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Dietary supplement

Supercritical Holy Basil Ingredients & Drug Interactions

by Natrium Health

Supercritical Holy Basil label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Supercritical Holy Basil against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Supercritical Holy Basil is a dietary supplement by Natrium Health with 1 active ingredient. Its ingredients are commonly taken for stress and anxiety, blood sugar support, respiratory complaints.Based on those ingredients, 212 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Ocimum sanctum Aerial Part Supercritical Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Supercritical Holy Basil by Natrium Health

Ask about any prescription or over-the-counter medication and we check it for interactions with Supercritical Holy Basil by Natrium Health — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Supercritical Holy Basil by Natrium Health

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: a supercritical extract of holy basil aerial parts (the aboveground portions of the plant). Supercritical extraction is a method that captures plant compounds using pressurized carbon dioxide, producing a concentrated form.

The liquid is carried in extra virgin olive oil as the inactive ingredient.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Holy Basil product and its label doesn't state a use — see Holy Basil's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The data we hold rates holy basil's evidence as insufficient for several uses people ask about — generalized anxiety, asthma, headache, respiratory infections, dental plaque, and diabetes. That means the studies to date aren't reliable enough for us to say whether it works for these conditions.

If you're considering it for one of these reasons, talk with your doctor or pharmacist about what the current science supports.

The evidence, ingredient by ingredient Holy Basil

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Holy basil extract is generally well tolerated in the short term, though long-term safety data are limited. The most common side effects from oral use are loose stools and nausea; a small number of trial participants experienced these.

Topical use in the mouth can cause a bitter taste. During pregnancy, the safety data advise against it — animal data raise concerns and human safety is not established.

The same goes for breastfeeding: there isn't enough reliable safety information, so avoid it while nursing. If you're pregnant or planning to become pregnant, talk with your doctor or pharmacist.

Side effects, ingredient by ingredient Holy Basil

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Holy Basil.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 212 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs like warfarin or aspirin (Moderate severity — increased bleeding risk), diabetes medications (Moderate severity — risk of low blood sugar), or pentobarbital or other sedatives (Moderate severity — strengthened sedative effects are possible).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Holy basil may be worth a conversation if you're exploring it for anxiety or general wellness, but the evidence for specific conditions is not yet solid. If you take blood thinners, diabetes medications, or sedatives, you need to check with your doctor or pharmacist before adding this product — the interactions are real enough to matter.

Pregnant and breastfeeding people should avoid it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 18, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Supercritical Holy Basil, straight from the product label.

Brand Natrium Health
Net contents 30 mL; 1 Fluid Ounce(s)
Market status On market
Date entered into DSLD Jul 18, 2023
DSLD ID 295297
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Supercritical Holy Basil by Natrium Health, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.5 mL
Maximum serving Sizes:
0.5 mL
Servings per container
60
IngredientAmount% DV
Ocimum sanctum Aerial Part Supercritical Extract150 mg--

Other ingredients: Extra Virgin Olive Oil

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Solution

Made in the USA with US and imported ingredients

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Shake well before using.

Suggested use: As a dietary supplement, take one half dropper (0.5mL) once daily.

Storage

Do not refrigerate.

Precautions

Disclaimer: Always consult with a qualified health physician before taking any new dietary supplements.

Warning: Do not consume more than 2mL per day.

Keep out of reach of children. Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, if you have any known or suspected medical conditions, and/or taking prescription or OTC medications.

Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, if you have any known or suspected medical conditions, and/or taking prescription or OTC medications.

Brand IP Statement(s)

Natrium Health Science Powered by Nature

FDA Disclaimer Statement

This product is not intended to diagnose, treat, cure or prevent any disease. These statements have not been evaluated by the FDA.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Supercritical Holy Basil by Natrium Health label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Supercritical Holy Basil label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Supercritical Holy Basil by Natrium Health

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.5 mL Dosage formLiquid Servings per container60 Amounts shown are per serving.

Ocimum sanctum Aerial Part Supercritical Extract

Interacts with
212 drugs
150 mg per serving Form: Caryophyllene, Eugenol

Holy basil (tulsi) is a traditional Ayurvedic herb most often used today for stress and general wellness, but the human evidence is mostly small and p...

Ocimum sanctum Aerial Part Supercritical Extract monograph & interactions

Other (inactive) ingredients: Extra Virgin Olive Oil. These complete the product’s ingredient list but are not active constituents.

Interaction report

Supercritical Holy Basil by Natrium Health Drug Interactions

Want to check YOUR meds against Supercritical Holy Basil?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
212Drugs
212 Moderate

Ingredients driving the most interactions

Ocimum sanctum Aerial Part Supercritical Extract 212

Individual Drug Interactions

The ingredients in Supercritical Holy Basil interact with 212 drugs. Click any drug to see the details.

