Interactions on record — worth a quick check against your medications. Based on 4 of 11 ingredients. Check your meds →
Dietary supplement

The Original Mango Madness Ingredients & Drug Interactions

by XTEND

The Original Mango Madness label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking The Original Mango Madness against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

The Original Mango Madness is a dietary supplement by XTEND with 11 active ingredients. Its ingredients are commonly taken for muscle recovery and sports performance, gut health and 'leaky gut', recovery from severe illness or injury.Based on those ingredients, 297 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin B6, Sodium, Potassium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against The Original Mango Madness by XTEND

Ask about any prescription or over-the-counter medication and we check it for interactions with The Original Mango Madness by XTEND — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of The Original Mango Madness by XTEND

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 8 of its 11 active ingredients.
  • “Electrolyte Blend” is a proprietary blend — the label gives one combined amount (1,140 mg) without saying how much of each component you get.

The Original Mango Madness contains 11 ingredients total. The active ones include L-Glutamine, Vitamin B6, amino acids (L-Leucine, L-Isoleucine, L-Valine), electrolytes (potassium and sodium in various forms), and Citrulline Malate.

Glutamine is included for muscle recovery and immune support; the branched-chain amino acids (leucine, isoleucine, valine) are building blocks for muscle protein; and citrulline malate is added for blood flow and exercise endurance. The electrolytes — potassium chloride, sodium chloride, and sodium citrate — help with hydration balance during and after workouts.

The product also contains inactive ingredients like citric acid, malic acid, silicon dioxide, natural and artificial flavors, sucralose, acesulfame potassium, and food colorants (FD&C Yellow #5 and FD&C Red Lake #40). These are fillers, binders, and flavoring agents typical in powder supplements.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Sickle cell disease — rated "Effective" (Glutamine) (Natural Medicines).
  • On file: Pyridoxine-dependent epilepsy — rated "Effective" (Vitamin B6) (Natural Medicines).
  • On file: Sideroblastic anemia — rated "Effective" (Vitamin B6) (Natural Medicines).
  • On file: Vitamin B6 deficiency — rated "Effective" (Vitamin B6) (Natural Medicines).
  • On file: Cystic fibrosis — rated "Likely Effective" (Sodium) (Natural Medicines).

Evidence for this product's ingredients is mixed. L-Glutamine is Effective for sickle cell disease and Possibly Effective for muscle wasting related to HIV/AIDS, postoperative recovery, and critical illness — though most of the data comes from high doses or clinical settings.

Vitamin B6 is Effective for certain rare anemias and deficiency states, and Possibly Effective for pregnancy-related nausea. The branched-chain amino acids (leucine, isoleucine, valine) are marketed for muscle recovery, but no effectiveness ratings are on file for them in our data.

Citrulline Malate and the electrolytes similarly have no established effectiveness ratings in the facts we hold. For workout support and amino acid supplementation outside of specific medical conditions, the evidence we have is incomplete.

The evidence, ingredient by ingredient Glutamine Vitamin B6 Sodium Potassium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-Glutamine is generally well tolerated in healthy adults, but people with kidney or liver disease should use it only under medical supervision. It may cause gastrointestinal upset — belching, bloating, constipation, diarrhea, flatulence, nausea, or vomiting — especially at higher doses.

A few rare cases of mood changes (mania or hypomania) have been reported in people with bipolar disorder taking glutamine supplements. Vitamin B6 is well tolerated at normal amounts, but high doses over time can cause nerve damage (sensory neuropathy).

Doses above 1,000 mg daily or very high cumulative intake pose the greatest risk, though neuropathy can occur with lower amounts too. Sodium is generally safe in normal dietary amounts, but too much raises blood pressure and strains the heart and kidneys.

Potassium from food is fine, but supplements can cause dangerously high blood levels, especially in people with kidney disease — high potassium can trigger dangerous heart rhythm problems.

Side effects, ingredient by ingredient Glutamine Vitamin B6 Sodium Potassium

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Potassium, Glutamine, Vitamin B6, Sodium.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: seizure medications; lithium; Parkinson's medications.
  • For scale: 297 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before taking this product if you're on anticonvulsants (like phenytoin or phenobarbital), blood pressure medications (ACE inhibitors, ARBs, or other antihypertensives), potassium-sparing diuretics (water pills that save potassium), lithium, corticosteroids, amiodarone, or levodopa. The sodium content and potassium content, along with vitamin B6 and glutamine, each have Moderate interactions with these drug types.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This is an amino acid and electrolyte blend designed for muscle recovery and workout performance. If you take anticonvulsants, blood pressure medications, lithium, or potassium-sparing water pills, you need to check with your pharmacist or doctor before starting — the sodium and potassium content, plus the vitamin B6 and glutamine, could interact.

