Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Three Imperial Mushrooms Ingredients & Drug Interactions

by Sun Ten

Three Imperial Mushrooms label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Three Imperial Mushrooms against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Three Imperial Mushrooms is a dietary supplement by Sun Ten with 5 active ingredients. Its ingredients are commonly taken for stress and energy support, immune support and colds, blood sugar management.Based on those ingredients, 661 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Reishi mushroom 10:1 extract, Shitake mushroom 10:1 extract, Beta 1,3 Glucan. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Three Imperial Mushrooms by Sun Ten

Ask about any prescription or over-the-counter medication and we check it for interactions with Three Imperial Mushrooms by Sun Ten — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Three Imperial Mushrooms by Sun Ten

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Three Imperial Mushrooms contains five active ingredients: American ginseng root 4:1 extract, reishi mushroom 10:1 extract, maitake mushroom 8:1 extract, shiitake mushroom 10:1 extract, and beta-1,3 glucan. The product also includes inactive ingredients — gelatin capsule, microcrystalline cellulose, and magnesium stearate — which serve as binders and fillers.

These extracts are concentrated forms of the whole mushroom or plant material (the numbers like 4:1 or 10:1 mean the starting weight was reduced to make a stronger powder). Each ingredient plays a different role in traditional use and modern supplement formulations.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Coronary heart disease (CHD) — rated "Likely Effective" (Beta-glucans) (Natural Medicines).
  • On file: Dyslipidemia — rated "Likely Effective" (Beta-glucans) (Natural Medicines).
  • On file: Upper respiratory tract infection (URTI) — rated "Possibly Effective" (American Ginseng) (Natural Medicines).

Evidence for this product's ingredients is mixed. American ginseng is possibly effective for upper respiratory tract infections, though evidence for anemia of chronic disease and breast cancer is too limited to rate.

Reishi mushroom appears possibly ineffective for high cholesterol (hyperlipidemia), and evidence for altitude sickness, Alzheimer disease, and athletic performance is insufficient. Maitake mushroom has insufficient evidence for hay fever, chemotherapy-related anemia and diarrhea, and chronic fatigue syndrome.

Shiitake mushroom is possibly ineffective for dental plaque and has insufficient evidence for chemotherapy-related anemia, atherosclerosis, breast cancer, and cancer. Beta-glucan, however, is likely effective for high cholesterol and heart disease.

If you're considering this blend for a specific condition, check whether that condition matches what the evidence actually supports. The facts we hold don't establish strong effectiveness for most of the conditions these ingredients are marketed for.

The evidence, ingredient by ingredient American Ginseng Reishi Mushroom Maitake Mushroom Shiitake Mushroom Beta-glucans

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

American ginseng is generally well tolerated in the short term in healthy adults, though long-term safety isn't well studied. It should be avoided during pregnancy — the data raises safety concerns — and during breastfeeding, where too little is known.

The most common adverse effect reported is headache. Reishi mushroom is generally well tolerated short-term, but long-term safety hasn't been fully studied, and it should be avoided in pregnancy and while breastfeeding due to lack of safety data.

Common side effects include dizziness, dry mouth, itching, nausea, rash, and stomach upset; respiratory allergy to reishi spores can occur. Maitake mushroom is generally well tolerated as food, but concentrated supplement safety hasn't been fully studied, and it should be avoided in pregnancy and breastfeeding due to insufficient data.

The most common adverse effects are gastrointestinal — diarrhea and stomach pain. Shiitake mushroom is generally well tolerated when cooked as food, though concentrated supplements should be avoided during pregnancy and breastfeeding due to lack of data.

Adverse effects include stomach discomfort, bloating, diarrhea, nausea, and vomiting; raw shiitake can cause shiitake dermatitis. Beta-glucan from food sources is generally well tolerated, though concentrated supplements lack long-term safety data and caution is advised while breastfeeding.

Skin reactions and contact dermatitis can occur with topical application.

