Interactions on record — worth a quick check against your medications. Based on 4 of 11 ingredients. Check your meds →
Dietary supplement

The Original Tropic Thunder Ingredients & Drug Interactions

by XTEND

The Original Tropic Thunder label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking The Original Tropic Thunder against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

The Original Tropic Thunder is a dietary supplement by XTEND with 11 active ingredients. Its ingredients are commonly taken for muscle recovery and sports performance, gut health and 'leaky gut', recovery from severe illness or injury.Based on those ingredients, 297 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin B6, Sodium, Potassium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against The Original Tropic Thunder by XTEND

Ask about any prescription or over-the-counter medication and we check it for interactions with The Original Tropic Thunder by XTEND — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of The Original Tropic Thunder by XTEND

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 8 of its 11 active ingredients.
  • “Electrolyte Blend” is a proprietary blend — the label gives one combined amount (1,140 mg) without saying how much of each component you get.

The Original Tropic Thunder contains 11 active ingredients designed to support muscle recovery and performance. L-glutamine, L-leucine, L-isoleucine, and L-valine are branched-chain and other amino acids that play roles in muscle protein metabolism and recovery.

Vitamin B6 supports energy metabolism and nerve function. The product also contains sodium (from sodium chloride and sodium citrate) and potassium (from potassium and potassium chloride) to help with electrolyte balance and hydration — key for post-workout recovery.

Citrulline malate is included for additional support. The remaining ingredients are inactive fillers and flavorings.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Muscle recovery and sports performance support.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, Postoperative recovery, Muscle protein synthesis, Endurance performance, Strength training.
  • The strongest evidence on file: Glutamine is rated "Possibly Effective" for Postoperative recovery (Natural Medicines).
  • Also on file: Glutamine is rated "Possibly Ineffective" for Athletic performance.
  • Also on file: Glutamine is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle damage.

The evidence supporting this product's ingredients is mixed and incomplete. L-glutamine is effective for sickle cell disease and possibly effective for HIV/AIDS-related wasting and recovery from surgery or critical illness, but those are medical conditions — not general muscle recovery.

Vitamin B6 is effective for sideblastic anemia and possibly effective for pregnancy-related nausea, not for athletic performance. Sodium's effectiveness is rated for cystic fibrosis and HIV medication side effects, not muscle recovery.

Potassium has no effectiveness ratings on file. For L-leucine, L-isoleucine, L-valine, and citrulline malate, we hold no effectiveness data.

This product may have a role in specific medical situations, but we cannot confirm from our data whether it works for general muscle recovery or athletic performance.

The evidence, ingredient by ingredient Glutamine Vitamin B6 Sodium Potassium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-glutamine is generally well tolerated at typical doses in healthy adults, though it can cause belching, bloating, constipation, diarrhea, flatulence, nausea, and headache — especially at high doses (10–30 grams daily). People with kidney or liver disease should use it only under medical supervision.

Vitamin B6 is well tolerated below 100 mg daily but can cause sensory nerve damage (neuropathy) at high doses over time, particularly above 1,000 mg daily or with cumulative doses of 1 gram or more. Sodium and potassium are well tolerated from diet, but too much sodium is linked to high blood pressure and heart strain, and too much potassium can cause serious heart rhythm problems, especially in people with kidney disease.

Glutamine is likely safe in pregnancy and lactation, but vitamin B6 has no pregnancy/lactation data on file, and sodium is possibly unsafe during lactation.

Side effects, ingredient by ingredient Glutamine Vitamin B6 Sodium Potassium

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Potassium, Glutamine, Vitamin B6, Sodium.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: seizure medications; lithium; Parkinson's medications.
  • For scale: 297 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check this product if you take anticonvulsants (phenytoin, phenobarbital, or others), blood pressure medications (antihypertensives), potassium-sparing diuretics, ACE inhibitors, angiotensin receptor blockers, lithium, amiodarone, or levodopa. These are the medication types with the strongest documented interactions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you're an athlete looking to support muscle recovery, talk to your pharmacist before adding this to your routine — especially if you take medications for blood pressure, heart rhythm, seizures, bipolar disorder, or HIV. The sodium and potassium content matters if you have kidney disease or take certain blood pressure or diuretic drugs.

Otherwise, it's generally well tolerated at typical doses in healthy people without those medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 11 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 18, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about The Original Tropic Thunder, straight from the product label.

