Interactions on record — worth a quick check against your medications. Based on 1 of 5 ingredients. Check your meds →
Dietary supplement

TruFlora Ingredients & Drug Interactions

by Master Supplements

TruFlora label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking TruFlora against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

TruFlora is a dietary supplement by Master Supplements with 5 active ingredients. Its ingredients are commonly taken for constipation, irritable bowel syndrome (ibs), diarrhea.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bacillus coagulans IS-2. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against TruFlora by Master Supplements

Ask about any prescription or over-the-counter medication and we check it for interactions with TruFlora by Master Supplements — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of TruFlora by Master Supplements

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 2 of its 5 active ingredients.
  • “Proprietary Probiotic Blend” is a proprietary blend — the label gives one combined amount (96.79 mg) without saying how much of each component you get.

TruFlora contains 5 active ingredients: a proprietary probiotic blend that includes Bacillus coagulans IS-2, Lactobacillus salivarius LS-33, and Lactobacillus plantarum LP-115 — all live beneficial bacteria — plus two enzymes, Beta-Glucanase and Hemicellulase, that help break down plant and grain fibers in your digestive tract. The capsule also holds several inactive ingredients: cellulose, microcrystalline cellulose (bulking agents), tapioca dextrin, sodium alginate, magnesium stearate, trisodium phosphate, maltodextrin, silicon dioxide, ascorbic acid, LactoStim, and calcium silicate.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: digestive and immune health support.
  • We looked for evidence on: Antibiotic-associated diarrhea, Clostridioides difficile infection, Constipation, Diarrhea, Dyspepsia, Flatulence — and 4 related terms.
  • The strongest evidence on file: Bacillus Coagulans is rated "Possibly Effective" for Constipation (Natural Medicines).
  • Also on file: Bacillus Coagulans is rated "Possibly Effective" for Irritable bowel syndrome (IBS).
  • Also on file: Bacillus Coagulans is rated "Insufficient Reliable Evidence To Rate" for Antibiotic-associated diarrhea, Inflammatory bowel disease (IBD), Diarrhea, Dyspepsia, and more.

Bacillus coagulans IS-2 is possibly effective for constipation and irritable bowel syndrome (IBS) — meaning there's some decent evidence it may help, but it's not conclusive. For antibiotic-associated diarrhea, athletic performance, cancer, and nonalcoholic fatty liver disease, the evidence is too thin or unreliable right now to say whether it works.

We don't have effectiveness data on file for the other probiotic and enzyme ingredients in this formula.

The evidence, ingredient by ingredient Bacillus Coagulans

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bacillus coagulans is generally well tolerated in healthy adults, though the evidence and product quality across probiotic brands vary. There's not enough reliable safety data overall, so talk to your doctor before using this product.

One concern: because probiotics contain live organisms, there's a theoretical risk they could cause infection in people with severely weakened immune systems, central lines (medical catheters), or very serious illness — including premature infants. Rare cases of bloodstream infection (bacteremia) and serious infection (sepsis) have been reported in those groups.

If you're in a high-risk category, check with your doctor or pharmacist first.

Side effects, ingredient by ingredient Bacillus Coagulans

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Bacillus Coagulans.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take TruFlora, check with us if you're on antibiotics. These are the main drugs we have documented interaction data for — taking them with this product may reduce how well the probiotic works.

If you take any other medications, run them through the checker on this page to be sure.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

TruFlora may help with constipation or IBS symptoms if you're generally healthy. The key thing to watch: don't take it at the same time as antibiotics, since they'll kill the live bacteria in the formula.

If you're immunocompromised, have a central line, or are very ill, talk to your pharmacist before starting it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about TruFlora, straight from the product label.