People with kidney disease should be especially cautious with potassium supplements. For otherwise healthy folks not on medications, talk to your pharmacist about dosing, especially if you have any existing medical conditions.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 11 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 18, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about The Original Mango Madness, straight from the product label.

Brand XTEND
Barcode (UPC) 181030000281
Net contents 420 Gram(s); 14.8 Ounce(s)
Market status On market
Date entered into DSLD Jul 18, 2023
DSLD ID 295114
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for The Original Mango Madness by XTEND, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
14 Gram(s)
Maximum serving Sizes:
14 Gram(s)
Servings per container
30
UPC/BARCODE
181030000281
IngredientAmount% DV
Calories0 Calorie(s)--
Total Carbohydrates0 Gram(s)--
L-Glutamine2500 mg--
Vitamin B6640 mcg38%
Sodium220 mg10%
Potassium170 mg4%
L-Leucine3500 mg--
Potassium Chloride0 NP--
L-Isoleucine1750 mg--
L-Valine1750 mg--
Sodium Chloride0 NP--
Total Sugars0 Gram(s)--
Sodium Citrate0 NP--
Electrolyte Blend1140 mg--
Citrulline Malate1000 mg--

Other ingredients: Citric Acid, Malic Acid, Silicon Dioxide, Natural & Artificial flavors, Sucralose, Acesulfame Potassium, FD&C Yellow #5, FD&C Red Lake #40

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Minimum fill line after settling. This product is sold by weight, not volume. The density of the powder varies, and significant settling of powder may occur during shipping and handling. This product contains the servings indicated when measured by weight. Instagram @XTEND

For over 10 years, XTEND has been making the best recovery products in the world.

Try all the sugar-free, mouthwatering flavors of XTEND to support your fitness goals. When to take XTEND for best results: Pre Workout XTEND energy Post Workout XTEND pro

The world's #1 BCAA brand Based upon cumulative global sales of all XTEND branded BCAA products from 2004 to present.

Suggested/Recommended/Usage/Directions

Recommended Use: As a dietary supplement, mix 1 serving in 10-14 fl. oz. of water (adjust for taste preference) and shake well. On training days, consume 1 serving during exercise and 1 serving after exercise. On non-training days, consume 2 servings throughout the day. For best results, use two servings per day.

When to take XTEND for best results: Intra Workout XTEND Original Combine with any XTEND branded product every day, even on rest days, to help maximize your recovery.

Brand IP Statement(s)

XTEND and the X logo are trademarks of SCIVATION, INC.

Formulation

Made in the U.S.A. using strategically sourced domestic and imported ingredients and components.

The official recovery brand of champions. Faster recovery is the key to better results.

Zero sugar Per Serving

Muscle recovery + electrolytes

Seals/Symbols

Informed Choice NSF Contents Certified

Precautions

Warning: This product is only intended for healthy adults, 18 years of age or older.

Do not use if pregnant or nursing. Consult with a licensed, qualified, healthcare professional before taking this or any dietary supplement product, especially if you are taking medication or have a medical condition.

Discontinue 2 weeks prior to surgery. Use only as directed. Do not use if safety seal is broken or missing.

Keep out of reach of children.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula

Powered by 7 grams of branched-chain amino acids (BCAAs), which have been clinically shown to support muscle recovery and growth, XTEND Original also contains hydrating electrolytes and additional performance ingredients to help you refuel, repair, and recover. If used as directed.

7g BCAA Muscle recovery + electrolytes

Mango Madness Naturally & artificially flavored

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

The Original Mango Madness by XTEND label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

The Original Mango Madness label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in The Original Mango Madness by XTEND

These are the 11 active ingredients this product is made of. Select any to open its full monograph.

Serving size14 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Glutamine

Interacts with
50 drugs
2500 mg per serving

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle c...

L-Glutamine monograph & interactions

Vitamin B6

Interacts with
210 drugs
640 mcg per serving Form: Pyridoxine Hydrochloride

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B6 monograph & interactions

Sodium

Interacts with
205 drugs
220 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Potassium

Interacts with
62 drugs
170 mg per serving

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...