Side effects, ingredient by ingredient American Ginseng Reishi Mushroom Maitake Mushroom Shiitake Mushroom Beta-glucans

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Maitake Mushroom, Shiitake Mushroom, Reishi Mushroom, American Ginseng, Beta-glucans.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 661 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Three Imperial Mushrooms, check with your doctor or pharmacist if you take warfarin or another blood thinner — American ginseng and maitake may reduce warfarin's effectiveness or increase its effect unpredictably. Also double-check if you're on blood pressure drugs (American ginseng, reishi, maitake, and beta-glucan may lower blood pressure further), diabetes medications (American ginseng, reishi, and maitake may increase low blood sugar risk), immunosuppressants (American ginseng, shiitake, and beta-glucan may interfere), antiplatelet drugs like aspirin (reishi may increase bleeding risk), an MAOI antidepressant (American ginseng may theoretically interfere), or any drug broken down by the liver enzyme CYP2D6 (shiitake may theoretically reduce levels).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Major medication interactions have been identified, and safety information is well characterized.

This product combines mushroom extracts and ginseng with some evidence for heart health and upper respiratory support, but also carries documented interactions — especially with warfarin and blood pressure or diabetes medications. If you're on any prescription drug, particularly blood thinners, blood pressure meds, diabetes drugs, or immunosuppressants, talk with your doctor or pharmacist before starting.

Pregnancy and breastfeeding are not appropriate times to take this product due to insufficient safety data.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Three Imperial Mushrooms, straight from the product label.

Brand Sun Ten
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Mar 24, 2016
DSLD ID 57993
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Three Imperial Mushrooms by Sun Ten, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
IngredientAmount% DV
American Ginseng root 4:1 extract75 mg--
Reishi mushroom 10:1 extract200 mg--
Maitake mushroom 8:1 extract100 mg--
Shitake mushroom 10:1 extract100 mg--
Beta 1,3 Glucan20 mg--

Other ingredients: Gelatin Capsule, Microcrystalline Cellulose, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General

V-3 5073001

Suggested/Recommended/Usage/Directions

DIRECTIONS: Take 1 capsule daily with warm water or as directed by your health care professional.

Precautions

CAUTION: If pregnant or nursing a baby, or taking medication, consult your health care professional before using this or any dietary supplement.

Keep out of reach of children.

Storage

STORAGE: Keep tightly closed in a cool, dry place.

Formulation

GUARANTEE: This product does not have any added sugar, salt, yeast, wheat, animal or dairy products, preservatives, colors or flavors.

Seals/Symbols

GMP Certified

General Statements

Healthy & Natural

FDA Statement of Identity

Dietary Supplement

Formula

San Zhi Pian

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Three Imperial Mushrooms by Sun Ten label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Three Imperial Mushrooms label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Three Imperial Mushrooms by Sun Ten

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

American Ginseng root 4:1 extract

Interacts with
217 drugs
75 mg per serving

American ginseng is an herbal root used as an 'adaptogen' to support energy, stress, immune function, and blood sugar. Some uses—such as reducing the...

American Ginseng root 4:1 extract monograph & interactions

Reishi mushroom 10:1 extract

Interacts with
375 drugs
200 mg per serving

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits...

Reishi mushroom 10:1 extract monograph & interactions

Maitake mushroom 8:1 extract

Interacts with
260 drugs
100 mg per serving

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and bl...

Maitake mushroom 8:1 extract monograph & interactions

Shitake mushroom 10:1 extract

Interacts with
312 drugs
100 mg per serving

Shiitake is a popular edible mushroom that is nutritious and safe to eat as food for most people. Some of its extracts (like lentinan and AHCC) have b...

Shitake mushroom 10:1 extract monograph & interactions

Beta 1,3 Glucan

Interacts with
293 drugs
20 mg per serving

Beta-glucans are natural fibers found in oats, barley, mushrooms, and yeast. The strongest evidence supports the oat and barley types for modestly low...

Beta 1,3 Glucan monograph & interactions

Other (inactive) ingredients: Gelatin Capsule, Microcrystalline Cellulose, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Three Imperial Mushrooms by Sun Ten Drug Interactions

Want to check YOUR meds against Three Imperial Mushrooms?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
661Drugs
2 Major 659 Moderate

Ingredients driving the most interactions

Reishi mushroom 10:1 extract 375
Shitake mushroom 10:1 extract 312
Beta 1,3 Glucan 293
Maitake mushroom 8:1 extract 260
American Ginseng root 4:1 extract 217

Individual Drug Interactions

The ingredients in Three Imperial Mushrooms interact with 661 drugs. Click any drug to see the details.

