST, WHEAT, SOY, ARTIFICIAL FLAVORS OR PRESERVATIVES - Gluten Free -

Suggested/Recommended/Usage/Directions

DIRECTIONS: Either take 1 capsule on an empty stomach or 30 minutes before a meal as a dietary supplement or as directed by a healthcare professional.

Precautions

KEEP OUT OF REACH OF CHILDREN.

Do not purchase if seal is broken.

Storage

Protect from heat, light & moisture. Store at 15-30(0)C (59-86(0)F).

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Super Probiotic Acidophilus by Windmill label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Super Probiotic Acidophilus label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Super Probiotic Acidophilus by Windmill

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Vegetable Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Lactase

No known
interactions
15 mg per serving

Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can red...

Lactase monograph & interactions

Lactobacillus acidophilus

Interacts with
182 drugs
2000000000 CFU per serving

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy p...

Lactobacillus acidophilus monograph & interactions

Other (inactive) ingredients: Calcium Sulfate, Maltodextrin, Cellulose, Silicon Dioxide, Stearic Acid, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Super Probiotic Acidophilus by Windmill Drug Interactions

Want to check YOUR meds against Super Probiotic Acidophilus?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Lactobacillus acidophilus 182

Individual Drug Interactions

The ingredients in Super Probiotic Acidophilus interact with 182 drugs. Click any drug to see the details.

1 of the 2 ingredients in Super Probiotic Acidophilus interact with drugs. Each result below shows which ingredient is responsible. Lactobacillus acidophilus

Each ingredient & the kinds of drugs it affects

For each ingredient in Super Probiotic Acidophilus with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus acidophilus1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Super Probiotic Acidophilus, from the product label.

Windmill

Web Address
www.windmillvitamins.com
Pharmacist Counseling Corner

Super Probiotic Acidophilus by Windmill: Common Questions

Does Super Probiotic Acidophilus by Windmill interact with any medications?
Yes. Based on its ingredients, Super Probiotic Acidophilus has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Super Probiotic Acidophilus contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my lactose intolerance?
The lactase in this product is rated effective for lactose intolerance. It works by breaking down lactose so your body can digest dairy better. Whether it works for you depends on how much lactose you're consuming and your own tolerance level — your pharmacist can help you figure out the right dose.
What's the probiotic supposed to do?
Lactobacillus acidophilus is a live beneficial bacterium. The evidence suggests it's possibly effective for irritable bowel syndrome, antibiotic-associated diarrhea, Helicobacter pylori infection, and bacterial vaginosis. It won't work for everyone, but it's well-studied for these conditions.
Can I take this while I'm on an antibiotic?
Not at the same time. Antibiotics kill bacteria, including the live organisms in this probiotic, which makes the probiotic less effective. Your doctor or pharmacist can tell you how to space them out — usually a few hours apart helps.
Are there side effects I should know about?
Most people tolerate this product well. Some people experience mild gastrointestinal symptoms like bloating, gas, stomach discomfort, or diarrhea, but these are uncommon. Rarely, someone can have an allergic reaction to lactase itself. If you have any unusual symptoms, talk to your pharmacist.
Is it safe during pregnancy?
Lactase is rated possibly safe in pregnancy, and Lactobacillus acidophilus is also rated possibly safe — but data are limited for both. Talk with your doctor or pharmacist before regular use during pregnancy to make sure it's right for your situation.
Can I breastfeed while taking this?
There isn't enough data on file to know whether either ingredient is safe during breastfeeding. Ask your doctor or pharmacist before using this product while breastfeeding so you can make an informed decision together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Super Probiotic Acidophilus is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Super Probiotic Acidophilus label
Go deeper

The Full Monographs Behind Super Probiotic Acidophilus’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactase

Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...

Read the full Lactase monograph → Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph →
Sources

Sources & How We Checked

Super Probiotic Acidophilus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactase 1 reference
  1. Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed

See these in context on the Lactase monograph →

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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