1 of the 1 ingredient in Supercritical Holy Basil interact with drugs. Each result below shows which ingredient is responsible. Ocimum sanctum Aerial Part Supercritical Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Supercritical Holy Basil with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Ocimum sanctum Aerial Part Supercritical Extract3 drug types · 212 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, holy basil seed oil might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Animal research shows that holy basil seed oil can prolong bleeding time, possibly due to inhibition of platelet aggregation. However, it is not known if this occurs in humans.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, holy basil might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Small clinical studies show that taking holy basil can decrease fasting blood glucose and other measures of glycemic control in patients with type 2 diabetes.

Likelihood Possible Evidence B
Pentobarbital (Nembutal)

Theoretically, holy basil seed oil might increase the sedative effects of pentobarbital.
Animal research shows that holy basil seed oil increases pentobarbitone-induced sleeping time. However, it is not known if this occurs in humans or if this applies to other barbiturates or sedatives.

Likelihood Possible Evidence D
Ocimum sanctum Aerial Part Supercritical Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Supercritical Holy Basil, from the product label.

Natrium Health

See all Natrium Health products
Name
Natrium Health
Street Address
8205 S. Priest Dr. #11750
City
Tempe
State
AZ
ZipCode
85284
Pharmacist Counseling Corner

Supercritical Holy Basil by Natrium Health: Common Questions

Does Supercritical Holy Basil by Natrium Health interact with any medications?
Yes. Based on its ingredients, Supercritical Holy Basil has a known interaction with 212 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Supercritical Holy Basil contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or nursing?
No — the safety data advise against it during pregnancy, and there isn't enough reliable information for breastfeeding. Talk with your doctor or pharmacist if you're planning a pregnancy or are currently nursing.
What are the most common side effects?
Loose stools and nausea are the main ones reported from oral use in trials. A bitter taste has been noted when used as a mouthwash.
Does holy basil actually work for anxiety?
The evidence we have isn't reliable enough to say. The rating is insufficient to know whether it helps with generalized anxiety or other common uses people mention.
How long can I safely take this?
Short-term use appears well tolerated, but good long-term safety data are limited. Talk with your pharmacist about how long you plan to use it.
What's the supercritical extract, and why is it different?
It's made using pressurized carbon dioxide to pull out the active plant compounds — a method that often gives a more concentrated result than standard extraction. You get the same active ingredient, just processed differently.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Supercritical Holy Basil is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Supercritical Holy Basil label
Go deeper

The Full Monographs Behind Supercritical Holy Basil’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Holy Basil

Interacts with 212 drugs

Holy basil (tulsi) is a traditional Ayurvedic herb most often used today for stress and general wellness, but the human evidence is mostly small and preliminary. It is generally well tolerat...

Read the full Holy Basil monograph →
Sources

Sources & How We Checked

Supercritical Holy Basil's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Holy Basil 8 references
  1. Agrawal P, Rai V, Singh RB. Randomized placebo-controlled, single blind trial of holy basil leaves in patients with noninsulin-dependent diabetes mellitus. Int J Clin Pharmacol Ther 1996;34:406-9.
  2. Sakina MR, Dandiya PC, Hamdard ME, Hameed A. Preliminary psychopharmacological evaluation of Ocimum sanctum leaf extract. J Ethnopharmacol 1990;28:143-50. PubMed
  3. Singh S, Rehan HM, Majumdar DK. Effect of Ocimum sanctum fixed oil on blood pressure, blood clotting time and pentobarbitone-induced sleeping time. J Ethnopharmacol 2001;78:139-43. PubMed
  4. Mondal, S., Varma, S., Bamola, V. D., Naik, S. N., Mirdha, B. R., Padhi, M. M., Mehta, N., and Mahapatra, S. C. Double-blinded randomized controlled trial for immunomodulatory effects of Tulsi (Ocimum sanctum Linn.) leaf extract on healthy volunteers. J PubMed
  5. Agarwal, P. and Nagesh, L. Comparative evaluation of efficacy of 0.2% Chlorhexidine, Listerine and Tulsi extract mouth rinses on salivary Streptococcus mutans count of high school children--RCT. Contemp.Clin Trials 2011;32(6):802-808. PubMed
  6. Vohora, S. B., Garg, S. K., and Chaudhury, R. R. Antifertility screening of plants. 3. Effect of six indigenous plants on early pregnancy in albino rats. Indian J Med Res 1969;57(5):893-899.
  7. Khanna S, Gupta SR, Grover JK. Effect of long term feeding of tulsi (Ocimum sanctum Linn) on reproductive performance of adult albino rats. Indian J Exp Biol 1986;24(5):302-4.
  8. Somasundaram G, Manimekalai K, Salwe KJ, Pandiamunian J. Evaluation of the antidiabetic effect of Ocimum sanctum in type 2 diabetes patients. Int J Life Sci Pharma Res 2012;2(3):75-81.

See these in context on the Holy Basil monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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