Interactions on record — worth a quick check against your medications. Based on 5 of 9 ingredients. Check your meds →
Dietary supplement

Aroma Block-R Ingredients & Drug Interactions

by EFX Sports

Aroma Block-R label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Aroma Block-R against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Aroma Block-R is a dietary supplement by EFX Sports with 9 active ingredients. Its ingredients are commonly taken for estrogen/hormone balance, acne and hormonal skin issues, prostate health support.Based on those ingredients, 1,113 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bioperine Black Pepper extract, 5,7-Dihydroxy Flavone, Indole-3-Carbinol. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Aroma Block-R by EFX Sports

Ask about any prescription or over-the-counter medication and we check it for interactions with Aroma Block-R by EFX Sports — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Aroma Block-R by EFX Sports

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 9 active ingredients.
  • “Aroma Block-R Proprietary Blend” is a proprietary blend — the label gives one combined amount (177 mg) without saying how much of each component you get.

Aroma Block-R contains 9 ingredients, four of which are active: diindolylmethane, indole-3-carbinol, boron, and black pepper extract (Bioperine). Three others — methoxyisoflavone, soy isoflavones, and Vaga extract — are included but we hold no interaction data for them.

The product also contains DHB and a proprietary blend. The remaining ingredients are inactive: sorbitol, microcrystalline cellulose, and several binding and flow agents.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: estrogen balance and hormone support for men.
  • We looked for evidence on: Benign prostatic hyperplasia (BPH), Prostate cancer, Sexual desire, testosterone support, hormonal balance.
  • The closest evidence on file: Black Pepper is rated "Insufficient Reliable Evidence To Rate" for Sexual desire (Natural Medicines).
  • Also on file: Chrysin is rated "Insufficient Reliable Evidence To Rate" for Cancer.
  • Also on file: Diindolylmethane is rated "Insufficient Reliable Evidence To Rate" for Benign prostatic hyperplasia (BPH), Prostate cancer.

The evidence for most of these ingredients is not established in our data. Diindolylmethane has insufficient reliable evidence for benign prostatic hyperplasia, breast cancer, colorectal cancer, cervical dysplasia, and breast pain.

Indole-3-carbinol similarly shows insufficient evidence for breast cancer, colorectal cancer, cervical dysplasia, liver disease, and fibromyalgia. Boron is likely effective for boron deficiency and possibly effective for vaginal candidiasis and radiation dermatitis, but is possibly ineffective for athletic performance.

Black pepper extract and chrysin both lack sufficient evidence for their listed uses (allergies, asthma, athletic performance, headache, depression, diarrhea for pepper; anxiety, athletic performance, cancer, HIV/AIDS, muscle strength, and gout for chrysin).

The evidence, ingredient by ingredient Diindolylmethane Indole-3-carbinol Boron Black Pepper Chrysin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Diindolylmethane is generally well tolerated short-term, but long-term safety isn't established — most common side effects are diarrhea, gas, headache, nausea, rash, and vomiting. A very rare but serious reaction called DRESS (drug rash with eosinophilia and systemic symptoms) has been reported.

One case of stroke was reported in a woman taking diindolylmethane, though her high stroke risk from other conditions made it unclear if the supplement played a role. Indole-3-carbinol appears well tolerated and commonly causes diarrhea, nausea, rash, tremor, and balance problems — especially at higher doses; one person taking 800 mg daily developed tremor and imbalance that resolved when the dose was halved.

Boron is generally safe at supplement doses below 20 mg daily, but high chronic doses can cause skin rash, hair loss, nausea, vomiting, and diarrhea. Black pepper is well tolerated as a food spice; concentrated supplements carry uncertain safety.

Chrysin appears well tolerated short-term, though long-term safety is unstudied.

Side effects, ingredient by ingredient Diindolylmethane Indole-3-carbinol Boron Black Pepper Chrysin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 5 matched ingredients can interact with medications — Black Pepper, Indole-3-carbinol, Chrysin, Diindolylmethane.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; lithium.
  • For scale: 1,114 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check with your pharmacist if you take propranolol, phenytoin, rifampin, nevirapine, cyclosporine, pentobarbital, atorvastatin, or theophylline — black pepper extract may raise their blood levels. Also check if you take estrogens, hormone replacement therapy, or birth control pills, as diindolylmethane and indole-3-carbinol may interfere.