Brand XTEND
Barcode (UPC) 812135020682
Net contents 1.26 Kilogram(s); 2.78 Pound(s)
Market status On market
Date entered into DSLD Jul 18, 2023
DSLD ID 292460
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for The Original Tropic Thunder by XTEND, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
14 Gram(s)
Maximum serving Sizes:
14 Gram(s)
Servings per container
90
UPC/BARCODE
812135020682
IngredientAmount% DV
Calories0 Calorie(s)--
Total Carbohydrates0 Gram(s)--
L-Glutamine2500 mg--
Vitamin B6640 mcg32%
Sodium220 mg9%
Potassium220 mg6%
L-Leucine3500 mg--
Potassium Chloride0 NP--
L-Isoleucine1750 mg--
L-Valine1750 mg--
Sodium Chloride0 NP--
Sodium Citrate0 NP--
Sugars0 Gram(s)--
Electrolyte Blend1140 mg--
Citrulline Malate1000 mg--

Other ingredients: Citric Acid, Natural & Artificial flavors, Malic Acid, Sucralose, Acesulfame Potassium, FD&C Yellow #5

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Recommended use: As a dietary supplement, mix each scoop in 10-14 fl. oz. of water (adjust for taste preference) and shake well. On training days, consume 1 scoop during exercise and 1 scoop after exercise. On non-training days, consume 2 scoops throughout the day. For best results, use two scoops per day.

When to take Xtend for best results: Pre Workout Xtend Energy Intra Workout Xtend The Original Post Workout Xtend Pro Combine with any Xtend branded product every day, even on rest days, to help maximize your recovery.

General Statements

Based upon cumulative global sales of all Xtend branded BCAA products from 2004 to present. The world's #1 BCAA brand

This product is sold by weight, not volume. Some settling of powder may occur during shipping and handling, which may affect density of powder. This product contains the servings indicated when measured exactly by weight.

The official recovery brand of champions. Faster recovery is the key to better results. For over 10 years, Xtend has been making the best recovery products in the world.

Brand IP Statement(s)

Xtend is a trademark of Scivation, Inc.

Formulation

Made in the U.S.A. using strategically sourced domestic and imported ingredients and components.

Try all the sugar-free, mouthwatering flavors of Xtend to support your fitness goals.

Muscle recovery + electrolytes

0 calories 0 g carb 0 g sugar Per serving

Seals/Symbols

NSF Contents Tested & Certified Informed-Choice.org Trusted by Sport

Precautions

Warning: This product is only intended for healthy adults, 18 years of age or older.

Do not use if pregnant or nursing. Consult with a licensed, qualified, healthcare professional before taking this or any dietary supplement product, especially if you are taking medication or have a medical condition.

Discontinue 2 weeks prior to surgery. Use only as directed. Do not use if safety seal is broken or missing.

Keep out of reach of children.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula

Powered by 7 grams of branched-chain amino acids (BCAAs), which have been clinically shown to support muscle recovery and growth, Xtend Original also contains hydrating electrolytes and additional performance ingredients to help you refuel, repair, and recover.

7g BCAA Muscle recovery + electrolytes

Tropic thunder Naturally & artificially flavored

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

The Original Tropic Thunder by XTEND label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

The Original Tropic Thunder label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in The Original Tropic Thunder by XTEND

These are the 11 active ingredients this product is made of. Select any to open its full monograph.

Serving size14 Gram(s) Dosage formPowder Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Glutamine

Interacts with
50 drugs
2500 mg per serving

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle c...

L-Glutamine monograph & interactions

Vitamin B6

Interacts with
210 drugs
640 mcg per serving Form: Pyridoxine Hydrochloride

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B6 monograph & interactions

Sodium

Interacts with
205 drugs
220 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Potassium

Interacts with
62 drugs
220 mg per serving

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...

Potassium monograph & interactions

L-Leucine

3500 mg per serving

L-Isoleucine

1750 mg per serving

L-Valine

1750 mg per serving

Electrolyte Blend

1140 mg per serving

Citrulline Malate

1000 mg per serving

Other (inactive) ingredients: Citric Acid, Natural & Artificial flavors, Malic Acid, Sucralose, Acesulfame Potassium, FD&C Yellow #5. These complete the product’s ingredient list but are not active constituents.

Interaction report

The Original Tropic Thunder by XTEND Drug Interactions

Want to check YOUR meds against The Original Tropic Thunder?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
297Drugs
292 Moderate 5 Minor

Ingredients driving the most interactions

Vitamin B6 210
Sodium 205
Potassium 62
L-Glutamine 50

Individual Drug Interactions

The ingredients in The Original Tropic Thunder interact with 297 drugs. Click any drug to see the details.