5 of the 5 ingredients in Three Imperial Mushrooms interact with drugs. Each result below shows which ingredient is responsible. Reishi mushroom 10:1 extract Shitake mushroom 10:1 extract Beta 1,3 Glucan Maitake mushroom 8:1 extract American Ginseng root 4:1 extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Three Imperial Mushrooms with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Reishi mushroom 10:1 extract3 drug types · 375 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
A dose of 1.5 grams daily of reishi mushroom does not seem to decrease platelet aggregation, but a higher dose of 3 grams daily does.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Animal research suggests that reishi mushroom decreases blood sugar. However, in patients with type 2 diabetes, taking reishi mushroom does not reduce fasting glucose levels, and its effects on glycated hemoglobin are inconsistent.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Reishi mushroom has shown hypotensive activity in animal research. Clinical evidence suggests that reishi mushroom reduces blood pressure in some, but not all, patients with hypertension.

Likelihood Possible Evidence D
Reishi mushroom 10:1 extract full monograph & interactions

Shitake mushroom 10:1 extract2 drug types · 312 drugs

Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.
In vitro studies suggest that the shiitake mushroom extract AHCC might induce the CYP2D6 enzyme. This effect has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, taking shiitake mushroom might decrease the effects of immunosuppressive therapy.
In vitro evidence suggests that shiitake mushroom extracts stimulate immune function.

Likelihood Possible Evidence D
Shitake mushroom 10:1 extract full monograph & interactions

Beta 1,3 Glucan2 drug types · 293 drugs

Antihypertensive Drugs

Theoretically, taking beta-glucans with antihypertensive drugs might increase the risk of hypotension.
Clinical research shows that taking beta-glucans may reduce systolic and diastolic blood pressure in some hypertensive individuals.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, beta-glucans might interfere with immunosuppressive therapy.
Some clinical research shows that beta-glucans have immunostimulant effects.

Likelihood Possible Evidence D
Beta 1,3 Glucan full monograph & interactions

Maitake mushroom 8:1 extract3 drug types · 260 drugs

Antidiabetes Drugs

Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that taking maitake mushroom polysaccharide (MMP) can lower blood glucose levels in patients with types 2 diabetes.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that maitake mushroom can lower blood pressure.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is limited evidence that maitake mushroom may increase the anticoagulant effects of warfarin.
In a case report, a patient previously stabilized on warfarin developed an elevated international normalized ratio (INR) of 5.1 after taking maitake mushroom (Grifron-Pro Maitake D-Fraction) 1 drop/kg daily in three divided doses for one week. The elevated INR resolved after holding warfarin for two days, then reducing the dose by 11%. It is thought that the beta-glucan constituent of maitake mushroom might cause warfarin dissociation from proteins, resulting in increased free warfarin levels and increased warfarin effects.

Likelihood Possible Evidence D
Maitake mushroom 8:1 extract full monograph & interactions

American Ginseng root 4:1 extract4 drug types · 217 drugs

Warfarin (Coumadin)

American ginseng seems to decrease the effectiveness of warfarin therapy.
Healthy patients receiving warfarin 5 mg daily, who also take American ginseng 1 gram twice daily, seem to have a significantly reduced international normalized ratio (INR).

Likelihood Likely Evidence B
Antidiabetes Drugs

Theoretically, taking American ginseng with antidiabetes drugs might increase the risk of hypoglycemia.
American ginseng seems to lower postprandial blood glucose. Theoretically, concomitant use with antidiabetes drugs might enhance blood glucose lowering effects and possibly cause hypoglycemia.

Likelihood Probable Evidence B
Immunosuppressants

Theoretically, American ginseng use might interfere with immunosuppressive therapy.
American ginseng seems to stimulate immune function. Theoretically, American ginseng might decrease the effectiveness of immunosuppressant drugs.

Likelihood Possible Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, American ginseng can interfere with MAOI therapy.
There is one case report of insomnia, headache, and tremors when an unspecified ginseng product was used with phenelzine (Nardil), an MAOI. There is also one case report of hypomania when an unspecified ginseng product was used with phenelzine. Theoretically, American ginseng may interfere with MAOI therapy.

Likelihood Possible Evidence D
American Ginseng root 4:1 extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Three Imperial Mushrooms, from the product label.