Brand Master Supplements
Barcode (UPC) 804879146230
Net contents 32 Capsule(s)
Market status On market
Date entered into DSLD Aug 22, 2025
DSLD ID 336273
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for TruFlora by Master Supplements, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
32
UPC/BARCODE
804879146230
IngredientAmount% DV
Proprietary Probiotic Blend96.79 mg--
Lactobacillus salivarius LS-330 NP--
Lactobacillus plantarum LP-1150 NP--
Beta-Glucanase73 mg--
Hemicellulase27 mg--
Bacillus coagulans IS-20 NP--

Other ingredients: Cellulose, Water, Tapioca Dextrin, Microcrystalline Cellulose, Sodium Alginate, Magnesium Stearate, Trisodium Phosphate, Maltodextrin, Silicon Dioxide, Ascorbic Acid, LactoStim, Calcium Silicate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Take 1 capsule daily. Take 2 capsules a day for additional digestive support. TruFlora can be taken with antibiotics; separate by 2 hours.

Formula

TruFlora is a high potency probiotic supplement containing 15 billion live CFU and 2 enzymes that work primarily in the small intestine to support digestive and immune health. CFU= Colony Forming Units

3 Probiotics 2 Enzymes

Precautions

Warning: If you are pregnant, nursing, on medication or have any medical condition consult a health care professional before using this product.

Discontinue use and consult a doctor if any adverse reaction occurs.

Keep out of reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

100% Money Back Guarantee

Vegan

GMO Free

Supports Regularity Bio-Cleansing Probiotic Patented Prebiotic Deep Delivery

Contains No: Eggs, Milk, Wheat, Soy, Casein, Nuts or Seafood Products.

Each batch is laboratory tested to meet strict quality control standards; guaranteed at time of expiration when kept refrigerated.

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Patented Prebiotic

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

TruFlora by Master Supplements label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

TruFlora label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in TruFlora by Master Supplements

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container32 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Probiotic Blend

96.79 mg per serving

Beta-Glucanase

73 mg per serving

Hemicellulase

27 mg per serving

Other (inactive) ingredients: Cellulose, Water, Tapioca Dextrin, Microcrystalline Cellulose, Sodium Alginate, Magnesium Stearate, Trisodium Phosphate, Maltodextrin, Silicon Dioxide, Ascorbic Acid, LactoStim, Calcium Silicate. These complete the product’s ingredient list but are not active constituents.

Interaction report

TruFlora by Master Supplements Drug Interactions

Want to check YOUR meds against TruFlora?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Bacillus coagulans IS-2 182

Individual Drug Interactions

The ingredients in TruFlora interact with 182 drugs. Click any drug to see the details.

1 of the 5 ingredients in TruFlora interact with drugs. Each result below shows which ingredient is responsible. Bacillus coagulans IS-2

Each ingredient & the kinds of drugs it affects

For each ingredient in TruFlora with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Bacillus coagulans IS-21 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B. coagulans.
B. coagulans preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. coagulans preparations by at least two hours.

Likelihood Probable Evidence D
Bacillus coagulans IS-2 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for TruFlora, from the product label.

Master Supplements

See all Master Supplements products
Name
Master Supplements, Inc.
City
Victoria
State
MN
ZipCode
55386
Phone Number
800 926-2961
Web Address
master-supplements.com
Pharmacist Counseling Corner

TruFlora by Master Supplements: Common Questions

Does TruFlora by Master Supplements interact with any medications?
Yes. Based on its ingredients, TruFlora has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
TruFlora contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this probiotic work if I'm on an antibiotic?
It may not work as well. Antibiotics kill bacteria — including the beneficial live organisms in TruFlora. Space out your antibiotic dose and this product by a few hours if you can, and ask your pharmacist for the best timing.
What's Bacillus coagulans, and why is it in this product?
It's a type of beneficial bacteria (a spore-forming Bacillus) included because it's possibly effective for constipation and IBS. The other probiotic strains and enzymes are meant to support digestive health overall.
Is TruFlora safe if I have a weakened immune system?
We don't have enough safety data for people with compromised immunity. Because the product contains live organisms, there's a small theoretical risk of infection in those cases. Check with your doctor or pharmacist first if that applies to you.
Can I take this while pregnant or breastfeeding?
The facts we have don't include safety information for pregnancy or lactation. Talk to your doctor or pharmacist before using TruFlora during pregnancy or while breastfeeding.
Does this product have a lot of fillers?
It contains a number of inactive ingredients like cellulose, tapioca dextrin, and silicon dioxide that help form the capsule and keep it stable. These are standard for probiotic supplements.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if TruFlora is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

TruFlora label
Go deeper

The Full Monographs Behind TruFlora’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bacillus Coagulans

Interacts with 182 drugs

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, and certain types of diarrhea. The eviden...