Blood thinners like warfarin and aspirin need attention too, since indole-3-carbinol and chrysin may increase bleeding risk.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you take any prescription medications — especially blood thinners, heart drugs, seizure medications, antiretrovirals, or birth control — talk to your pharmacist before starting this product. The black pepper extract and hormone-related ingredients carry the biggest medication interaction risks.

Boron is safe at typical supplement doses but should be avoided if you're pregnant or breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 9 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 24, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Aroma Block-R, straight from the product label.

Brand EFX Sports
Barcode (UPC) 737190003053
Net contents 30 Tablet(s)
Market status On market
Date entered into DSLD Feb 24, 2017
DSLD ID 71281
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult Male (18-50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Aroma Block-R by EFX Sports, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
UPC/BARCODE
737190003053
IngredientAmount% DV
Methoxyisoflavone0 NP--
Diindolylmethane0 NP--
Indole-3-Carbinol0 NP--
Soy Isoflavones0 NP--
Boron0 NP--
Bioperine Black Pepper extract0 NP--
Aroma Block-R Proprietary Blend177 mg--
5,7-Dihydroxy Flavone0 NP--
Vaga [Cyanotis vaga] extract0 NP--
DHB0 NP--

Other ingredients: Sorbitol, Microcrystalline Cellulose, Hydroxypropyl Methylcellulose, Prosolve Cellulose, Croscarmellose Sodium, Silicon Dioxide, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Block Aroma Block-R tablets Alpha-male crushing estrogen may have met its match! Powered by our synergistic blend of phyto-nutrients and pressed into a delayed release tablet, Aroma Block-R packs the 1 tablet power to complete the Test Charge experience.

Patent and international patents pending. Bioperine is a registered trademark of Sabinsa Corporation. Proudly manufactured by All American Pharmaceutical

2016 EFX Sports

Aroma Block-R

What is the Test Charge kit? It's a natural testosterone support system that works with the body's natural physiological processes.

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 1 tablet daily before bedtime. Use daily for 30 consecutive days.

For best results Test Charge users should exercise with maximum intensity while following a nutrient rich, calorically dense diet. The Test Charge kit does not need to be cycled. Individual results may vary.

Storage

Storage: Keep lids tightly closed in a cool, dry place away from children. Protect from heat, light and moisture.

Precautions

Storage: Keep lids tightly closed in a cool, dry place away from children.

Warning: For healthy men only.

Not intended for use by women or those under 18 years of age.

If you are under a doctor's care consult with your physician before using.

Contains: Soy

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Made in USA. In God we trust.

EU Plant# 1000135313

Vitality Power Testosterone support kit 3 products in 1 kit 30 day supply

General

AA27

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Informed-sport.com Trusted by sport

Formulation

Drug free

Formula

Contains: Soy

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Aroma Block-R by EFX Sports label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Aroma Block-R label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Aroma Block-R by EFX Sports

These are the 9 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Aroma Block-R Proprietary Blend

177 mg per serving

Other (inactive) ingredients: Sorbitol, Microcrystalline Cellulose, Hydroxypropyl Methylcellulose, Prosolve Cellulose, Croscarmellose Sodium, Silicon Dioxide, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Aroma Block-R by EFX Sports Drug Interactions

Want to check YOUR meds against Aroma Block-R?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,113Drugs
1,091 Moderate 22 Minor

Ingredients driving the most interactions

Bioperine Black Pepper extract 1,019
5,7-Dihydroxy Flavone 358
Indole-3-Carbinol 294
Diindolylmethane 269

Individual Drug Interactions

The ingredients in Aroma Block-R interact with 1,113 drugs. Click any drug to see the details.