Sun Ten

See all Sun Ten products
Name
Sun Ten Laboratories
Street Address
9250 Jeronimo Rd,
City
Irvine
State
CA
ZipCode
92618
Pharmacist Counseling Corner

Three Imperial Mushrooms by Sun Ten: Common Questions

Does Three Imperial Mushrooms by Sun Ten interact with any medications?
Yes. Based on its ingredients, Three Imperial Mushrooms has a known interaction with 661 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Three Imperial Mushrooms contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
No. American ginseng is rated possibly unsafe in pregnancy based on lab research, and reishi, maitake, and shiitake all have too little safety data — the information we hold advises against use during pregnancy and breastfeeding. Talk with your doctor before taking this product if you're planning pregnancy, pregnant, or nursing.
What is beta-glucan, and why is it in here?
Beta-glucan is a type of fiber found in mushrooms, oats, and yeast. It's in this blend likely because it's been shown to help with cholesterol and heart health — it's the only ingredient here with strong evidence (likely effective) for those uses.
Does American ginseng really help with colds?
The data says American ginseng is possibly effective for upper respiratory tract infections — so there's some evidence, but it's not definite. Whether it will work for you individually depends on your specific illness and other factors.
What side effects might I get from this?
The most common ones reported are headache (from ginseng), dizziness and stomach upset (from reishi), diarrhea and stomach pain (from maitake), and nausea or stomach discomfort (from shiitake). Raw or poorly cooked shiitake can cause a rare skin rash called shiitake dermatitis.
Is this safe to take long-term?
The data doesn't support long-term safety — manufacturers note that long-term use hasn't been well studied for ginseng, reishi, maitake, and shiitake. If you're thinking of taking this regularly, talk it over with your doctor or pharmacist.
Can I take this with my blood pressure medication?
That depends on which blood pressure drug you take and the dose of this product. Four of the five ingredients here may lower blood pressure further, which could be unsafe. Check with your doctor or pharmacist before combining them.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Three Imperial Mushrooms label
Go deeper

The Full Monographs Behind Three Imperial Mushrooms’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

American Ginseng

Interacts with 217 drugs

American ginseng is an herbal root used as an 'adaptogen' to support energy, stress, immune function, and blood sugar. Some uses—such as reducing the chance or length of colds and modestly l...

Read the full American Ginseng monograph → Herb & supplement monograph

Reishi Mushroom

Interacts with 375 drugs

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits is limited or low-quality, so it should...

Read the full Reishi Mushroom monograph → Herb & supplement monograph

Maitake Mushroom

Interacts with 260 drugs

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and blood pressure effects. The human evidence...

Read the full Maitake Mushroom monograph → Herb & supplement monograph

Shiitake Mushroom

Interacts with 312 drugs

Shiitake is a popular edible mushroom that is nutritious and safe to eat as food for most people. Some of its extracts (like lentinan and AHCC) have been studied as immune support, mainly al...

Read the full Shiitake Mushroom monograph → Herb & supplement monograph

Beta-glucans

Interacts with 293 drugs

Beta-glucans are natural fibers found in oats, barley, mushrooms, and yeast. The strongest evidence supports the oat and barley types for modestly lowering cholesterol and blood sugar, while...

Read the full Beta-glucans monograph →
Sources

Sources & How We Checked

Three Imperial Mushrooms's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 115 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

American Ginseng 12 references
  1. Shader RI, Greenblatt DJ. Phenelzine and the dream machine-ramblings and reflections. J Clin Psychopharmacol 1985;5:65. PubMed
  2. Jones BD, Runikis AM. Interaction of ginseng with phenelzine. J Clin Psychopharmacol 1987;7:201-2. PubMed
  3. Janetzky K, Morreale AP. Probable interaction between warfarin and ginseng. Am J Health Syst Pharm 1997;54:692-3. PubMed
  4. Vuksan V, Sievenpiper JL, Koo VY, et al. American ginseng (Panax quinquefolius L) reduces postprandial glycemia in nondiabetic subjects and subjects with type 2 diabetes mellitus. Arch Intern Med 2000;160:1009-13. PubMed
  5. Vuksan V, Stavro MP, Sievenpiper JL, et al. Similar postprandial glycemic reductions with escalation of dose and administration time of American ginseng in type 2 diabetes. Diabetes Care 2000;23:1221-6. PubMed
  6. Chan LY, Chiu PY, Lau TK. An in-vitro study of ginsenoside Rb(1)-induced teratogenicity using a whole rat embryo culture model. Hum Reprod 2003;18:2166-8..
  7. McElhaney JE, Gravenstein S, Cole SK, et al. A Placebo-Controlled Trial of a Proprietary Extract of North American Ginseng (CVT-E002) to Prevent Acute Respiratory Illness in Institutionalized Older Adults. J Am Geriatr Soc 2004;52:13-9. PubMed
  8. Yuan CS, Wei G, Dey L, et al. American ginseng reduces warfarin's effect in healthy patients: a randomized, controlled trial. Ann Intern Med 2004;141:23-7.
  9. Predy GN, Goel V, Lovlin R, et al. Efficacy of an extract of North American ginseng containing poly-furanosyl-pyranosyl-saccharides for preventing upper respiratory tract infections: a randomized controlled trial. CMAJ 2005;173:1043-8.. PubMed
  10. McElhaney JE, Goel V, Toane B, et al. Efficacy of COLD-fX in the prevention of respiratory symptoms in community-dwelling adults: a randomized, double-blinded, placebo controlled trial. J Altern Complement Med 2006;12:153-7. PubMed
  11. Predy GN, Goel V, Lovlin RE, et al. Immune modulating effects of daily supplementation of COLD-fX (a proprietary extract of North American ginseng) in healthy adults. J Clin Biochem Nutr 2006;39:162-167. DOI
  12. Stavro PM, Woo M, Leiter LA, et al. Long-term intake of North American ginseng has no effect on 24-hour blood pressure and renal function. Hypertension 2006;47(4):791-6. PubMed