4 of the 11 ingredients in The Original Tropic Thunder interact with drugs. Each result below shows which ingredient is responsible. Vitamin B6 Sodium Potassium L-Glutamine

Each ingredient & the kinds of drugs it affects

For each ingredient in The Original Tropic Thunder with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin B65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
Vitamin B6 full monograph & interactions

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions

Potassium3 drug types · 62 drugs

Ace Inhibitors (Aceis)

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Angiotensin Receptor Blockers (Arbs)

Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Potassium-Sparing Diuretics

Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.

Likelihood Likely Evidence C
Potassium full monograph & interactions

L-Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
L-Glutamine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for The Original Tropic Thunder, from the product label.

XTEND

See all XTEND products
Name
Nutrabolt
Street Address
3891 S. Traditions Dr.
City
Bryan
State
TX
ZipCode
77807
Phone Number
1.866.996.3489
Web Address
www.scivation.com
Pharmacist Counseling Corner

The Original Tropic Thunder by XTEND: Common Questions

Does The Original Tropic Thunder by XTEND interact with any medications?
Yes. Based on its ingredients, The Original Tropic Thunder has a known interaction with 297 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
The Original Tropic Thunder contains 11 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant or breastfeeding?
L-glutamine is likely safe in pregnancy and lactation. Vitamin B6 has no pregnancy or breastfeeding safety data on file — talk to your doctor or pharmacist before using it during pregnancy or lactation. Sodium is possibly unsafe while breastfeeding. For the other ingredients in this product, we hold no pregnancy or breastfeeding information, so check with your healthcare provider for personalized advice.
What's in the electrolyte blend?
The product lists an electrolyte blend that includes potassium and sodium (from potassium chloride, sodium chloride, and sodium citrate), but we don't have a full ingredient breakdown for the blend itself beyond those components.
Could this cause digestive upset?
Yes. L-glutamine, especially at higher doses, commonly causes belching, bloating, constipation, diarrhea, flatulence, nausea, and gastrointestinal pain. Potassium can cause abdominal pain, belching, diarrhea, flatulence, nausea, and vomiting. Start with the recommended dose and see how you tolerate it.
Is there any caffeine or banned substances in this?
We don't have ingredient or composition data beyond what's listed. Check the label or contact the manufacturer if you need to verify the product for caffeine, banned substances, or specific certifications.
Can I take this if I have kidney disease?
The sodium and especially potassium in this product require caution with kidney disease — high potassium can be dangerous if your kidneys don't excrete it properly. L-glutamine also requires medical supervision in kidney disease. Talk to your doctor or pharmacist before using this product.
What are the amino acids in this for?
L-glutamine, L-leucine, L-isoleucine, and L-valine are amino acids involved in muscle protein metabolism and recovery. L-glutamine is effective for sickle cell disease and possibly effective for recovery from surgery and critical illness. The others don't have effectiveness ratings on file for athletic recovery — the evidence isn't established in our data.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

The Original Tropic Thunder label
Go deeper

The Full Monographs Behind The Original Tropic Thunder’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glutamine

Interacts with 50 drugs

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...

Read the full Glutamine monograph → Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph → Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Potassium

Interacts with 62 drugs

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...

Read the full Potassium monograph →
Sources

Sources & How We Checked

The Original Tropic Thunder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 93 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

Vitamin B6 32 references
  1. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Geerling BJ, Dagnelie PC, Badart-Smook A, et al. Diet as a risk factor for the development of ulcerative colitis. Am J Gastroenterol 2000;95:1008-13. PubMed
  4. South M. Neonatal seizures after pyridoxine use -- reply. Lancet 1999;354:2083. PubMed
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  6. Baxter P, Aicardi J. Neonatal seizures after pyridoxine use. Lancet 1999;354:2082-3. PubMed
  7. Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
  8. Schaumburg H, Kaplan J, Windebank A. Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. N Engl J Med 1983;309:445-8. PubMed
  9. Gordon N. Pyridoxine dependency: an update. Dev Med Child Neurol 1997;39:63-5. PubMed
  10. Lewis PJ. Pain in the hand and wrist. Pyridoxine supplements may help patients with carpal tunnel syndrome. BMJ 1995;310:1534. PubMed
  11. Kaufman G. Pyridoxine against amiodarone-induced photosensitivity (letter). Lancet 1984;1:51-2. PubMed
  12. Mulrow JP, Mulrow CD, McKenna WJ. Pyridoxine and amiodarone-induced photosensitivity. Ann Intern Med 1985;103:68-9. PubMed
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Sodium 38 references
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See these in context on the Sodium monograph →

Potassium 12 references
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  2. Gennaro A. Remington: The Science and Practice of Pharmacy. 19th ed. Lippincott: Williams & Wilkins, 1996.
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See these in context on the Potassium monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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