Read the full Bacillus Coagulans monograph →
Sources

Sources & How We Checked

TruFlora's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 20 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bacillus Coagulans 20 references
  1. Saxelin M, Chuang NH, Chassy B, et al. Lactobacilli and bacteremia in southern Finland 1989-1992. Clin Infect Dis 1996;22:564-6. PubMed
  2. Tynkkynen S, Singh KV, Varmanen P. Vancomycin resistance factor of Lactobacillus rhamnosus GG in relation to enterococcal vancomycin resistance (van) genes. Int J Food Microbiol 1998;41:195-204. PubMed
  3. Klein G, Zill E, Schindler R, et al. Peritonitis associated with vancomycin-resistant Lactobacillus rhamnosus in a continuous ambulatory peritoneal dialysis patient; organism identification, antibiotic therapy, and case report. J Clin Microbiol 1998;36:
  4. Kalima P, Masterton RG, Roddie PH, et al. Lactobacillus rhamnosus infection in a child following bone marrow transplant. J Infect 1996;32:165-7. PubMed
  5. Goldin BR. Health Benefits of probiotics. Br J Nutr 1998;80:S203-7. DOI
  6. Rautio M, Jousimies-Somer H, Kauma H, et al. Liver abscess due to Lactobacillus rhamnosus strain indistinguishable from L. rhamnosus strain GG. Clin Infect Dis 1999;28:1159-60.
  7. MacGregor G, Smith AJ, Thakker B, Kinsella J. Yoghurt biotherapy: contraindicated in immunosuppressed patients? Postgrad Med J 2002;78:366-7. PubMed
  8. Land MH, Rouster-Stevens K, Woods CR, et al. Lactobacillus sepsis associated with probiotic therapy. Pediatrics 2005;115:178-81.
  9. De Groote MA, Frank DN, Dowell E, et al. Lactobacillus rhamnosus GG bacteremia associated with probiotic use in a child with short gut syndrome. Pediatr Infect Dis J 2005;24:278-80. PubMed
  10. Vahabnezhad E, Mochon AB, Wozniak LJ, Ziring DA. Lactobacillus bacteremia associated with probiotic use in a pediatric patient with ulcerative colitis. J Clin Gastroenterol. 2013;47(5):437-9. PubMed
  11. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  12. Sendil S, Shrimanker I, Mansoora Q, Goldman J, Nookala VK. Lactobacillus rhamnosus bacteremia in an immunocompromised renal transplant patient. Cureus. 2020;12(2):e6887. PubMed
  13. Albarillo FS, Shah U, Joyce C, Slade D. Lactobacillus rhamnosus Infection: A single-center 4-year descriptive analysis. J Glob Infect Dis. 2020;12(3):119-123. PubMed
  14. Pasala S, Singer L, Arshad T, Roach K. Lactobacillus endocarditis in a healthy patient with probiotic use. IDCases. 2020;22:e00915. PubMed
  15. Agrawal S, Tuchman ES, Bruce MJ, Theodorou ME. Fatal Lactobacillus endocarditis in a patient with transcatheter aortic valve replacement. BMJ Case Rep. 2020;13(11):e236835.
  16. Antoun M, Hattab Y, Akhrass FA, Hamilton LD. Uncommon pathogen, Lactobacillus, causing infective endocarditis: Case report and review. Case Rep Infect Dis. 2020;2020:8833948. PubMed
  17. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  18. Franko B, Vaillant M, Recule C, Vautrin E, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics. Med Mal Infect. 2013;43(4):171-3. PubMed
  19. Campbell RE, Miller A, Afroze A. Native valve endocarditis secondary to Lactobacillus paracasei bacteremia. Consultant. 2020;60(9):27-8. DOI
  20. Kato K, Funabashi N, Takaoka H, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics with advanced and severe bicuspid aortic valve stenosis complicated with diffuse left ventricular mid-layer fibrosis. Int J Cardiol. 2016;224:157-161. PubMed

See these in context on the Bacillus Coagulans monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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