See these in context on the American Ginseng monograph →

Reishi Mushroom 17 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Tao J, Feng KY. Experimental and clinical studies on inhibitory effect of ganoderma lucidum on platelet aggregation. J Tongji Med Univ 1990;10:240-3. PubMed
  3. Singh AB, Gupta SK, Pereira BM, Prakash D. Sensitization to Ganoderma lucidum in patients with respiratory allergy in India. Clin Exp Allergy 1995;25:440-7.
  4. Lee SY, Rhee HM. Cardiovascular effects of mycelium extract of Ganoderma lucidum: inhibition of sympathetic outflow as a mechanism of its hypotensive action. Chem Pharm Bull (Tokyo) 1990;38:1359-64. PubMed
  5. Kwok Y, Ng KFJ, Li, CCF, et al. A prospective, randomized, double-blind, placebo-controlled study of the platelet and global hemostatic effects of Ganoderma lucidum (Ling-Zhi) in healthy volunteers. Anesth Analg 2005;101:423-6. PubMed
  6. Wanmuang, H., Leopairut, J., Kositchaiwat, C., Wananukul, W., and Bunyaratvej, S. Fatal fulminant hepatitis associated with Ganoderma lucidum (Lingzhi) mushroom powder. J Med Assoc Thai. 2007;90(1):179-181.
  7. Seto, S. W., Lam, T. Y., Tam, H. L., Au, A. L., Chan, S. W., Wu, J. H., Yu, P. H., Leung, G. P., Ngai, S. M., Yeung, J. H., Leung, P. S., Lee, S. M., and Kwan, Y. W. Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db
  8. Chu, T. T., Benzie, I. F., Lam, C. W., Fok, B. S., Lee, K. K., and Tomlinson, B. Study of potential cardioprotective effects of Ganoderma lucidum (Lingzhi): results of a controlled human intervention trial. Br.J.Nutr. 2012;107(7):1017-1027.
  9. Jin, X., Ruiz, Beguerie J., Sze, D. M., and Chan, G. C. Ganoderma lucidum (Reishi mushroom) for cancer treatment. Cochrane.Database.Syst.Rev. 2012;6:CD007731.
  10. Kabir, Y., Kimura, S., and Tamura, T. Dietary effect of Ganoderma lucidum mushroom on blood pressure and lipid levels in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol.(Tokyo) 1988;34(4):433-438. PubMed
  11. Kanmatsuse, K., Kajiwara, N., Hayashi, K., Shimogaichi, S., Fukinbara, I., Ishikawa, H., and Tamura, T. [Studies on Ganoderma lucidum. I. Efficacy against hypertension and side effects]. Yakugaku Zasshi 1985;105(10):942-947. PubMed
  12. Gao, Y., Lan, J., Dai, X., Ye, J., and Zhou, S. A Phase I/II Study of Ling Zhi Mushroom Ganoderma lucidum(W.Curt: Fr.) Lloyd (Aphyllophoromycetideae) Extract in Patients with Type II Diabetes Mellitus. International Journal of Medicinal Mushrooms 2004;6. DOI
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Maitake Mushroom 8 references
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Shiitake Mushroom 67 references
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Beta-glucans 11 references
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