4 of the 9 ingredients in Aroma Block-R interact with drugs. Each result below shows which ingredient is responsible. Bioperine Black Pepper extract 5,7-Dihydroxy Flavone Indole-3-Carbinol Diindolylmethane

Each ingredient & the kinds of drugs it affects

For each ingredient in Aroma Block-R with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Bioperine Black Pepper extract17 drug types · 1,019 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, black pepper might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
In vitro research shows that piperine, a constituent of black pepper, seems to inhibit platelet aggregation. This has not been reported in humans.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, black pepper might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research shows that piperine, a constituent of black pepper, can reduce blood glucose levels. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence D
Atorvastatin (Lipitor)

Theoretically, black pepper might increase blood levels of atorvastatin.
Animal research shows that taking piperine, a constituent of black pepper, 35 mg/kg can increase the maximum serum concentration of atorvastatin three-fold. This has not been reported in humans.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically, black pepper might increase the effects and side effects of cyclosporine.
In vitro research shows that piperine, a constituent of black pepper, increases the bioavailability of cyclosporine. This has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, black pepper might increase levels of drugs metabolized by CYP2D6.
In vitro research suggests that some constituents of black pepper inhibit CYP2D6. This has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.
In vitro research and pharmacokinetic simulation data suggest that piperine, a constituent of black pepper, as well as the pepper fruit seem to inhibit CYP3A4. This has not been reported in humans.

Likelihood Possible Evidence D
Lithium

Theoretically, black pepper might increase blood levels of lithium due to its diuretic effects. The dose of lithium might need to be reduced.
Black pepper is thought to have diuretic properties.

Likelihood Probable Evidence D
Nevirapine (Viramune)

Black pepper might increase blood levels of nevirapine.
Clinical research shows that piperine, a constituent of black pepper, increases the plasma concentration of nevirapine. However, no adverse effects were observed in this study.

Likelihood Probable Evidence D
P-Glycoprotein Substrates

Theoretically, black pepper might increase levels of P-glycoprotein substrates.
In vitro research shows that piperine, a constituent of black pepper, seems to inhibit P-glycoprotein.

Likelihood Possible Evidence D
Pentobarbital (Nembutal)

Theoretically, black pepper might increase the sedative effects of pentobarbital.
Animal research shows that piperine, a constituent of black pepper, increases pentobarbital-induced sleeping time.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

Black pepper might increase blood levels of phenytoin.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption, slow elimination, and increase levels of phenytoin. Taking a single dose of black pepper 1 gram along with phenytoin seems to double the serum concentration of phenytoin. Consuming a soup with black pepper providing piperine 44 mg/200 mL of soup along with phenytoin also seems to increase phenytoin levels when compared with consuming the same soup without black pepper.

Likelihood Possible Evidence B
Propranolol (Inderal)

Black pepper might increase blood levels of propranolol.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and slow elimination of propranolol.

Likelihood Possible Evidence B
Rifampin (Rifadin)

Black pepper might increase blood levels of rifampin.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and serum levels of rifampin.

Likelihood Possible Evidence B
Theophylline

Black pepper might increase blood levels of theophylline.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and slow elimination of theophylline.

Likelihood Possible Evidence D
Amoxicillin (Amoxil, Trimox)

Theoretically, black pepper might increase the effects and side effects of amoxicillin.
Animal research shows that taking piperine, a constituent of black pepper, with amoxicillin increases plasma levels of amoxicillin. This has not been reported in humans.

Likelihood Possible Evidence D
Carbamazepine (Tegretol)

Theoretically, black pepper might increase blood levels of carbamazepine, potentially increasing the effects and side effects of carbamazepine.
One clinical study in patients taking carbamazepine 300 mg or 500 mg twice daily shows that taking a single 20 mg dose of purified piperine, a constituent of black pepper, increases carbamazepine levels. Piperine may increase carbamazepine absorption by increasing blood flow to the GI tract, increasing the surface area of the small intestine, or inhibiting cytochrome P450 3A4 (CYP3A4) in the gut wall. Absorption was significantly increased by 7-10 mcg/mL/hour. The time to eliminate carbamazepine was also increased by 4-8 hours. Although carbamazepine levels were increased, this did not appear to increase side effects. In vitro research also shows that piperine can increase carbamazepine levels by 11% in a time-dependent manner.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, black pepper might decrease levels and clinical effects of drugs metabolized by CYP1A2.
In vitro research suggests that black pepper induces CYP1A2. This has not been reported in humans.

Likelihood Possible Evidence D
Bioperine Black Pepper extract full monograph & interactions

5,7-Dihydroxy Flavone9 drug types · 358 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, chrysin might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro evidence suggests that chrysin might inhibit platelet aggregation.