Potassium monograph & interactions

L-Leucine

3500 mg per serving

L-Isoleucine

1750 mg per serving

L-Valine

1750 mg per serving

Electrolyte Blend

1140 mg per serving

Citrulline Malate

1000 mg per serving

Other (inactive) ingredients: Citric Acid, Malic Acid, Silicon Dioxide, Natural & Artificial flavors, Sucralose, Acesulfame Potassium, FD&C Yellow #5, FD&C Red Lake #40. These complete the product’s ingredient list but are not active constituents.

Interaction report

The Original Mango Madness by XTEND Drug Interactions

Want to check YOUR meds against The Original Mango Madness?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
297Drugs
292 Moderate 5 Minor

Ingredients driving the most interactions

Vitamin B6 210
Sodium 205
Potassium 62
L-Glutamine 50

Individual Drug Interactions

The ingredients in The Original Mango Madness interact with 297 drugs. Click any drug to see the details.

4 of the 11 ingredients in The Original Mango Madness interact with drugs. Each result below shows which ingredient is responsible. Vitamin B6 Sodium Potassium L-Glutamine

Each ingredient & the kinds of drugs it affects

For each ingredient in The Original Mango Madness with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin B65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
Vitamin B6 full monograph & interactions

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions

Potassium3 drug types · 62 drugs

Ace Inhibitors (Aceis)

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Angiotensin Receptor Blockers (Arbs)

Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Potassium-Sparing Diuretics

Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.

Likelihood Likely Evidence C
Potassium full monograph & interactions

L-Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
L-Glutamine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for The Original Mango Madness, from the product label.

XTEND

See all XTEND products
Name
Nutrabolt
City
Austin
State
TX
ZipCode
78749
Phone Number
1.866.996.3489
Web Address
www.officialXTEND.com
Pharmacist Counseling Corner

The Original Mango Madness by XTEND: Common Questions

Does The Original Mango Madness by XTEND interact with any medications?
Yes. Based on its ingredients, The Original Mango Madness has a known interaction with 297 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
The Original Mango Madness contains 11 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe if I take blood pressure medication?
Not without checking first. The sodium in this product can reduce how well some blood pressure drugs work, and the vitamin B6 and potassium may add to the blood-pressure-lowering effect, which could cause your pressure to drop too far. Talk to your pharmacist with your exact medications before starting.
Can I take this if I have kidney disease?
You should check with your doctor first. L-Glutamine and potassium supplements both require medical supervision if your kidneys aren't working normally, because they can build up in your blood and cause problems.
What is L-Glutamine in this product for?
Glutamine is an amino acid your body uses for muscle repair and immune function. It's Effective for sickle cell disease and Possibly Effective for muscle recovery after surgery or during serious illness, though most of the strong evidence comes from higher doses used in clinical settings.
Does this actually help with muscle recovery?
Glutamine and the branched-chain amino acids (leucine, isoleucine, valine) are marketed for that purpose, and glutamine has some clinical evidence for recovery after surgery and in critically ill patients. However, we don't have established effectiveness ratings for all the amino acids in this blend for general workout recovery.
Can I take this while pregnant or breastfeeding?
L-Glutamine is rated Likely Safe in pregnancy. Sodium is also Likely Safe in normal amounts but rated Possibly Unsafe at high intakes during lactation. Potassium is Likely Safe in pregnancy but requires a doctor's guidance before supplementing while breastfeeding. We don't have safety data on file for L-Leucine, L-Isoleucine, L-Valine, or Citrulline Malate in pregnancy or lactation, so talk to your OB or pharmacist before using this.
What side effects might I notice?
L-Glutamine commonly causes bloating, belching, diarrhea, constipation, flatulence, nausea, or vomiting — usually mild. Vitamin B6 at normal doses is well tolerated but can cause headache or nausea. Potassium may cause abdominal pain, diarrhea, or nausea if your level gets too high. Sodium is fine at normal dietary amounts but can worsen blood pressure and heart strain if you overdo it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

The Original Mango Madness label
Go deeper

The Full Monographs Behind The Original Mango Madness’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glutamine

Interacts with 50 drugs

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...

Read the full Glutamine monograph → Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph → Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Potassium

Interacts with 62 drugs

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...

Read the full Potassium monograph →
Sources

Sources & How We Checked

The Original Mango Madness's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 93 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

Vitamin B6 32 references
  1. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Geerling BJ, Dagnelie PC, Badart-Smook A, et al. Diet as a risk factor for the development of ulcerative colitis. Am J Gastroenterol 2000;95:1008-13. PubMed
  4. South M. Neonatal seizures after pyridoxine use -- reply. Lancet 1999;354:2083. PubMed
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Sodium 38 references
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See these in context on the Sodium monograph →

Potassium 12 references
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See these in context on the Potassium monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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