Likelihood Possible Evidence D
Aromatase Inhibitors

Theoretically, chrysin might increase the effects and adverse effects of aromatase inhibitors.
In vitro research suggests that chrysin might decrease estrogen synthesis by acting as an aromatase (estrogen synthetase) inhibitor..

Likelihood Possible Evidence D
Contraceptive Drugs

Theoretically, chrysin might reduce the efficacy of estrogen-containing contraceptive drugs.
In vitro research suggests that chrysin might have antiestrogenic activity.

Likelihood Possible Evidence D
Diclofenac (Voltaren, Others)

Theoretically, chrysin might increase the effects and adverse effects of diclofenac.
In vitro research suggests that chrysin and its sulfate conjugate inhibit diclofenac metabolism. It is speculated that chrysin and its sulfate conjugate reduce the metabolism of diclofenac by inhibiting cytochrome P450 2C9. This effect has not been reported in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, chrysin might decrease the effects of estrogen therapy.
In vitro research suggests that chrysin might have antiestrogenic activity.

Likelihood Possible Evidence D
Mephenytoin (Mesantoin)

Theoretically, chrysin might increase the effects and adverse effects of mephenytoin.
In vitro research suggests that chrysin and its sulfate and glucuronide conjugates inhibit S-mephenytoin metabolism. It is speculated that chrysin and its conjugates reduce the metabolism of S-mephenytoin by inhibiting cytochrome P450 2C19. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, chrysin might increase levels of drugs metabolized by CYP1A2.
In vitro research suggests that chrysin inhibits CYP1A2 isozymes. However, chrysin does not appear to inhibit CYP1A2-dependent caffeine metabolism in animals. Due to chrysin's low bioavailability and rapid metabolism to glucuronide and sulfate conjugates, this interaction is unlikely.

Likelihood Unlikely Evidence D
Glucuronidated Drugs

Theoretically, chrysin might increase the clearance of drugs that are UGT1A1 substrates, thereby reducing their effectiveness.
In vitro research suggests that chrysin might induce UDP-glucuronosyltransferase 1A1 (UGT1A1).

Likelihood Unlikely Evidence D
Testosterone

Theoretically, chrysin might increase the effects and adverse effects of testosterone.
In vitro research suggests that chrysin and its sulfate conjugate inhibit testosterone metabolism. It is speculated that chrysin and its sulfate conjugate reduce the metabolism of testosterone by inhibiting cytochrome P450 3A4. This effect has not been reported in humans.

Likelihood Possible Evidence D
5,7-Dihydroxy Flavone full monograph & interactions

Indole-3-Carbinol3 drug types · 294 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, indole-3-carbinol might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
In vitro research shows that indole-3-carbinol inhibits platelet aggregation.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Animal research shows that indole-3-carbinol induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Estrogens

Indole-3-carbinol might interfere with the effects of estrogen therapy.
Preliminary clinical and in vitro evidence shows that indole-3-carbinol has antiestrogenic activity.

Likelihood Possible Evidence D
Indole-3-Carbinol full monograph & interactions

Diindolylmethane3 drug types · 269 drugs

Diuretic Drugs

Theoretically, diindolylmethane might increase the risk of hyponatremia if used with sodium-depleting diuretics.
Large doses of diindolylmethane (600 mg daily) have been associated with two cases of asymptomatic hyponatremia in clinical research.

Likelihood Possible Evidence B
Estrogens

Theoretically, diindolylmethane might increase or decrease the effects of estrogens.
Diindolylmethane might have mild estrogenic or antiestrogenic effects. Theoretically, large amounts of diindolylmethane might interfere with hormone replacement therapy.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.
In vitro evidence suggests that diindolylmethane can induce CYP1A2. Theoretically, it might increase metabolism of CYP1A2 substrates and lower serum concentrations. This interaction has not been reported in humans.

Likelihood Unlikely Evidence D
Diindolylmethane full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Aroma Block-R, from the product label.

EFX Sports

See all EFX Sports products
Name
EFX Sports
City
San Jose
State
CA
ZipCode
95124
Phone Number
(888) 238-1864
Web Address
EFXSPORTS.com
Pharmacist Counseling Corner

Aroma Block-R by EFX Sports: Common Questions

Does Aroma Block-R by EFX Sports interact with any medications?
Yes. Based on its ingredients, Aroma Block-R has a known interaction with 1,113 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Aroma Block-R contains 9 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is it safe to take if I'm pregnant or breastfeeding?
Diindolylmethane and indole-3-carbinol should be avoided in pregnancy and breastfeeding due to insufficient safety data and possible hormone effects. Boron is possibly unsafe in pregnancy at supplement doses. Chrysin is not recommended during pregnancy or breastfeeding. Black pepper in food amounts is likely safe in pregnancy but possibly unsafe in supplement strength. Talk with your doctor or pharmacist for personalized advice.
What's black pepper extract doing in here?
Black pepper extract (piperine) is included as a bioavailability enhancer — it can help the body absorb other compounds more efficiently. The downside is that it also increases absorption and blood levels of certain medications, which is why it needs a careful check against your prescription list.
Does this product work for muscle building or athletic performance?
The evidence we hold doesn't establish that these ingredients are effective for athletic performance or muscle strength. While some are marketed for those uses, we don't have reliable data supporting them.
What are the most common side effects I might notice?
The most likely side effects are gastrointestinal: diarrhea, nausea, gas, and indigestion. Headache and rash are also reported. Balance or tremor problems have been seen at higher doses of indole-3-carbinol. Most people tolerate it without problems, but stop and call your pharmacist if anything concerns you.
Can I take this long-term?
Long-term safety for diindolylmethane and chrysin is not well established. Both have been studied mainly short-term. If you're considering ongoing use, check with your pharmacist to weigh the unknowns against your needs.
Why is boron in this if it's a mineral supplement?
Boron is included for its possible effects on bone and hormone metabolism. It's generally safe at the doses in supplements, though high doses can cause toxicity. The amount in this product is what matters — if you have questions about the dose, ask your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Aroma Block-R label
Go deeper

The Full Monographs Behind Aroma Block-R’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Diindolylmethane

Interacts with 269 drugs

Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and cancer prevention. Although early lab s...

Read the full Diindolylmethane monograph → Herb & supplement monograph

Indole-3-carbinol

Interacts with 294 drugs

Indole-3-carbinol (I3C) is a compound formed when you eat cruciferous vegetables like broccoli and cabbage, and it is sold as a supplement mainly for hormone-related and cell-protective effe...

Read the full Indole-3-carbinol monograph → Herb & supplement monograph

Boron

Boron is a trace mineral found in many plant foods and sold as a supplement, mainly promoted for bone, joint, and hormone health. The human evidence for most of these uses is limited or prel...

Read the full Boron monograph → Herb & supplement monograph

Black Pepper

Interacts with 1,019 drugs

Black pepper is a common kitchen spice that is generally safe in the amounts used in food. Its extract, piperine, is mostly added to supplements to help the body absorb other ingredients (li...

Read the full Black Pepper monograph → Herb & supplement monograph

Chrysin

Interacts with 358 drugs

Chrysin is a plant flavonoid sold mainly as a bodybuilding supplement claimed to raise testosterone or block estrogen, but human studies have not shown these benefits, largely because the bo...

Read the full Chrysin monograph →
Sources

Sources & How We Checked

Aroma Block-R's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 81 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Diindolylmethane 14 references
  1. Natl Inst Health, Natl Inst Environmental Health Sci. Indole-3-carbinol. Available at: http://ntp-server.niehs.nih.gov.
  2. Balk JL. Indole-3-carbinol for cancer prevention. Altern Med Alert 2000; 3:105-7.
  3. Riby JE, Chang GHF, Firestone GL, Bjeldanes LF. Ligand-independent activation of estrogen receptor function by 3,3'-diindolylmethane in human breast cancer cells. Biochem Pharmacol 2000;60:167-77. PubMed
  4. Lake BG, Tredger JM, Renwick AB, et al. 3'3-diindolylmethane induces CYP1A2 in cultured precision-cut human liver slices. Xenobiotica 1998;28:803-11. PubMed
  5. Dalessandri, K. M., Firestone, G. L., Fitch, M. D., Bradlow, H. L., and Bjeldanes, L. F. Pilot study: effect of 3,3'-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer. Nutr Canc PubMed
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Boron 6 references
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Chrysin 23 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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